BRPI0510044A - composição farmacêutica, kit, método para tratar um indivìduo, e, uso de uma primeira e uma segunda quantidade de um ou mais glicocorticóides - Google Patents
composição farmacêutica, kit, método para tratar um indivìduo, e, uso de uma primeira e uma segunda quantidade de um ou mais glicocorticóidesInfo
- Publication number
- BRPI0510044A BRPI0510044A BRPI0510044-5A BRPI0510044A BRPI0510044A BR PI0510044 A BRPI0510044 A BR PI0510044A BR PI0510044 A BRPI0510044 A BR PI0510044A BR PI0510044 A BRPI0510044 A BR PI0510044A
- Authority
- BR
- Brazil
- Prior art keywords
- glucocorticoids
- pharmaceutical composition
- glucocorticoid
- individual
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
Abstract
COMPOSIçãO FARMACêUTICA, KIT, MéTODO PARA TRATAR UM INDIVìDUO, E, USO DE UMA PRIMEIRA E UMA SEGUNDA QUANTIDADE DE UM OU MAIS GLICOCORTICóIDES. A invenção refere-se a terapia de substituição de glicocorticóide e fornece composições farmacêuticas e kits projetados para suprir um ou mais glicocorticóides a um indivíduo em necessidade deles, de uma maneira que resulte em níveis de soro de glicocorticóide que essencialmente imitam aqueles de um indivíduo saudável, por um período de tempo clinicamente relevante. A composição farmacêutica compreende um ou mais glicocorticóides, em que uma primeira parte de um ou mais glicocorticóides é substancial e imediatamente liberada durante um período prolongado de tempo de pelo menos cerca de 8 horas, e a quantidade do um ou mais glicocorticóides da primeira parte, expressa como equivalentes de hidrocortisona, está em uma faixa de cerca de 15 a cerca de 50% dos equivalentes totais de hidrocortisona. A invenção também refere-se a um método de tratar doenças requerendo tratamento por glicocorticóide, tal como em indivíduos tendo um distúrbio de deficiência de glicocorticóide. Em outro aspecto, a invenção refere-se ao uso de uma primeira e uma segunda quantidade de um ou mais glicocorticóides, para a preparação de uma composição farmacêutica ou kit para o tratamento de um distúrbio de deficiência de glicocorticóide.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56420504P | 2004-04-22 | 2004-04-22 | |
SE0401031A SE0401031D0 (sv) | 2004-04-22 | 2004-04-22 | A new glucocorticoid replacement therapy |
PCT/EP2005/004400 WO2005102271A2 (en) | 2004-04-22 | 2005-04-21 | Pharmaceutical compositions for glucocorticoid replacement therapy |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0510044A true BRPI0510044A (pt) | 2007-10-16 |
BRPI0510044B1 BRPI0510044B1 (pt) | 2019-01-29 |
BRPI0510044B8 BRPI0510044B8 (pt) | 2021-05-25 |
Family
ID=35197481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0510044A BRPI0510044B8 (pt) | 2004-04-22 | 2005-04-21 | composição farmacêutica, e, uso de uma composição farmacêutica |
Country Status (26)
Country | Link |
---|---|
US (3) | US8425937B2 (pt) |
EP (2) | EP3072507B1 (pt) |
JP (2) | JP5149618B2 (pt) |
CN (2) | CN103006592B (pt) |
AU (1) | AU2005235370B2 (pt) |
BR (1) | BRPI0510044B8 (pt) |
CA (1) | CA2564000C (pt) |
CY (2) | CY1118275T1 (pt) |
DK (2) | DK1744730T3 (pt) |
ES (2) | ES2600556T3 (pt) |
HK (1) | HK1179525A1 (pt) |
HR (2) | HRP20161380T1 (pt) |
HU (2) | HUE053248T2 (pt) |
IL (2) | IL178776A (pt) |
LT (2) | LT1744730T (pt) |
ME (1) | ME02584B (pt) |
MX (2) | MXPA06012011A (pt) |
NZ (1) | NZ585340A (pt) |
PL (2) | PL1744730T3 (pt) |
PT (2) | PT3072507T (pt) |
RS (2) | RS61501B1 (pt) |
SE (1) | SE0401031D0 (pt) |
SG (1) | SG188081A1 (pt) |
SI (1) | SI3072507T1 (pt) |
WO (1) | WO2005102271A2 (pt) |
ZA (1) | ZA200609680B (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2563609C (en) * | 2004-04-22 | 2012-11-06 | Duocort Ab | Pharmaceutical compositions for acute glucocorticoid therapy |
SE0401031D0 (sv) * | 2004-04-22 | 2004-04-22 | Duocort Ab | A new glucocorticoid replacement therapy |
AU2006322050A1 (en) * | 2005-12-06 | 2007-06-14 | Monosol Rx, Llc | Topical film compositions for delivery of actives |
FR2926722B1 (fr) * | 2008-01-25 | 2010-09-03 | Substipharm Dev | Formulation pharmaceutique appropriee pour la preparation de comprimes orodispersibles de prednisolone |
RS51649B (en) * | 2008-07-21 | 2011-10-31 | Dr. Falk Pharma Gmbh. | PHARMACEUTICAL FORMULATION FOR THE TREATMENT OF THE UPPER DIGESTIVE TRACT |
EP2416783B1 (en) | 2009-04-07 | 2018-11-07 | Shire Viropharma Incorporated | Improved glucocorticoid therapy |
BR112012029466A2 (pt) * | 2010-05-20 | 2017-03-01 | Duocort Phama Ab | "composição de glicocorticoide, método melhorado para tratar a deficiência de glicocorticoide, e, método para dar origem a uma dosagem individualizada de glicocorticoides" |
GB201119985D0 (en) * | 2011-11-19 | 2012-01-04 | Diurnal Ltd | Treatment of adrenal insufficiency |
GB201202433D0 (en) * | 2012-02-13 | 2012-03-28 | Diurnal Ltd | Controlled drug release |
JP2014086673A (ja) | 2012-10-26 | 2014-05-12 | Mitsubishi Electric Corp | モノリシック集積回路 |
NZ747657A (en) | 2012-11-02 | 2019-12-20 | Murray And Poole Entpr Ltd | Treatment or prevention of cardiovascular events via the administration of a colchicine derivative |
MY198452A (en) | 2013-04-16 | 2023-08-29 | Murray And Poole Enterprises Ltd | Sustained-release formulations of colchicine and methods of using same |
GB201308933D0 (en) | 2013-05-17 | 2013-07-03 | Diurnal Ltd | Paediatric composition |
MX348595B (es) * | 2013-08-02 | 2017-06-21 | Laboratorio Raam De Sahuayo S A De C V | Composicion farmaceutica con agentes antiinflamatorios y proceso de produccion. |
EP2886108B2 (de) | 2013-12-23 | 2022-11-02 | Dr. Falk Pharma Gmbh | Optimierte pharmazeutische Formulierung zur Behandlung von entzündlichen Veränderungen des Ösophagus |
JP6754533B2 (ja) | 2015-03-30 | 2020-09-16 | コーセプト セラピューティクス, インコーポレイテッド | 副腎機能不全を処置するための糖質コルチコイドと組み合わせた糖質コルチコイドレセプターアンタゴニストの使用 |
CN107115308B (zh) * | 2016-02-23 | 2021-02-23 | 天津金耀集团有限公司 | 一种氢化可的松双相缓释片剂组合物 |
RU2748437C2 (ru) * | 2019-10-28 | 2021-05-25 | Федеральное государственное бюджетное учреждение науки Институт цитологии Российской академии наук (ИНЦ РАН) | Производное гидрокортизона в качестве средства для лечения болезни Альцгеймера |
FR3116439B1 (fr) * | 2020-11-26 | 2023-08-04 | Laboratoire Dielen | Comprimé pelliculé contenant au moins un principe actif, adapté à l’administration par voie orale dudit au moins un principe actif chez des sujets humains |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2260384C3 (de) * | 1972-12-09 | 1979-11-29 | Hoechst Ag, 6000 Frankfurt | Oral zu applizierendes Corticosteroid-Präparat |
US5316772A (en) * | 1990-12-19 | 1994-05-31 | Solvay & Cie, S.A. (Societe Anonyme) | Bilayered oral pharmaceutical composition with pH dependent release |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5314697A (en) | 1992-10-23 | 1994-05-24 | Schering Corporation | Stable extended release oral dosage composition comprising loratadine and pseudoephedrine |
CA2179382C (en) | 1994-01-31 | 2009-11-10 | Takao Mizumoto | Intrabuccally dissolving compressed moldings and production process thereof |
US5534263A (en) | 1995-02-24 | 1996-07-09 | Alza Corporation | Active agent dosage form comprising a matrix and at least two insoluble bands |
US5976573A (en) | 1996-07-03 | 1999-11-02 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
DE19718012C1 (de) * | 1997-04-29 | 1998-10-08 | Jenapharm Gmbh | Verfahren zur Herstellung peroral anwendbarer fester Arzneiformen mit gesteuerter Wirkstoffabgabe |
US6602521B1 (en) | 1998-09-29 | 2003-08-05 | Impax Pharmaceuticals, Inc. | Multiplex drug delivery system suitable for oral administration |
US6500459B1 (en) | 1999-07-21 | 2002-12-31 | Harinderpal Chhabra | Controlled onset and sustained release dosage forms and the preparation thereof |
US6156743A (en) | 1999-10-18 | 2000-12-05 | Whitcomb; John E. | Method of decreasing fatigue |
AR026148A1 (es) * | 2000-01-21 | 2003-01-29 | Osmotica Argentina S A | Dispositivo osmotico con pasaje preformado que aumenta de tamano |
US20030190360A1 (en) | 2001-03-13 | 2003-10-09 | Baichwal Anand R. | Chronotherapeutic dosage forms containing glucocorticosteroid and methods of treatment |
JP2005508836A (ja) * | 2001-03-15 | 2005-04-07 | エンテロン ファーマシューティカルズ インコーポレーティッド | 局所作用性コルチコステロイドを用いる胃腸管の炎症性疾患の治療方法 |
GB0119848D0 (en) | 2001-08-15 | 2001-10-10 | Univ Sheffield | Delayed and sustained drug release |
US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
DE60308647T2 (de) | 2002-02-07 | 2007-08-09 | Pharmacia Corp. | Pharmazeutische darreichungsform zur mukosalen verabreichung |
GB0400031D0 (en) | 2004-01-03 | 2004-02-04 | Univ Sheffield | Depression treatment |
CA2563609C (en) | 2004-04-22 | 2012-11-06 | Duocort Ab | Pharmaceutical compositions for acute glucocorticoid therapy |
SE0401031D0 (sv) * | 2004-04-22 | 2004-04-22 | Duocort Ab | A new glucocorticoid replacement therapy |
GB0623740D0 (en) | 2006-11-28 | 2007-01-10 | Diurnal Ltd | Treatment of disease |
EP2416783B1 (en) | 2009-04-07 | 2018-11-07 | Shire Viropharma Incorporated | Improved glucocorticoid therapy |
BR112012029466A2 (pt) | 2010-05-20 | 2017-03-01 | Duocort Phama Ab | "composição de glicocorticoide, método melhorado para tratar a deficiência de glicocorticoide, e, método para dar origem a uma dosagem individualizada de glicocorticoides" |
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2004
- 2004-04-22 SE SE0401031A patent/SE0401031D0/xx unknown
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2005
- 2005-04-21 EP EP16169413.8A patent/EP3072507B1/en active Active
- 2005-04-21 PL PL05735076T patent/PL1744730T3/pl unknown
- 2005-04-21 NZ NZ585340A patent/NZ585340A/en active IP Right Revival
- 2005-04-21 PT PT161694138T patent/PT3072507T/pt unknown
- 2005-04-21 US US11/587,514 patent/US8425937B2/en active Active
- 2005-04-21 CA CA2564000A patent/CA2564000C/en active Active
- 2005-04-21 WO PCT/EP2005/004400 patent/WO2005102271A2/en active Application Filing
- 2005-04-21 PT PT57350761T patent/PT1744730T/pt unknown
- 2005-04-21 ES ES05735076.1T patent/ES2600556T3/es active Active
- 2005-04-21 CN CN201210499801.8A patent/CN103006592B/zh active Active
- 2005-04-21 RS RS20210233A patent/RS61501B1/sr unknown
- 2005-04-21 SI SI200532291T patent/SI3072507T1/sl unknown
- 2005-04-21 HU HUE16169413A patent/HUE053248T2/hu unknown
- 2005-04-21 CN CN2005800118623A patent/CN1942176B/zh active Active
- 2005-04-21 LT LTEP05735076.1T patent/LT1744730T/lt unknown
- 2005-04-21 DK DK05735076.1T patent/DK1744730T3/en active
- 2005-04-21 DK DK16169413.8T patent/DK3072507T3/da active
- 2005-04-21 PL PL16169413T patent/PL3072507T3/pl unknown
- 2005-04-21 RS RS20160749A patent/RS55198B1/sr unknown
- 2005-04-21 AU AU2005235370A patent/AU2005235370B2/en active Active
- 2005-04-21 LT LTEP16169413.8T patent/LT3072507T/lt unknown
- 2005-04-21 EP EP05735076.1A patent/EP1744730B1/en active Active
- 2005-04-21 ME MEP-2016-250A patent/ME02584B/me unknown
- 2005-04-21 MX MXPA06012011A patent/MXPA06012011A/es active IP Right Grant
- 2005-04-21 SG SG2013005244A patent/SG188081A1/en unknown
- 2005-04-21 MX MX2013004889A patent/MX344197B/es unknown
- 2005-04-21 BR BRPI0510044A patent/BRPI0510044B8/pt active IP Right Grant
- 2005-04-21 ES ES16169413T patent/ES2857600T3/es active Active
- 2005-04-21 JP JP2007508863A patent/JP5149618B2/ja active Active
- 2005-04-21 HU HUE05735076A patent/HUE030546T2/en unknown
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2006
- 2006-10-19 IL IL178776A patent/IL178776A/en active IP Right Grant
- 2006-11-21 ZA ZA200609680A patent/ZA200609680B/xx unknown
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2012
- 2012-08-03 JP JP2012173158A patent/JP5681679B2/ja active Active
- 2012-12-20 US US13/722,013 patent/US20130129823A1/en not_active Abandoned
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2013
- 2013-06-07 HK HK13106780.6A patent/HK1179525A1/zh unknown
- 2013-07-08 IL IL227375A patent/IL227375A/en active IP Right Grant
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2014
- 2014-04-17 US US14/255,332 patent/US10583146B2/en active Active
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2016
- 2016-10-24 HR HRP20161380TT patent/HRP20161380T1/hr unknown
- 2016-10-26 CY CY20161101091T patent/CY1118275T1/el unknown
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2021
- 2021-03-01 HR HRP20210348TT patent/HRP20210348T1/hr unknown
- 2021-03-05 CY CY20211100191T patent/CY1124074T1/el unknown
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/01/2019, OBSERVADAS AS CONDICOES LEGAIS. |
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B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/04/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |