BRPI0519893A2 - derivados da piperidina-2, 6-diona e o seu uso como inibidores do fator de necrose tumoral - Google Patents

derivados da piperidina-2, 6-diona e o seu uso como inibidores do fator de necrose tumoral

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Publication number
BRPI0519893A2
BRPI0519893A2 BRPI0519893-3A BRPI0519893A BRPI0519893A2 BR PI0519893 A2 BRPI0519893 A2 BR PI0519893A2 BR PI0519893 A BRPI0519893 A BR PI0519893A BR PI0519893 A2 BRPI0519893 A2 BR PI0519893A2
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Prior art keywords
alkyl
membered
derivatives
piperidine
chr
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BRPI0519893-3A
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English (en)
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Hesheng Zhang
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Tianjin Heway Bio Tech Co Ltd
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Publication of BRPI0519893A2 publication Critical patent/BRPI0519893A2/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVADOS DA PIPERIDINA-2, 6-DIONA E ó SEU USO COMO INIBIDORES DO FATOR DE NECROSE TUMORAL. Esta invenção dirige-se aos derivados da piperklina-2,6-diona, ou respectivos sais orgânicos e inorgânicos, métodos para sintetizar estes derivados, e a sua aplicação como ingredientes farmacologicamente activos como inibklores do TNFa segregado nas células, sendo os derivados da piperidina-2,6-diona da fórmula geral (I): (I), em que n representa 1, 2, 3, 4, 5 ou 6; R¹ representa de um a quatro dos mesmos ou diferentes substituintes seleccionados de F, CI, Br, C~ 1-4~ alquilo, OH, OC~ 1-4~ alquilo, NO~ 2~, NHC(O)C~ 1-4~ alquilo, NH~ 2~, NH(C~ 1-4~ alquilo), N(C~ 1-4~ alquilo)~ 2~; R² representa OR³, NR³R^ 4^, N(R³)COR^ 4^, O~ 2~CR^ 5^; R^ 3^ e R^ 4^ representam independentemente e em cada ocorrência H ou C~ 1-4~ alquilo; R^ 5^ representa CHR^ 6^NR^ 7^R^ 8^, CHR^ 6^NR^ 9^C(O)CHR^ 10^NR^ 7^ R^ 8^, um heterociclo W ou CHR^ 6^NR^ 9^C(O)W; R^ 6^, R^ 9^, R^ 10^ representam bdependentemente e em cada ocorrência H, ou C~ 1-4~ alquilo; R^ 7^ e R^ 8^ representam independentemente e em cada ocorrência H, C~ 1-4~ alquilo, ou e R^ 8^ conjuntamente representam 1,3-propileno, 1 ,4-butileno, 1 ,5-pentileno, ou 1 ,6-hexileno; W representa um heterociclo de quatro membros, de cinco membros, de seis membros, de sete membros ou de oito membros, saturado ou insabrado.
BRPI0519893-3A 2005-04-07 2005-09-13 derivados da piperidina-2, 6-diona e o seu uso como inibidores do fator de necrose tumoral BRPI0519893A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB2005100132923A CN100383139C (zh) 2005-04-07 2005-04-07 可抑制细胞释放肿瘤坏死因子的哌啶-2，6-二酮衍生物
PCT/CN2005/001467 WO2006105697A1 (en) 2005-04-07 2005-09-13 Piperidyl-2, 6-dione derivatives used to inhibit cells from releasing tumor necrosis factor

Publications (1)

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BRPI0519893A2 true BRPI0519893A2 (pt) 2009-03-31

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BRPI0519893-3A BRPI0519893A2 (pt) 2005-04-07 2005-09-13 derivados da piperidina-2, 6-diona e o seu uso como inibidores do fator de necrose tumoral

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US (5) US8637545B2 (pt)
EP (1) EP1867649B1 (pt)
JP (1) JP5059745B2 (pt)
KR (1) KR20080004485A (pt)
CN (1) CN100383139C (pt)
AU (1) AU2005330099A1 (pt)
BR (1) BRPI0519893A2 (pt)
CA (1) CA2604021A1 (pt)
ES (1) ES2401281T3 (pt)
WO (1) WO2006105697A1 (pt)
ZA (1) ZA200709122B (pt)

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US9669015B2 (en) 2017-06-06
US20190247383A1 (en) 2019-08-15
KR20080004485A (ko) 2008-01-09
US20180050025A1 (en) 2018-02-22
US8637545B2 (en) 2014-01-28
US9085563B2 (en) 2015-07-21
CA2604021A1 (en) 2006-10-12
US10166222B2 (en) 2019-01-01
US20080051432A1 (en) 2008-02-28
ES2401281T3 (es) 2013-04-18
AU2005330099A1 (en) 2006-10-12
US20150272940A1 (en) 2015-10-01
JP2008534631A (ja) 2008-08-28
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WO2006105697A1 (en) 2006-10-12

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