BRPI0414722A - meios sem produto animal e processos para obtenção de uma toxina botulìnica - Google Patents
meios sem produto animal e processos para obtenção de uma toxina botulìnicaInfo
- Publication number
- BRPI0414722A BRPI0414722A BRPI0414722-7A BRPI0414722A BRPI0414722A BR PI0414722 A BRPI0414722 A BR PI0414722A BR PI0414722 A BRPI0414722 A BR PI0414722A BR PI0414722 A BRPI0414722 A BR PI0414722A
- Authority
- BR
- Brazil
- Prior art keywords
- obtaining
- processes
- toxin
- animal
- botulically
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/842—Clostridium
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
"MEIOS SEM PRODUTO ANIMAL E PROCESSOS PARA OBTENçãO DE UMA TOXINA BOTULìNICA". A presente invenção refere-se a meio e processos para a fermentação de Clostridium botulinum e obtenção de uma toxina botulínica para uso em formulação de composições farmacêuticas de toxina botulínica. Os meios de crescimento podem conter níveis significativamente reduzidos de subprodutos de carne ou de laticínios usando produtos à base não-animais para substituir os produtos derivados de animal. Preferencialmente, os meio usados são substancialmente livres de produtos derivados de animal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/672,876 US7148041B2 (en) | 2003-09-25 | 2003-09-25 | Animal product free media and processes for obtaining a botulinum toxin |
PCT/US2004/027775 WO2005035749A2 (en) | 2003-09-25 | 2004-08-25 | Animal product free media and processes for obtaining a botulinum toxin |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414722A true BRPI0414722A (pt) | 2006-11-21 |
Family
ID=34376493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414722-7A BRPI0414722A (pt) | 2003-09-25 | 2004-08-25 | meios sem produto animal e processos para obtenção de uma toxina botulìnica |
Country Status (18)
Country | Link |
---|---|
US (4) | US7148041B2 (pt) |
EP (2) | EP1664292B1 (pt) |
JP (3) | JP2007506427A (pt) |
KR (1) | KR101100567B1 (pt) |
CN (1) | CN1856569B (pt) |
AR (1) | AR045813A1 (pt) |
AT (1) | ATE469215T1 (pt) |
AU (1) | AU2004280450B2 (pt) |
BR (1) | BRPI0414722A (pt) |
CA (1) | CA2540072A1 (pt) |
DE (1) | DE602004027393D1 (pt) |
DK (1) | DK1664292T3 (pt) |
ES (1) | ES2344843T3 (pt) |
MX (1) | MXPA06003029A (pt) |
NZ (1) | NZ545503A (pt) |
PL (1) | PL1664292T3 (pt) |
TW (1) | TWI294914B (pt) |
WO (1) | WO2005035749A2 (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7148041B2 (en) * | 2003-09-25 | 2006-12-12 | Allergan, Inc. | Animal product free media and processes for obtaining a botulinum toxin |
US7452697B2 (en) * | 2003-09-25 | 2008-11-18 | Allergan, Inc. | Chromatographic method and system for purifying a botulinum toxin |
US7160699B2 (en) * | 2003-09-25 | 2007-01-09 | Allergan, Inc. | Media for clostridium bacterium and processes for obtaining a clostridial toxin |
JP4913074B2 (ja) * | 2005-03-03 | 2012-04-11 | アラーガン、インコーポレイテッド | 動物由来産物不含方法およびボツリヌス毒素を精製するための方法 |
US8168206B1 (en) * | 2005-10-06 | 2012-05-01 | Allergan, Inc. | Animal protein-free pharmaceutical compositions |
AR061669A1 (es) | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
US10792344B2 (en) | 2006-06-29 | 2020-10-06 | Merz Pharma Gmbh & Co. Kgaa | High frequency application of botulinum toxin therapy |
DK1893033T3 (da) * | 2006-07-07 | 2009-01-05 | Alpro Nv | Fremgangsmåde til fremstilling af en mælkeproduktanalog |
KR20090120222A (ko) * | 2008-05-19 | 2009-11-24 | (주)메디톡스 | 식물 유래 성분 함유 배지 및 가요성 폐쇄 용기를 이용하여클로스트리디움 보툴리눔 독소를 생산하는 방법 |
JP5792718B2 (ja) | 2009-06-24 | 2015-10-14 | ソパーカー、チャールズ エヌ.エス.SOPARKAR,Charles N.S. | 処置前治療用メタロプロテアーゼ準備パック |
US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
EP2275527A1 (en) * | 2009-07-17 | 2011-01-19 | ActoGeniX NV | Animal component-free culture medium for bacterial fermentation |
KR101134146B1 (ko) * | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
WO2012109387A1 (en) | 2011-02-08 | 2012-08-16 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
BR112014029585A2 (pt) | 2012-05-30 | 2017-07-25 | Harvard College | neurotoxina botulínica engendrada |
BR102012013110A2 (pt) | 2012-05-31 | 2014-05-27 | Cristalia Prod Quimicos Farm | Meio de cultura para bactérias do gênero clostridium livre de componentes de origem animal e processo para produção de sobrenadante contendo uma ou mais proteases com atividade colagenolítica e gelatinolítica |
RU2535115C1 (ru) | 2013-05-15 | 2014-12-10 | Бости Трейдинг Лтд | Фармацевтический состав, содержащий нейротоксин ботулина |
WO2014197837A1 (en) * | 2013-06-06 | 2014-12-11 | University Of Florida Research Foundation, Inc. | Materials and methods for producing a biological toxin |
ES2895853T3 (es) | 2015-03-26 | 2022-02-22 | Harvard College | Neurotoxina botulínica modificada |
KR101729251B1 (ko) * | 2015-04-28 | 2017-04-21 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
KR101723168B1 (ko) * | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
KR101723167B1 (ko) | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
CA2984986C (en) * | 2015-05-06 | 2023-05-23 | Wageningen Universiteit | Method of culturing akkermansia |
US11242515B2 (en) | 2016-05-16 | 2022-02-08 | President And Fellows Of Harvard College | Method for purification and activation of botulinum neurotoxin |
EP3504226A1 (en) | 2016-08-24 | 2019-07-03 | President and Fellows of Harvard College | Engineered botulinum neurotoxin |
HUE046290T2 (hu) | 2016-09-13 | 2020-02-28 | Allergan Inc | Stabilizált, nem-fehérje clostridialis toxin készítmények |
KR102197224B1 (ko) | 2019-03-29 | 2020-12-31 | (주)제테마 | 배지 조성물 |
KR102209159B1 (ko) | 2019-03-29 | 2021-01-29 | (주)제테마 | 독소의 제조방법 |
US10851363B1 (en) * | 2019-05-22 | 2020-12-01 | Boke Zhang | Multilayer nano-cell containing biomolecules |
KR102287437B1 (ko) * | 2019-08-14 | 2021-08-09 | 주식회사 프로톡스 | 보툴리눔 독소의 제조방법 |
TW202136518A (zh) * | 2019-12-20 | 2021-10-01 | 瑞士商葛德瑪控股公司 | 生產肉毒桿菌毒素的方法 |
WO2024102345A1 (en) | 2022-11-07 | 2024-05-16 | Allergan, Inc. | Prevention of post-operative atrial fibrillation with a botulinum toxin |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4401683A (en) * | 1981-07-06 | 1983-08-30 | Fmc Corporation | Carbohydrate food products resistant to Clostridium botulinum and the formation of enterotoxin |
US5314822A (en) | 1992-10-15 | 1994-05-24 | Merck & Co., Inc. | Method of clonal growth of Streptococcus pneumoniae |
US5902565A (en) * | 1993-12-24 | 1999-05-11 | Csl Limited | Spray dried vaccine preparation comprising aluminium adsorbed immunogens |
AU2907695A (en) | 1994-08-08 | 1996-03-07 | Wisconsin Alumni Research Foundation | Purification and pharmaceutical compositions containing type g botulinum neurotoxin |
ES2293681T3 (es) | 1997-05-28 | 2008-03-16 | Novartis Vaccines And Diagnostics S.R.L. | Medio de cultivo con extracto de soja como fuente de aminoacidos pero sin complejos proteinicos de origen animal. |
US6171605B1 (en) | 1999-07-08 | 2001-01-09 | Color Access, Inc. | Self tanning compositions containing DHA and propolis extract |
US6558926B1 (en) | 1999-07-16 | 2003-05-06 | Massachusetts Institute Of Technology | Method for production of tetanus toxin using media substantially free of animal products |
WO2001036655A2 (en) | 1999-11-12 | 2001-05-25 | Eli Lilly And Company | Method for optimization of a medium for glycopeptide fermentation |
CA2494241C (en) | 2000-02-08 | 2011-06-14 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions |
US20030118598A1 (en) * | 2000-02-08 | 2003-06-26 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
JP2003009897A (ja) | 2001-07-03 | 2003-01-14 | Keiji Oguma | ボツリヌス毒素の分離・精製法 |
WO2003083133A1 (fr) * | 2002-03-29 | 2003-10-09 | Asahi Kasei Pharma Corporation | Methode de detection d'une intolerance legere au glucose ou d'une hyposecretion d'insuline |
US20040235139A1 (en) | 2002-12-23 | 2004-11-25 | Demain Arnold L. | Clostridium difficile culture and toxin production methods |
EP1493478B1 (en) | 2003-07-02 | 2007-04-04 | Filtertek Inc. | Multiple bridge retainer |
US7452697B2 (en) | 2003-09-25 | 2008-11-18 | Allergan, Inc. | Chromatographic method and system for purifying a botulinum toxin |
US7148041B2 (en) * | 2003-09-25 | 2006-12-12 | Allergan, Inc. | Animal product free media and processes for obtaining a botulinum toxin |
US7160699B2 (en) | 2003-09-25 | 2007-01-09 | Allergan, Inc. | Media for clostridium bacterium and processes for obtaining a clostridial toxin |
JP4913074B2 (ja) | 2005-03-03 | 2012-04-11 | アラーガン、インコーポレイテッド | 動物由来産物不含方法およびボツリヌス毒素を精製するための方法 |
-
2003
- 2003-09-25 US US10/672,876 patent/US7148041B2/en active Active
-
2004
- 2004-08-25 CA CA002540072A patent/CA2540072A1/en not_active Abandoned
- 2004-08-25 CN CN2004800276872A patent/CN1856569B/zh active Active
- 2004-08-25 BR BRPI0414722-7A patent/BRPI0414722A/pt not_active IP Right Cessation
- 2004-08-25 DE DE602004027393T patent/DE602004027393D1/de active Active
- 2004-08-25 AU AU2004280450A patent/AU2004280450B2/en active Active
- 2004-08-25 MX MXPA06003029A patent/MXPA06003029A/es active IP Right Grant
- 2004-08-25 PL PL04782286T patent/PL1664292T3/pl unknown
- 2004-08-25 JP JP2006528006A patent/JP2007506427A/ja active Pending
- 2004-08-25 ES ES04782286T patent/ES2344843T3/es active Active
- 2004-08-25 KR KR1020067005858A patent/KR101100567B1/ko active IP Right Grant
- 2004-08-25 EP EP04782286A patent/EP1664292B1/en not_active Revoked
- 2004-08-25 EP EP10001404A patent/EP2177607A1/en not_active Withdrawn
- 2004-08-25 AT AT04782286T patent/ATE469215T1/de active
- 2004-08-25 DK DK04782286.1T patent/DK1664292T3/da active
- 2004-08-25 WO PCT/US2004/027775 patent/WO2005035749A2/en active Application Filing
- 2004-08-25 NZ NZ545503A patent/NZ545503A/en unknown
- 2004-09-14 TW TW093127791A patent/TWI294914B/zh active
- 2004-09-23 AR ARP040103444A patent/AR045813A1/es not_active Application Discontinuation
-
2005
- 2005-12-07 US US11/296,001 patent/US7445914B2/en not_active Expired - Lifetime
- 2005-12-07 US US11/296,015 patent/US7189541B2/en not_active Expired - Lifetime
-
2008
- 2008-09-19 US US12/234,537 patent/US8008044B2/en not_active Expired - Lifetime
-
2012
- 2012-01-05 JP JP2012000366A patent/JP2012070759A/ja active Pending
-
2014
- 2014-12-04 JP JP2014246215A patent/JP2015051019A/ja active Pending
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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