BRPI0512180A - plasmìdio de dna; composição imunogênica para induzir uma resposta imune a antìgenos selecionados em um hospedeiro vertebrado; método de imunização de um hospedeiro invertebrado contra antìgenos selecionado; composição imunogênica para induzir uma resposta imune ao vìrus da imunodeficiência humana (hiv) em um hospedeiro vertebrado; método para imunizar um hospedeiro vertebrado contra antìgenos selecionados; composição imunogênica; e uso de uma composição imunogênica - Google Patents

plasmìdio de dna; composição imunogênica para induzir uma resposta imune a antìgenos selecionados em um hospedeiro vertebrado; método de imunização de um hospedeiro invertebrado contra antìgenos selecionado; composição imunogênica para induzir uma resposta imune ao vìrus da imunodeficiência humana (hiv) em um hospedeiro vertebrado; método para imunizar um hospedeiro vertebrado contra antìgenos selecionados; composição imunogênica; e uso de uma composição imunogênica

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Publication number
BRPI0512180A
BRPI0512180A BRPI0512180-9A BRPI0512180A BRPI0512180A BR PI0512180 A BRPI0512180 A BR PI0512180A BR PI0512180 A BRPI0512180 A BR PI0512180A BR PI0512180 A BRPI0512180 A BR PI0512180A
Authority
BR
Brazil
Prior art keywords
immunogenic composition
induce
immune response
immunizing
host
Prior art date
Application number
BRPI0512180-9A
Other languages
English (en)
Inventor
Maninder K Sidhu
John H Eldridge
Michael Egan
Zimra Israel
Original Assignee
Wyeth Corp
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Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0512180A publication Critical patent/BRPI0512180A/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
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    • A—HUMAN NECESSITIES
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    • A61K2039/55511—Organic adjuvants
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    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
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    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
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    • C12N2740/10011—Retroviridae
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    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/60—Vectors comprising a special translation-regulating system from viruses

Abstract

PLASMìDIO DE DNA; COMPOSIçãO IMUNOGêNICA PARA INDUZIR UMA RESPOSTA IMUNE A ANTìGENOS SELECIONADOS EM UM HOSPEDEIRO VERTEBRADO; MéTODO DE IMUNIZAçãO DE UM HOSPEDEIRO INVERTEBRADO CONTRA ANTìGENOS SELECIONADO; COMPOSIçãO IMUNOGêNICA PARA INDUZIR UMA RESPOSTA IMUNE AO VìRUS DA IMUNODEFICIêNCIA HUMANA (HIV) EM UM HOSPEDEIRO VERTEBRADO; MéTODO PARA IMUNIZAR UM HOSPEDEIRO VERTEBRADO CONTRA ANTìGENOS SELECIONADOS; COMPOSIçãO IMUNOGêNICA; E USO DE UMA COMPOSIçãO IMUNOGêNICA A invenção fornece um plasmídio de DNA compreendendo:(a) uma primeira unidade transcricional compreendendo uma seqüência de nucleotídeo que codifica um primeiro polipeptídeo operavelmente ligado a elementos regulatórios incluindo um primeiro promotor e um primeiro sinal de poliadenilação; (b) uma segunda unidade transcricional compreendendo uma seqüência de nucleotídeo que codifica um segundo polipeptídeo operavelmente ligado a elementos regulatórios incluindo um segundo promotor e um segundo sinal de poliadenilação; (c) uma terceira unidade transcricional compreendendo uma seqüência de nucleotídeo que codifica um terceiro polipeptídeo operavelmente ligado a elementos regulatórios incluindo um terceiro promotor e um terceiro sinal de poliadenilação; e onde o citado primeiro, o citado segundo e o citado terceiro promotor são derivados de diferentes unidades transcricionais; e onde o citado primeiro, o citado segundo e o citado terceiro sinal de poliadenilação são derivados e diferentes unidades transcricionais; A invenção também está relacionada a composições imunogênicas para induzir uma resposta imune ao HIV compreendendo as combinações de dois, três ou quatro p1asmídios, onde cada plasmídio está expressando um antígeno definido, que pode ser um antíqeno único ou a fusão de dois ou três antígenos.
BRPI0512180-9A 2004-06-17 2005-06-15 plasmìdio de dna; composição imunogênica para induzir uma resposta imune a antìgenos selecionados em um hospedeiro vertebrado; método de imunização de um hospedeiro invertebrado contra antìgenos selecionado; composição imunogênica para induzir uma resposta imune ao vìrus da imunodeficiência humana (hiv) em um hospedeiro vertebrado; método para imunizar um hospedeiro vertebrado contra antìgenos selecionados; composição imunogênica; e uso de uma composição imunogênica BRPI0512180A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58043804P 2004-06-17 2004-06-17
US62498304P 2004-11-03 2004-11-03
US66227505P 2005-03-16 2005-03-16
PCT/US2005/021168 WO2006009746A2 (en) 2004-06-17 2005-06-15 Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to hiv

Publications (1)

Publication Number Publication Date
BRPI0512180A true BRPI0512180A (pt) 2008-02-12

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BRPI0512180-9A BRPI0512180A (pt) 2004-06-17 2005-06-15 plasmìdio de dna; composição imunogênica para induzir uma resposta imune a antìgenos selecionados em um hospedeiro vertebrado; método de imunização de um hospedeiro invertebrado contra antìgenos selecionado; composição imunogênica para induzir uma resposta imune ao vìrus da imunodeficiência humana (hiv) em um hospedeiro vertebrado; método para imunizar um hospedeiro vertebrado contra antìgenos selecionados; composição imunogênica; e uso de uma composição imunogênica

Country Status (16)

Country Link
US (2) US20070190031A1 (pt)
EP (2) EP2116605B1 (pt)
JP (3) JP2008503211A (pt)
KR (1) KR101216278B1 (pt)
AR (1) AR049309A1 (pt)
AU (2) AU2005265008A1 (pt)
BR (1) BRPI0512180A (pt)
CA (1) CA2570114C (pt)
DK (1) DK2116605T3 (pt)
ES (1) ES2386507T3 (pt)
IL (1) IL180109A0 (pt)
MX (1) MXPA06014794A (pt)
PL (1) PL2116605T3 (pt)
PT (1) PT2116605E (pt)
TW (1) TW200613554A (pt)
WO (1) WO2006009746A2 (pt)

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