BRPI0714593A2 - antagonistas de receptores da subfamÍlia 3 (edg-3, s1p3) do gene de diferenciaÇço endotelial para a prevenÇço e tratamento de doenÇas oculares, composiÇÕes compreendendo os referidos antagonistas, e usos dos mesmos - Google Patents
antagonistas de receptores da subfamÍlia 3 (edg-3, s1p3) do gene de diferenciaÇço endotelial para a prevenÇço e tratamento de doenÇas oculares, composiÇÕes compreendendo os referidos antagonistas, e usos dos mesmos Download PDFInfo
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- BRPI0714593A2 BRPI0714593A2 BRPI0714593-4A BRPI0714593A BRPI0714593A2 BR PI0714593 A2 BRPI0714593 A2 BR PI0714593A2 BR PI0714593 A BRPI0714593 A BR PI0714593A BR PI0714593 A2 BRPI0714593 A2 BR PI0714593A2
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- Prior art keywords
- antagonist
- alkyl
- receptor
- pharmaceutically acceptable
- eye
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US83308006P | 2006-07-25 | 2006-07-25 | |
| US60/833,080 | 2006-07-25 | ||
| PCT/US2007/074351 WO2008014338A2 (en) | 2006-07-25 | 2007-07-25 | Antagonists of endothelial differentiation gene subfamily 3 (edg-3, s1p3) receptors for prevention and treatment of ocular disorders |
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| EP (1) | EP2068856A2 (enExample) |
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| AU2005264431B2 (en) * | 2004-07-16 | 2010-08-19 | Kyorin Pharmaceutical Co., Ltd. | Method of effectively using medicine and method concerning prevention of side effect |
| PT2511262T (pt) | 2004-10-12 | 2017-03-30 | Kyorin Seiyaku Kk | Processo para a produção de cloridrato de 2-amino-2-[2-[4-(3- benziloxi-feniltio)-2-clorofenil[etil]-1,3-propanodiol |
| BRPI0617077A2 (pt) * | 2005-10-07 | 2015-01-06 | Kyorin Seiyaku Kk | Agente terapêutico para tratamento de doenças do fígado contendo 2-amina-1, 3-propanediol derivativo como ingrediente ativo, e método para tratamento de doenças do fígado |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| NZ574011A (en) * | 2006-08-08 | 2011-10-28 | Kyorin Seiyaku Kk | Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient |
| CA2659599C (en) * | 2006-08-08 | 2014-06-17 | Kyorin Pharmaceutical Co., Ltd. | Amino alcohol derivative and immunosuppressive agent having same as an active ingredient |
| TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
| US20110009453A1 (en) * | 2008-03-17 | 2011-01-13 | Donello John E | s1p3 receptor inhibitors for treating inflammation |
| WO2010129553A1 (en) * | 2009-05-05 | 2010-11-11 | Allergan, Inc. | S1p3 receptor inhibitors for treating conditions of the eye |
| RU2012105453A (ru) * | 2009-08-11 | 2013-09-20 | Аллерган, Инк. | Изотиозолы для лечения состояний глаз |
| WO2011038446A1 (en) * | 2009-09-30 | 2011-04-07 | Stiefel Research Australia Pty Ltd | Cosmetic foam |
| CN102146411B (zh) * | 2011-01-06 | 2013-01-02 | 中国人民解放军第三军医大学第三附属医院 | 新型双功能抗瘢痕和组织纤维化寡聚核苷酸药物 |
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| WO1995013811A1 (de) * | 1993-11-17 | 1995-05-26 | Byk Nederland Bv | Verwendung substituierter thiazolidinderivate zur behandlung von erhöhtem augeninnendruck |
| US5545626A (en) * | 1994-01-19 | 1996-08-13 | The Trustees Of Columbia University In The City Of New York | Method of treating glaucoma with oligonucleotides |
| US5750652A (en) * | 1994-01-21 | 1998-05-12 | Yale University | Deltex proteins |
| EP1253929B1 (en) * | 2000-02-09 | 2007-05-23 | BAS Medical, Inc. | Use of relaxin to treat diseases related to vasoconstriction |
| JP2001261575A (ja) * | 2000-03-13 | 2001-09-26 | General Hospital Corp | 血管収縮を調節する方法とその組成物 |
| JP2002332278A (ja) * | 2001-05-08 | 2002-11-22 | Human Science Shinko Zaidan | Ｅｄｇ受容体拮抗作用を有する複素環誘導体 |
| KR20040104566A (ko) * | 2002-04-30 | 2004-12-10 | 알콘, 인코퍼레이티드 | 안압 저하 및 녹내장성 망막병증/시신경병증 치료를 위한특유의 수단으로서의 결합 조직 성장 인자 (ｃｔｇｆ)의활성 및/또는 발현 조절, 저해, 또는 변조제 |
| EP1546110A4 (en) * | 2002-07-30 | 2008-03-26 | Univ Virginia | COMPOUNDS WITH EFFECT ON SIGNAL TRANSMISSION BY SPHINGOSINE-1-PHOSPHATE |
| CA2495917A1 (en) * | 2002-08-28 | 2004-03-11 | Merck Frosst Canada & Co. | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma |
| FR2845003A1 (fr) * | 2002-09-30 | 2004-04-02 | Merck Sante Sas | Utilisation de derives de thiazolidinedione comme inhibiteurs de l'aldose reductase |
| US20060173046A1 (en) * | 2003-07-15 | 2006-08-03 | Bell Ian M | Hydroxypyridine cgrp receptor antagonists |
| JP2005247691A (ja) * | 2004-03-01 | 2005-09-15 | Toa Eiyo Ltd | Ｓ１ｐ３受容体拮抗薬 |
| US7888527B2 (en) * | 2004-12-06 | 2011-02-15 | University Of Virginia Patent Foundation | Aryl amide sphingosine 1-phosphate analogs |
| EP1935874A4 (en) * | 2005-10-12 | 2010-10-13 | Toa Eiyo Ltd | S1P3 RECEPTOR ANTAGONIST |
| CN101460458A (zh) * | 2006-02-15 | 2009-06-17 | 阿勒根公司 | 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物 |
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2007
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- 2007-07-25 BR BRPI0714593-4A patent/BRPI0714593A2/pt not_active IP Right Cessation
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| ZA200900316B (en) | 2010-05-26 |
| JP2009544734A (ja) | 2009-12-17 |
| CA2657480A1 (en) | 2008-01-31 |
| US20080025973A1 (en) | 2008-01-31 |
| US20100183629A1 (en) | 2010-07-22 |
| WO2008014338A3 (en) | 2008-12-24 |
| CN101505744A (zh) | 2009-08-12 |
| MX2009000907A (es) | 2009-02-04 |
| EP2068856A2 (en) | 2009-06-17 |
| WO2008014338A2 (en) | 2008-01-31 |
| AU2007279311A1 (en) | 2008-01-31 |
| KR20090033886A (ko) | 2009-04-06 |
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