BRPI0508560A - uso de antagonistas do receptor cb1 para a produção de uma composição útil para o tratamento de doenças hepáticas - Google Patents
uso de antagonistas do receptor cb1 para a produção de uma composição útil para o tratamento de doenças hepáticasInfo
- Publication number
- BRPI0508560A BRPI0508560A BRPI0508560-8A BRPI0508560A BRPI0508560A BR PI0508560 A BRPI0508560 A BR PI0508560A BR PI0508560 A BRPI0508560 A BR PI0508560A BR PI0508560 A BRPI0508560 A BR PI0508560A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- receptor antagonists
- liver disease
- produce
- composition useful
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
USO DE ANTAGONISTAS DO RECEPTOR CB1 PARA A PRODUçãO DE UMA COMPOSIçãO úTIL PARA O TRATAMENTO DE DOENçAS HEPáTICAS.A presente invenção refere-se ao uso de antagonistas para o receptor CB1 para o preparo de uma composição para o tratamento de doenças hepáticas e preferivelmente ao uso de N-piperidinos5 5-(4-clorofenil)-1-(2,4-diclorofenil)-4 metilpirazol-3-carboximida.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04290633A EP1574211A1 (en) | 2004-03-09 | 2004-03-09 | Use of antagonists of the CB1 receptor for the manufacture of a composition useful for the treatment of hepatic diseases |
PCT/EP2005/003285 WO2005084652A2 (en) | 2004-03-09 | 2005-03-08 | Use of antagonists of the cb1 receptor for the manufacture of a composition useful for the treatment of hepatic diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0508560A true BRPI0508560A (pt) | 2007-08-14 |
Family
ID=34814417
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0508560-8A BRPI0508560A (pt) | 2004-03-09 | 2005-03-08 | uso de antagonistas do receptor cb1 para a produção de uma composição útil para o tratamento de doenças hepáticas |
Country Status (27)
Country | Link |
---|---|
US (2) | US8236763B2 (pt) |
EP (3) | EP1574211A1 (pt) |
JP (1) | JP2007527893A (pt) |
KR (1) | KR20070026415A (pt) |
CN (1) | CN1929828A (pt) |
AR (1) | AR048087A1 (pt) |
AT (1) | ATE520393T1 (pt) |
AU (1) | AU2005218937B2 (pt) |
BR (1) | BRPI0508560A (pt) |
CA (1) | CA2557976A1 (pt) |
CY (1) | CY1112078T1 (pt) |
DK (1) | DK1725223T3 (pt) |
ES (1) | ES2371552T3 (pt) |
HK (1) | HK1094674A1 (pt) |
IL (1) | IL177465A0 (pt) |
MA (1) | MA28454B1 (pt) |
MX (1) | MXPA06010287A (pt) |
NO (1) | NO20064603L (pt) |
PL (1) | PL1725223T3 (pt) |
PT (1) | PT1725223E (pt) |
RU (1) | RU2402328C2 (pt) |
SI (1) | SI1725223T1 (pt) |
TN (1) | TNSN06272A1 (pt) |
TW (1) | TWI337540B (pt) |
UA (1) | UA94025C2 (pt) |
WO (1) | WO2005084652A2 (pt) |
ZA (1) | ZA200607159B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2861303A1 (fr) * | 2003-10-24 | 2005-04-29 | Sanofi Synthelabo | Utilisation d'un derive de pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique |
US7875647B2 (en) | 2006-09-29 | 2011-01-25 | Green Cross Corporation | Heteroaryl-pyrazole derivatives as cannabinoid CB1 receptor antagonists |
WO2012007847A2 (en) * | 2010-07-15 | 2012-01-19 | Oleg Iliich Epshtein | Pharmaceutical compositions and methods of treatment |
US20120288442A1 (en) * | 2011-05-11 | 2012-11-15 | Atomic Energy Council-Institute Of Nuclear Energy Research | Nuclear Imaging Method Using Molecular Target Detection Agent for Liver Fibrosis |
EP2919779B1 (en) | 2012-11-13 | 2021-01-06 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Cannabinoid receptor mediating compounds |
US11155521B2 (en) | 2012-11-13 | 2021-10-26 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Cannabinoid receptor mediating compounds |
PE20170258A1 (es) | 2014-03-27 | 2017-03-23 | Bird Rock Bio Inc | Anticuerpos que se unen al receptor cannabinoide 1 (cb1) humano |
AU2015255765A1 (en) | 2014-05-09 | 2016-11-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Pyrazole derivatives and their use as cannabinoid receptor mediators |
WO2017058771A1 (en) | 2015-09-30 | 2017-04-06 | Bird Rock Bio, Inc. | Antibodies that bind human cannabinoid 1 (cb1) recetor |
WO2017184412A1 (en) * | 2016-04-18 | 2017-10-26 | Eli Lilly And Company | Purine cannabinoid agonist for treating nonalcoholic steatohepatitis and fibrosis |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4100161A (en) * | 1974-04-15 | 1978-07-11 | The Johns Hopkins University | Promotion of protein synthesis and suppression of urea formation in the body by keto analogs of essential amino acids |
AT394493B (de) * | 1989-05-11 | 1992-04-10 | Homosan Ag | Pharmazeutisches praeparat zur behandlung von lebererkrankungen |
US5492891A (en) * | 1991-09-05 | 1996-02-20 | Novo Nordisk A/S | Method for treatment of patients with chronic liver disease |
FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2713225B1 (fr) | 1993-12-02 | 1996-03-01 | Sanofi Sa | N-pipéridino-3-pyrazolecarboxamide substitué. |
US5596106A (en) | 1994-07-15 | 1997-01-21 | Eli Lilly And Company | Cannabinoid receptor antagonists |
US6143752A (en) * | 1997-08-01 | 2000-11-07 | Oren; Ran | Method for preventing or arresting liver damage in humans |
US5939429A (en) * | 1997-09-30 | 1999-08-17 | Virginia Commonwealth University | Cardiovascular uses of cannabinoid compounds |
FR2789079B3 (fr) | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
US7056890B2 (en) * | 1999-06-14 | 2006-06-06 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
FR2805818B1 (fr) | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant |
FR2805817B1 (fr) | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation |
FR2805810B1 (fr) | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Compositions pharmaceutiques contenant des derives de 3- amino-azetidine, les nouveaux derives et leur preparation |
FR2809621B1 (fr) | 2000-05-12 | 2002-09-06 | Sanofi Synthelabo | Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles comme antidiarrheiques |
US6465436B2 (en) * | 2000-06-01 | 2002-10-15 | Mclean Hospital | Method for treating alcohol intoxication and alcohol abuse |
EE200300019A (et) * | 2000-07-11 | 2004-10-15 | Bayer Aktiengesellschaft | Parapoxvirus ovis tüvede kasutamine organite fibrooside vastu |
WO2003063781A2 (en) * | 2002-01-29 | 2003-08-07 | Merck & Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
EP1496838B1 (en) | 2002-03-12 | 2010-11-03 | Merck Sharp & Dohme Corp. | Substituted amides |
FR2837706A1 (fr) | 2002-03-28 | 2003-10-03 | Sanofi Synthelabo | Utilisation d'un antagoniste des recepteurs aux cannabinoides cb1 pour la preparation de medicaments utiles pour traiter les dysfonctionnements sexuels et/ou ameliorer les performances sexuelles |
US20050154202A1 (en) * | 2002-04-05 | 2005-07-14 | Hagmann William K. | Substituted aryl amides |
FR2838439B1 (fr) * | 2002-04-11 | 2005-05-20 | Sanofi Synthelabo | Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant |
FR2838438A1 (fr) * | 2002-04-11 | 2003-10-17 | Sanofi Synthelabo | Derives de diphenylpyridine,leur preparation, les compositions pharmaceutiques en contenant |
EP1499306A4 (en) | 2002-04-12 | 2007-03-28 | Merck & Co Inc | BICYCLIC AMIDE |
US20040034968A1 (en) * | 2002-06-14 | 2004-02-26 | Hufcor, Inc. | 360 Degree hinge and door closure apparatus |
SE0202242D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Compounds |
SE0202240D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Genes |
ATE375349T1 (de) * | 2002-08-02 | 2007-10-15 | Merck & Co Inc | Substituierte furo(2,3-b)pyridin derivate |
FR2849032B1 (fr) * | 2002-12-23 | 2006-04-28 | Sanofi Synthelabo | Derive de 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-n -(piperidin-1-yl)-1h-pyrazole-3-carboxamide, sa preparation, son application en therapeuthique |
US20040214804A1 (en) * | 2003-04-25 | 2004-10-28 | Pharmacia Corporation | Combination of an aldosterone receptor antagonist and an anti-obesity agent |
EP1663215A1 (en) * | 2003-09-02 | 2006-06-07 | Solvay Pharmaceuticals GmbH | Novel medical use of selective cb1- receptor antagonists |
US7320805B2 (en) * | 2003-10-01 | 2008-01-22 | Institut National De La Sante Et De La Recherche Medicale | CB2 receptors blocks accumulation of human hepatic myofibroblasts: a novel artifibrogenic pathway in the liver |
CN1867332A (zh) * | 2003-10-24 | 2006-11-22 | 索尔瓦药物有限公司 | 包含选择性cb1-拮抗剂和脂肪酶抑制剂的肥胖症的联合治疗 |
FR2861303A1 (fr) | 2003-10-24 | 2005-04-29 | Sanofi Synthelabo | Utilisation d'un derive de pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique |
GB0403780D0 (en) * | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Therapeutic agents |
-
2004
- 2004-03-09 EP EP04290633A patent/EP1574211A1/en not_active Withdrawn
-
2005
- 2005-03-08 PL PL05733278T patent/PL1725223T3/pl unknown
- 2005-03-08 UA UAA200610602A patent/UA94025C2/ru unknown
- 2005-03-08 RU RU2006134707/15A patent/RU2402328C2/ru not_active IP Right Cessation
- 2005-03-08 MX MXPA06010287A patent/MXPA06010287A/es not_active Application Discontinuation
- 2005-03-08 ES ES05733278T patent/ES2371552T3/es active Active
- 2005-03-08 SI SI200531413T patent/SI1725223T1/sl unknown
- 2005-03-08 PT PT05733278T patent/PT1725223E/pt unknown
- 2005-03-08 EP EP10012234.0A patent/EP2305220B1/en not_active Not-in-force
- 2005-03-08 KR KR1020067018490A patent/KR20070026415A/ko not_active Application Discontinuation
- 2005-03-08 JP JP2007502312A patent/JP2007527893A/ja active Pending
- 2005-03-08 US US10/598,736 patent/US8236763B2/en active Active
- 2005-03-08 CA CA002557976A patent/CA2557976A1/en not_active Abandoned
- 2005-03-08 AU AU2005218937A patent/AU2005218937B2/en not_active Ceased
- 2005-03-08 AT AT05733278T patent/ATE520393T1/de active
- 2005-03-08 DK DK05733278.5T patent/DK1725223T3/da active
- 2005-03-08 CN CNA2005800075168A patent/CN1929828A/zh active Pending
- 2005-03-08 EP EP05733278A patent/EP1725223B1/en active Active
- 2005-03-08 BR BRPI0508560-8A patent/BRPI0508560A/pt not_active IP Right Cessation
- 2005-03-08 WO PCT/EP2005/003285 patent/WO2005084652A2/en active Application Filing
- 2005-03-09 TW TW094107190A patent/TWI337540B/zh not_active IP Right Cessation
- 2005-03-09 AR ARP050100905A patent/AR048087A1/es unknown
-
2006
- 2006-08-13 IL IL177465A patent/IL177465A0/en unknown
- 2006-08-28 ZA ZA200607159A patent/ZA200607159B/xx unknown
- 2006-09-06 MA MA29302A patent/MA28454B1/fr unknown
- 2006-09-08 TN TNP2006000272A patent/TNSN06272A1/en unknown
- 2006-10-09 NO NO20064603A patent/NO20064603L/no not_active Application Discontinuation
-
2007
- 2007-01-09 HK HK07100301.7A patent/HK1094674A1/xx not_active IP Right Cessation
-
2011
- 2011-11-17 CY CY20111101109T patent/CY1112078T1/el unknown
-
2012
- 2012-06-28 US US13/535,891 patent/US8604060B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2204 DE 02/04/2013. |