BRPI0612900A8 - Métodos para produzir metionina, para aperfeiçoar o uso de dmds para produção de metionina, e, para identificar um alelo mutante, composição, produto contendo metionina, microorganismo, gene isolado, o-acetil-homosserina sulfidrilase mutante ou enzimas de o-succinil-homosserina sulfidrilase, e organismo - Google Patents

Métodos para produzir metionina, para aperfeiçoar o uso de dmds para produção de metionina, e, para identificar um alelo mutante, composição, produto contendo metionina, microorganismo, gene isolado, o-acetil-homosserina sulfidrilase mutante ou enzimas de o-succinil-homosserina sulfidrilase, e organismo

Info

Publication number
BRPI0612900A8
BRPI0612900A8 BRPI0612900A BRPI0612900A BRPI0612900A8 BR PI0612900 A8 BRPI0612900 A8 BR PI0612900A8 BR PI0612900 A BRPI0612900 A BR PI0612900A BR PI0612900 A BRPI0612900 A BR PI0612900A BR PI0612900 A8 BRPI0612900 A8 BR PI0612900A8
Authority
BR
Brazil
Prior art keywords
methionine
homoserine
dmds
sulphydrylase
mutant
Prior art date
Application number
BRPI0612900A
Other languages
English (en)
Inventor
Haefner Stefan
Herold Andrea
Klopprogge Corinna
Rogers Yocum R
Zelder Oskar
Schröder Hartwig
K Williams Mark
Original Assignee
Basf Ag
Basf Se
Evonik Degussa Gmbh
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Basf Se, Evonik Degussa Gmbh, Evonik Operations Gmbh filed Critical Basf Ag
Publication of BRPI0612900A2 publication Critical patent/BRPI0612900A2/pt
Publication of BRPI0612900A8 publication Critical patent/BRPI0612900A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

Abstract

MÉTODOS PARA PRODUZIR METIONINA, PARA APERFEIÇOAR O USO DE DMDS PARA PRODUÇÃO DE METIONINA, E, PARA IDENTIFICAR UM ALELO MUTANTE, COMPOSIÇÃO, PRODUTO CONTENDO METIONINA, MICROORGANISMO, GENE ISOLADO, OACETIL-HOMOSSERINA SULFIDRILASE MUTANTE OU ENZIMAS DE O-SUCCINIL-HOMOSSERINA SULFIDRILASE, E ORGANISMO. A presente invenção proporcionar organismos e processos aperfeiçoados para a produção de metionina. A invenção demonstra que um organismo AmetE AmetH, por exemplo, mutantes de C. glutamicum ou E. coli, pode usar uma fonte de sulfeto terminada com metila, p. ex., dissulfeto de dimetila (DMDS), como uma fonte tanto de um grupo metila como de enxofre, contornando a necessidade de atividade MetH/MetE/ e MetF e a necessidade de reduzir sulfato, para a necessidade de reduzir sulfato, para a síntese de metionina. Também se descreve nesta patente dados que implicam MetY (também denominado MetZ) como um enzima que incorpora uma fonte de sulfeto terminada com metila, p. ex., DMDS, em metionina. Uma cepa AmetF AmetB de C. glutamicum pode usar uma fonte de sulfeto terminada com metila, p. ex., DMDS, como uma fonte, tanto de um grupo metila como de sulfeto. Adicionalmente, a produção de metionina por meio de organismos prototróficos manipulados que superproduzem O-acetil-homosserina foi aperfeiçoada com a adição de uma fonte de sulfeto terminada com metila, p. ex., DMDS.
BRPI0612900A 2005-07-18 2006-07-18 Métodos para produzir metionina, para aperfeiçoar o uso de dmds para produção de metionina, e, para identificar um alelo mutante, composição, produto contendo metionina, microorganismo, gene isolado, o-acetil-homosserina sulfidrilase mutante ou enzimas de o-succinil-homosserina sulfidrilase, e organismo BRPI0612900A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70069805P 2005-07-18 2005-07-18
US71390705P 2005-09-01 2005-09-01
PCT/US2006/027855 WO2007011939A2 (en) 2005-07-18 2006-07-18 Use of dimethyl disulfide for methionine production in microorganisms

Publications (2)

Publication Number Publication Date
BRPI0612900A2 BRPI0612900A2 (pt) 2014-10-14
BRPI0612900A8 true BRPI0612900A8 (pt) 2022-07-19

Family

ID=37669511

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0612900A BRPI0612900A8 (pt) 2005-07-18 2006-07-18 Métodos para produzir metionina, para aperfeiçoar o uso de dmds para produção de metionina, e, para identificar um alelo mutante, composição, produto contendo metionina, microorganismo, gene isolado, o-acetil-homosserina sulfidrilase mutante ou enzimas de o-succinil-homosserina sulfidrilase, e organismo

Country Status (10)

Country Link
US (1) US8399214B2 (pt)
EP (1) EP1907558B1 (pt)
JP (1) JP2009501548A (pt)
KR (1) KR20080033413A (pt)
AT (1) ATE489471T1 (pt)
BR (1) BRPI0612900A8 (pt)
CA (1) CA2615315C (pt)
DE (1) DE602006018468D1 (pt)
RU (1) RU2413001C2 (pt)
WO (1) WO2007011939A2 (pt)

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ES2575906T3 (es) 2007-04-11 2016-07-04 Cj Cheiljedang Corporation Composiciones y métodos de producir metionina
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WO2010020290A1 (en) * 2008-08-22 2010-02-25 Metabolic Explorer Producing methionine without n-acetyl methionine
KR101048593B1 (ko) * 2009-02-27 2011-07-12 씨제이제일제당 (주) 메칠머캅탄과 디메칠설파이드의 혼합물을 사용하여 메치오닌 생산능을 증가시키는 방법
DE102009030342A1 (de) 2009-06-25 2010-12-30 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von organisch chemischen Verbindungen
US20120295317A1 (en) 2009-12-17 2012-11-22 Basf Se Processes and Recombinant Microorganisms for the Production of Cadaverine
JP5819316B2 (ja) * 2009-12-30 2015-11-24 メタボリック エクスプローラー コハク酸デヒドロゲナーゼを過剰発現させることによるメチオニンの増産
KR101250651B1 (ko) * 2010-12-21 2013-04-03 씨제이제일제당 (주) 신규 ｏ-아세틸호모세린 설피드릴라제 또는 변이체 및 이를 이용한 메치오닌 전환 방법
EP2479279A1 (de) 2011-01-20 2012-07-25 Evonik Degussa GmbH Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren
CN103492553B (zh) 2011-02-22 2018-06-12 巴斯夫欧洲公司 用于生产尸胺的方法和重组微生物
DE102011006716A1 (de) 2011-04-04 2012-10-04 Evonik Degussa Gmbh Mikroorganismus und Verfahren zur fermentativen Herstellung einer organisch-chemischen Verbindung
DE102011118019A1 (de) 2011-06-28 2013-01-03 Evonik Degussa Gmbh Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens
EP2762571A1 (de) 2013-01-30 2014-08-06 Evonik Industries AG Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren
BR112016004367B1 (pt) 2013-08-30 2022-06-14 Evonik Operations Gmbh Microrganismo recombinante e método para a produção fermentativa de metionina e/ou seus derivados
KR101555750B1 (ko) * 2013-10-23 2015-09-25 씨제이제일제당 (주) O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법
KR101555749B1 (ko) * 2013-10-23 2015-09-25 씨제이제일제당 (주) O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법
WO2015109265A1 (en) * 2014-01-16 2015-07-23 Calysta, Inc. Microorganisms for the enhanced production of amino acids and related methods
MY194223A (en) 2014-09-01 2022-11-22 Evonik Operations Gmbh Method and microorganism for methionine production by fermentation with improved methionine efflux
FR3041658B1 (fr) * 2015-09-30 2017-10-20 Arkema France Procede de production de l-methionine
FR3041659B1 (fr) * 2015-09-30 2017-10-20 Arkema France Procede de production de l-methionine
ES2748226T3 (es) * 2015-11-27 2020-03-16 Evonik Operations Gmbh Procedimiento de producción de L-metionina
EP3296404A1 (en) 2016-09-15 2018-03-21 Evonik Degussa GmbH Modified microorganism for production of methionine
JP7188385B2 (ja) * 2016-10-26 2022-12-13 味の素株式会社 Ｌ－メチオニンまたは合成にｓ－アデノシルメチオニンを要求する代謝物の製造方法
EP3354742A1 (en) 2017-01-26 2018-08-01 Metabolic Explorer Methods and microorganisms for the production of glycolic acid and/or glyoxylic acid

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Also Published As

Publication number Publication date
CA2615315C (en) 2015-10-06
ATE489471T1 (de) 2010-12-15
KR20080033413A (ko) 2008-04-16
WO2007011939A2 (en) 2007-01-25
EP1907558A2 (en) 2008-04-09
BRPI0612900A2 (pt) 2014-10-14
RU2008138584A (ru) 2010-04-10
DE602006018468D1 (de) 2011-01-05
RU2413001C2 (ru) 2011-02-27
WO2007011939A3 (en) 2007-07-05
CA2615315A1 (en) 2007-01-25
US8399214B2 (en) 2013-03-19
EP1907558B1 (en) 2010-11-24
JP2009501548A (ja) 2009-01-22
US20090281353A1 (en) 2009-11-12

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Legal Events

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B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO NO ORIGINAL, TRASLADO OU FOTOCOPIA AUTENTICADA.

B25D Requested change of name of applicant approved

Owner name: BASF SE (DE)

B25A Requested transfer of rights approved

Owner name: EVONIK DEGUSSA GMBH (DE)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C12P 13/12 (2006.01), C12N 15/77 (2006.01), C12N 1

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B25D Requested change of name of applicant approved

Owner name: EVONIK OPERATIONS GMBH (DE)

B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time