EA201000926A1 - Пиперазины в качестве агентов против ожирения - Google Patents
Пиперазины в качестве агентов против ожиренияInfo
- Publication number
- EA201000926A1 EA201000926A1 EA201000926A EA201000926A EA201000926A1 EA 201000926 A1 EA201000926 A1 EA 201000926A1 EA 201000926 A EA201000926 A EA 201000926A EA 201000926 A EA201000926 A EA 201000926A EA 201000926 A1 EA201000926 A1 EA 201000926A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- piperasins
- compounds
- agents against
- against obesity
- dyslipidemia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Настоящее изобретение относится к новым соединениям формулы (I)к фармацевтическим композициям, содержащим эти соединения, к способам их получения и к применению этих соединений в качестве миметиков модулятора лептинового рецептора в изготовлении лекарственных средств против состояний, ассоциированных с увеличением массы, сахарного диабета 2 типа и дислипидемий.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0702696 | 2007-12-05 | ||
US2298308P | 2008-01-23 | 2008-01-23 | |
PCT/EP2008/066877 WO2009071658A1 (en) | 2007-12-05 | 2008-12-05 | Piperazines as anti-obesity agents |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201000926A1 true EA201000926A1 (ru) | 2011-02-28 |
Family
ID=40409928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201000926A EA201000926A1 (ru) | 2007-12-05 | 2008-12-05 | Пиперазины в качестве агентов против ожирения |
Country Status (17)
Country | Link |
---|---|
US (3) | US7851471B2 (ru) |
EP (1) | EP2229362A1 (ru) |
JP (1) | JP2011506294A (ru) |
KR (1) | KR20100093104A (ru) |
CN (1) | CN102026975A (ru) |
AU (1) | AU2008333173A1 (ru) |
BR (1) | BRPI0819989A2 (ru) |
CA (1) | CA2707555A1 (ru) |
CO (1) | CO6280487A2 (ru) |
CR (1) | CR11479A (ru) |
DO (1) | DOP2010000167A (ru) |
EA (1) | EA201000926A1 (ru) |
EC (1) | ECSP10010234A (ru) |
IL (1) | IL205874A0 (ru) |
MX (1) | MX2010006259A (ru) |
WO (1) | WO2009071658A1 (ru) |
ZA (1) | ZA201003976B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102015668A (zh) * | 2007-12-05 | 2011-04-13 | 阿斯利康(瑞典)有限公司 | 用作瘦蛋白受体调节剂的哌嗪衍生物及其用途 |
MX2010006220A (es) * | 2007-12-05 | 2010-08-17 | Astrazeneca Ab | Derivados de morfolina como agentes antiobesidad. |
KR101810975B1 (ko) * | 2010-07-08 | 2017-12-20 | 에스케이바이오팜 주식회사 | 카바모일옥시 아릴알칸노일 아릴피페라진계 화합물을 포함하는 약학적 조성물 |
JP2014507458A (ja) | 2011-03-11 | 2014-03-27 | グラクソ グループ リミテッド | Sykインヒビターとしてのピリド[3,4−B]ピラジン誘導体 |
US11807622B2 (en) | 2019-01-30 | 2023-11-07 | Insilico Medicine Ip Limited | TLR 9 inhibitors |
US10689360B1 (en) * | 2019-01-30 | 2020-06-23 | Insilico Medicine Ip Limited | TLR inhibitors |
CN113149891B (zh) * | 2020-01-07 | 2024-02-02 | 南京药石科技股份有限公司 | 一种2-氨基-2-(1-甲基-4-哌啶基)乙醇的制备方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3420193A1 (de) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
CN1221426A (zh) | 1996-06-06 | 1999-06-30 | 史密丝克莱恩比彻姆有限公司 | 来普亭(鄂毕肽)片段 |
TW434220B (en) | 1998-02-02 | 2001-05-16 | Shiseido Co Ltd | 1,2-di-substituted piperidine derivative, a hair growth agent, and an agent for external use to the skin |
JP2001131149A (ja) | 1999-11-08 | 2001-05-15 | Sumitomo Pharmaceut Co Ltd | 選択的セロトニン再取り込み阻害剤 |
JP2001261657A (ja) | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
BR0114321A (pt) | 2000-09-29 | 2003-07-01 | Glaxo Group Ltd | Composto, composição farmacêutica, uso de um composto, método de tratamento ou profilaxia de doenças inflamatórias, e, processo para preparar um composto |
ES2197003B1 (es) * | 2002-04-08 | 2005-03-16 | J. URIACH & CIA S.A. | Nuevos compuestos antagonistas de integrinas alfa. |
CN1809545A (zh) | 2003-06-20 | 2006-07-26 | 艾尼纳制药公司 | N-苯基-哌嗪衍生物和预防或者治疗5HT2c受体相关疾病的方法 |
SG163577A1 (en) * | 2004-12-03 | 2010-08-30 | Schering Corp | Substituted piperazines as cb1 antagonists |
DE102005000666B3 (de) | 2005-01-04 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2007025613A2 (en) | 2005-07-15 | 2007-03-08 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain |
EP1787679A1 (en) | 2005-07-29 | 2007-05-23 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain |
US7790726B2 (en) | 2005-08-16 | 2010-09-07 | Chemocentryx, Inc. | Monocyclic and bicyclic compounds and methods of use |
EP1991211A1 (en) | 2006-02-28 | 2008-11-19 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome |
EP2227461A1 (en) * | 2007-12-05 | 2010-09-15 | AstraZeneca AB (Publ) | New compounds iii |
CN102015668A (zh) * | 2007-12-05 | 2011-04-13 | 阿斯利康(瑞典)有限公司 | 用作瘦蛋白受体调节剂的哌嗪衍生物及其用途 |
MX2010006220A (es) * | 2007-12-05 | 2010-08-17 | Astrazeneca Ab | Derivados de morfolina como agentes antiobesidad. |
JP2011522007A (ja) | 2008-06-04 | 2011-07-28 | アストラゼネカ アクチボラグ | レプチン受容体修飾因子模倣剤としての新しいピリジン誘導体 |
EP2321276A1 (en) | 2008-06-04 | 2011-05-18 | AstraZeneca AB | New compounds vii |
US20110275637A1 (en) | 2008-06-04 | 2011-11-10 | Emma Chapman | Piperazine derivatives and their use as leptin receptor modulators |
CN102159545A (zh) | 2008-06-04 | 2011-08-17 | 阿斯利康(瑞典)有限公司 | 小分子瘦蛋白受体调节剂 |
-
2008
- 2008-12-05 KR KR1020107014723A patent/KR20100093104A/ko not_active Application Discontinuation
- 2008-12-05 CA CA2707555A patent/CA2707555A1/en not_active Abandoned
- 2008-12-05 MX MX2010006259A patent/MX2010006259A/es not_active Application Discontinuation
- 2008-12-05 BR BRPI0819989 patent/BRPI0819989A2/pt not_active IP Right Cessation
- 2008-12-05 US US12/315,698 patent/US7851471B2/en not_active Expired - Fee Related
- 2008-12-05 US US12/744,359 patent/US20110059969A1/en not_active Abandoned
- 2008-12-05 CN CN2008801266306A patent/CN102026975A/zh active Pending
- 2008-12-05 JP JP2010536469A patent/JP2011506294A/ja active Pending
- 2008-12-05 WO PCT/EP2008/066877 patent/WO2009071658A1/en active Application Filing
- 2008-12-05 AU AU2008333173A patent/AU2008333173A1/en not_active Abandoned
- 2008-12-05 EA EA201000926A patent/EA201000926A1/ru unknown
- 2008-12-05 EP EP08856144A patent/EP2229362A1/en not_active Withdrawn
-
2010
- 2010-05-20 IL IL205874A patent/IL205874A0/en unknown
- 2010-06-03 ZA ZA2010/03976A patent/ZA201003976B/en unknown
- 2010-06-04 DO DO2010000167A patent/DOP2010000167A/es unknown
- 2010-06-04 EC EC2010010234A patent/ECSP10010234A/es unknown
- 2010-06-04 CR CR11479A patent/CR11479A/es not_active Application Discontinuation
- 2010-06-04 CO CO10068022A patent/CO6280487A2/es not_active Application Discontinuation
- 2010-11-01 US US12/917,085 patent/US20110046135A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20110059969A1 (en) | 2011-03-10 |
AU2008333173A1 (en) | 2009-06-11 |
KR20100093104A (ko) | 2010-08-24 |
JP2011506294A (ja) | 2011-03-03 |
IL205874A0 (en) | 2010-11-30 |
CN102026975A (zh) | 2011-04-20 |
WO2009071658A1 (en) | 2009-06-11 |
EP2229362A1 (en) | 2010-09-22 |
US20110046135A1 (en) | 2011-02-24 |
CO6280487A2 (es) | 2011-05-20 |
US7851471B2 (en) | 2010-12-14 |
ZA201003976B (en) | 2011-04-28 |
BRPI0819989A2 (pt) | 2015-05-12 |
MX2010006259A (es) | 2010-08-23 |
CA2707555A1 (en) | 2009-06-11 |
DOP2010000167A (es) | 2010-06-30 |
ECSP10010234A (es) | 2010-07-30 |
CR11479A (es) | 2010-07-19 |
US20090181967A1 (en) | 2009-07-16 |
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