BRPI0707425A2 - construção de anticorpo de domìnio, molécula isolada de ácido nucleico, composição farmacêutica, e, métodos para detectar tnf-alfa humano em uma amostra, e para tratar um distúrbio - Google Patents

construção de anticorpo de domìnio, molécula isolada de ácido nucleico, composição farmacêutica, e, métodos para detectar tnf-alfa humano em uma amostra, e para tratar um distúrbio Download PDF

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Publication number
BRPI0707425A2
BRPI0707425A2 BRPI0707425-5A BRPI0707425A BRPI0707425A2 BR PI0707425 A2 BRPI0707425 A2 BR PI0707425A2 BR PI0707425 A BRPI0707425 A BR PI0707425A BR PI0707425 A2 BRPI0707425 A2 BR PI0707425A2
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BR
Brazil
Prior art keywords
seq
domain antibody
sequence
antibody construct
thr
Prior art date
Application number
BRPI0707425-5A
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English (en)
Portuguese (pt)
Inventor
Anthony Gerard Doyle
Benjamin P Woolven
Ian M Tomlinson
Jennifer A Lee
Philip Anthony Jennings
Original Assignee
Arana Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2006900456A external-priority patent/AU2006900456A0/en
Application filed by Arana Therapeutics Ltd filed Critical Arana Therapeutics Ltd
Publication of BRPI0707425A2 publication Critical patent/BRPI0707425A2/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
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    • G01N2333/525Tumor necrosis factor [TNF]
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    • G01MEASURING; TESTING
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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BRPI0707425-5A 2006-02-01 2007-02-01 construção de anticorpo de domìnio, molécula isolada de ácido nucleico, composição farmacêutica, e, métodos para detectar tnf-alfa humano em uma amostra, e para tratar um distúrbio BRPI0707425A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2006900456A AU2006900456A0 (en) 2006-02-01 Domain antibody construct
AU2006900456 2006-02-01
US81750706P 2006-06-28 2006-06-28
US60/817507 2006-06-28
PCT/AU2007/000085 WO2007087673A1 (en) 2006-02-01 2007-02-01 Domain antibody construct

Publications (1)

Publication Number Publication Date
BRPI0707425A2 true BRPI0707425A2 (pt) 2011-05-03

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ID=45220168

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0707425-5A BRPI0707425A2 (pt) 2006-02-01 2007-02-01 construção de anticorpo de domìnio, molécula isolada de ácido nucleico, composição farmacêutica, e, métodos para detectar tnf-alfa humano em uma amostra, e para tratar um distúrbio

Country Status (12)

Country Link
US (2) US7846439B2 (cg-RX-API-DMAC7.html)
EP (1) EP1987064A4 (cg-RX-API-DMAC7.html)
JP (2) JP5259423B2 (cg-RX-API-DMAC7.html)
KR (1) KR20090039666A (cg-RX-API-DMAC7.html)
CN (2) CN103232540A (cg-RX-API-DMAC7.html)
AU (1) AU2007211829C9 (cg-RX-API-DMAC7.html)
BR (1) BRPI0707425A2 (cg-RX-API-DMAC7.html)
CA (1) CA2640661A1 (cg-RX-API-DMAC7.html)
EA (1) EA017417B1 (cg-RX-API-DMAC7.html)
MX (1) MX2008009792A (cg-RX-API-DMAC7.html)
NZ (1) NZ569988A (cg-RX-API-DMAC7.html)
WO (1) WO2007087673A1 (cg-RX-API-DMAC7.html)

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WO2007087673A1 (en) 2006-02-01 2007-08-09 Arana Therapeutics Limited Domain antibody construct
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WO2008092209A1 (en) * 2007-02-01 2008-08-07 Arana Therapeutics Limited Protein construct with improved properties
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CA2758964A1 (en) * 2009-04-16 2010-10-21 Abbott Biotherapeutics Corp. Anti-tnf-.alpha. antibodies and their uses
AU2012310328A1 (en) * 2011-09-23 2014-04-10 Technophage, Investigação E Desenvolvimento Em Biotecnologia, S.A. Anti-Tumor Necrosis Factor-alpha agents and uses thereof
CN104045715B (zh) * 2013-03-15 2018-05-01 兰州大学 二聚体化融合蛋白的制备及应用
AU2016304764C1 (en) * 2015-08-07 2023-06-01 Imaginab, Inc. Antigen binding constructs to target molecules
US11266745B2 (en) 2017-02-08 2022-03-08 Imaginab, Inc. Extension sequences for diabodies

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US7846439B2 (en) 2010-12-07
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AU2007211829C8 (en) 2013-06-27
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US20070202105A1 (en) 2007-08-30
CN101400703A (zh) 2009-04-01
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CA2640661A1 (en) 2007-08-09
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