BRPI0612411B8 - célula hospedeira de microrganismo transgênico e método para produzir um composto isoprenoide em uma célula hospedeira - Google Patents
célula hospedeira de microrganismo transgênico e método para produzir um composto isoprenoide em uma célula hospedeiraInfo
- Publication number
- BRPI0612411B8 BRPI0612411B8 BRPI0612411A BRPI0612411A BRPI0612411B8 BR PI0612411 B8 BRPI0612411 B8 BR PI0612411B8 BR PI0612411 A BRPI0612411 A BR PI0612411A BR PI0612411 A BRPI0612411 A BR PI0612411A BR PI0612411 B8 BRPI0612411 B8 BR PI0612411B8
- Authority
- BR
- Brazil
- Prior art keywords
- host cell
- present
- nucleic acid
- isoprenoid
- producing
- Prior art date
Links
- -1 isoprenoid compound Chemical class 0.000 title abstract 3
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 150000003505 terpenes Chemical class 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69706705P | 2005-07-05 | 2005-07-05 | |
| US60/697,067 | 2005-07-05 | ||
| PCT/US2006/025572 WO2007005604A2 (en) | 2005-07-05 | 2006-06-29 | Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0612411A2 BRPI0612411A2 (pt) | 2010-11-09 |
| BRPI0612411A8 BRPI0612411A8 (pt) | 2017-12-26 |
| BRPI0612411B1 BRPI0612411B1 (pt) | 2020-05-05 |
| BRPI0612411B8 true BRPI0612411B8 (pt) | 2021-05-25 |
Family
ID=37605033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0612411A BRPI0612411B8 (pt) | 2005-07-05 | 2006-06-29 | célula hospedeira de microrganismo transgênico e método para produzir um composto isoprenoide em uma célula hospedeira |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8163980B2 (https=) |
| EP (2) | EP1919514B1 (https=) |
| JP (1) | JP2009504138A (https=) |
| KR (2) | KR101487304B1 (https=) |
| CN (4) | CN101495499B (https=) |
| AP (1) | AP3827A (https=) |
| BR (1) | BRPI0612411B8 (https=) |
| CA (1) | CA2613469C (https=) |
| DK (1) | DK1919514T3 (https=) |
| ES (2) | ES2386554T3 (https=) |
| IL (1) | IL188376A (https=) |
| MX (1) | MX2008000200A (https=) |
| PL (1) | PL1919514T3 (https=) |
| PT (1) | PT1919514E (https=) |
| SG (1) | SG176459A1 (https=) |
| SI (1) | SI1919514T1 (https=) |
| WO (1) | WO2007005604A2 (https=) |
| ZA (1) | ZA200800889B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2298859A3 (en) | 2004-07-27 | 2011-05-25 | The Regents of the University of California | Genetically modified host cells and use of same for producing isoprenoid compounds |
| CN101495499B (zh) * | 2005-07-05 | 2013-09-04 | 加利福尼亚大学董事会 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| WO2007140339A2 (en) | 2006-05-26 | 2007-12-06 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
| EP2066778B1 (en) * | 2006-09-26 | 2016-01-27 | The Regents of The University of California | Production of isoprenoids and isoprenoid precursors |
| WO2008150461A2 (en) | 2007-06-01 | 2008-12-11 | Sapphire Energy | High throughput screening of genetically modified photosynthetic organisms |
| NZ583620A (en) | 2007-09-11 | 2012-08-31 | Sapphire Energy Inc | Methods of producing organic fuel products with photosynthetic organisms |
| EP2444415A1 (en) * | 2010-10-20 | 2012-04-25 | Genoplante-Valor | 1-Deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis |
| US10000773B2 (en) | 2011-11-01 | 2018-06-19 | Firmenich Sa | Cytochrome P450 and use thereof for the enzymatic oxidation of terpenes |
| JP5827601B2 (ja) | 2012-07-04 | 2015-12-02 | 住友ゴム工業株式会社 | 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| WO2014037373A1 (en) * | 2012-09-07 | 2014-03-13 | Sanofi | Fusion proteins for treating a metabolic syndrome |
| PL224377B1 (pl) * | 2012-11-02 | 2016-12-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczep Trichoderma atroviride, sposób otrzymywania i zastosowanie szczepu Trichoderma atroviride jako środka biobójczego |
| CA2924541A1 (en) * | 2013-09-19 | 2015-03-26 | Firmenich Sa | Method for producing fragrant alcohols |
| US10457949B2 (en) * | 2014-08-21 | 2019-10-29 | Chung-Ang University Industry-Academy Cooperation Foundation | rDNA NTS-based gene multiple insertion cassette set and GRAS-grade recombinant yeast strain |
| US11697830B2 (en) * | 2015-04-15 | 2023-07-11 | Ramon Gonzalez | Iterative platform for the synthesis of alpha functionalized products |
| EP3283615A4 (en) * | 2015-04-15 | 2018-09-05 | William Marsh Rice University | Iterative platform for the synthesis of alpha functionalized products |
| CN105177007B (zh) * | 2015-10-30 | 2017-11-10 | 上海交通大学 | 一种调控基因在非分泌型腺毛中表达的启动子及其应用 |
| CN105274109B (zh) * | 2015-10-30 | 2017-12-29 | 上海交通大学 | 一种调控基因在非分泌型腺毛中表达的启动子及其应用 |
| CN105483236A (zh) * | 2015-12-26 | 2016-04-13 | 吉林省农业科学院 | 转基因植物中cry1C基因的LAMP检测引物组、试剂盒及检测方法 |
| CN105567685B (zh) * | 2016-01-18 | 2018-07-13 | 上海交通大学 | AaPDR3基因启动子及其应用 |
| SG10201913280UA (en) | 2016-09-20 | 2020-03-30 | 22Nd Century Limited Llc | Trichome specific promoters for the manipulation of cannabinoids and other compounds in glandular trichomes |
| WO2018111194A1 (en) * | 2016-12-16 | 2018-06-21 | Temasek Life Sciences Laboratory Limited | Targets for improving terpene production in rhodosporidium toruloides |
| CA3056929A1 (en) | 2017-03-24 | 2018-09-27 | Trait Biosciences, Inc. | High level in vivo biosynthesis and isolation of water-soluble cannabinoids in plant systems |
| US11946059B2 (en) | 2017-07-11 | 2024-04-02 | Trait Biosciences, Inc. | In vivo generation of water-soluble cannabinoids in plant cell suspension cultures |
| US11905543B2 (en) | 2017-07-11 | 2024-02-20 | Trait Biosceinces, Inc. | In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures |
| CA3069178A1 (en) | 2017-07-11 | 2019-01-17 | Trait Biosciences, Inc. | Generation of water-soluble cannabinoid compounds in yeast and plant cell suspension cultures and compositions of matter |
| EP3877519B1 (en) | 2018-11-09 | 2026-03-11 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| CN115176023A (zh) * | 2020-01-23 | 2022-10-11 | 阿米瑞斯公司 | 紫穗槐-4,11-二烯12-单加氧酶变体及其用途 |
| CN111621508B (zh) * | 2020-06-11 | 2022-07-01 | 云南中烟工业有限责任公司 | 烟草萜类合成酶NtTPS7基因及其载体与应用 |
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| US5451513A (en) | 1990-05-01 | 1995-09-19 | The State University of New Jersey Rutgers | Method for stably transforming plastids of multicellular plants |
| CA2132961A1 (en) * | 1992-03-27 | 1993-10-14 | International Flower Developments Pty. Ltd. | Genetic sequences encoding flavonoid pathway enzymes and uses therefor |
| FR2689905B1 (fr) * | 1992-04-13 | 1995-07-13 | Orsan | Procede de clonage d'une sequence d'adn codant pour une nadph cytochrome p450 reductase et sequences d'adn codant pour une nadph-cytochrome p450 reductase, notamment de plantes. |
| US5576198A (en) | 1993-12-14 | 1996-11-19 | Calgene, Inc. | Controlled expression of transgenic constructs in plant plastids |
| US5545817A (en) | 1994-03-11 | 1996-08-13 | Calgene, Inc. | Enhanced expression in a plant plastid |
| US5545818A (en) | 1994-03-11 | 1996-08-13 | Calgene Inc. | Expression of Bacillus thuringiensis cry proteins in plant plastids |
| KR20060099543A (ko) | 1994-12-09 | 2006-09-19 | 임페리얼 컬리지 이노베이션스 리미티드 | 유전자의 동정 |
| TR199902183T2 (xx) * | 1997-03-07 | 1999-12-21 | Novartis Ag | Sitokrom P450 monoksigenazlar |
| US6900012B1 (en) | 1997-06-03 | 2005-05-31 | The University Of Chicago | Plant artificial chromosome compositions and methods |
| US6083731A (en) | 1997-06-24 | 2000-07-04 | Washington State University Research Foundation | Recombinant materials and methods for the production of limonene hydroxylases |
| US6080849A (en) | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| EP0982404A1 (en) * | 1998-08-27 | 2000-03-01 | Wallaart, Thorvald Eelco | DNA encoding amorpha-4,11-diene synthase |
| US6645747B1 (en) | 1999-09-21 | 2003-11-11 | E. I. Du Pont De Nemours And Company | Cis-prenyltransferases from plants |
| US6369212B1 (en) | 2000-02-07 | 2002-04-09 | Korea Kumbo Petrochemical Co., Ltd. | Cytochrome P450 gene highly expressed in the incompatible interaction |
| US7501268B2 (en) * | 2000-12-28 | 2009-03-10 | Toyota Jidosha Kabushiki Kaisha | Methods of producing prenyl alcohols |
| GB0105924D0 (en) | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
| EP1373476B1 (en) * | 2001-03-09 | 2011-06-15 | University Of Kentucky Research Foundation | Cytochrome p450s and uses thereof |
| AUPR446701A0 (en) * | 2001-04-18 | 2001-05-17 | Gene Stream Pty Ltd | Transgenic mammals for pharmacological and toxicological studies |
| CN1589327A (zh) | 2001-09-17 | 2005-03-02 | 植物研究国际公司 | 用于生物转化的植物酶 |
| US20040162420A1 (en) | 2002-10-16 | 2004-08-19 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| US6733996B2 (en) | 2002-08-26 | 2004-05-11 | Trustees Of Dartmouth College | Methods for regulating gene expression using light |
| CN101495499B (zh) * | 2005-07-05 | 2013-09-04 | 加利福尼亚大学董事会 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| CA2630305A1 (en) * | 2005-10-24 | 2007-05-03 | National Research Council Of Canada | A novel gene encoding amorphadiene hydroxylase and a process to produce artemisinic alcohol therewith |
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2006
- 2006-06-29 CN CN2006800246664A patent/CN101495499B/zh active Active
- 2006-06-29 PT PT06785959T patent/PT1919514E/pt unknown
- 2006-06-29 ES ES06785959T patent/ES2386554T3/es active Active
- 2006-06-29 CA CA2613469A patent/CA2613469C/en active Active
- 2006-06-29 JP JP2008519611A patent/JP2009504138A/ja not_active Withdrawn
- 2006-06-29 CN CN201710271576.5A patent/CN106939323B/zh active Active
- 2006-06-29 EP EP06785959A patent/EP1919514B1/en active Active
- 2006-06-29 SG SG2011081403A patent/SG176459A1/en unknown
- 2006-06-29 ES ES12158465.0T patent/ES2621657T3/es active Active
- 2006-06-29 MX MX2008000200A patent/MX2008000200A/es active IP Right Grant
- 2006-06-29 WO PCT/US2006/025572 patent/WO2007005604A2/en not_active Ceased
- 2006-06-29 CN CN201310335874.8A patent/CN103667370B/zh active Active
- 2006-06-29 EP EP12158465.0A patent/EP2489672B1/en active Active
- 2006-06-29 KR KR1020137011897A patent/KR101487304B1/ko active Active
- 2006-06-29 BR BRPI0612411A patent/BRPI0612411B8/pt active IP Right Grant
- 2006-06-29 CN CN201610412819.8A patent/CN105950667A/zh active Pending
- 2006-06-29 SI SI200631367T patent/SI1919514T1/sl unknown
- 2006-06-29 ZA ZA200800889A patent/ZA200800889B/xx unknown
- 2006-06-29 DK DK06785959.5T patent/DK1919514T3/da active
- 2006-06-29 US US11/917,875 patent/US8163980B2/en active Active
- 2006-06-29 KR KR1020087002992A patent/KR101444090B1/ko active Active
- 2006-06-29 AP AP2013006962A patent/AP3827A/en active
- 2006-06-29 PL PL06785959T patent/PL1919514T3/pl unknown
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2007
- 2007-12-24 IL IL188376A patent/IL188376A/en active IP Right Grant
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2012
- 2012-03-21 US US13/426,387 patent/US8759632B2/en active Active
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 05/05/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/06/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |