BRPI0509654A - cloreto de cetilpiridìnio como agente antimicrobiano em composições oftálmicas - Google Patents

cloreto de cetilpiridìnio como agente antimicrobiano em composições oftálmicas

Info

Publication number
BRPI0509654A
BRPI0509654A BRPI0509654-5A BRPI0509654A BRPI0509654A BR PI0509654 A BRPI0509654 A BR PI0509654A BR PI0509654 A BRPI0509654 A BR PI0509654A BR PI0509654 A BRPI0509654 A BR PI0509654A
Authority
BR
Brazil
Prior art keywords
solution
ophthalmic compositions
cetylpyridinium chloride
poly
component
Prior art date
Application number
BRPI0509654-5A
Other languages
English (en)
Inventor
Zhi-Jian Yu
Stanley W Huth
Original Assignee
Advanced Medical Optics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medical Optics Inc filed Critical Advanced Medical Optics Inc
Publication of BRPI0509654A publication Critical patent/BRPI0509654A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005Other compounding ingredients characterised by their effect
    • C11D3/0078Compositions for cleaning contact lenses, spectacles or lenses
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14Organic compounds not covered by groups A61L12/10 or A61L12/12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/143Quaternary ammonium compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/143Quaternary ammonium compounds
    • A61L12/145Polymeric quaternary ammonium compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/008Polymeric surface-active agents
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/22Carbohydrates or derivatives thereof
    • C11D3/222Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/26Organic compounds containing nitrogen
    • C11D3/28Heterocyclic compounds containing nitrogen in the ring
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/34Organic compounds containing sulfur
    • C11D3/349Organic compounds containing sulfur additionally containing nitrogen atoms, e.g. nitro, nitroso, amino, imino, nitrilo, nitrile groups containing compounds or their derivatives or thio urea
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/34Organic compounds containing sulfur
    • C11D3/3409Alkyl -, alkenyl -, cycloalkyl - or terpene sulfates or sulfonates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Eyeglasses (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

CLORETO DE CETILPIRIDìNIO COMO AGENTE ANTIMICROBIANO EM COMPOSIçõES OFTáLMICAS. A presente invenção refere-se a uma solução multipropósito para cuidados com lentes de contato com alta atividade antimicrobiana compreendendo, em um meio líquido aquoso, cloreto de cetilpiridínio e um tensoativo não-iónico. Em uma modalidade da invenção, o tensoativo não-iónico é um copolímero em bloco poli(oxipropileno)-poli(oxietileno). A solução, opcionalmente, pode incluir também componentes antimicrobianos adicionais, um componente tampão, um componente indutor de viscosidade, um tensoativo, taurina, propilenoglicol e/ou um componente de tonicidade. Essa solução. adicionalmente, evita perdas da integridade da membrana do tecido ocular durante o uso de lentes de contato.
BRPI0509654-5A 2004-04-07 2005-03-31 cloreto de cetilpiridìnio como agente antimicrobiano em composições oftálmicas BRPI0509654A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/820,486 US7578996B2 (en) 2004-04-07 2004-04-07 Cetylpyridinium chloride as an antimicrobial agent in ophthalmic compositions
PCT/US2005/011009 WO2005097960A1 (en) 2004-04-07 2005-03-31 Cetylpyridinium chloride as an antimicrobial agent in ophthalmic compositions

Publications (1)

Publication Number Publication Date
BRPI0509654A true BRPI0509654A (pt) 2007-10-09

Family

ID=34972927

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509654-5A BRPI0509654A (pt) 2004-04-07 2005-03-31 cloreto de cetilpiridìnio como agente antimicrobiano em composições oftálmicas

Country Status (11)

Country Link
US (2) US7578996B2 (pt)
EP (1) EP1733014B1 (pt)
JP (1) JP2007532953A (pt)
CN (1) CN1942571B (pt)
AT (1) ATE426655T1 (pt)
AU (1) AU2005230851B2 (pt)
BR (1) BRPI0509654A (pt)
CA (1) CA2562546C (pt)
DE (1) DE602005013498D1 (pt)
ES (2) ES2321214T3 (pt)
WO (1) WO2005097960A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006331995A1 (en) 2005-12-20 2007-07-05 Johnson & Johnson Vision Care, Inc. Method for removing unreacted components from hydrogel ophthalmic lenses
US20070264226A1 (en) * 2006-05-10 2007-11-15 Karagoezian Hampar L Synergistically enhanced disinfecting solutions
US8759321B2 (en) * 2007-06-13 2014-06-24 Bausch & Lomb Incorporated Ophthalmic composition with hyaluronic acid and polymeric biguanide
TWI551305B (zh) * 2007-08-31 2016-10-01 諾華公司 相對黏稠封裝溶液之用途
US8119112B2 (en) * 2008-01-31 2012-02-21 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid
US20110046033A1 (en) 2008-01-31 2011-02-24 Jinzhong Zhang Multipurpose Lens Care Solution with Benefits to Corneal Epithelial Barrier Function
US9096819B2 (en) 2008-01-31 2015-08-04 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer
US20100286010A1 (en) * 2008-09-03 2010-11-11 Erning Xia Ophthalmic Compositions with Hyaluronic Acid
US9125405B2 (en) * 2008-10-28 2015-09-08 Bausch & Lomb Incorporated Contact lens solution with a tertiary amine oxide
WO2012080918A2 (en) * 2010-12-14 2012-06-21 Ecolab Usa Inc. Wear resistant antimicrobial compositions and methods of use
JP6236390B2 (ja) * 2011-10-08 2017-11-22 ネクスト サイエンス エルエルシー 抗微生物性組成物とその使用方法
EP2785176A4 (en) * 2011-11-06 2015-05-06 Nbip Llc ANTIMICROBIAL COMPOSITIONS AND RELATED METHODS
CN102552914A (zh) * 2012-01-31 2012-07-11 江西科伦药业有限公司 一种能同时调节pH值及渗透压的组合物及其制备方法
US8324171B1 (en) 2012-02-06 2012-12-04 Bausch & Lomb Incorporated Ophthalmic compositions containing diglycine
US8664180B2 (en) 2012-02-06 2014-03-04 Bausch & Lomb Incorporated Ophthalmic compositions containing diglycine
CN102835398A (zh) * 2012-09-28 2012-12-26 山东潍坊润丰化工有限公司 一种二氯吡啶酸胆碱水剂和原药的制备方法
WO2015148472A1 (en) * 2014-03-24 2015-10-01 S.C. Johnson & Son, Inc. Corrosive ingredient (s) - containing compositions having reduced toxicity and method of obtaining
GB201621050D0 (en) * 2016-12-12 2017-01-25 Provita Eurotech Ltd Antimicrobial compositions
JP7490570B2 (ja) * 2018-04-27 2024-05-27 アラーガン、インコーポレイテッド 抗微生物有効性の増強及び毒性の減少を有する亜塩素酸ナトリウム組成物
JP7253128B2 (ja) * 2018-06-13 2023-04-06 京都バイオファーマ製薬株式会社 デプシペプチド系抗生物質を含有する外用組成物
EP3813583A1 (en) 2018-06-27 2021-05-05 Bausch & Lomb Incorporated Packaging solutions
AU2019343188A1 (en) 2018-09-21 2021-05-20 Aufbau Medical Innovations Limited Compositions and methods for glaucoma
MX2022006217A (es) * 2019-12-05 2022-09-19 Cis Pharma Ag Soluciones de desinfeccion de multiples propositos con alto hialuronato para aplicaciones oftalmicas.

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278447A (en) 1963-12-02 1966-10-11 Cloro Bac Products Inc Process for stabilizing chlorine dioxide solution
USB724600I5 (pt) * 1968-04-26
AR207548A1 (es) * 1972-08-11 1976-10-15 Flow Pharma Inc Composicion acuosa para limpiar y tratar lentes de contacto
US4043911A (en) 1975-03-24 1977-08-23 Baylor College Of Medicine Sterilization of holding tanks and toilet bowls by quaternary compounds
US4758595A (en) 1984-12-11 1988-07-19 Bausch & Lomb Incorporated Disinfecting and preserving systems and methods of use
US4908147A (en) 1986-02-19 1990-03-13 Ciba-Geigy Corporation Aqueous self preserving soft contact lens solution and method
US5110493A (en) 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
IE920838A1 (en) 1991-03-18 1992-09-23 Allergan Inc Contact lens disinfecting compositions
US5252246A (en) 1992-01-10 1993-10-12 Allergan, Inc. Nonirritating nonionic surfactant compositions
WO1994027436A1 (en) 1993-05-20 1994-12-08 Decicco Benedict T Preservative systems with enhanced antimicrobial activity
JP3297969B2 (ja) 1994-12-26 2002-07-02 ライオン株式会社 点眼剤
EP0855187A3 (en) 1997-01-24 2001-01-17 Senju Pharmaceutical Co., Ltd. Agent for contact lenses
US20030228393A1 (en) * 2002-05-31 2003-12-11 Zhao Iris Ginron Multi-phase food & beverage
US6020375A (en) 1997-06-13 2000-02-01 Senju Pharmaceutical Co., Ltd. Bactericidal composition
US6482799B1 (en) * 1999-05-25 2002-11-19 The Regents Of The University Of California Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial
JP3677421B2 (ja) * 1999-12-27 2005-08-03 扶桑薬品工業株式会社 涙液分泌促進組成物
JP4074067B2 (ja) 2000-04-25 2008-04-09 和光純薬工業株式会社 抗原生生物製剤
KR20020041118A (ko) * 2000-11-27 2002-06-01 김용철 박홍양 가금류의 뉴캐슬병의 치료 및 예방 제제
TW200300448A (en) * 2001-11-21 2003-06-01 Novartis Ag Conditioning solution for contact lenses
JP2005515992A (ja) * 2001-12-05 2005-06-02 ミトコー、インク 眼病治療のための多環式フェノール化合物の使用方法
US20040120916A1 (en) * 2002-12-23 2004-06-24 Advanced Medical Optics, Inc. Contact lens care compositions, methods of use and preparation which protect ocular tissue membrane integrity

Also Published As

Publication number Publication date
JP2007532953A (ja) 2007-11-15
US20050226841A1 (en) 2005-10-13
EP1733014A1 (en) 2006-12-20
CA2562546C (en) 2013-11-19
US20090318512A1 (en) 2009-12-24
CN1942571A (zh) 2007-04-04
CA2562546A1 (en) 2005-10-20
ATE426655T1 (de) 2009-04-15
EP1733014B1 (en) 2009-03-25
AU2005230851A1 (en) 2005-10-20
DE602005013498D1 (de) 2009-05-07
ES2323827B1 (es) 2010-04-19
AU2005230851B2 (en) 2010-12-23
WO2005097960A1 (en) 2005-10-20
CN1942571B (zh) 2012-02-15
ES2321214T3 (es) 2009-06-03
ES2323827A1 (es) 2009-07-24
US7578996B2 (en) 2009-08-25

Similar Documents

Publication Publication Date Title
BRPI0509654A (pt) cloreto de cetilpiridìnio como agente antimicrobiano em composições oftálmicas
BRPI0509651A (pt) alquilamina como um agente antimicrobiano em composições oftálmicas
BR0316300A (pt) Composições multipropósito, que incluem propilenoglicol ou glicerina, para cuidar de lentes de contato
BR9815009A (pt) Composições de múltiplas finalidades para o cuidado de lentes de contato.
NO20092036L (no) Anvendelse av PEO-PBO blokk kopolymerer i oyeblandinger
BR0317688A (pt) Composições para cuidado com lentes de contato, métodos de uso e preparação que protege integridade de membranas de tecidos oculares
MX2009011391A (es) Emulsion oftalmica aceite en agua que contiene prostaglandinas.
DK2380576T3 (da) Anvendelse af natriumdeoxycholat til ikke-kirurgisk fjernelse af fedt
BR9808016A (pt) Composições e métodos para redução da hipertensão ocular
BRPI0106913B8 (pt) composições transparentes de limpeza em barra que são eficazes e não são irritantes para os olhos
BRPI0519355A2 (pt) compostos para tratamento contra flaviviridae
DE60215866D1 (de) Medikament, enthaltend cyanidin-3-glykosid als wirkstoff gegen fettsucht und diabetes
JP2012189993A (ja) コンタクトレンズ用液体組成物
UY37497A (es) Formulación tópica que comprende n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida
BRPI0417175A (pt) composições, método para produzir essas composições, solução que as compreende e métodos para utilizar as mesmas
CY1111384T1 (el) Διαμορφωση των επιπεδων εκφρασης toy trpv
JPWO2012043004A1 (ja) コンタクトレンズ用ゲル状洗浄剤
AR042873A1 (es) Composiciones con contenido de quitina para el cuidado de lentes de contacto
JP5709482B2 (ja) シリコーンハイドロゲルコンタクトレンズ用眼科組成物
DK1692092T3 (da) Anvendelse af bis-aminer til forstærkning af den antimikrobielle aktivitet af vandige sammensætninger
BRPI0215189B8 (pt) composição viscoelástica aquosa, estéril, para uso em procedimentos cirúrgicos oftálmicos
CL2012000061A1 (es) Composición oftálmica acuosa estéril que comprende un copolímero de bloque de óxido de etileno óxido de butileno (eo-bo) y una galactomanana; y uso para el tratamiento del ojo seco.
JP2012126668A (ja) 染着除去剤組成物および染着除去方法
BR0301525A (pt) Composição de lavagem das matérias queratìnicas e uso de uma composição
AR070466A1 (es) Composiciones de gemifloxacina oculares, procedimiento de preparacion y uso

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]