BRPI0417996A - agentes para tratamento de retinopatia diabética e formação de gánglios em degeneração macular - Google Patents

agentes para tratamento de retinopatia diabética e formação de gánglios em degeneração macular

Info

Publication number
BRPI0417996A
BRPI0417996A BRPI0417996-0A BRPI0417996A BRPI0417996A BR PI0417996 A BRPI0417996 A BR PI0417996A BR PI0417996 A BRPI0417996 A BR PI0417996A BR PI0417996 A BRPI0417996 A BR PI0417996A
Authority
BR
Brazil
Prior art keywords
agents
macular degeneration
diabetic retinopathy
formation
treating diabetic
Prior art date
Application number
BRPI0417996-0A
Other languages
English (en)
Inventor
Robert A Landers
David P Bingaman
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of BRPI0417996A publication Critical patent/BRPI0417996A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"AGENTES PARA TRATAMENTO DE RETINOPATIA DIABéTICA E FORMAçãO DE GáNGLIOS EM DEGENERAçãO MACULAR". Agentes que estimulam a translocação nuclear de proteína Nrf2 e os aumentos subseqüentes em produtos genéticos que desintoxicam e eliminam metabólitos citotóxicos são providos em um método para tratar retinopatia diabética ou formação de drusas em degeneração macular relacionada com a idade. Os agentes estruturalmente diversos que atuam sobre a via Nrf2/ARE induzem a expressão de enzimas e proteínas que têm propriedades citoprotetoras quimicamente versáteis e são uma defesa contra metabólitos e xenobióticos tóxicos. Agentes incluem certos eletrófilos e oxidantes tais como um aceptor de Adição Michael, difenol, tiocarbamato, quinona, 1,2-ditiol-3-tiona, hidroxianisoóis butilados, flavonóide ou outra genisteina, um isotiocianato, 3,5-di-terc-butil-4-hidroxitolueno, etoxiquina, uma coumarina, combinações dos mesmos, ou um derivado ou análogo farmacologicamente ativo dos mesmos.
BRPI0417996-0A 2003-12-22 2004-12-17 agentes para tratamento de retinopatia diabética e formação de gánglios em degeneração macular BRPI0417996A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53181103P 2003-12-22 2003-12-22
PCT/US2004/042562 WO2005063249A1 (en) 2003-12-22 2004-12-17 Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration

Publications (1)

Publication Number Publication Date
BRPI0417996A true BRPI0417996A (pt) 2007-04-27

Family

ID=34738705

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417996-0A BRPI0417996A (pt) 2003-12-22 2004-12-17 agentes para tratamento de retinopatia diabética e formação de gánglios em degeneração macular

Country Status (9)

Country Link
US (2) US20050137147A1 (pt)
EP (1) EP1696926A1 (pt)
JP (1) JP2007515422A (pt)
AU (1) AU2004308911B2 (pt)
BR (1) BRPI0417996A (pt)
CA (1) CA2548146A1 (pt)
MX (1) MXPA06006862A (pt)
WO (1) WO2005063249A1 (pt)
ZA (1) ZA200605378B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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ZA200604862B (en) * 2003-12-22 2007-10-31 Alcon Inc Agents for treatment of glaucomatous retinopathy and optic neuropathy
WO2005102345A1 (en) * 2004-03-30 2005-11-03 Alcon, Inc. Use of rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance
WO2006030907A1 (ja) * 2004-09-16 2006-03-23 Redox Bioscience Inc. 網膜保護剤
WO2007005879A2 (en) * 2005-07-01 2007-01-11 The Johns Hopkins University Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
FR2902326B1 (fr) * 2006-06-20 2008-12-05 Oreal Utilisation de la coumarine, de butylated hydroxyanisole et d'ethoxyquine pour le traitement de la canitie
WO2008016095A1 (fr) * 2006-08-02 2008-02-07 Santen Pharmaceutical Co., Ltd. REMÈDE PRÉVENTIF OU CURATIF POUR LES KÉRATOCONJONCTIVITES CONTENANT UN ACTIVATEUR DE Nrf2 EN TANT QUE MATIÈRE ACTIVE
WO2008111497A1 (ja) * 2007-03-08 2008-09-18 Santen Pharmaceutical Co., Ltd. トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤
US20090324740A1 (en) * 2008-06-13 2009-12-31 Albritton Iv Ford D Novel nasal spray
CA2747418A1 (en) * 2008-12-16 2010-07-01 Onconova Therapeutics, Inc. Methods for determining efficacy of a therapeutic regimen against deleterious effects of cytotoxic agents
US20130288985A1 (en) * 2010-07-15 2013-10-31 The Schepens Eye Research Institute Inc. Compositions and methods of treatment of corneal endothelium disorders
WO2014179568A2 (en) * 2013-05-02 2014-11-06 Odin Biotech Two-layer ocular implant
EP3919052A4 (en) * 2019-01-09 2022-10-05 Fuso Pharmaceutical Industries, Ltd. PHARMACEUTICAL COMPOSITION FOR INTRAOCULAR OR ORAL ADMINISTRATION FOR THE TREATMENT OF RETINAR DISEASES
CN112716938A (zh) * 2021-02-25 2021-04-30 新疆医科大学 鞣花酸在制备缓解眼组织病变的药物中的用途

Family Cites Families (32)

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US4456757A (en) * 1981-03-20 1984-06-26 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonyl derivatives and process for the preparation thereof
US4678783B1 (en) * 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
US4959389A (en) * 1987-10-19 1990-09-25 Speiser Peter P Pharmaceutical preparation for the treatment of psoriatic arthritis
US5124154A (en) * 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
JP3193301B2 (ja) * 1995-09-14 2001-07-30 麒麟麦酒株式会社 生理活性タンパク質ｐ１６０
US5906819A (en) * 1995-11-20 1999-05-25 Kirin Beer Kabushiki Kaisha Rho target protein Rho-kinase
US5681854A (en) * 1995-11-22 1997-10-28 Alcon Laboratories, Inc. Use of aliphatic carboxylic acid derivatives in ophthalmic disorders
ATE289815T1 (de) * 1995-12-21 2005-03-15 Alcon Lab Inc Verwendung von substituierten isochinolinsulfonyl-verbindungen zur herstellung eines medikaments für die behandlung von glaukom und okularer ischämie
AU1557497A (en) * 1996-02-02 1997-08-22 Nippon Shinyaku Co. Ltd. Isoquinoline derivatives and drugs
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DK0956865T4 (da) * 1996-08-12 2010-11-22 Mitsubishi Tanabe Pharma Corp Medikamenter omfattende Rho-kinaseinhibitor
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US5958946A (en) * 1998-01-20 1999-09-28 Styczynski; Peter Modulation of hair growth
US6274338B1 (en) * 1998-02-24 2001-08-14 President And Fellows Of Harvard College Human c-Maf compositions and methods of use thereof
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US6020383A (en) * 1999-01-11 2000-02-01 Eastman Chemicals Company Method for reducing blood cholesterol and/or blood triglycerides
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GB0030727D0 (en) * 2000-12-15 2001-01-31 Lumitech Uk Ltd Methods and kits for detecting kinase activity
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US6884816B2 (en) * 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
TW201041580A (en) * 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
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Also Published As

Publication number Publication date
CA2548146A1 (en) 2005-07-14
EP1696926A1 (en) 2006-09-06
JP2007515422A (ja) 2007-06-14
US20100204244A1 (en) 2010-08-12
AU2004308911A1 (en) 2005-07-14
US20050137147A1 (en) 2005-06-23
WO2005063249A1 (en) 2005-07-14
ZA200605378B (en) 2008-01-30
MXPA06006862A (es) 2007-01-26
AU2004308911B2 (en) 2010-08-26

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 8A E 9A ANUIDADES.

B08I Application fees: publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA.

B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 8A, 9A, 10A, 11A, 12A, 13A, 14A E 15A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.