BRPI0606557A2 - método de inibição do abrigo de her2, método de redução do nìvel em soro de domìnio extracelular (ecd) de her2 em mamìferos, métodos de tratamento de cáncer em mamìferos, método de redução do nìvel de p95 her2 em célula e método de diagnóstico - Google Patents

método de inibição do abrigo de her2, método de redução do nìvel em soro de domìnio extracelular (ecd) de her2 em mamìferos, métodos de tratamento de cáncer em mamìferos, método de redução do nìvel de p95 her2 em célula e método de diagnóstico

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Publication number
BRPI0606557A2
BRPI0606557A2 BRPI0606557-0A BRPI0606557A BRPI0606557A2 BR PI0606557 A2 BRPI0606557 A2 BR PI0606557A2 BR PI0606557 A BRPI0606557 A BR PI0606557A BR PI0606557 A2 BRPI0606557 A2 BR PI0606557A2
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BR
Brazil
Prior art keywords
her2
level reduction
reduction method
ecd
extracellular domain
Prior art date
Application number
BRPI0606557-0A
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English (en)
Inventor
Kendall D Carey
Ralph H Schwall
Mark X Sliwkowski
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BRPI0606557A2 publication Critical patent/BRPI0606557A2/pt

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    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)

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Abstract

MéTODO DE INIBIçãO DO ABRIGO DE HER2, MéTODO DE REDUçãO DO NìVEL EM SORO DE DOMìNIO EXTRACELULAR (ECD) DE HER2 EM MAMìFEROS, MéTODOS DE TRATAMENTO DE CáNCER EM MAMìFEROS, MéTODO DE REDUçãO DO NìVEL DE P95 HER2 EM CéLULA E MéTODO DE DIAGNóSTICO. O presente pedido descreve o uso de antagonistas de metaloproteases de matrizes (MMPs), especialmente MMP-15, para inibir o abrigo de HER2.
BRPI0606557-0A 2005-02-09 2006-02-09 método de inibição do abrigo de her2, método de redução do nìvel em soro de domìnio extracelular (ecd) de her2 em mamìferos, métodos de tratamento de cáncer em mamìferos, método de redução do nìvel de p95 her2 em célula e método de diagnóstico BRPI0606557A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65134805P 2005-02-09 2005-02-09
PCT/US2006/004926 WO2006086730A2 (en) 2005-02-09 2006-02-09 Inhibiting her2 shedding with matrix metalloprotease antagonists

Publications (1)

Publication Number Publication Date
BRPI0606557A2 true BRPI0606557A2 (pt) 2009-06-30

Family

ID=36793798

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606557-0A BRPI0606557A2 (pt) 2005-02-09 2006-02-09 método de inibição do abrigo de her2, método de redução do nìvel em soro de domìnio extracelular (ecd) de her2 em mamìferos, métodos de tratamento de cáncer em mamìferos, método de redução do nìvel de p95 her2 em célula e método de diagnóstico

Country Status (14)

Country Link
US (1) US20060177448A1 (pt)
EP (1) EP1846558A2 (pt)
JP (1) JP2008530123A (pt)
KR (1) KR20070100968A (pt)
CN (1) CN101115836A (pt)
AU (1) AU2006213659A1 (pt)
BR (1) BRPI0606557A2 (pt)
CA (1) CA2595395A1 (pt)
IL (1) IL184564A0 (pt)
MX (1) MX2007009566A (pt)
NO (1) NO20074544L (pt)
RU (1) RU2007133660A (pt)
WO (1) WO2006086730A2 (pt)
ZA (1) ZA200706247B (pt)

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WO2006086730A2 (en) 2006-08-17
WO2006086730A3 (en) 2007-03-01
CA2595395A1 (en) 2006-08-17
ZA200706247B (en) 2008-11-26
IL184564A0 (en) 2008-12-29
RU2007133660A (ru) 2009-03-20
KR20070100968A (ko) 2007-10-15
AU2006213659A1 (en) 2006-08-17
CN101115836A (zh) 2008-01-30
NO20074544L (no) 2007-11-08
EP1846558A2 (en) 2007-10-24
JP2008530123A (ja) 2008-08-07
US20060177448A1 (en) 2006-08-10
MX2007009566A (es) 2009-02-16

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