BRPI0508364A - derivados de 4-benzimidazol-2-ilpiridazin-3-ona - Google Patents
derivados de 4-benzimidazol-2-ilpiridazin-3-onaInfo
- Publication number
- BRPI0508364A BRPI0508364A BRPI0508364-8A BRPI0508364A BRPI0508364A BR PI0508364 A BRPI0508364 A BR PI0508364A BR PI0508364 A BRPI0508364 A BR PI0508364A BR PI0508364 A BRPI0508364 A BR PI0508364A
- Authority
- BR
- Brazil
- Prior art keywords
- benzimidazol
- compounds
- derivatives
- ylpyridazin
- kinase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DERIVADOS DE 4-BENZIMIDAZOL-2-ILPIRIDAZIN-3-ONA. A presente invenção refere-se a compostos da fórmula geral (l), onde a definição dos substituintes A, B, D, E, R¬ 1¬ e R¬ 2¬ são detalhadas na descrição, e os seus sais fisioligicamente tolerados, a um processo para a preparação destes compostos e a seu uso como produtos farmacêuticos. Estes compostos são inibidores de quinase, em particular inibidores da quinase CDK2 (quinase 2 dependente de ciclina).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004010207A DE102004010207A1 (de) | 2004-03-02 | 2004-03-02 | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
PCT/EP2005/002569 WO2005085231A1 (en) | 2004-03-02 | 2005-02-18 | Novel 4-benzimidazol-2-ylpyridazin-3-one derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0508364A true BRPI0508364A (pt) | 2007-07-24 |
Family
ID=34853913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0508364-8A BRPI0508364A (pt) | 2004-03-02 | 2005-02-18 | derivados de 4-benzimidazol-2-ilpiridazin-3-ona |
Country Status (14)
Country | Link |
---|---|
US (2) | US7470689B2 (pt) |
EP (1) | EP1723137A1 (pt) |
JP (1) | JP4792455B2 (pt) |
KR (1) | KR20070008582A (pt) |
CN (1) | CN101061108A (pt) |
AR (1) | AR047987A1 (pt) |
AU (1) | AU2005219563A1 (pt) |
BR (1) | BRPI0508364A (pt) |
CA (1) | CA2555161A1 (pt) |
DE (1) | DE102004010207A1 (pt) |
IL (1) | IL177204A0 (pt) |
TW (1) | TW200538452A (pt) |
UY (1) | UY28783A1 (pt) |
WO (1) | WO2005085231A1 (pt) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013075199A1 (pt) | 2011-11-25 | 2013-05-30 | Universidade Federal De Santa Catarina | "compostos acil-hidrazonas e oxadiazóis, composições farmacêuticas compreendendo os mesmos e seus usos |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004010194A1 (de) * | 2004-03-02 | 2005-10-13 | Aventis Pharma Deutschland Gmbh | 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate, ihre Herstellung und Verwendung in Arzneimitteln |
EP1604988A1 (en) * | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals |
EP1598348A1 (en) | 2004-05-18 | 2005-11-23 | Aventis Pharma Deutschland GmbH | Novel pyridazinone derivatives as inhibitors of CDK2 |
US8629147B2 (en) | 2005-11-03 | 2014-01-14 | Chembridge Corporation | Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders |
EP2069312B1 (en) * | 2006-07-25 | 2012-11-07 | Cephalon, Inc. | Pyridizinone derivatives |
CN101538245B (zh) | 2008-03-18 | 2011-02-16 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物及其制备方法和制备药物的用途 |
US9212146B2 (en) | 2008-03-18 | 2015-12-15 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Substituted pyridazinones for the treatment of tumors |
US20150051208A1 (en) * | 2013-08-14 | 2015-02-19 | Boehringer Ingelheim International Gmbh | Pyridinones |
WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
CA2982664A1 (en) * | 2015-04-16 | 2016-10-20 | Merck Patent Gmbh | 3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one derivatives |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
CN111393374A (zh) * | 2020-05-08 | 2020-07-10 | 张建蒙 | 氧代二氢哒嗪类衍生物及其在抗肿瘤药物中的应用 |
CN115650968B (zh) * | 2022-12-27 | 2023-03-21 | 英矽智能科技(上海)有限公司 | 作为cdk选择性抑制剂的新型哒嗪酮化合物 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4324580A1 (de) | 1993-07-22 | 1995-01-26 | Thomae Gmbh Dr K | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US6727102B1 (en) * | 1997-06-20 | 2004-04-27 | Leuven Research & Development Vzw | Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins |
CA2294548A1 (en) * | 1997-08-22 | 1999-03-04 | Abbott Laboratories | Pyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors |
TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
PL200674B1 (pl) * | 1999-06-28 | 2009-01-30 | Janssen Pharmaceutica Nv | Pochodna benzoimidazolu lub imidazopirydyny i sposób jej otrzymywania oraz kompozycja farmaceutyczna i sposób jej otrzymywania |
GB0007934D0 (en) | 2000-03-31 | 2000-05-17 | Darwin Discovery Ltd | Chemical compounds |
SK12002003A3 (en) * | 2001-03-28 | 2004-10-05 | Bristol Myers Squibb Co | Novel tyrosine kinase inhibitors |
US7232897B2 (en) * | 2001-04-24 | 2007-06-19 | Harvard University, President And Fellows Of Harvard College | Compositions and methods for modulating NH2-terminal Jun Kinase activity |
CA2452253C (en) * | 2001-07-27 | 2009-06-02 | Yamanouchi Pharmaceutical Co., Ltd. | Novel crystal of arylethenesulfonamide derivative and preparation process thereof |
EP1298125A1 (en) | 2001-09-26 | 2003-04-02 | Aventis Pharma S.A. | Substituted benzimidazole compounds and their use for the treatment of cancer |
JP5039268B2 (ja) * | 2001-10-26 | 2012-10-03 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | ベンゾイミダゾールおよび類縁体および蛋白キナーゼ阻害剤としてのその使用 |
AU2002364587A1 (en) * | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
CA2474239A1 (en) | 2002-01-18 | 2003-07-24 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
JP4656838B2 (ja) | 2002-02-06 | 2011-03-23 | バーテックス ファーマシューティカルズ インコーポレイテッド | Gsk−3の阻害剤として有用なヘテロアリール化合物 |
ES2250883T3 (es) * | 2002-02-28 | 2006-04-16 | Sanofi-Aventis | Derivados de 2-piridinil y 2-pirimidinil-6,7,8,9-tetrahidropirimido(1,2-a)pirimidin-4-ona sustituidos con heteroarilo. |
HU227255B1 (en) * | 2002-04-26 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Novel piperidine-alkyl-amino-pyridazine derivatives, pharmaceutical compositions containing the same and process for the preparation of the active ingredient |
JP2005531607A (ja) * | 2002-06-05 | 2005-10-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤として置換ピロリン |
US7232828B2 (en) * | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
FR2847253B1 (fr) | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
MXPA05005554A (es) * | 2002-12-12 | 2005-07-26 | Aventis Pharma Sa | Derivados de aminoindazol y su utilizacion como inhibidores de quinasas. |
IL157751A0 (en) * | 2003-02-28 | 2004-03-28 | Yissum Res Dev Co | New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them |
CN1759103A (zh) * | 2003-03-18 | 2006-04-12 | 兴和株式会社 | 水溶性苯基哒嗪衍生物及含有该衍生物的医药品 |
DE102004010194A1 (de) | 2004-03-02 | 2005-10-13 | Aventis Pharma Deutschland Gmbh | 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate, ihre Herstellung und Verwendung in Arzneimitteln |
US7232939B2 (en) * | 2004-05-28 | 2007-06-19 | E.I. Du Pont De Nemours And Company | Nucleic acid molecules encoding cyclotide polypeptides and methods of use |
BRPI0609685A2 (pt) * | 2005-04-06 | 2010-04-20 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para tratamento e/ou profilaxia de enfermidades que estão associados com a modulação de receptores de cb1, e utilização dos mesmos |
US7619083B2 (en) * | 2005-07-01 | 2009-11-17 | Bristol-Myers Squibb Company | Intermediates useful in preparing certain pyrrolotriazine compounds and process for making such intermediates |
-
2004
- 2004-03-02 DE DE102004010207A patent/DE102004010207A1/de not_active Withdrawn
-
2005
- 2005-02-18 CN CNA2005800068037A patent/CN101061108A/zh active Pending
- 2005-02-18 WO PCT/EP2005/002569 patent/WO2005085231A1/en not_active Application Discontinuation
- 2005-02-18 EP EP05715943A patent/EP1723137A1/en not_active Withdrawn
- 2005-02-18 JP JP2007501246A patent/JP4792455B2/ja not_active Expired - Fee Related
- 2005-02-18 AU AU2005219563A patent/AU2005219563A1/en not_active Abandoned
- 2005-02-18 KR KR1020067017737A patent/KR20070008582A/ko not_active Application Discontinuation
- 2005-02-18 BR BRPI0508364-8A patent/BRPI0508364A/pt not_active IP Right Cessation
- 2005-02-18 CA CA002555161A patent/CA2555161A1/en not_active Abandoned
- 2005-03-01 TW TW094105970A patent/TW200538452A/zh unknown
- 2005-03-02 UY UY28783A patent/UY28783A1/es unknown
- 2005-03-02 AR ARP050100790A patent/AR047987A1/es unknown
-
2006
- 2006-08-01 IL IL177204A patent/IL177204A0/en unknown
- 2006-08-31 US US11/513,574 patent/US7470689B2/en not_active Expired - Fee Related
-
2008
- 2008-10-15 US US12/251,572 patent/US7754713B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013075199A1 (pt) | 2011-11-25 | 2013-05-30 | Universidade Federal De Santa Catarina | "compostos acil-hidrazonas e oxadiazóis, composições farmacêuticas compreendendo os mesmos e seus usos |
Also Published As
Publication number | Publication date |
---|---|
US20070173503A1 (en) | 2007-07-26 |
IL177204A0 (en) | 2006-12-10 |
AR047987A1 (es) | 2006-03-15 |
AU2005219563A1 (en) | 2005-09-15 |
JP2007531712A (ja) | 2007-11-08 |
EP1723137A1 (en) | 2006-11-22 |
US7470689B2 (en) | 2008-12-30 |
UY28783A1 (es) | 2005-09-30 |
US20090042880A1 (en) | 2009-02-12 |
WO2005085231A1 (en) | 2005-09-15 |
DE102004010207A1 (de) | 2005-09-15 |
JP4792455B2 (ja) | 2011-10-12 |
CN101061108A (zh) | 2007-10-24 |
US7754713B2 (en) | 2010-07-13 |
TW200538452A (en) | 2005-12-01 |
KR20070008582A (ko) | 2007-01-17 |
CA2555161A1 (en) | 2005-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE A 8.6 NA RPI 2099 DE 29/03/2011. |