BRPI0518191A - métodos e composições para reduzir a toxicidade de um composto farmacêutico - Google Patents
métodos e composições para reduzir a toxicidade de um composto farmacêuticoInfo
- Publication number
- BRPI0518191A BRPI0518191A BRPI0518191-7A BRPI0518191A BRPI0518191A BR PI0518191 A BRPI0518191 A BR PI0518191A BR PI0518191 A BRPI0518191 A BR PI0518191A BR PI0518191 A BRPI0518191 A BR PI0518191A
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- pharmaceutical
- adverse gastrointestinal
- pharmaceutical compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
MéTODOS E COMPOSIçõES PARA REDUZIR A TOXICIDADE DE UM COMPOSTO FARMACêUTICO. A presente descrição se refere a soluções aquosas claras de um ou mais ácidos biliares e/ou um produto de conversão de amido solúvel aquoso ou um polissacarídeo não amido. As soluções da descrição podem ser administradas a um sujeito em conjunto com um composto farmacêutico dotado de um ou mais efeitos tóxicos. Em algumas modalidades, as soluções da descrição são administradas a um mamífero em conjunto com um composto farmacêutico associado com neurotoxicidade periférica (por exemplo, cispíatina e/ou suramina) para reduzir ou eliminar o(s) efeito(s) neuropático(s).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61919904P | 2004-10-15 | 2004-10-15 | |
PCT/US2005/037211 WO2006044771A2 (en) | 2004-10-15 | 2005-10-14 | Methods and compositions for reducing toxicity of a pharmaceutical compound |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0518191A true BRPI0518191A (pt) | 2008-11-04 |
Family
ID=36203610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0518191-7A BRPI0518191A (pt) | 2004-10-15 | 2005-10-14 | métodos e composições para reduzir a toxicidade de um composto farmacêutico |
Country Status (11)
Country | Link |
---|---|
US (1) | US7932243B2 (pt) |
EP (1) | EP1809330B1 (pt) |
JP (1) | JP2008516977A (pt) |
KR (1) | KR20070084211A (pt) |
CN (1) | CN101039699B (pt) |
AT (1) | ATE506955T1 (pt) |
AU (1) | AU2005295541B2 (pt) |
BR (1) | BRPI0518191A (pt) |
CA (1) | CA2584184A1 (pt) |
DE (1) | DE602005027727D1 (pt) |
WO (1) | WO2006044771A2 (pt) |
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US20050158408A1 (en) * | 1998-07-24 | 2005-07-21 | Yoo Seo H. | Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof |
US20070072828A1 (en) * | 1998-07-24 | 2007-03-29 | Yoo Seo H | Bile preparations for colorectal disorders |
US7772220B2 (en) * | 2004-10-15 | 2010-08-10 | Seo Hong Yoo | Methods and compositions for reducing toxicity of a pharmaceutical compound |
US7303768B2 (en) * | 1998-07-24 | 2007-12-04 | Seo Hong Yoo | Preparation of aqueous clear solution dosage forms with bile acids |
US7145125B2 (en) | 2003-06-23 | 2006-12-05 | Advanced Optical Technologies, Llc | Integrating chamber cone light using LED sources |
CN101035541B (zh) * | 2004-08-30 | 2012-05-30 | 柳署弘 | 溶解的udca在局灶缺血模型中的神经保护作用 |
EP1809330B1 (en) | 2004-10-15 | 2011-04-27 | Seo Hong Yoo | Compositions for reducing toxicity of cisplatin, carboplatin, and oxaliplatin |
DE602005025391D1 (de) * | 2004-11-01 | 2011-01-27 | Seo Hong Yoo | Verfahren und zusammensetzungen zur verringerung der neurodegeneration bei amyotrophischer lateralsklerose |
AU2007230718B2 (en) * | 2006-03-28 | 2012-05-10 | Javelin Pharmaceuticals, Inc. | Formulations of low dose non-steroidal anti-inflammatory drugs and beta-cyclodextrin |
AU2007230716B2 (en) * | 2006-03-28 | 2012-05-03 | Javelin Pharmaceuticals, Inc. | Formulations of low dose diclofenac and beta-cyclodextrin |
JP2010503667A (ja) * | 2006-09-15 | 2010-02-04 | ホン ユー,ソ | 大腸疾患用胆汁製剤 |
EP2293801A1 (en) * | 2008-06-06 | 2011-03-16 | N.V. Nutricia | Method for preventing corticosteroid usage |
CZ302789B6 (cs) * | 2009-11-25 | 2011-11-09 | Zentiva, K. S. | Zpusob zvýšení rozpustnosti farmaceuticky aktivních látek a cílený (kontrolovaný) transport do streva |
KR20140012029A (ko) | 2010-10-21 | 2014-01-29 | 알티유 파머수티컬즈, 엘엘시 | 즉시 사용가능한 케토로락 제제 |
US10369108B2 (en) | 2013-03-15 | 2019-08-06 | Mylan Laboratories, Inc. | Hot melt granulation formulations of poorly water-soluble active agents |
US9662342B2 (en) * | 2014-05-09 | 2017-05-30 | AuroMedics Pharma LLC | Formulations of cyclophosphamide liquid concentrate |
SG11201610228RA (en) | 2014-06-27 | 2017-01-27 | Medytox Inc | Methods and compositions of bile acids and salts for reduction of fat |
KR102204406B1 (ko) * | 2019-01-23 | 2021-01-18 | (주)샤페론 | 타우로데옥시콜린산 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 염증성 장질환 예방 또는 치료용 조성물 |
WO2021083336A1 (zh) * | 2019-11-01 | 2021-05-06 | 北京大学 | 胆汁酸及其衍生物在制备gpr39激动剂中的用途 |
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EP1809330B1 (en) | 2004-10-15 | 2011-04-27 | Seo Hong Yoo | Compositions for reducing toxicity of cisplatin, carboplatin, and oxaliplatin |
DE602005025391D1 (de) | 2004-11-01 | 2011-01-27 | Seo Hong Yoo | Verfahren und zusammensetzungen zur verringerung der neurodegeneration bei amyotrophischer lateralsklerose |
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-
2005
- 2005-10-14 EP EP05813305A patent/EP1809330B1/en not_active Not-in-force
- 2005-10-14 BR BRPI0518191-7A patent/BRPI0518191A/pt not_active IP Right Cessation
- 2005-10-14 JP JP2007536987A patent/JP2008516977A/ja active Pending
- 2005-10-14 DE DE602005027727T patent/DE602005027727D1/de active Active
- 2005-10-14 KR KR1020077010964A patent/KR20070084211A/ko not_active Application Discontinuation
- 2005-10-14 CA CA002584184A patent/CA2584184A1/en not_active Abandoned
- 2005-10-14 WO PCT/US2005/037211 patent/WO2006044771A2/en active Application Filing
- 2005-10-14 CN CN2005800348841A patent/CN101039699B/zh not_active Expired - Fee Related
- 2005-10-14 AT AT05813305T patent/ATE506955T1/de not_active IP Right Cessation
- 2005-10-14 AU AU2005295541A patent/AU2005295541B2/en not_active Ceased
-
2006
- 2006-03-10 US US11/373,554 patent/US7932243B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2005295541A1 (en) | 2006-04-27 |
ATE506955T1 (de) | 2011-05-15 |
KR20070084211A (ko) | 2007-08-24 |
CN101039699A (zh) | 2007-09-19 |
EP1809330B1 (en) | 2011-04-27 |
US20060188530A1 (en) | 2006-08-24 |
CN101039699B (zh) | 2011-07-27 |
DE602005027727D1 (de) | 2011-06-09 |
US7932243B2 (en) | 2011-04-26 |
EP1809330A2 (en) | 2007-07-25 |
AU2005295541B2 (en) | 2011-02-17 |
WO2006044771A3 (en) | 2007-03-29 |
WO2006044771A2 (en) | 2006-04-27 |
JP2008516977A (ja) | 2008-05-22 |
CA2584184A1 (en) | 2006-04-27 |
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