BRPI0708429A2 - método para formar uma espuma absorvente seca, espuma absorvente seca, compósito, uso de uma espuma ou de um compósito, e, métodos para inibir a proliferação celular, para fixar um compósito ao tecido e para evitar a adesão de tecido a tecido adjacente - Google Patents
método para formar uma espuma absorvente seca, espuma absorvente seca, compósito, uso de uma espuma ou de um compósito, e, métodos para inibir a proliferação celular, para fixar um compósito ao tecido e para evitar a adesão de tecido a tecido adjacente Download PDFInfo
- Publication number
- BRPI0708429A2 BRPI0708429A2 BRPI0708429-3A BRPI0708429A BRPI0708429A2 BR PI0708429 A2 BRPI0708429 A2 BR PI0708429A2 BR PI0708429 A BRPI0708429 A BR PI0708429A BR PI0708429 A2 BRPI0708429 A2 BR PI0708429A2
- Authority
- BR
- Brazil
- Prior art keywords
- foam
- gel
- chitosan
- composite
- polysaccharide
- Prior art date
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
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Landscapes
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Glass Compositions (AREA)
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- Coloring Foods And Improving Nutritive Qualities (AREA)
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Applications Claiming Priority (7)
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|---|---|---|---|
| US77786906P | 2006-03-01 | 2006-03-01 | |
| US60/777869 | 2006-03-01 | ||
| US87284406P | 2006-12-05 | 2006-12-05 | |
| US60/872844 | 2006-12-05 | ||
| US87417406P | 2006-12-11 | 2006-12-11 | |
| US60/874174 | 2006-12-11 | ||
| PCT/US2007/005435 WO2007103208A2 (en) | 2006-03-01 | 2007-03-01 | Biodegradable foam |
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| Publication Number | Publication Date |
|---|---|
| BRPI0708429A2 true BRPI0708429A2 (pt) | 2011-05-31 |
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| BRPI0708429-3A BRPI0708429A2 (pt) | 2006-03-01 | 2007-03-01 | método para formar uma espuma absorvente seca, espuma absorvente seca, compósito, uso de uma espuma ou de um compósito, e, métodos para inibir a proliferação celular, para fixar um compósito ao tecido e para evitar a adesão de tecido a tecido adjacente |
| BRPI0708422-6A BRPI0708422A2 (pt) | 2006-03-01 | 2007-03-01 | Método para formar um compósito, compósito, métodos para promover a proliferação celular no compósito, para inibir a proliferação celular e para recuperar células do compósito, uso de um compósito, e , métodos para fixar um compósito a um tecido, para remover o crescimento celular, para induzir a geleificação in situ dentro dos poros de uma espuma de alginato, para prevenir a adesão de tecido a tecido adjacene e para formar uma espuma absorvente seca |
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| BRPI0708422-6A BRPI0708422A2 (pt) | 2006-03-01 | 2007-03-01 | Método para formar um compósito, compósito, métodos para promover a proliferação celular no compósito, para inibir a proliferação celular e para recuperar células do compósito, uso de um compósito, e , métodos para fixar um compósito a um tecido, para remover o crescimento celular, para induzir a geleificação in situ dentro dos poros de uma espuma de alginato, para prevenir a adesão de tecido a tecido adjacene e para formar uma espuma absorvente seca |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20070254016A1 (https=) |
| EP (2) | EP1988937A2 (https=) |
| JP (2) | JP2009529926A (https=) |
| AT (1) | ATE517645T1 (https=) |
| AU (2) | AU2007224137A1 (https=) |
| BR (2) | BRPI0708429A2 (https=) |
| CA (2) | CA2643083A1 (https=) |
| IL (2) | IL193640A (https=) |
| NO (2) | NO20083696L (https=) |
| WO (2) | WO2007103208A2 (https=) |
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| US8668737B2 (en) | 1997-10-10 | 2014-03-11 | Senorx, Inc. | Tissue marking implant |
| US8361082B2 (en) | 1999-02-02 | 2013-01-29 | Senorx, Inc. | Marker delivery device with releasable plug |
| US9820824B2 (en) | 1999-02-02 | 2017-11-21 | Senorx, Inc. | Deployment of polysaccharide markers for treating a site within a patent |
| US7983734B2 (en) | 2003-05-23 | 2011-07-19 | Senorx, Inc. | Fibrous marker and intracorporeal delivery thereof |
| US7877133B2 (en) | 2003-05-23 | 2011-01-25 | Senorx, Inc. | Marker or filler forming fluid |
| GB0508531D0 (en) | 2005-04-27 | 2005-06-01 | Smith & Nephew | Sai with ultrasound |
| US9579077B2 (en) | 2006-12-12 | 2017-02-28 | C.R. Bard, Inc. | Multiple imaging mode tissue marker |
| EP2155810A4 (en) * | 2007-06-13 | 2013-07-03 | Fmc Corp | ALGINATE-COATED, POLYSAC-CHARIDE-CONTAINING FOAM COMPOSITE, MANUFACTURING METHOD AND USES THEREOF |
| DE102007037051A1 (de) * | 2007-07-24 | 2009-01-29 | Aesculap Ag | Flächiges Implantat |
| US8221783B2 (en) * | 2007-09-10 | 2012-07-17 | Boston Scientific Scimed, Inc. | Medical devices with triggerable bioadhesive material |
| WO2009038783A1 (en) * | 2007-09-19 | 2009-03-26 | Surmodics, Inc. | Biocompatible foams, systems, and methods |
| DE102007051059B4 (de) * | 2007-10-18 | 2014-04-03 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Bioverbundmaterial für die kontrollierte Freisetzung von Wirkstoffen |
| US8673354B2 (en) | 2007-11-05 | 2014-03-18 | Technion Research And Development Foundation Ltd. | Adhesives and methods of applying the same |
| GB0722820D0 (en) | 2007-11-21 | 2008-01-02 | Smith & Nephew | Vacuum assisted wound dressing |
| ES2555204T3 (es) | 2007-11-21 | 2015-12-29 | T.J. Smith & Nephew Limited | Dispositivo de succión y venda |
| ES2776709T3 (es) | 2007-11-21 | 2020-07-31 | Smith & Nephew | Apósito para heridas |
| US11253399B2 (en) | 2007-12-06 | 2022-02-22 | Smith & Nephew Plc | Wound filling apparatuses and methods |
| GB0723875D0 (en) | 2007-12-06 | 2008-01-16 | Smith & Nephew | Wound management |
| US20130096518A1 (en) | 2007-12-06 | 2013-04-18 | Smith & Nephew Plc | Wound filling apparatuses and methods |
| GB0803564D0 (en) | 2008-02-27 | 2008-04-02 | Smith & Nephew | Fluid collection |
| US9327061B2 (en) * | 2008-09-23 | 2016-05-03 | Senorx, Inc. | Porous bioabsorbable implant |
| GB0902816D0 (en) | 2009-02-19 | 2009-04-08 | Smith & Nephew | Fluid communication path |
| WO2010117266A1 (en) | 2009-04-06 | 2010-10-14 | Broockeville Corporation N.V. | In situ gelling alginate systems |
| EP2437797B1 (en) | 2009-06-01 | 2013-08-14 | Technion Research & Development Foundation Ltd. | Multi components adhesives, manufacturing thereof, and applications thereof |
| IN2012DN01100A (https=) * | 2009-08-07 | 2015-04-10 | Fmc Corp | |
| US10207022B2 (en) * | 2009-09-01 | 2019-02-19 | Medoderm Gmbh | Chitosan tissue dressing |
| US9061095B2 (en) | 2010-04-27 | 2015-06-23 | Smith & Nephew Plc | Wound dressing and method of use |
| JP5937070B2 (ja) * | 2010-06-22 | 2016-06-22 | ウニヴェルシテ ド ルアンUniversite De Rouen | 3d細胞培養に用いる改良された架橋ヒアルロナンヒドロゲル |
| GB201011173D0 (en) | 2010-07-02 | 2010-08-18 | Smith & Nephew | Provision of wound filler |
| WO2012048289A1 (en) | 2010-10-08 | 2012-04-12 | Board Of Regents, The University Of Texas System | Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications |
| JP6078472B2 (ja) | 2010-11-25 | 2017-02-08 | スミス アンド ネフュー ピーエルシーSmith & Nephew Public Limited Company | 組成物i−iiおよび生成物ならびにそれらの使用 |
| GB201020005D0 (en) | 2010-11-25 | 2011-01-12 | Smith & Nephew | Composition 1-1 |
| EP2688397B1 (en) | 2011-03-21 | 2016-07-20 | University of Reading | Transport of cells in alginate hydrogels |
| WO2012149242A1 (en) * | 2011-04-29 | 2012-11-01 | Kci Licensing, Inc. | Aptamer -modified polymeric materials for the binding of therapeutic factors in a wound environment |
| RU2471824C1 (ru) * | 2011-07-26 | 2013-01-10 | Учреждение Российской академии наук Институт высокомолекулярных соединений РАН | Биосовместимый биодеградируемый пористый композиционный материал и способ его получения |
| US20150159066A1 (en) | 2011-11-25 | 2015-06-11 | Smith & Nephew Plc | Composition, apparatus, kit and method and uses thereof |
| US20130288932A1 (en) * | 2012-04-27 | 2013-10-31 | Halliburton Energy Services, Inc. | Methods of cryodesiccating a broth comprising a biopolymer of an exopolysaccharide |
| WO2014039414A1 (en) * | 2012-09-07 | 2014-03-13 | 3M Innovative Properties Company | Silcone compositions and related methods |
| CA2893064C (en) * | 2012-12-07 | 2021-05-04 | Baxter International Inc. | Hemostatic foam |
| US11565027B2 (en) | 2012-12-11 | 2023-01-31 | Board Of Regents, The University Of Texas System | Hydrogel membrane for adhesion prevention |
| EP3505197B1 (en) * | 2012-12-11 | 2023-09-06 | Board of Regents, The University of Texas System | Hydrogel membrane for adhesion prevention |
| US20140242676A1 (en) * | 2013-02-01 | 2014-08-28 | Los Alamos National Security, Llc | Artificial leaf-like microphotobioreactor and methods for making the same |
| EP2968647B1 (en) | 2013-03-15 | 2022-06-29 | Smith & Nephew plc | Wound dressing sealant and use thereof |
| US20160120706A1 (en) | 2013-03-15 | 2016-05-05 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
| CN105339019A (zh) * | 2013-05-29 | 2016-02-17 | 株式会社大塚制药工场 | 防粘连材料 |
| FR3039555B1 (fr) | 2015-07-30 | 2017-08-18 | Univ Toulouse Iii - Paul Sabatier | Procede de preparation de matrices poreuses polymeres biocompatibles et biodegradables trimensionnelles et applications |
| JP6719182B2 (ja) * | 2015-08-05 | 2020-07-08 | 株式会社武蔵野化学研究所 | エンドトキシンの測定用試料の前処理方法 |
| US20170157283A1 (en) | 2015-12-08 | 2017-06-08 | Medtronic Xomed, Inc. | Dissolvable nasal sinus sponge |
| CA3015172A1 (en) * | 2016-02-18 | 2017-08-24 | Privo Technologies, Inc. | Two-stage microparticle-based therapeutic delivery system and method |
| US11464597B2 (en) | 2016-07-13 | 2022-10-11 | The University Of Tokyo | Adhesion-preventing composition |
| EP3412710B1 (en) * | 2016-12-23 | 2021-11-10 | LG Chem, Ltd. | Method for producing porous superabsorbent polymer |
| WO2018151849A1 (en) * | 2017-02-17 | 2018-08-23 | Privo Technologies, Inc. | Particle-based multi-layer therapeutic delivery device and method |
| US10478403B1 (en) | 2017-05-03 | 2019-11-19 | Privo Technologies, Inc. | Intraoperative topically-applied non-implantable rapid release patch |
| FR3068039B1 (fr) | 2017-06-22 | 2020-07-10 | Jellynov | Composition auto-moussante en milieu acide et procede de preparation |
| US10980913B2 (en) | 2018-03-05 | 2021-04-20 | Ethicon Llc | Sealant foam compositions for lung applications |
| EP3873991A4 (en) | 2018-11-02 | 2022-07-27 | Covalon Technologies Inc. | FOAM COMPOSITIONS, FOAM MATRICES AND PROCESSES |
| FR3089224B1 (fr) | 2018-12-04 | 2020-12-11 | Jellynov | Composition auto-moussante en milieu acide et procédé de préparation |
| ES3044684T3 (en) * | 2019-02-07 | 2025-11-27 | Biorez Inc | Composite scaffold for the repair, reconstruction, and regeneration of soft tissues |
| EP3924061A1 (en) | 2019-02-15 | 2021-12-22 | Johnson & Johnson Consumer Inc. | Moldable gel cleanser |
| NL2022788B1 (en) * | 2019-03-22 | 2020-09-28 | No Ceuticals B V | Chitosan nitrate for use as a nitric oxide donor (NO donor) |
| US20220289999A1 (en) * | 2019-07-11 | 2022-09-15 | StenCo, LLC | Biodegradable material |
| CN110960722A (zh) * | 2019-12-14 | 2020-04-07 | 广东泰宝医疗科技股份有限公司 | 一种抗菌藻酸盐创口贴及其制备方法 |
| CN111888524A (zh) * | 2020-08-04 | 2020-11-06 | 宁波迪创医疗科技有限公司 | 一种组织填充材料及其制备方法、组织工程支架和应用 |
| JP7072124B1 (ja) | 2020-09-29 | 2022-05-19 | 日東電工株式会社 | 発泡体及びその製造方法 |
| KR20240041285A (ko) | 2021-06-01 | 2024-03-29 | 프리보 테크놀로지스, 인코포레이티드 | 향상된 2단계 미세입자 기반 국소 치료제 전달 시스템 |
| WO2023060076A1 (en) * | 2021-10-04 | 2023-04-13 | Cruz Foam, Inc. | Biodegradable foam with alginate |
| WO2023064542A1 (en) * | 2021-10-14 | 2023-04-20 | Kimberly-Clark Worldwide, Inc. | Biodegradable and renewable superabsorbent material |
| CN114403240B (zh) * | 2022-01-07 | 2023-07-21 | 华南农业大学 | 一种新型米糠蛋白基起酥油替代物及其在烘焙食品中的应用 |
| EP4417243A1 (de) * | 2023-02-15 | 2024-08-21 | Heraeus Medical GmbH | Implantat zur verzögerten wirkstofffreisetzung |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2128551A (en) | 1934-01-11 | 1938-08-30 | Algin Corp Of America | Method of treating seaweed |
| US2036934A (en) | 1934-04-21 | 1936-04-07 | Kelco Co | Process for making alginic acid and product |
| US2246125A (en) * | 1941-04-01 | 1941-06-17 | Gen Electric | Electric discharge device |
| US2426125A (en) | 1944-04-03 | 1947-08-19 | Kelco Co | Manufacture of glycol alginates |
| US3772266A (en) * | 1972-10-19 | 1973-11-13 | Kelco Co | Process for the preparation of propylene glycol alginate from partially neutralized alginic acid |
| CA1019326A (en) * | 1974-07-16 | 1977-10-18 | Uniroyal Ltd. | Process for the production of alkylene glycol alginates |
| DE2437090A1 (de) * | 1974-08-01 | 1976-02-19 | Hoechst Ag | Reinigungsmittel |
| GB1570485A (en) | 1975-11-18 | 1980-07-02 | Robinson & Sons Ltd | Absorbent material for aqueous fluids |
| US4292972A (en) | 1980-07-09 | 1981-10-06 | E. R. Squibb & Sons, Inc. | Lyophilized hydrocolloio foam |
| US5735902A (en) | 1987-07-20 | 1998-04-07 | Regen Biologics, Inc. | Hand implant device |
| DE3832643A1 (de) * | 1988-09-26 | 1990-03-29 | Patent Treuhand Ges Fuer Elektrische Gluehlampen Mbh | Verfahren zur herstellung einer reflexionsbeschichtung bei hochdruckentladungslampen |
| US4948575A (en) | 1989-01-24 | 1990-08-14 | Minnesota Mining And Manufacturing Company | Alginate hydrogel foam wound dressing |
| US5260345A (en) * | 1991-08-12 | 1993-11-09 | The Procter & Gamble Company | Absorbent foam materials for aqueous body fluids and absorbent articles containing such materials |
| CA2080035A1 (en) | 1991-10-15 | 1993-04-16 | George Colegrove | Gelled foams |
| US5851461A (en) * | 1992-06-19 | 1998-12-22 | Albany International Research Co. | Method of producing polysaccharide foams |
| US5840777A (en) * | 1992-06-19 | 1998-11-24 | Albany International Corp. | Method of producing polysaccharide foams |
| CA2116037C (en) * | 1992-06-19 | 2000-01-04 | Dana B. Eagles | Method of producing polysaccharide foams |
| IL104441A (en) | 1993-01-19 | 2001-01-28 | Yossi Res Dev Company Of The H | Sponges from hydrocolloids and method for their production |
| US20030224022A1 (en) | 1993-01-19 | 2003-12-04 | Amos Nussinovitch | Hydrocolloid cellular solid matrices |
| US5709854A (en) * | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| TW369414B (en) | 1994-09-30 | 1999-09-11 | Yamanouchi Pharma Co Ltd | Bone formation transplant |
| US6294202B1 (en) * | 1994-10-06 | 2001-09-25 | Genzyme Corporation | Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers |
| US5891558A (en) * | 1994-11-22 | 1999-04-06 | Tissue Engineering, Inc. | Biopolymer foams for use in tissue repair and reconstruction |
| US5709934A (en) | 1994-11-22 | 1998-01-20 | Tissue Engineering, Inc. | Bipolymer foams having extracellular matrix particulates |
| NO953115L (no) | 1995-06-07 | 1996-12-09 | Albany Int Research | Fremgangsmåte for fremstilling av polysakkaridskum |
| JP2822174B2 (ja) * | 1996-03-01 | 1998-11-11 | オーミケンシ株式会社 | キチンキトサン繊維及び構造体の製造法 |
| GB9608222D0 (en) | 1996-04-20 | 1996-06-26 | Innovative Tech Ltd | Dehydrated hydrogels |
| IL118376A0 (en) * | 1996-05-22 | 1996-09-12 | Univ Ben Gurion | Polysaccharide sponges for cell culture and transplantation |
| US6054142A (en) | 1996-08-01 | 2000-04-25 | Cyto Therapeutics, Inc. | Biocompatible devices with foam scaffolds |
| ES2317657T3 (es) * | 1996-09-19 | 2009-04-16 | The Regents Of The University Of Michigan | Polimeros que contienen polisacaridos tales como alginatos o alginatos modificados. |
| GB2318577B (en) | 1996-10-28 | 2000-02-02 | Johnson & Johnson Medical | Solvent dried polysaccharide sponges |
| GB9704749D0 (en) * | 1997-03-07 | 1997-04-23 | Univ London | Tissue Implant |
| ATE249491T1 (de) | 1997-03-31 | 2003-09-15 | Univ Michigan | Offenporige bioabbaubare matrize |
| JP2001520274A (ja) * | 1997-10-17 | 2001-10-30 | アドバンスト・メディカル・ソリューションズ・リミテッド | 発泡材料 |
| IL124957A0 (en) * | 1998-06-16 | 1999-01-26 | Univ Ben Gurion | Active ingredient delivery systems and devices based on porous matrices |
| KR100298846B1 (ko) | 1998-09-24 | 2003-10-22 | 한국원자력연구소 | 중화키토산스폰지또는중화키토산/콜라겐혼합스폰지를이용한인공진피 |
| US7128929B1 (en) * | 1999-04-29 | 2006-10-31 | Scherr George H | Alginate foam compositions |
| WO2001006973A1 (en) * | 1999-07-28 | 2001-02-01 | United States Surgical Corporation | Hyaluronic acid anti-adhesion barrier |
| JP4044291B2 (ja) * | 2000-01-24 | 2008-02-06 | クラレメディカル株式会社 | 水膨潤性高分子ゲルおよびその製造法 |
| AU2001234623A1 (en) | 2000-01-28 | 2001-08-07 | Orthogene, Inc. | Gel-infused sponges for tissue repair and augmentation |
| US20030095993A1 (en) * | 2000-01-28 | 2003-05-22 | Hanne Bentz | Gel-infused sponges for tissue repair and augmentation |
| IT1320163B1 (it) | 2000-02-15 | 2003-11-18 | Novamont Spa | Foglia e prodotti formati a base di amido espanso. |
| AU2000231640A1 (en) | 2000-03-03 | 2001-09-12 | Rolf Siegel | Agent for the treatment of wounds |
| US6565960B2 (en) | 2000-06-01 | 2003-05-20 | Shriners Hospital Of Children | Polymer composite compositions |
| JP4493826B2 (ja) * | 2000-09-29 | 2010-06-30 | 株式会社クラレ | 多糖類スポンジの製造法及び多糖類スポンジ |
| FR2816847B1 (fr) * | 2000-11-22 | 2006-07-14 | Assist Publ Hopitaux De Paris | Biomateriaux polymeriques poreux, procede de preparation et utilisations |
| US7041868B2 (en) * | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Bioabsorbable wound dressing |
| US20050147656A1 (en) * | 2001-06-14 | 2005-07-07 | Hemcon, Inc. | Tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
| BR0210406A (pt) * | 2001-06-14 | 2006-04-04 | Providence Health Sys Oregon | curativo de ferimento, e, métodos de controle de sangramento severo, e de produção de um curativo de ferimento capaz de controlar o sangramento severo |
| US20060004314A1 (en) * | 2001-06-14 | 2006-01-05 | Hemcon, Inc. | Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan |
| US7371403B2 (en) | 2002-06-14 | 2008-05-13 | Providence Health System-Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
| US6696077B2 (en) | 2001-07-26 | 2004-02-24 | George H. Scherr | Silver alginate foam compositions |
| US20030186826A1 (en) | 2001-11-01 | 2003-10-02 | The Procter & Gamble Company | Method of using personal care compositions containing a high density, water disintegratable, polymeric foam |
| US20030180242A1 (en) | 2001-11-01 | 2003-09-25 | The Procter & Gamble Company | Personal care compositions containing a water-disintegratable polymeric foam |
| WO2003089506A1 (en) | 2002-04-22 | 2003-10-30 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
| US20050137512A1 (en) * | 2003-12-23 | 2005-06-23 | Campbell Todd D. | Wound dressing and method for controlling severe, life-threatening bleeding |
| US7993922B2 (en) * | 2002-10-18 | 2011-08-09 | Reliance Life Sciences Pvt. Ltd. | Three-dimensional tissue equivalent using macromass culture |
| US20040082063A1 (en) * | 2002-10-18 | 2004-04-29 | Reliance Life Sciences Pvt. Ltd. | Tissue-like organization of cells and macroscopic tissue-like constructs, generated by macromass culture of cells, and the method of macromass culture |
| KR100984184B1 (ko) | 2003-03-18 | 2010-09-28 | 에스케이케미칼주식회사 | 알긴산 스폰지 및 그의 제조방법 |
| US7674837B2 (en) | 2003-09-08 | 2010-03-09 | Fmc Biopolymer As | Gelled biopolymer based foam |
| CA2548305C (en) | 2003-12-23 | 2014-07-15 | Fmc Biopolymer As | Use of alginate matrices to control cell growth |
| GB0329773D0 (en) * | 2003-12-23 | 2004-01-28 | Perry Forbes G D | Torque equalisation in toric transmissions |
| US20050148963A1 (en) * | 2004-01-05 | 2005-07-07 | Brennan H. G. | Bioabsorbable surgical sponge |
| CN1297600C (zh) | 2004-07-30 | 2007-01-31 | 胡靖� | 环保防伪型全生物降解塑料发泡及流延成型方法 |
| EP1799232B1 (en) * | 2004-10-12 | 2015-10-07 | FMC Biopolymer AS | Self-gelling alginate systems and uses thereof |
| US7700355B2 (en) * | 2005-01-07 | 2010-04-20 | Industrial Technology Research Institute | Methods of producing a porous matrix for culturing and recovering cells |
| JP2007068879A (ja) * | 2005-09-09 | 2007-03-22 | National Cardiovascular Center | 生体埋込部材及び人工組織 |
| JP2007143833A (ja) * | 2005-11-28 | 2007-06-14 | National Cardiovascular Center | 生体埋込部材及び人工組織 |
| WO2007070660A2 (en) | 2005-12-13 | 2007-06-21 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
| US20070249044A1 (en) * | 2006-01-30 | 2007-10-25 | University Of Illinois At Chicago | Microstructures in three dimensional gel suspensions for growth of cells |
| CN100415304C (zh) | 2006-03-13 | 2008-09-03 | 西北大学 | 一种可生物降解止血海绵材料及其制备方法 |
| US20070240080A1 (en) * | 2006-04-11 | 2007-10-11 | Invensys Systems, Inc. | Strategy editor for process control supporting drag and drop connections to declarations |
-
2007
- 2007-03-01 CA CA 2643083 patent/CA2643083A1/en not_active Abandoned
- 2007-03-01 US US11/712,611 patent/US20070254016A1/en not_active Abandoned
- 2007-03-01 EP EP20070752153 patent/EP1988937A2/en not_active Withdrawn
- 2007-03-01 CA CA2643084A patent/CA2643084C/en not_active Expired - Fee Related
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| CA2643083A1 (en) | 2007-09-13 |
| EP1988942A2 (en) | 2008-11-12 |
| IL193621A (en) | 2013-08-29 |
| CA2643084A1 (en) | 2007-09-13 |
| AU2007224138B2 (en) | 2012-07-19 |
| BRPI0708422A2 (pt) | 2011-05-31 |
| JP2009528437A (ja) | 2009-08-06 |
| US20070254016A1 (en) | 2007-11-01 |
| WO2007103209A2 (en) | 2007-09-13 |
| US20080033392A1 (en) | 2008-02-07 |
| WO2007103208A3 (en) | 2008-12-24 |
| US9028872B2 (en) | 2015-05-12 |
| IL193621A0 (en) | 2009-05-04 |
| EP1988937A2 (en) | 2008-11-12 |
| WO2007103209A3 (en) | 2008-12-24 |
| IL193640A (en) | 2012-12-31 |
| NO20083729L (no) | 2008-11-12 |
| CA2643084C (en) | 2015-12-29 |
| ATE517645T1 (de) | 2011-08-15 |
| AU2007224137A1 (en) | 2007-09-13 |
| NO20083696L (no) | 2008-11-12 |
| EP1988942B1 (en) | 2011-07-27 |
| JP2009529926A (ja) | 2009-08-27 |
| WO2007103208A2 (en) | 2007-09-13 |
| AU2007224138A1 (en) | 2007-09-13 |
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