MA30966B1 - Combinaison d'inhibiteurs de iap et d'inhibiteurs de flt3 - Google Patents

Combinaison d'inhibiteurs de iap et d'inhibiteurs de flt3

Info

Publication number
MA30966B1
MA30966B1 MA31946A MA31946A MA30966B1 MA 30966 B1 MA30966 B1 MA 30966B1 MA 31946 A MA31946 A MA 31946A MA 31946 A MA31946 A MA 31946A MA 30966 B1 MA30966 B1 MA 30966B1
Authority
MA
Morocco
Prior art keywords
combination
inhibitors
iap
flt3
active agents
Prior art date
Application number
MA31946A
Other languages
English (en)
Inventor
James Douglas Griffin
Leigh Zawel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA30966B1 publication Critical patent/MA30966B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'INVENTION CONCERNE DES COMBINAISONS D'INHIBITEURS DE IAP ET D'INHIBITEURS DE FLT3, DES COMPOSITIONS PHARMACOLOGIQUES COMPRENANT UNE TELLE COMBINAISON, DES PROCÉDÉS DE TRAITEMENT DE MALIGNITÉS HÉMATOLOGIQUES, NOTAMMENT LA LEUCÉMIE AIGUË MYÉLOÏDE (LAM). LES COMPOSITIONS PHARMACOLOGIQUES DE L'INVENTION COMPRENNENT UN COMPOSÉ INHIBANT LA LIAISON DE LA PROTÉINE SMAC (ACTIVATEUR DE CASPASE DÉRIVÉ DE MITOCHONDRIES DITES SECONDAIRES) À L'INHIBITEUR D'APOPTOSE (INHIBITEUR DE IAP) COMBINÉ À AU MOINS UN PRINCIPE PHARMACEUTIQUEMENT ACTIF. L'INVENTION CONCERNE ÉGALEMENT L'UTILISATION DE CES COMBINAISONS POUR TRAITER UNE LEUCÉMIE AIGUË MYÉLOÏDE. L'INVENTION CONCERNE ENCORE UN CONDITIONNEMENT COMMERCIAL CONTENANT CETTE COMBINAISON.
MA31946A 2006-11-28 2009-06-03 Combinaison d'inhibiteurs de iap et d'inhibiteurs de flt3 MA30966B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86744806P 2006-11-28 2006-11-28
US89108807P 2007-02-22 2007-02-22

Publications (1)

Publication Number Publication Date
MA30966B1 true MA30966B1 (fr) 2009-12-01

Family

ID=39386468

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31946A MA30966B1 (fr) 2006-11-28 2009-06-03 Combinaison d'inhibiteurs de iap et d'inhibiteurs de flt3

Country Status (20)

Country Link
US (1) US8492429B2 (fr)
EP (1) EP2089024B1 (fr)
JP (1) JP5394249B2 (fr)
KR (1) KR20090087094A (fr)
AT (1) ATE509629T1 (fr)
AU (1) AU2007325280B2 (fr)
BR (1) BRPI0719543A2 (fr)
CA (1) CA2670498A1 (fr)
CO (1) CO6210722A2 (fr)
EC (1) ECSP099472A (fr)
GT (1) GT200900142A (fr)
IL (1) IL198551A0 (fr)
MA (1) MA30966B1 (fr)
MX (1) MX2009005621A (fr)
NO (1) NO20092417L (fr)
PL (1) PL2089024T3 (fr)
PT (1) PT2089024E (fr)
RU (1) RU2456983C2 (fr)
TN (1) TN2009000206A1 (fr)
WO (1) WO2008067280A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2607940C (fr) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Composes liants de domaine bir
WO2007048224A1 (fr) 2005-10-25 2007-05-03 Aegera Therapeutics Inc. Composés de liaison au domaine iap bir
TWI504597B (zh) 2006-03-16 2015-10-21 Pharmascience Inc 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics Inc composto de ligação de domìnio bir da iap
US20100056495A1 (en) * 2006-07-24 2010-03-04 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
AU2009246347A1 (en) 2008-05-16 2009-11-19 Dana Farber Cancer Institute, Inc. Immunomodulation by IAP inhibitors
US20100317593A1 (en) * 2009-06-12 2010-12-16 Astrazeneca Ab 2,3-dihydro-1h-indene compounds
SG182724A1 (en) 2010-02-12 2012-08-30 Pharmascience Inc Iap bir domain binding compounds
EP2760446A1 (fr) 2011-09-30 2014-08-06 Tetralogic Pharmaceuticals Corporation Mimétique de smac (birinapant) à utiliser dans le traitement de maladies de prolifération (cancer)
WO2014205516A1 (fr) 2013-06-25 2014-12-31 The Walter And Eliza Hall Institute Of Medical Research Methode de traitement d'une infection intracelllulaire
US10441654B2 (en) 2014-01-24 2019-10-15 Children's Hospital Of Eastern Ontario Research Institute Inc. SMC combination therapy for the treatment of cancer
CN113490497A (zh) 2019-02-22 2021-10-08 韩美药品株式会社 包括flt3抑制剂和低甲基化剂的用于治疗急性髓系白血病的药物组合物
KR20200102948A (ko) 2019-02-22 2020-09-01 한미약품 주식회사 Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물
US20220110913A1 (en) 2019-02-22 2022-04-14 Hanmi Pharm. Co., Ltd Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia
AU2020256166A1 (en) 2019-04-02 2021-10-14 Aligos Therapeutics, Inc. Compounds targeting PRMT5
WO2021220178A1 (fr) 2020-04-29 2021-11-04 Cominnex Zrt. Antagonistes d'iap et leurs applications thérapeutiques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1453661A1 (ru) * 1972-11-17 1989-10-30 Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе Противоопухолевое средство "продимин
BR0312408A (pt) 2002-07-02 2005-04-19 Novartis Ag Inibidores de peptìdeo de ligação de proteìna smac a inibidor de apoptose de proteìnas (iap)
KR20080083220A (ko) * 2004-04-07 2008-09-16 노파르티스 아게 Ｉａｐ 억제제
ES2684120T3 (es) 2005-12-20 2018-10-01 Novartis Ag Combinación de un inhibidor de IAP y un taxano
PE20080951A1 (es) * 2006-08-02 2008-09-11 Novartis Ag DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS

Also Published As

Publication number Publication date
US20100056467A1 (en) 2010-03-04
AU2007325280A1 (en) 2008-06-05
CO6210722A2 (es) 2010-10-20
EP2089024B1 (fr) 2011-05-18
TN2009000206A1 (en) 2010-10-18
KR20090087094A (ko) 2009-08-14
MX2009005621A (es) 2009-06-12
JP5394249B2 (ja) 2014-01-22
IL198551A0 (en) 2010-02-17
CA2670498A1 (fr) 2008-06-05
PL2089024T3 (pl) 2011-10-31
GT200900142A (es) 2010-06-24
JP2010511059A (ja) 2010-04-08
RU2456983C2 (ru) 2012-07-27
NO20092417L (no) 2009-08-25
WO2008067280A3 (fr) 2008-08-07
ATE509629T1 (de) 2011-06-15
AU2007325280B2 (en) 2011-03-10
PT2089024E (pt) 2011-08-31
ECSP099472A (es) 2009-10-30
EP2089024A2 (fr) 2009-08-19
US8492429B2 (en) 2013-07-23
BRPI0719543A2 (pt) 2014-02-25
WO2008067280A2 (fr) 2008-06-05
RU2009124590A (ru) 2011-01-10

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