BRPI0413372A - composto e composições de nitrofuranos de quinazolinil halogenados, seus métodos de preparação e usos como agentes antibacterianos - Google Patents
composto e composições de nitrofuranos de quinazolinil halogenados, seus métodos de preparação e usos como agentes antibacterianosInfo
- Publication number
- BRPI0413372A BRPI0413372A BRPI0413372-2A BRPI0413372A BRPI0413372A BR PI0413372 A BRPI0413372 A BR PI0413372A BR PI0413372 A BRPI0413372 A BR PI0413372A BR PI0413372 A BRPI0413372 A BR PI0413372A
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxy
- substituted
- unsubstituted
- antibacterial agents
- nitrofurans
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- ASGWCEUDXQVGMY-UHFFFAOYSA-N 2-(2-nitrofuran-3-yl)quinazoline Chemical group O1C=CC(C=2N=C3C=CC=CC3=CN=2)=C1[N+](=O)[O-] ASGWCEUDXQVGMY-UHFFFAOYSA-N 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 101150065749 Churc1 gene Proteins 0.000 abstract 1
- 102100038239 Protein Churchill Human genes 0.000 abstract 1
- -1 QUINAZOLINYL Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 229940064004 antiseptic throat preparations Drugs 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000007928 solubilization Effects 0.000 abstract 1
- 238000005063 solubilization Methods 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49333603P | 2003-08-08 | 2003-08-08 | |
| PCT/CA2004/001466 WO2005014585A1 (en) | 2003-08-08 | 2004-08-06 | Halogenated quinazolinyl nitrofurans as antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0413372A true BRPI0413372A (pt) | 2006-10-17 |
Family
ID=34135234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0413372-2A BRPI0413372A (pt) | 2003-08-08 | 2004-08-06 | composto e composições de nitrofuranos de quinazolinil halogenados, seus métodos de preparação e usos como agentes antibacterianos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7410974B2 (enExample) |
| EP (1) | EP1660486A4 (enExample) |
| JP (1) | JP2007501809A (enExample) |
| CN (1) | CN1832941A (enExample) |
| AU (1) | AU2004262533A1 (enExample) |
| BR (1) | BRPI0413372A (enExample) |
| CA (1) | CA2534405A1 (enExample) |
| MX (1) | MXPA06001552A (enExample) |
| WO (1) | WO2005014585A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010016646A1 (en) * | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
| US20080146562A1 (en) * | 2003-08-08 | 2008-06-19 | Ulysses Pharmaceutical Products Inc., | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| US7410974B2 (en) | 2003-08-08 | 2008-08-12 | Ulysses Pharmaceutical Products, Inc. | Halogenated Quinazolinyl nitrofurans as antibacterial agents |
| MX2007003374A (es) * | 2004-09-23 | 2007-06-05 | Ulysses Pharmaceutical Products Inc | Antibioticos carbociclicos y heterociclicos y uso de los mismos. |
| EP2535426A3 (en) | 2006-03-02 | 2013-07-24 | The Uab Research Foundation | Mycobacterial disease detection, treatment, and drug discovery |
| US20110053964A1 (en) * | 2006-08-22 | 2011-03-03 | Roger Tung | 4-aminoquinazoline derivatives and methods of use thereof |
| CN101594870A (zh) * | 2006-08-22 | 2009-12-02 | 康塞特医药品有限公司 | 4-氨基喹唑啉衍生物及其使用方法 |
| WO2008113161A1 (en) * | 2007-03-19 | 2008-09-25 | Ulysses Pharmaceutical Products Inc. | Phosphate prodrugs of quinazolinyl nitrofurans, methods of obtaining, and use of same |
| HUE041512T2 (hu) | 2010-03-30 | 2019-05-28 | Helperby Therapeutics Ltd | Új kombináció és alkalmazás |
| GB201013207D0 (en) | 2010-08-05 | 2010-09-22 | Helperby Therapeutics Ltd | Novel combination |
| JP2013532716A (ja) | 2010-08-05 | 2013-08-19 | ヘルパービー セラピューティクス リミテッド | ピロロキノリン化合物と、β−ラクタム系抗微生物剤、ムピロシンまたはクロルヘキシジンとの組み合わせ |
| GB201015079D0 (en) | 2010-09-10 | 2010-10-27 | Helperby Therapeutics Ltd | Novel use |
| GB201305277D0 (en) | 2013-03-22 | 2013-05-01 | Helperby Therapeutics Ltd | Novel combination and use |
| GB201307989D0 (en) | 2013-05-02 | 2013-06-12 | Helperby Therapeutics Ltd | Novel combinations and use |
| GB201401617D0 (en) | 2014-01-30 | 2014-03-19 | Helperby Therapeutics Ltd | Novel combination and use |
| CN107530397A (zh) | 2014-12-18 | 2018-01-02 | 赫尔普百治疗有限公司 | 新型组合和用途 |
| CN107683136A (zh) | 2015-04-11 | 2018-02-09 | 赫尔普百治疗有限公司 | 口腔组合物 |
| GB201518969D0 (en) | 2015-10-27 | 2015-12-09 | Helperby Therapeutics Ltd | Triple combination |
| CN105796564B (zh) * | 2016-04-12 | 2017-07-11 | 青岛市市立医院 | 一种防治牙体牙髓感染的药物组合物 |
| GB201610869D0 (en) | 2016-06-22 | 2016-08-03 | Helperby Therapeutics Ltd | Combination |
| GB201612093D0 (en) | 2016-07-12 | 2016-08-24 | Helperby Therapeutics Ltd | Combination |
| GB201616014D0 (en) | 2016-09-20 | 2016-11-02 | Helperby Therapeutics Ltd | Combination |
| GB201616909D0 (en) | 2016-10-05 | 2016-11-16 | Helperby Therapeutics Ltd | Combination |
| GB201703898D0 (en) | 2017-03-10 | 2017-04-26 | Helperby Therapeautics Ltd | Method |
| GB201704620D0 (en) | 2017-03-23 | 2017-05-10 | Helperby Therapeautics Ltd | Combinations |
| GB201709193D0 (en) | 2017-06-09 | 2017-07-26 | Helperby Therapeutics Ltd | Combination |
| CN107021960B (zh) * | 2017-06-10 | 2018-07-31 | 上海普康药业有限公司 | 一种治疗恶性肿瘤的药物 |
| CN108690012A (zh) * | 2017-06-10 | 2018-10-23 | 曹艳 | 一种治疗革兰氏阳性菌引起的感染的药物及其合成方法 |
| GB201807046D0 (en) | 2018-04-30 | 2018-06-13 | Helperby Therapeutics Ltd | Combination |
| GB201913068D0 (en) | 2019-09-10 | 2019-10-23 | Helperby Therapeutics Ltd | Combination |
| GB201914847D0 (en) | 2019-10-14 | 2019-11-27 | Helperby Therapeutics Ltd | Combination |
| GB202213750D0 (en) | 2022-09-20 | 2022-11-02 | Helperby Therapeutics Ltd | Antimicrobial |
| GB202213753D0 (en) | 2022-09-20 | 2022-11-02 | Helperby Therapeutics Ltd | Antimicrobial combinations |
| GB202314387D0 (en) | 2023-09-20 | 2023-11-01 | Helperby Therapeutics Ltd | Antimicrobial combinations |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3324122A (en) * | 1964-12-14 | 1967-06-06 | Norwich Pharma Co | Series of 4-substituted-2-(5-nitro-2-furyl) quinazolines |
| US3542784A (en) * | 1968-04-05 | 1970-11-24 | Norwich Pharma Co | 4-(hydroxyanilino)-2-(5-nitro-2-furyl)quinazolines |
| DE2140280A1 (de) | 1970-08-12 | 1972-02-17 | Chemische Fabrik von Heyden GmbH, 8000 München | 4 Amino 2 eckige Klammer auf 2 (5 Nitro 2 furyl)vinyl eckige Klammer zu chinazolinderivate, Herstellungsver fahren dafür und Arzneimittel daraus |
| US3974277A (en) * | 1974-09-06 | 1976-08-10 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines as growth promotants and feed efficiency enhancing agents |
| US3973021A (en) * | 1974-09-06 | 1976-08-03 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(phydroxyanilino)quinazoline as a bactericide |
| US3970648A (en) * | 1974-09-06 | 1976-07-20 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines |
| JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | ４−アミノキナゾリン誘導体およびそれを含有する医薬品 |
| US6148377A (en) * | 1996-11-22 | 2000-11-14 | Mangosoft Corporation | Shared memory computer networks |
| EP0977989A1 (en) | 1997-02-04 | 2000-02-09 | Trega Biosciences, Inc. | 4-substituted-quinoline derivatives and 4-substitute-quinoline combinatorial libraries |
| US5925527A (en) | 1997-02-04 | 1999-07-20 | Trega Biosciences, Inc. | Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries |
| EP0964860B1 (en) * | 1997-02-28 | 2004-04-21 | Pfizer Products Inc. | Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions |
| ATE267817T1 (de) * | 1997-02-28 | 2004-06-15 | Pfizer Prod Inc | Atropisomere von 3-aryl-4(3h)-chinazolinonen und ihre verwendung als ampa-rezeptor |
| US6184377B1 (en) * | 1997-12-15 | 2001-02-06 | Sepracor Inc. | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof |
| US6943159B1 (en) * | 1998-02-18 | 2005-09-13 | Neurosearch A/S | Compounds and their use as positive AMPA receptor modulators |
| US20020025968A1 (en) * | 1998-04-15 | 2002-02-28 | Rifat Pamukcu | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives |
| US20040131628A1 (en) * | 2000-03-08 | 2004-07-08 | Bratzler Robert L. | Nucleic acids for the treatment of disorders associated with microorganisms |
| WO2001081346A2 (en) | 2000-04-25 | 2001-11-01 | Icos Corporation | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
| US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| US6479499B1 (en) * | 2000-06-28 | 2002-11-12 | National Science Council | 2-phenyl-4-quinazolinone compounds, 2-phenyl-4-alkoxy-quinazoline compounds and their pharmaceutical compositions |
| JP4329003B2 (ja) * | 2001-03-23 | 2009-09-09 | バイエル コーポレイション | Ｒｈｏキナーゼ阻害剤 |
| US7645878B2 (en) * | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
| AU2003235956A1 (en) | 2002-04-26 | 2003-11-10 | Nippon Shinyaku Co., Ltd. | Quinazoline derivative and medicine |
| JP2006507352A (ja) | 2002-07-09 | 2006-03-02 | ポイント セラピューティクス， インコーポレイテッド | イソロイシンのボロプロリン化合物に関する方法および組成物 |
| US7410974B2 (en) | 2003-08-08 | 2008-08-12 | Ulysses Pharmaceutical Products, Inc. | Halogenated Quinazolinyl nitrofurans as antibacterial agents |
-
2004
- 2004-08-06 US US10/567,660 patent/US7410974B2/en not_active Expired - Fee Related
- 2004-08-06 EP EP04761630A patent/EP1660486A4/en not_active Withdrawn
- 2004-08-06 CA CA002534405A patent/CA2534405A1/en not_active Abandoned
- 2004-08-06 BR BRPI0413372-2A patent/BRPI0413372A/pt not_active IP Right Cessation
- 2004-08-06 JP JP2006522859A patent/JP2007501809A/ja not_active Withdrawn
- 2004-08-06 AU AU2004262533A patent/AU2004262533A1/en not_active Abandoned
- 2004-08-06 CN CNA2004800228169A patent/CN1832941A/zh active Pending
- 2004-08-06 WO PCT/CA2004/001466 patent/WO2005014585A1/en not_active Ceased
- 2004-08-06 MX MXPA06001552A patent/MXPA06001552A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06001552A (es) | 2006-09-04 |
| WO2005014585A1 (en) | 2005-02-17 |
| JP2007501809A (ja) | 2007-02-01 |
| US7410974B2 (en) | 2008-08-12 |
| CN1832941A (zh) | 2006-09-13 |
| EP1660486A4 (en) | 2006-12-13 |
| US20060258693A1 (en) | 2006-11-16 |
| AU2004262533A1 (en) | 2005-02-17 |
| WO2005014585A8 (en) | 2005-09-09 |
| CA2534405A1 (en) | 2005-02-17 |
| EP1660486A1 (en) | 2006-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0413372A (pt) | composto e composições de nitrofuranos de quinazolinil halogenados, seus métodos de preparação e usos como agentes antibacterianos | |
| PA8524501A1 (es) | Antibioticos macrolidos | |
| BRPI0618374A2 (pt) | uso de um composto ou um derivado do mesmo farmaceuticamente aceitável, métodos para matar microorganismos clinicamente latentes em um mamìfero, para tratar ou prevenir uma infecção microbiana em um mamìfero, para esterilizar um objeto, para preservar um material inorgánico ou orgánico, para tratar uma doença, para reduzir a dose de agente antimicrobiano convencional requerida para tratar uma infecção microbiana e para tratar uma doença de protozoário em um mamìfero, produto combinado, formulação, uso de um produto combinado, composto, e, processo para a preparação do mesmo | |
| CL2004000400A1 (es) | Compuestos derivados de piridina sustituida con 1,3-oxazol y con isoxazol, composicion farmaceutica, procedimiento de preparacion, utiles como agentes antibacteriano, activo contra la bacteria gram negativa. | |
| NO20061657L (no) | Pyrolderivater med antibakteriell aktivitet | |
| BRPI0307267B8 (pt) | uso de compostos inibidores de beta-lactamases e composições farmacêuticas para terapia antibacteriana | |
| BRPI0923326A2 (pt) | Composto, composição farmacêutica, métodos para inibir girasse de dna bacteriana e/ou topisomerase iv bacteriana, para produzir um efeito antibacteriano em um animal de sangue quente, e para tratar uma infecção bacteriana, uso de um composto, e, processo para preparar um composto. | |
| BR0016605A (pt) | Oxazolidinonas possuindo uma funcionalidade sulfoximina e seus usos como agente antimicrobiano | |
| BR112013025275A2 (pt) | derivados de cefalosporina e suas composições farmacêuticas | |
| BR112022012020A2 (pt) | Novos compostos e seu uso | |
| NZ600912A (en) | Topical use of hydroxytyrosol and derivatives for the prevention of hiv infection | |
| AP2003002942A0 (en) | New derivatives of oxazolidinones as bacterial agents | |
| TW200630378A (en) | Macrolones-amino substituted quinolones | |
| DK1132392T3 (da) | Ketolid-antibiotika | |
| BR0114763A (pt) | Cetolìdeos antibacterianos | |
| WO2009116044A3 (en) | Guanine nucleotide derivatives for treating bacterial infections | |
| AR039727A1 (es) | Difluorotioacetamidas de oxazolidinonas como agentes antibacterianos y composicion farmaceutica en base a ellas | |
| HRP20050517B1 (hr) | N-sulfonil-4-metilenamino-3-hidroksi-2-piridoni kao antimikrobni lijekovi | |
| TN2009000374A1 (fr) | Macrolides a base d'erythromycine | |
| ES2108149T3 (es) | Derivado de cefalosporina. | |
| BR112023027268A2 (pt) | Compostos inovadores e seu uso | |
| ATE271062T1 (de) | Makrolid-antibiotika | |
| WO2002018353A3 (en) | Oxazolidinone chemotherapeutic agents | |
| SV2002000211A (es) | Derivados de higromicina ref. pc10726abcz/bb | |
| BRPI0515564A (pt) | antibióticos carbo e heterocìclicos e uso dos mesmos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 6A. E 7A. ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 6A E 7A ANUIDADES. |