BRPI0413413A - feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada - Google Patents
feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhoradaInfo
- Publication number
- BRPI0413413A BRPI0413413A BRPI0413413-3A BRPI0413413A BRPI0413413A BR PI0413413 A BRPI0413413 A BR PI0413413A BR PI0413413 A BRPI0413413 A BR PI0413413A BR PI0413413 A BRPI0413413 A BR PI0413413A
- Authority
- BR
- Brazil
- Prior art keywords
- piperidine
- improved
- vivo efficacy
- antimicrobial activity
- derivatives
- Prior art date
Links
- 230000000845 anti-microbial effect Effects 0.000 title abstract 3
- -1 Piperidine-substituted phenyloxazolidinones Chemical class 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- HWQXSBXGABRYGV-UHFFFAOYSA-N 3-phenyl-1,3-oxazolidin-2-one;piperidine Chemical class C1CCNCC1.O=C1OCCN1C1=CC=CC=C1 HWQXSBXGABRYGV-UHFFFAOYSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003515 anti-microbian Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN924MU2003 | 2003-09-08 | ||
| PCT/IN2004/000276 WO2005054234A2 (en) | 2003-09-08 | 2004-09-08 | Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0413413A true BRPI0413413A (pt) | 2007-01-09 |
Family
ID=34640331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0413413-3A BRPI0413413A (pt) | 2003-09-08 | 2004-09-08 | feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7687627B2 (enExample) |
| EP (1) | EP1664038A2 (enExample) |
| JP (1) | JP4917432B2 (enExample) |
| AU (1) | AU2004295208A1 (enExample) |
| BR (1) | BRPI0413413A (enExample) |
| CA (1) | CA2537559C (enExample) |
| EA (1) | EA200600374A1 (enExample) |
| WO (1) | WO2005054234A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7687627B2 (en) * | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
| WO2007004049A1 (en) * | 2005-07-06 | 2007-01-11 | Pharmacia & Upjohn Company Llc | Oxazolidinones containing azetidine as antibacterial agents |
| JP5313126B2 (ja) * | 2006-05-09 | 2013-10-09 | ウォックハート リミテッド | 置換ピペリジノフェニルオキサゾリジノン |
| CN101616588B (zh) * | 2006-09-25 | 2013-09-25 | 沃克哈特研究中心 | 取代的哌啶子基苯基噁唑烷酮 |
| WO2009037542A2 (en) * | 2007-09-20 | 2009-03-26 | Glenmark Pharmaceuticals, S.A. | Spirocyclic compounds as stearoyl coa desaturase inhibitors |
| EP2072513A1 (en) * | 2007-12-17 | 2009-06-24 | Ferrer Internacional, S.A. | A cyano piperidinyl-phenil-oxazolidinone and use thereof |
| EP2254892B1 (en) | 2008-03-26 | 2014-04-23 | Global Alliance For Tb Drug Development | Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones |
| EP2141161A1 (en) * | 2008-07-01 | 2010-01-06 | Ferrer Internacional, S.A. | 3-cyanopyrrolidinyl-phenyl-oxazolidinones as antibacterial agents |
| EP2410854B1 (en) * | 2009-03-27 | 2016-06-29 | Council of Scientific & Industrial Research | Substituted 1, 4-dioxa-8-azaspiro ý4,5¨decanes useful as fungicides and a process for the preparation thereof |
| CA2816515A1 (en) * | 2010-11-03 | 2012-05-10 | Wockhardt Limited | Process for the preparation of phosphoric acid mono-(1-{4-[(s)-5-(acetylaminomethyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethylpiperidin-4-yl) ester |
| US9359344B2 (en) | 2011-09-29 | 2016-06-07 | Xuanzhu Pharma Co., Ltd. | Biaryl heterocycle substituted oxazolidinone antibacterial agents |
| WO2015066413A1 (en) * | 2013-11-01 | 2015-05-07 | Novartis Ag | Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections |
| WO2016079757A2 (en) * | 2014-11-19 | 2016-05-26 | Symed Labs Limited | Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives |
| WO2019081210A1 (en) * | 2017-10-27 | 2019-05-02 | Huntsman International Llc | CATALYSTS FOR MANUFACTURING OXAZOLIDINONE MATERIALS |
| CN112543756A (zh) * | 2018-07-25 | 2021-03-23 | 卡迪拉保健有限公司 | 用于治疗哺乳动物感染的经取代噁唑烷酮类 |
| WO2020234636A1 (en) | 2019-05-17 | 2020-11-26 | Cadila Healthcare Limited | Novel compounds for the treatment of mammalian infections |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3344145A (en) * | 1963-10-21 | 1967-09-26 | Geschickter Fund Med Res | N-substituted phenoxyalkyl or phenylthioalkyl-mono azaspiroalkanes |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| US5489689A (en) * | 1993-09-30 | 1996-02-06 | Mallinckrodt Chemical, Inc. | Preparation of piperidine derivatives |
| US5668286A (en) * | 1994-03-15 | 1997-09-16 | Pharmacia & Upjohn Company | Oxazolidinone derivatives and pharmaceutical compositions containing them |
| JPH0873455A (ja) * | 1994-03-15 | 1996-03-19 | Upjohn Co:The | オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物 |
| SI0788498T1 (en) * | 1994-10-26 | 2001-12-31 | Upjohn Co | Phenyloxazolidinone antimicrobials |
| ES2214546T3 (es) * | 1995-09-15 | 2004-09-16 | PHARMACIA & UPJOHN COMPANY | N-oxidos de aminoariloxazolidinona. |
| GB9702213D0 (en) * | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| RU2208613C2 (ru) * | 1997-05-30 | 2003-07-20 | Фармация Энд Апджон Компани | Оксазолидиноновые антибактериальные агенты, содержащие тиокарбонильную функциональную группу |
| CA2333332A1 (en) * | 1998-06-05 | 1999-12-16 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| GB9821938D0 (en) * | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
| JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
| JP3270834B2 (ja) * | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
| CA2374383A1 (en) * | 1999-07-28 | 2001-02-08 | Pharmacia & Upjohn Company | Oxazolidinones and their use as antiinfectives |
| US6608081B2 (en) * | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| GB2356389B (en) * | 1999-09-02 | 2003-07-16 | Bruce Stanley Gunton | Loading bay dock control |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| WO2002046156A2 (en) * | 2000-12-06 | 2002-06-13 | Sepracor, Inc. | 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands |
| JP2005503435A (ja) * | 2001-04-17 | 2005-02-03 | メルク アンド カンパニー インコーポレーテッド | ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体 |
| DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| CA2492194A1 (en) * | 2002-07-11 | 2004-01-22 | Wockhardt Limited | Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoproteins sites |
| US7405228B2 (en) * | 2002-07-11 | 2008-07-29 | Wockhardt Limited | Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites |
| AU2003274676A1 (en) * | 2002-07-11 | 2004-02-02 | Yati Chugh | Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them |
| KR100490643B1 (ko) * | 2002-10-29 | 2005-05-19 | 한국과학기술연구원 | 새로운 메틸리덴 피페리딘일 옥사졸리딘온 유도체 및이들의 제조방법 |
| US7687627B2 (en) * | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
| JP5313126B2 (ja) * | 2006-05-09 | 2013-10-09 | ウォックハート リミテッド | 置換ピペリジノフェニルオキサゾリジノン |
-
2004
- 2004-09-07 US US10/935,708 patent/US7687627B2/en not_active Expired - Fee Related
- 2004-09-08 WO PCT/IN2004/000276 patent/WO2005054234A2/en not_active Ceased
- 2004-09-08 AU AU2004295208A patent/AU2004295208A1/en not_active Abandoned
- 2004-09-08 JP JP2006526008A patent/JP4917432B2/ja not_active Expired - Fee Related
- 2004-09-08 CA CA2537559A patent/CA2537559C/en not_active Expired - Fee Related
- 2004-09-08 BR BRPI0413413-3A patent/BRPI0413413A/pt not_active IP Right Cessation
- 2004-09-08 EA EA200600374A patent/EA200600374A1/ru unknown
- 2004-09-08 EP EP04817639A patent/EP1664038A2/en not_active Withdrawn
-
2010
- 2010-02-12 US US12/705,258 patent/US8729269B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005054234A3 (en) | 2005-09-29 |
| CA2537559A1 (en) | 2005-06-16 |
| US20050143421A1 (en) | 2005-06-30 |
| US7687627B2 (en) | 2010-03-30 |
| AU2004295208A1 (en) | 2005-06-16 |
| JP2007505102A (ja) | 2007-03-08 |
| WO2005054234A2 (en) | 2005-06-16 |
| US8729269B2 (en) | 2014-05-20 |
| EA200600374A1 (ru) | 2006-08-25 |
| EP1664038A2 (en) | 2006-06-07 |
| JP4917432B2 (ja) | 2012-04-18 |
| CA2537559C (en) | 2012-11-20 |
| WO2005054234A8 (en) | 2006-11-23 |
| US20100144735A1 (en) | 2010-06-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0413413A (pt) | feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada | |
| BG106825A (en) | Substituted oxazolidinones and their use in the field of blood coagulation | |
| BRPI0618374A2 (pt) | uso de um composto ou um derivado do mesmo farmaceuticamente aceitável, métodos para matar microorganismos clinicamente latentes em um mamìfero, para tratar ou prevenir uma infecção microbiana em um mamìfero, para esterilizar um objeto, para preservar um material inorgánico ou orgánico, para tratar uma doença, para reduzir a dose de agente antimicrobiano convencional requerida para tratar uma infecção microbiana e para tratar uma doença de protozoário em um mamìfero, produto combinado, formulação, uso de um produto combinado, composto, e, processo para a preparação do mesmo | |
| ES2177422A1 (es) | Composiciones acaricidas. | |
| BR0214035A (pt) | Composto | |
| CO5700767A2 (es) | Procedimiento de tratamiento de rechazo de transplantes | |
| BRPI0415758A (pt) | combinações de substáncias ativas fungicidas sinergìsticas | |
| DE50214206D1 (de) | Kombinationstherapie substituierter oxazolidinone | |
| BRPI0415449A (pt) | combinações de compostos ativos fungicidas sinergìsticos | |
| DE69529670D1 (de) | Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen | |
| ES2186550B2 (es) | Nuevos derivados de oxazolidinonas como antibacterianos. | |
| BR0308133A (pt) | Forma polimórfica cristalina de cloridrato de irinotecan | |
| AR029420A1 (es) | Derivados de piperidiniloxi y pirrolidiniloxi oxazolidinona, un procedimiento para su preparacion, intermediarios y el uso de dichos derivados para la fabricacion de un medicamento antibacteriano | |
| DE602007011975D1 (de) | Thiadiazolderivate zur behandlung neurodegenerativer krankheiten | |
| BR0214703A (pt) | Derivados de aminoacetonitrila e seu uso para controlar parasitas | |
| BR0306855A (pt) | Método para o tratamento de distúrbios cognitivos | |
| BRPI0417902A (pt) | piperazinas úteis no tratamento da dor | |
| BR0108115A (pt) | Uso de uma quantidade eficaz de pelo menos um composto de tipo retinóide como agente antibacteriano e processo de tratamento cosmético para limpar a pele ou corrigir se odor | |
| AR039727A1 (es) | Difluorotioacetamidas de oxazolidinonas como agentes antibacterianos y composicion farmaceutica en base a ellas | |
| BR0309878A (pt) | Heterotriciclil-6-alquilideno-penemas como inibidores de beta-lactamase | |
| ATE478688T1 (de) | Verbindungen für den transfer von oligonukleotiden | |
| ATE417052T1 (de) | Oxazaborolidine als bakterielle effektoren | |
| BRPI0407271A (pt) | Composição anti-helmìntica | |
| NO20063619L (no) | Diarylmetylpiperazinderivater, fremstilling og anvendelse derav | |
| DE60030300D1 (de) | Topische behandlung zur vorbeugung von augeninfektionen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 3A, 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |