ECSP10010234A - Piperazinas como agentes antiobesidad - Google Patents
Piperazinas como agentes antiobesidadInfo
- Publication number
- ECSP10010234A ECSP10010234A EC2010010234A ECSP10010234A ECSP10010234A EC SP10010234 A ECSP10010234 A EC SP10010234A EC 2010010234 A EC2010010234 A EC 2010010234A EC SP10010234 A ECSP10010234 A EC SP10010234A EC SP10010234 A ECSP10010234 A EC SP10010234A
- Authority
- EC
- Ecuador
- Prior art keywords
- piperazinas
- compounds
- antiobesity agents
- preparation
- dyslipidemias
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se refiere a nuevos compuestos de fórmula (I), a composiciones farmacéuticas que comprenden estos compuestos, a procesos para su preparación y al uso de estos compuestos como miméticos moduladores del receptor de leptina en la preparación de medicamentos para afecciones asociadas con el aumento de peso, la diabetes tipo 2 y las dislipidemias.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0702696 | 2007-12-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP10010234A true ECSP10010234A (es) | 2010-07-30 |
Family
ID=40409928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2010010234A ECSP10010234A (es) | 2007-12-05 | 2010-06-04 | Piperazinas como agentes antiobesidad |
Country Status (17)
Country | Link |
---|---|
US (3) | US7851471B2 (es) |
EP (1) | EP2229362A1 (es) |
JP (1) | JP2011506294A (es) |
KR (1) | KR20100093104A (es) |
CN (1) | CN102026975A (es) |
AU (1) | AU2008333173A1 (es) |
BR (1) | BRPI0819989A2 (es) |
CA (1) | CA2707555A1 (es) |
CO (1) | CO6280487A2 (es) |
CR (1) | CR11479A (es) |
DO (1) | DOP2010000167A (es) |
EA (1) | EA201000926A1 (es) |
EC (1) | ECSP10010234A (es) |
IL (1) | IL205874A0 (es) |
MX (1) | MX2010006259A (es) |
WO (1) | WO2009071658A1 (es) |
ZA (1) | ZA201003976B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2240447A2 (en) * | 2007-12-05 | 2010-10-20 | AstraZeneca AB (Publ) | Morpholine derivates as antiobesity agents |
WO2009071668A2 (en) * | 2007-12-05 | 2009-06-11 | Biovitrum Ab (Publ) | Piperazine derivatives and their use as leptin receptor modulators |
KR101810975B1 (ko) * | 2010-07-08 | 2017-12-20 | 에스케이바이오팜 주식회사 | 카바모일옥시 아릴알칸노일 아릴피페라진계 화합물을 포함하는 약학적 조성물 |
JP2014507458A (ja) | 2011-03-11 | 2014-03-27 | グラクソ グループ リミテッド | Sykインヒビターとしてのピリド[3,4−B]ピラジン誘導体 |
US10689360B1 (en) * | 2019-01-30 | 2020-06-23 | Insilico Medicine Ip Limited | TLR inhibitors |
US11807622B2 (en) | 2019-01-30 | 2023-11-07 | Insilico Medicine Ip Limited | TLR 9 inhibitors |
CN113149891B (zh) * | 2020-01-07 | 2024-02-02 | 南京药石科技股份有限公司 | 一种2-氨基-2-(1-甲基-4-哌啶基)乙醇的制备方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3420193A1 (de) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
AR008765A1 (es) | 1996-06-06 | 2000-02-23 | Smithkline Beecham Plc | Un peptido o un derivado, analogo o variante, funcional del mismo, un peptido recombinante o sintetico del mismo, una secuencia nucleotidica y vectorque la contiene, una celula huesped transformada, un procedimiento para su preparacion, una composicion farmaceutica que lo comprende, un compuesto del |
US6057337A (en) * | 1998-02-02 | 2000-05-02 | Shiseido Co., Ltd. | 1,2-DI-substituted piperidine derivative, hair growth promoter and external composition for skin using the same |
JP2001131149A (ja) | 1999-11-08 | 2001-05-15 | Sumitomo Pharmaceut Co Ltd | 選択的セロトニン再取り込み阻害剤 |
JP2001261657A (ja) | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
IL155092A0 (en) | 2000-09-29 | 2003-10-31 | Glaxo Group Ltd | Compounds useful in the treatment of inflammatory diseases |
ES2197003B1 (es) * | 2002-04-08 | 2005-03-16 | J. URIACH & CIA S.A. | Nuevos compuestos antagonistas de integrinas alfa. |
EA200600071A1 (ru) | 2003-06-20 | 2006-08-25 | Арена Фармасьютикалз, Инк. | Производные n-фенилпиперазина и способы профилактики или лечения заболеваний, связанных с 5ht-рецептором |
AU2005311930B9 (en) * | 2004-12-03 | 2009-09-10 | Merck Sharp & Dohme Corp. | Substituted piperazines as CB1 antagonists |
DE102005000666B3 (de) | 2005-01-04 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US20090325975A1 (en) | 2005-07-15 | 2009-12-31 | Helmut H Buschmann | Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain |
EP1787679A1 (en) | 2005-07-29 | 2007-05-23 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain |
US7790726B2 (en) | 2005-08-16 | 2010-09-07 | Chemocentryx, Inc. | Monocyclic and bicyclic compounds and methods of use |
WO2007098939A1 (en) | 2006-02-28 | 2007-09-07 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome |
EP2240447A2 (en) | 2007-12-05 | 2010-10-20 | AstraZeneca AB (Publ) | Morpholine derivates as antiobesity agents |
WO2009071668A2 (en) | 2007-12-05 | 2009-06-11 | Biovitrum Ab (Publ) | Piperazine derivatives and their use as leptin receptor modulators |
WO2009071677A1 (en) | 2007-12-05 | 2009-06-11 | Biovitrum Ab (Publ) | New compounds iii |
JP2011522813A (ja) | 2008-06-04 | 2011-08-04 | アストラゼネカ アクチボラグ | 低分子レプチン受容体修飾因子 |
EP2313096A1 (en) | 2008-06-04 | 2011-04-27 | AstraZeneca AB (Publ) | New compounds v |
EP2321276A1 (en) | 2008-06-04 | 2011-05-18 | AstraZeneca AB | New compounds vii |
CN102143747A (zh) | 2008-06-04 | 2011-08-03 | 阿斯利康(瑞典)有限公司 | 作为瘦蛋白受体调节剂模拟物的新的吡啶衍生物 |
-
2008
- 2008-12-05 WO PCT/EP2008/066877 patent/WO2009071658A1/en active Application Filing
- 2008-12-05 AU AU2008333173A patent/AU2008333173A1/en not_active Abandoned
- 2008-12-05 CN CN2008801266306A patent/CN102026975A/zh active Pending
- 2008-12-05 MX MX2010006259A patent/MX2010006259A/es not_active Application Discontinuation
- 2008-12-05 JP JP2010536469A patent/JP2011506294A/ja active Pending
- 2008-12-05 EA EA201000926A patent/EA201000926A1/ru unknown
- 2008-12-05 EP EP08856144A patent/EP2229362A1/en not_active Withdrawn
- 2008-12-05 US US12/315,698 patent/US7851471B2/en not_active Expired - Fee Related
- 2008-12-05 KR KR1020107014723A patent/KR20100093104A/ko not_active Application Discontinuation
- 2008-12-05 US US12/744,359 patent/US20110059969A1/en not_active Abandoned
- 2008-12-05 CA CA2707555A patent/CA2707555A1/en not_active Abandoned
- 2008-12-05 BR BRPI0819989 patent/BRPI0819989A2/pt not_active IP Right Cessation
-
2010
- 2010-05-20 IL IL205874A patent/IL205874A0/en unknown
- 2010-06-03 ZA ZA2010/03976A patent/ZA201003976B/en unknown
- 2010-06-04 EC EC2010010234A patent/ECSP10010234A/es unknown
- 2010-06-04 CO CO10068022A patent/CO6280487A2/es not_active Application Discontinuation
- 2010-06-04 CR CR11479A patent/CR11479A/es not_active Application Discontinuation
- 2010-06-04 DO DO2010000167A patent/DOP2010000167A/es unknown
- 2010-11-01 US US12/917,085 patent/US20110046135A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DOP2010000167A (es) | 2010-06-30 |
IL205874A0 (en) | 2010-11-30 |
KR20100093104A (ko) | 2010-08-24 |
ZA201003976B (en) | 2011-04-28 |
CO6280487A2 (es) | 2011-05-20 |
US20110059969A1 (en) | 2011-03-10 |
AU2008333173A1 (en) | 2009-06-11 |
US20090181967A1 (en) | 2009-07-16 |
MX2010006259A (es) | 2010-08-23 |
CN102026975A (zh) | 2011-04-20 |
EA201000926A1 (ru) | 2011-02-28 |
BRPI0819989A2 (pt) | 2015-05-12 |
EP2229362A1 (en) | 2010-09-22 |
CA2707555A1 (en) | 2009-06-11 |
WO2009071658A1 (en) | 2009-06-11 |
JP2011506294A (ja) | 2011-03-03 |
US20110046135A1 (en) | 2011-02-24 |
US7851471B2 (en) | 2010-12-14 |
CR11479A (es) | 2010-07-19 |
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