CA2537559C - Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy - Google Patents

Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy Download PDF

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Publication number
CA2537559C
CA2537559C CA2537559A CA2537559A CA2537559C CA 2537559 C CA2537559 C CA 2537559C CA 2537559 A CA2537559 A CA 2537559A CA 2537559 A CA2537559 A CA 2537559A CA 2537559 C CA2537559 C CA 2537559C
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CA
Canada
Prior art keywords
oxo
ylmethyl
oxazolidin
fluorophenyl
acetamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2537559A
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English (en)
French (fr)
Other versions
CA2537559A1 (en
Inventor
Prasad Keshav Deshpande
Milind Dattatraya Sindkhedkar
Mahesh Shriram Phansalkar
Ravindra Dattatrya Yeole
Shrikant Vinayak Gupte
Yati Chugh
Nitin Shetty
Sachin Subhash Bhagwat
Noel John De Souza
Mahesh Vithalbhai Patel
Milind Chintaman Shukla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wockhardt Ltd
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Publication of CA2537559A1 publication Critical patent/CA2537559A1/en
Application granted granted Critical
Publication of CA2537559C publication Critical patent/CA2537559C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA2537559A 2003-09-08 2004-09-08 Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy Expired - Fee Related CA2537559C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN924MU2003 2003-09-08
IN924/MUM/2003 2003-09-08
PCT/IN2004/000276 WO2005054234A2 (en) 2003-09-08 2004-09-08 Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy

Publications (2)

Publication Number Publication Date
CA2537559A1 CA2537559A1 (en) 2005-06-16
CA2537559C true CA2537559C (en) 2012-11-20

Family

ID=34640331

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2537559A Expired - Fee Related CA2537559C (en) 2003-09-08 2004-09-08 Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy

Country Status (8)

Country Link
US (2) US7687627B2 (enExample)
EP (1) EP1664038A2 (enExample)
JP (1) JP4917432B2 (enExample)
AU (1) AU2004295208A1 (enExample)
BR (1) BRPI0413413A (enExample)
CA (1) CA2537559C (enExample)
EA (1) EA200600374A1 (enExample)
WO (1) WO2005054234A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
WO2007004049A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidinones containing azetidine as antibacterial agents
JP5313126B2 (ja) * 2006-05-09 2013-10-09 ウォックハート リミテッド 置換ピペリジノフェニルオキサゾリジノン
CN101616588B (zh) * 2006-09-25 2013-09-25 沃克哈特研究中心 取代的哌啶子基苯基噁唑烷酮
WO2009037542A2 (en) * 2007-09-20 2009-03-26 Glenmark Pharmaceuticals, S.A. Spirocyclic compounds as stearoyl coa desaturase inhibitors
EP2072513A1 (en) * 2007-12-17 2009-06-24 Ferrer Internacional, S.A. A cyano piperidinyl-phenil-oxazolidinone and use thereof
EP2254892B1 (en) 2008-03-26 2014-04-23 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
EP2141161A1 (en) * 2008-07-01 2010-01-06 Ferrer Internacional, S.A. 3-cyanopyrrolidinyl-phenyl-oxazolidinones as antibacterial agents
EP2410854B1 (en) * 2009-03-27 2016-06-29 Council of Scientific & Industrial Research Substituted 1, 4-dioxa-8-azaspiro ý4,5¨decanes useful as fungicides and a process for the preparation thereof
CA2816515A1 (en) * 2010-11-03 2012-05-10 Wockhardt Limited Process for the preparation of phosphoric acid mono-(1-{4-[(s)-5-(acetylaminomethyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethylpiperidin-4-yl) ester
US9359344B2 (en) 2011-09-29 2016-06-07 Xuanzhu Pharma Co., Ltd. Biaryl heterocycle substituted oxazolidinone antibacterial agents
WO2015066413A1 (en) * 2013-11-01 2015-05-07 Novartis Ag Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
WO2019081210A1 (en) * 2017-10-27 2019-05-02 Huntsman International Llc CATALYSTS FOR MANUFACTURING OXAZOLIDINONE MATERIALS
CN112543756A (zh) * 2018-07-25 2021-03-23 卡迪拉保健有限公司 用于治疗哺乳动物感染的经取代噁唑烷酮类
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

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US3344145A (en) * 1963-10-21 1967-09-26 Geschickter Fund Med Res N-substituted phenoxyalkyl or phenylthioalkyl-mono azaspiroalkanes
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
US5489689A (en) * 1993-09-30 1996-02-06 Mallinckrodt Chemical, Inc. Preparation of piperidine derivatives
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
SI0788498T1 (en) * 1994-10-26 2001-12-31 Upjohn Co Phenyloxazolidinone antimicrobials
ES2214546T3 (es) * 1995-09-15 2004-09-16 PHARMACIA & UPJOHN COMPANY N-oxidos de aminoariloxazolidinona.
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
RU2208613C2 (ru) * 1997-05-30 2003-07-20 Фармация Энд Апджон Компани Оксазолидиноновые антибактериальные агенты, содержащие тиокарбонильную функциональную группу
CA2333332A1 (en) * 1998-06-05 1999-12-16 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
GB9821938D0 (en) * 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
CA2374383A1 (en) * 1999-07-28 2001-02-08 Pharmacia & Upjohn Company Oxazolidinones and their use as antiinfectives
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB2356389B (en) * 1999-09-02 2003-07-16 Bruce Stanley Gunton Loading bay dock control
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2002046156A2 (en) * 2000-12-06 2002-06-13 Sepracor, Inc. 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands
JP2005503435A (ja) * 2001-04-17 2005-02-03 メルク アンド カンパニー インコーポレーテッド ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
CA2492194A1 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoproteins sites
US7405228B2 (en) * 2002-07-11 2008-07-29 Wockhardt Limited Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites
AU2003274676A1 (en) * 2002-07-11 2004-02-02 Yati Chugh Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them
KR100490643B1 (ko) * 2002-10-29 2005-05-19 한국과학기술연구원 새로운 메틸리덴 피페리딘일 옥사졸리딘온 유도체 및이들의 제조방법
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
JP5313126B2 (ja) * 2006-05-09 2013-10-09 ウォックハート リミテッド 置換ピペリジノフェニルオキサゾリジノン

Also Published As

Publication number Publication date
WO2005054234A3 (en) 2005-09-29
CA2537559A1 (en) 2005-06-16
US20050143421A1 (en) 2005-06-30
US7687627B2 (en) 2010-03-30
AU2004295208A1 (en) 2005-06-16
JP2007505102A (ja) 2007-03-08
WO2005054234A2 (en) 2005-06-16
US8729269B2 (en) 2014-05-20
EA200600374A1 (ru) 2006-08-25
EP1664038A2 (en) 2006-06-07
BRPI0413413A (pt) 2007-01-09
JP4917432B2 (ja) 2012-04-18
WO2005054234A8 (en) 2006-11-23
US20100144735A1 (en) 2010-06-10

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Effective date: 20220308

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