BRPI0717883A2 - Compostos lipídicos, composição contendo os mesmos e uso dos referidos compostos - Google Patents
Compostos lipídicos, composição contendo os mesmos e uso dos referidos compostos Download PDFInfo
- Publication number
- BRPI0717883A2 BRPI0717883A2 BRPI0717883-2A BRPI0717883A BRPI0717883A2 BR PI0717883 A2 BRPI0717883 A2 BR PI0717883A2 BR PI0717883 A BRPI0717883 A BR PI0717883A BR PI0717883 A2 BRPI0717883 A2 BR PI0717883A2
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- hydrogen atom
- formula
- compound
- alkenyl
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- 150000001875 compounds Chemical class 0.000 title claims description 87
- -1 LIPID COMPOUNDS Chemical class 0.000 title claims description 68
- 239000000203 mixture Substances 0.000 title claims description 33
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 234
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 70
- 125000003342 alkenyl group Chemical group 0.000 claims description 61
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 45
- 125000000217 alkyl group Chemical group 0.000 claims description 34
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 34
- 239000000651 prodrug Substances 0.000 claims description 29
- 229940002612 prodrug Drugs 0.000 claims description 29
- 239000003814 drug Substances 0.000 claims description 24
- 150000002632 lipids Chemical class 0.000 claims description 20
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims description 17
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims description 17
- 125000003545 alkoxy group Chemical group 0.000 claims description 17
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 230000002265 prevention Effects 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 239000012453 solvate Substances 0.000 claims description 12
- 125000004414 alkyl thio group Chemical group 0.000 claims description 9
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- 238000002360 preparation method Methods 0.000 claims description 9
- 125000003282 alkyl amino group Chemical group 0.000 claims description 8
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 6
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- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims description 5
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- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims description 5
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- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
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- 230000002093 peripheral effect Effects 0.000 claims description 2
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- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 2
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
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- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/14—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/24—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with monohydroxylic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/40—Succinic acid esters
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
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Landscapes
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Applications Claiming Priority (13)
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| US85573306P | 2006-11-01 | 2006-11-01 | |
| US60/855,733 | 2006-11-01 | ||
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| US85626806P | 2006-11-03 | 2006-11-03 | |
| US85626706P | 2006-11-03 | 2006-11-03 | |
| US85626906P | 2006-11-03 | 2006-11-03 | |
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| SE0602352 | 2006-11-03 | ||
| US60/856,267 | 2006-11-03 | ||
| US60/856,268 | 2006-11-03 | ||
| PCT/IB2007/004588 WO2008132552A2 (en) | 2006-11-01 | 2007-11-01 | Omega-3 lipid compounds |
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| WO (1) | WO2008142482A2 (enExample) |
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| JP5337479B2 (ja) | 2005-05-04 | 2013-11-06 | プロノヴァ・バイオファーマ・ノルゲ・アーエス | 新規化合物 |
| US8399516B2 (en) * | 2006-11-01 | 2013-03-19 | Pronova Biopharma Norge As | Alpha-substituted omega-3 lipids that are activators or modulators of the peroxisome proliferators-activated receptor (PPAR) |
| MX2009004337A (es) * | 2006-11-01 | 2009-05-22 | Pronova Biopharma Norge As | Compuestos lipidos omega-3. |
| KR20100100818A (ko) * | 2007-10-31 | 2010-09-15 | 프로노바 바이오파마 노르지 에이에스 | 새로운 ｄｈａ 유도체 및 약물로서 그들의 사용 |
| RU2504373C2 (ru) | 2008-03-26 | 2014-01-20 | ОРАМЕД Лтд. | Способы и композиции для перорального введения протеинов |
| ES2345241B1 (es) | 2009-03-16 | 2011-09-08 | Lipopharma Therapeutics | Uso de 2-hidroxiderivados de acidos grasos poliinsaturados como medicamentos. |
| NZ599618A (en) | 2009-10-30 | 2014-08-29 | Tharos Ltd | Solvent-free process for obtaining phospholipids and neutral enriched krill oils |
| WO2013149384A1 (en) * | 2012-04-05 | 2013-10-10 | Nippon Suisan Kaisha, Ltd. | Brain atrophy prevention agent |
| EP3158995B1 (en) | 2012-08-09 | 2018-05-23 | Dynamis Therapeutics, Inc. | Meglumine for reducing high triglyceride levels |
| CN104902921A (zh) | 2013-01-03 | 2015-09-09 | 奥拉姆德有限公司 | 用于治疗nafld、肝性脂肪变性及其后遗症的方法和组合物 |
| EP2826384A1 (de) | 2013-07-16 | 2015-01-21 | Evonik Industries AG | Verfahren zur Trocknung von Biomasse |
| WO2015171516A1 (en) | 2014-05-05 | 2015-11-12 | Thetis Pharmaceuticals Llc | Compositions and methods relating to ionic salts of peptides |
| CN107075540A (zh) | 2014-10-02 | 2017-08-18 | 赢创德固赛有限公司 | 用于制备具有高细胞稳定性的含pufa生物质的方法 |
| CA2958439C (en) | 2014-10-02 | 2022-09-20 | Evonik Industries Ag | Feedstuff of high abrasion resistance and good stability in water, containing pufas |
| BR112017005388B1 (pt) | 2014-10-02 | 2022-09-13 | Evonik Operations Gmbh | Alimento para animais contendo biomassa de aurantiochytrium |
| CN106793803B (zh) | 2014-10-02 | 2021-03-09 | 赢创运营有限公司 | 通过挤压含pufa的生物质来制备含pufa的饲料的方法 |
| WO2016086114A1 (en) * | 2014-11-25 | 2016-06-02 | Artdem, Llc | Sports drink formulation |
| CN108024984A (zh) * | 2015-06-26 | 2018-05-11 | 普罗诺瓦生物医药挪威公司 | 用于治疗nafld的组合物 |
| JP6636133B2 (ja) * | 2015-07-22 | 2020-01-29 | オメイコス セラピューティクス ゲーエムベーハー | 心疾患の治療に対するｃｙｐ−エイコサノイドの代謝的にロバストな類縁体 |
| GB201521085D0 (en) * | 2015-11-30 | 2016-01-13 | Biozep As | Use |
| WO2022049168A1 (en) * | 2020-09-04 | 2022-03-10 | Dsm Ip Assets B.V. | 17(s)-hdpa for metabolic-syndrome related disorders |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2836628A (en) * | 1955-10-17 | 1958-05-27 | Monsanto Chemicals | Unsaturated branched-chain alcohols and methods of preparing same |
| SU523073A1 (ru) * | 1975-03-31 | 1976-07-30 | Всесоюзный научно-исследовательский институт синтетических и натуральных душистых веществ | Алкил-(алкенил)-замещенные 2,2диалкилпентен-4-ола, как душистые вещества в парфюмерных композици х и отдушках |
| US4132719A (en) * | 1978-04-20 | 1979-01-02 | Mcneilab Inc. | Dibromoalkylglycidic acid derivatives |
| US4264517A (en) * | 1978-12-11 | 1981-04-28 | G.D. Searle & Co. | Alkylphenyl 5Z,8Z,11Z,14Z,17Z-eicosapentaenoates |
| US4647685A (en) * | 1985-04-25 | 1987-03-03 | Eli Lilly And Company | 2-alkoxy-1-((2-trialkylaminoethoxy)phosphinyloxy)-alkenes and alkynes, hydroxy inner salts |
| GB8819110D0 (en) * | 1988-08-11 | 1988-09-14 | Norsk Hydro As | Antihypertensive drug & method for production |
| GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
| ITMI20012384A1 (it) * | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
| EP1501493B1 (en) * | 2002-05-03 | 2009-10-07 | Pronova BioPharma Norge AS | Use of epa and dha in secondary prevention of strokes |
| AU2003252324A1 (en) * | 2002-08-07 | 2004-03-11 | Kao Corporation | Fat composition |
| CA2512757A1 (en) * | 2003-02-12 | 2004-08-26 | Galderma Research & Development, S.N.C. | Compounds which are modulators of the ppar-type receptors and their use in cosmetic or pharmaceutical compositions |
| JP2006519244A (ja) * | 2003-03-05 | 2006-08-24 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病患者の治療におけるω−３−脂肪酸の使用 |
| US20040235948A1 (en) * | 2003-03-05 | 2004-11-25 | Solvay Pharmaceuticals Gmbh | Treatment of diabetic patients with omega-3-fatty acids |
| JP4588984B2 (ja) * | 2003-07-31 | 2010-12-01 | プロノヴァ・バイオファーマ・ノルゲ・アーエス | 高度不飽和脂肪酸誘導体およびそれを含有する医薬組成物 |
| SE0303513D0 (sv) * | 2003-12-19 | 2003-12-19 | Pronova Biocare As | Use of a fatty acid composition comprising at least one of epa and dha or any combinations thereof |
| US20060135610A1 (en) * | 2004-12-22 | 2006-06-22 | Bortz Jonathan D | Cardiovascular compositions |
-
2007
- 2007-11-01 WO PCT/IB2007/004613 patent/WO2008142482A2/en not_active Ceased
- 2007-11-01 JP JP2009533985A patent/JP2010508262A/ja active Pending
- 2007-11-01 EP EP07874033A patent/EP2102139A2/en not_active Withdrawn
- 2007-11-01 RU RU2009120568/04A patent/RU2009120568A/ru not_active Application Discontinuation
- 2007-11-01 RU RU2009120534/04A patent/RU2509071C2/ru not_active IP Right Cessation
- 2007-11-01 BR BRPI0717883-2A patent/BRPI0717883A2/pt not_active IP Right Cessation
- 2007-11-01 US US12/446,249 patent/US20110166228A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2102139A2 (en) | 2009-09-23 |
| WO2008142482A3 (en) | 2009-06-04 |
| RU2509071C2 (ru) | 2014-03-10 |
| RU2009120534A (ru) | 2010-12-10 |
| RU2009120568A (ru) | 2010-12-10 |
| US20110166228A1 (en) | 2011-07-07 |
| JP2010508262A (ja) | 2010-03-18 |
| WO2008142482A2 (en) | 2008-11-27 |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2435 DE 05-09-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |