BRPI0719543A2 - Combinação de inibidores de iap e inibidores de flt3 - Google Patents
Combinação de inibidores de iap e inibidores de flt3 Download PDFInfo
- Publication number
- BRPI0719543A2 BRPI0719543A2 BRPI0719543-5A BRPI0719543A BRPI0719543A2 BR PI0719543 A2 BRPI0719543 A2 BR PI0719543A2 BR PI0719543 A BRPI0719543 A BR PI0719543A BR PI0719543 A2 BRPI0719543 A2 BR PI0719543A2
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- aryl
- substituted
- cycloalkyl
- het
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title abstract description 38
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 title description 28
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 title description 28
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 23
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- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US60/891,088 | 2007-02-22 | ||
| PCT/US2007/085579 WO2008067280A2 (en) | 2006-11-28 | 2007-11-27 | Combination of iap inhibitors and flt3 inhibitors |
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| US7772177B2 (en) | 2005-05-18 | 2010-08-10 | Aegera Therapeutics, Inc. | BIR domain binding compounds |
| WO2007048224A1 (en) | 2005-10-25 | 2007-05-03 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物 |
| AU2007250443B2 (en) | 2006-05-16 | 2013-06-13 | Pharmascience Inc. | IAP BIR domain binding compounds |
| US20100056495A1 (en) * | 2006-07-24 | 2010-03-04 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US9750729B2 (en) * | 2008-05-16 | 2017-09-05 | Dana-Farber Cancer Institute, Inc. | Immunomodulation by IAP inhibitors |
| US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
| WO2011098904A1 (en) | 2010-02-12 | 2011-08-18 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| CA2850330A1 (en) | 2011-09-30 | 2013-04-04 | Tetralogic Pharmaceuticals Corporation | Smac mimetic (birinapant) for use in the treatment of proliferative diseases (cancer) |
| CN105451726B (zh) | 2013-06-25 | 2021-03-16 | 沃尔特和伊利莎豪医学研究所 | 治疗细胞内感染的方法 |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| PH12021551985A1 (en) | 2019-02-22 | 2022-08-22 | Hanmi Pharmaceutical Co Ltd | Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia |
| KR20200102948A (ko) | 2019-02-22 | 2020-09-01 | 한미약품 주식회사 | Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물 |
| EA202191984A1 (ru) | 2019-02-22 | 2021-11-19 | Ханми Фарм. Ко., Лтд. | Фармацевтическая композиция, содержащая ингибитор flt3 и гипометилирующий агент, для лечения острого миелолейкоза |
| AU2020256166A1 (en) | 2019-04-02 | 2021-10-14 | Aligos Therapeutics, Inc. | Compounds targeting PRMT5 |
| EA202290154A1 (ru) | 2019-06-27 | 2022-03-29 | Ханми Фарм. Ко., Лтд. | Фармацевтическая композиция для лечения острого миелоидного лейкоза, содержащая ингибитор flt3 и химиотерапевтические агенты |
| WO2021220178A1 (en) | 2020-04-29 | 2021-11-04 | Cominnex Zrt. | Iap antagonists and their therapeutic applications |
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| WO2007075525A2 (en) * | 2005-12-20 | 2007-07-05 | Novartis Ag | Combination of an iap-inhibitor and a taxane7 |
| PE20110220A1 (es) * | 2006-08-02 | 2011-04-11 | Novartis Ag | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS |
-
2007
- 2007-11-27 KR KR1020097013350A patent/KR20090087094A/ko not_active Abandoned
- 2007-11-27 AT AT07868853T patent/ATE509629T1/de active
- 2007-11-27 BR BRPI0719543-5A patent/BRPI0719543A2/pt not_active IP Right Cessation
- 2007-11-27 US US12/516,062 patent/US8492429B2/en not_active Expired - Fee Related
- 2007-11-27 MX MX2009005621A patent/MX2009005621A/es active IP Right Grant
- 2007-11-27 EP EP07868853A patent/EP2089024B1/en active Active
- 2007-11-27 WO PCT/US2007/085579 patent/WO2008067280A2/en not_active Ceased
- 2007-11-27 AU AU2007325280A patent/AU2007325280B2/en not_active Ceased
- 2007-11-27 JP JP2009539434A patent/JP5394249B2/ja not_active Expired - Fee Related
- 2007-11-27 PL PL07868853T patent/PL2089024T3/pl unknown
- 2007-11-27 PT PT07868853T patent/PT2089024E/pt unknown
- 2007-11-27 RU RU2009124590/15A patent/RU2456983C2/ru not_active IP Right Cessation
- 2007-11-27 CA CA002670498A patent/CA2670498A1/en not_active Abandoned
-
2009
- 2009-05-04 IL IL198551A patent/IL198551A0/en unknown
- 2009-05-22 TN TNP2009000206A patent/TN2009000206A1/fr unknown
- 2009-05-27 GT GT200900142A patent/GT200900142A/es unknown
- 2009-06-03 MA MA31946A patent/MA30966B1/fr unknown
- 2009-06-24 NO NO20092417A patent/NO20092417L/no not_active Application Discontinuation
- 2009-06-25 CO CO09066298A patent/CO6210722A2/es not_active Application Discontinuation
- 2009-06-26 EC EC2009009472A patent/ECSP099472A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009005621A (es) | 2009-06-12 |
| RU2009124590A (ru) | 2011-01-10 |
| PL2089024T3 (pl) | 2011-10-31 |
| US8492429B2 (en) | 2013-07-23 |
| JP2010511059A (ja) | 2010-04-08 |
| AU2007325280B2 (en) | 2011-03-10 |
| AU2007325280A1 (en) | 2008-06-05 |
| JP5394249B2 (ja) | 2014-01-22 |
| ECSP099472A (es) | 2009-10-30 |
| WO2008067280A3 (en) | 2008-08-07 |
| PT2089024E (pt) | 2011-08-31 |
| CO6210722A2 (es) | 2010-10-20 |
| RU2456983C2 (ru) | 2012-07-27 |
| EP2089024A2 (en) | 2009-08-19 |
| NO20092417L (no) | 2009-08-25 |
| TN2009000206A1 (en) | 2010-10-18 |
| WO2008067280A2 (en) | 2008-06-05 |
| GT200900142A (es) | 2010-06-24 |
| IL198551A0 (en) | 2010-02-17 |
| US20100056467A1 (en) | 2010-03-04 |
| KR20090087094A (ko) | 2009-08-14 |
| CA2670498A1 (en) | 2008-06-05 |
| MA30966B1 (fr) | 2009-12-01 |
| EP2089024B1 (en) | 2011-05-18 |
| ATE509629T1 (de) | 2011-06-15 |
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