BR112022012020A2 - Novos compostos e seu uso - Google Patents

Novos compostos e seu uso

Info

Publication number
BR112022012020A2
BR112022012020A2 BR112022012020A BR112022012020A BR112022012020A2 BR 112022012020 A2 BR112022012020 A2 BR 112022012020A2 BR 112022012020 A BR112022012020 A BR 112022012020A BR 112022012020 A BR112022012020 A BR 112022012020A BR 112022012020 A2 BR112022012020 A2 BR 112022012020A2
Authority
BR
Brazil
Prior art keywords
compounds
new compounds
gram
lhsb
lhsa
Prior art date
Application number
BR112022012020A
Other languages
English (en)
Inventor
Gerusz Vincent
Bravo Juan
Pauls Heinz
Berman Judd
Finn Terry
Original Assignee
Debiopharm Int Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Int Sa filed Critical Debiopharm Int Sa
Publication of BR112022012020A2 publication Critical patent/BR112022012020A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

NOVOS COMPOSTOS E SEU USO. A presente invenção fornece compostos de fórmula geral (I) ou pró-drogas, sais e/ou solvatos farmaceuticamente aceitáveis dos mesmos, em que LHS é selecionado a partir do grupo consistindo em LHSa e LHSb e em que, o asterisco (*) marca o ponto de fixação; Esses compostos apresentam atividade antibacteriana contra bactérias Gram-negativas e Gram-positivas, especialmente S. aureus, E. coli, K. pneumoniae e A. baumannii. Composições farmacêuticas contendo esses compostos, usos terapêuticos dos mesmos e métodos para fabricar os mesmos também são fornecidos.
BR112022012020A 2019-12-19 2020-12-18 Novos compostos e seu uso BR112022012020A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2019061119 2019-12-19
PCT/EP2020/087308 WO2021123372A1 (en) 2019-12-19 2020-12-18 Novel compounds and their use

Publications (1)

Publication Number Publication Date
BR112022012020A2 true BR112022012020A2 (pt) 2022-09-20

Family

ID=69185634

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022012020A BR112022012020A2 (pt) 2019-12-19 2020-12-18 Novos compostos e seu uso

Country Status (13)

Country Link
US (1) US20230159519A1 (pt)
EP (1) EP4077324A1 (pt)
JP (1) JP2023507400A (pt)
KR (1) KR20220130697A (pt)
CN (1) CN115151541A (pt)
AU (1) AU2020409843A1 (pt)
BR (1) BR112022012020A2 (pt)
CA (1) CA3161108A1 (pt)
CL (1) CL2022001660A1 (pt)
CO (1) CO2022010084A2 (pt)
IL (1) IL293980A (pt)
MX (1) MX2022007412A (pt)
WO (1) WO2021123372A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11883393B2 (en) 2019-12-19 2024-01-30 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
EP4359079A1 (en) * 2021-06-23 2024-05-01 Debiopharm International S.A. Novel compounds and their use
CN113999251A (zh) * 2021-11-12 2022-02-01 海南海灵化学制药有限公司 一种阿扑西林钠的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005085228A1 (ja) 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd. シクロアルカノピリジン誘導体
JP2009518399A (ja) * 2005-12-05 2009-05-07 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉ阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物
CA2658506C (en) * 2006-07-20 2016-01-26 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab 1 inhibitors
EP2758376A4 (en) 2011-09-19 2015-04-29 Vitas Pharma Res Private Ltd HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FATTY ACID BIOSYNTHESIS FOR BACTERIAL INFECTIONS
RS58898B1 (sr) 2012-06-19 2019-08-30 Debiopharm Int Sa Prolek derivati (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamida
US11691967B2 (en) * 2018-03-12 2023-07-04 The Board Of Trustees Of The University Of Illinois Antibiotics effective for gram-negative pathogens

Also Published As

Publication number Publication date
AU2020409843A1 (en) 2022-07-14
US20230159519A1 (en) 2023-05-25
CN115151541A (zh) 2022-10-04
EP4077324A1 (en) 2022-10-26
CA3161108A1 (en) 2021-06-24
CL2022001660A1 (es) 2023-03-17
WO2021123372A1 (en) 2021-06-24
IL293980A (en) 2022-08-01
KR20220130697A (ko) 2022-09-27
JP2023507400A (ja) 2023-02-22
MX2022007412A (es) 2022-09-19
CO2022010084A2 (es) 2022-09-30

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