BRPI0408732A - processo para a preparação de um ciano-isobenzofurano - Google Patents
processo para a preparação de um ciano-isobenzofuranoInfo
- Publication number
- BRPI0408732A BRPI0408732A BRPI0408732-1A BRPI0408732A BRPI0408732A BR PI0408732 A BRPI0408732 A BR PI0408732A BR PI0408732 A BRPI0408732 A BR PI0408732A BR PI0408732 A BRPI0408732 A BR PI0408732A
- Authority
- BR
- Brazil
- Prior art keywords
- fluorophenyl
- isobenzofurancarbonitrile
- dihydro
- hydroxymethyl
- cyanoisobenzofuran
- Prior art date
Links
- DNEVVXBMQZYGEI-UHFFFAOYSA-N 2-benzofuran-1-carbonitrile Chemical compound C1=CC=CC2=C(C#N)OC=C21 DNEVVXBMQZYGEI-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- -1 4-fluorophenyl magnesium halide Chemical class 0.000 abstract 3
- WDWABVHVASZWHB-UHFFFAOYSA-N 1,1-bis(4-fluorophenyl)-3h-2-benzofuran-5-carbonitrile Chemical compound C1=CC(F)=CC=C1C1(C=2C=CC(F)=CC=2)C2=CC=C(C#N)C=C2CO1 WDWABVHVASZWHB-UHFFFAOYSA-N 0.000 abstract 2
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 abstract 1
- YXCRMKYHFFMNPT-UHFFFAOYSA-N 1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound C1=CC(F)=CC=C1C1C2=CC=C(C#N)C=C2CO1 YXCRMKYHFFMNPT-UHFFFAOYSA-N 0.000 abstract 1
- XEEGWTLAFIZLSF-UHFFFAOYSA-N 1-oxo-3h-2-benzofuran-5-carbonitrile Chemical compound N#CC1=CC=C2C(=O)OCC2=C1 XEEGWTLAFIZLSF-UHFFFAOYSA-N 0.000 abstract 1
- GDOCLIOVHKLEOU-UHFFFAOYSA-N 4-(4-fluorobenzoyl)-3-(hydroxymethyl)benzonitrile Chemical compound OCC1=CC(C#N)=CC=C1C(=O)C1=CC=C(F)C=C1 GDOCLIOVHKLEOU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 229960001653 citalopram Drugs 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000479A ITMI20030479A1 (it) | 2003-03-13 | 2003-03-13 | Procedimento per la preparazione di un ciano-isobenzofurano. |
| PCT/EP2004/002522 WO2004080988A1 (en) | 2003-03-13 | 2004-03-09 | Process for the preparation of a cyano-isobenzofuran |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0408732A true BRPI0408732A (pt) | 2006-03-07 |
Family
ID=32983208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0408732-1A BRPI0408732A (pt) | 2003-03-13 | 2004-03-09 | processo para a preparação de um ciano-isobenzofurano |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7411077B2 (https=) |
| EP (1) | EP1601662A1 (https=) |
| JP (1) | JP2006520351A (https=) |
| KR (1) | KR20050108376A (https=) |
| CN (1) | CN1761658A (https=) |
| AU (1) | AU2004220410A1 (https=) |
| BR (1) | BRPI0408732A (https=) |
| CA (1) | CA2514458A1 (https=) |
| HR (1) | HRP20050893A2 (https=) |
| IT (1) | ITMI20030479A1 (https=) |
| MX (1) | MXPA05008411A (https=) |
| WO (1) | WO2004080988A1 (https=) |
| ZA (1) | ZA200505592B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE428421T1 (de) | 2004-09-17 | 2009-05-15 | Eisai R&D Man Co Ltd | Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften |
| WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
| US20170290333A1 (en) | 2014-12-30 | 2017-10-12 | Dow Agrosciences Llc | Picolinamide compounds with fungicidal activity |
| CA3030551C (en) | 2016-07-07 | 2025-05-06 | Corteva Agriscience Llc | PROCESSES FOR PREPARATION OF 4-ALCOXY-3-(ACYL OR ALKYL)OXYPICOLINAMIDES |
| CN108929245A (zh) * | 2017-05-25 | 2018-12-04 | 万全万特制药江苏有限公司 | 艾司西酞普兰工艺杂质的制备方法 |
| CN108947869A (zh) * | 2017-05-25 | 2018-12-07 | 万全万特制药江苏有限公司 | 一种艾司西酞普兰工艺杂质的制备方法 |
| CN120097946A (zh) * | 2025-02-28 | 2025-06-06 | 浙江工业大学 | 一种应用脱水膜强化5-氰二醇盐酸盐醚化制西酞普兰溴酸盐的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| ES2148120T3 (es) * | 1997-07-08 | 2002-01-16 | Lundbeck & Co As H | Metodo para la preparacion de citalopram. |
| UA62985C2 (en) * | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
| EA002770B1 (ru) * | 1997-11-11 | 2002-08-29 | Х.Лундбекк А/С | Способ получения циталопрама |
| US6310222B1 (en) * | 1999-11-01 | 2001-10-30 | Sumika Fine Chemicals Co., Ltd. | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate |
| JP3641420B2 (ja) * | 1999-11-01 | 2005-04-20 | 住友化学株式会社 | ５−フタランカルボニトリル化合物の製造方法、その中間体およびその製造方法 |
| US6433196B1 (en) | 2000-02-17 | 2002-08-13 | Sumika Fine Chemicals Co., Ltd. | Production method of citalopram, intermediate therefor and production method of the intermediate |
| JP3735026B2 (ja) * | 2000-02-17 | 2006-01-11 | 住友化学株式会社 | シタロプラムの製造方法、およびその中間体とその製造方法 |
-
2003
- 2003-03-13 IT IT000479A patent/ITMI20030479A1/it unknown
-
2004
- 2004-03-09 JP JP2006504646A patent/JP2006520351A/ja active Pending
- 2004-03-09 BR BRPI0408732-1A patent/BRPI0408732A/pt not_active IP Right Cessation
- 2004-03-09 ZA ZA200505592A patent/ZA200505592B/en unknown
- 2004-03-09 US US10/549,062 patent/US7411077B2/en not_active Expired - Fee Related
- 2004-03-09 HR HR20050893A patent/HRP20050893A2/hr not_active Application Discontinuation
- 2004-03-09 WO PCT/EP2004/002522 patent/WO2004080988A1/en not_active Ceased
- 2004-03-09 MX MXPA05008411A patent/MXPA05008411A/es unknown
- 2004-03-09 CA CA002514458A patent/CA2514458A1/en not_active Abandoned
- 2004-03-09 EP EP04718658A patent/EP1601662A1/en not_active Withdrawn
- 2004-03-09 CN CNA2004800068530A patent/CN1761658A/zh active Pending
- 2004-03-09 AU AU2004220410A patent/AU2004220410A1/en not_active Abandoned
- 2004-03-09 KR KR1020057016274A patent/KR20050108376A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN1761658A (zh) | 2006-04-19 |
| ZA200505592B (en) | 2006-09-27 |
| HRP20050893A2 (en) | 2005-12-31 |
| ITMI20030479A1 (it) | 2004-09-14 |
| US20060183925A1 (en) | 2006-08-17 |
| AU2004220410A1 (en) | 2004-09-23 |
| JP2006520351A (ja) | 2006-09-07 |
| WO2004080988A1 (en) | 2004-09-23 |
| EP1601662A1 (en) | 2005-12-07 |
| CA2514458A1 (en) | 2004-09-23 |
| US7411077B2 (en) | 2008-08-12 |
| KR20050108376A (ko) | 2005-11-16 |
| MXPA05008411A (es) | 2005-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 6A, 7A E 8A ANUIDADES. |