BRPI0312472B8 - composição compreendendo dois complexos iscom diferentes - Google Patents
composição compreendendo dois complexos iscom diferentesInfo
- Publication number
- BRPI0312472B8 BRPI0312472B8 BRPI0312472A BR0312472A BRPI0312472B8 BR PI0312472 B8 BRPI0312472 B8 BR PI0312472B8 BR PI0312472 A BRPI0312472 A BR PI0312472A BR 0312472 A BR0312472 A BR 0312472A BR PI0312472 B8 BRPI0312472 B8 BR PI0312472B8
- Authority
- BR
- Brazil
- Prior art keywords
- complexes
- iscom
- composition
- complex
- mixture
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
"preparação de uma composição compreendendo um mistura de complexos de iscom e uso da dita composição". a presente invenção se refere a uma composição compreendendo uma mistura de pelo menos dois complexos imunoestimuladores (daqui em diante referidos como iscom sigla em inglês de 'immunostimulating complexes), cada complexo compreendendo substancialmente uma fração de saponina de quillaja saponaria molina. os complexos podem ser complexos de iscom ou complexos de matriz de iscom. a invenção também concerne o uso de tal mistura para a preparação de um produto farmacêutico imunomodulador e um coadjuvante, formulações para imunização, por exemplo, para produção de anticorpos monoclonais e uma vacina. de acordo com a invenção, também são incluídos kits de frações compreendendo pelo menos duas frações, em que cada fração compreende um complexo de iscom ou um complexo de matriz de iscom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0202110-3 | 2002-07-05 | ||
| SE0202110A SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Iscom preparation and use thereof |
| PCT/SE2003/001180 WO2004004762A1 (en) | 2002-07-05 | 2003-07-07 | Iscom preparation and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0312472A BR0312472A (pt) | 2005-04-26 |
| BRPI0312472B1 BRPI0312472B1 (pt) | 2019-07-16 |
| BRPI0312472B8 true BRPI0312472B8 (pt) | 2021-05-25 |
Family
ID=20288449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0312472A BRPI0312472B8 (pt) | 2002-07-05 | 2003-07-07 | composição compreendendo dois complexos iscom diferentes |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20060121065A1 (pt) |
| EP (1) | EP1539231B1 (pt) |
| JP (1) | JP4636877B2 (pt) |
| AT (1) | ATE434443T1 (pt) |
| AU (1) | AU2003245220B2 (pt) |
| BR (1) | BRPI0312472B8 (pt) |
| CA (1) | CA2491457C (pt) |
| DE (1) | DE60328108D1 (pt) |
| DK (1) | DK1539231T3 (pt) |
| ES (1) | ES2328474T3 (pt) |
| NZ (1) | NZ537661A (pt) |
| SE (1) | SE0202110D0 (pt) |
| WO (1) | WO2004004762A1 (pt) |
| ZA (1) | ZA200500073B (pt) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| SE0301998D0 (sv) * | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| CN101107009B (zh) | 2005-01-20 | 2014-08-06 | 伊斯克诺瓦公司 | 包含纤连蛋白结合蛋白或纤连蛋白结合肽的疫苗组合物 |
| EP1764369A1 (de) * | 2005-09-16 | 2007-03-21 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
| JP2009534303A (ja) | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
| EP2035035A2 (en) | 2006-06-09 | 2009-03-18 | Novartis AG | Immunogenic compositions for streptococcus agalactiae |
| EP1902727A1 (de) * | 2006-09-22 | 2008-03-26 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
| WO2008031878A1 (en) * | 2006-09-15 | 2008-03-20 | Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH | A composition for therapy and/or for prophylaxis of hbv-infections and hbv-mediated diseases |
| EP2185191B1 (en) | 2007-06-27 | 2012-09-12 | Novartis AG | Low-additive influenza vaccines |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| CN107281478B (zh) | 2010-07-23 | 2022-04-01 | 诺瓦瓦克斯公司 | 流感疫苗 |
| AP3390A (en) | 2010-09-20 | 2015-08-31 | Crucell Holland Bv | Therapeutic vaccination against active tuberculosis |
| EP4176871A1 (en) | 2011-10-03 | 2023-05-10 | Canqura Oncology Ab | Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds |
| EA033386B1 (ru) | 2011-11-28 | 2019-10-31 | Janssen Vaccines & Prevention Bv | Рекомбинантные иммуногенные полипептиды стеблевого домена гемагглютинина вируса гриппа а и их применение |
| WO2013135615A1 (en) | 2012-03-12 | 2013-09-19 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| US9119813B2 (en) | 2012-03-22 | 2015-09-01 | Crucell Holland B.V. | Vaccine against RSV |
| CA2867955C (en) | 2012-03-22 | 2023-02-07 | Crucell Holland B.V. | Vaccine against rsv |
| CA2900008A1 (en) | 2013-02-07 | 2014-08-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| MY172181A (en) | 2013-03-08 | 2019-11-15 | Janssen Vaccines & Prevention Bv | Acellular pertussis vaccine |
| AR095962A1 (es) | 2013-04-01 | 2015-11-25 | Moreinx Ab | Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos |
| AP2015008815A0 (en) | 2013-04-25 | 2015-10-31 | Crucell Holland Bv | Stabilized soluble prefusion rsv f polypeptides |
| MX369317B (es) | 2013-05-30 | 2019-11-05 | Janssen Vaccines & Prevention Bv | Vacunas contra el virus de la influenza y sus usos. |
| PE20160045A1 (es) | 2013-06-17 | 2016-02-18 | Crucell Holland Bv | Polipeptidos f de prefusion del virus sincicial respiratorio (rsv) solubles y estabilizados |
| EP3016679B1 (en) | 2013-07-02 | 2019-03-27 | Janssen Vaccines & Prevention B.V. | Method for preparing virosomes |
| EP3017040B1 (en) | 2013-07-02 | 2018-06-06 | Janssen Vaccines & Prevention B.V. | Method for preparing virosomes |
| KR101821712B1 (ko) | 2013-08-22 | 2018-01-24 | 주식회사 아데나 | 삼칠근 추출물, 비누풀잎 추출물, 검정콩 잎 추출물, 녹두 잎 추출물 및 호랑이콩 잎 추출물을 포함하는 Ｔｈ2-매개 면역 질환 개선, 예방 또는 치료용 조성물 |
| EP3166962B1 (en) | 2014-07-10 | 2019-08-21 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
| EA035461B1 (ru) | 2014-11-04 | 2020-06-19 | Янссен Вэксинс Энд Превеншн Б.В. | Терапевтические вакцины против hpv16 |
| EP3283634B1 (en) | 2015-04-14 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
| CN116059336A (zh) | 2015-07-07 | 2023-05-05 | 扬森疫苗与预防公司 | 针对rsv的疫苗 |
| WO2017005848A1 (en) | 2015-07-07 | 2017-01-12 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion rsv f polypeptides |
| EA037295B1 (ru) | 2015-08-20 | 2021-03-05 | Янссен Вэксинс Энд Превеншн Б.В. | Терапевтические вакцины против hpv18 |
| EP3344288A1 (en) | 2015-09-02 | 2018-07-11 | Janssen Vaccines & Prevention B.V. | Stabilized viral class i fusion proteins |
| RU2730625C2 (ru) | 2015-09-03 | 2020-08-24 | Новавакс, Инк. | Вакцинные композиции, характеризующиеся улучшенной стабильностью и иммуногенностью |
| RU2723039C2 (ru) | 2015-12-23 | 2020-06-08 | Пфайзер Инк. | Мутанты белка f rsv |
| SI3439672T1 (sl) | 2016-04-05 | 2021-02-26 | Janssen Vaccines & Prevention B.V. | Stabiliziran topen pre-fuzijski F protein RSV za uporabo v profilaksi okužbe z RSV |
| KR102401247B1 (ko) | 2016-04-05 | 2022-05-25 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv에 대한 백신 |
| MX2018013340A (es) | 2016-05-02 | 2019-08-21 | Janssen Vaccines & Prevention Bv | Combinaciones de vacunas terapeuticas para el vph. |
| RU2758238C2 (ru) | 2016-05-12 | 2021-10-26 | Янссен Вэксинс Энд Превеншн Б.В. | Эффективный и сбалансированный двунаправленный промотор |
| WO2017207477A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
| MX2018014699A (es) | 2016-05-30 | 2019-02-28 | Janssen Vaccines & Prevention Bv | Proteinas f de prefusion del vrs estabilizadas. |
| EP3472327B1 (en) | 2016-06-20 | 2020-08-19 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
| JP7229151B2 (ja) | 2016-07-14 | 2023-02-27 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Ｈｐｖワクチン |
| KR102111244B1 (ko) | 2017-02-09 | 2020-05-15 | 얀센 백신스 앤드 프리벤션 비.브이. | 이종 유전자의 발현을 위한 강력한 짧은 프로모터 |
| AU2018267971A1 (en) | 2017-05-17 | 2019-11-07 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
| EA202090738A1 (ru) | 2017-09-15 | 2020-06-10 | Янссен Вэксинс Энд Превеншн Б.В. | Способ безопасного индуцирования иммунитета против rsv |
| LT3743106T (lt) | 2018-01-23 | 2022-09-26 | Janssen Vaccines & Prevention B.V. | Gripo viruso vakcinos ir jų panaudojimo būdai |
| KR20210004959A (ko) | 2018-03-19 | 2021-01-13 | 노바백스, 인코포레이티드 | 다가 인플루엔자 나노입자 백신 |
| GB201807303D0 (en) | 2018-05-03 | 2018-06-20 | London School Of Hygeine & Tropical Medicine | Glyconjugate vaccines |
| CN113286616A (zh) | 2018-05-23 | 2021-08-20 | Adc治疗有限公司 | 分子佐剂 |
| WO2020099383A1 (en) | 2018-11-13 | 2020-05-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
| JP2022530439A (ja) | 2019-04-25 | 2022-06-29 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 組換えインフルエンザ抗原 |
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| EP3969044A1 (en) | 2019-05-15 | 2022-03-23 | Janssen Vaccines & Prevention B.V. | Co-administration of seasonal influenza vaccine and an adenovirus based respiratory syncytial virus vaccine |
| CA3152957A1 (en) | 2019-09-05 | 2021-03-11 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
| US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
| BR112022014808A2 (pt) | 2020-01-31 | 2022-09-20 | Beth Israel Deaconess Medical Ct Inc | Composições e métodos para vacinas para prevenir e tratar infecção pelo coronavírus-sars-cov-2 |
| EP4149537A1 (en) | 2020-05-11 | 2023-03-22 | Janssen Pharmaceuticals, Inc. | Rna replicon encoding a stabilized corona virus spike protein |
| US20210346492A1 (en) | 2020-05-11 | 2021-11-11 | Janssen Pharmaceuticals, Inc. | SARS-CoV-2 Vaccines |
| IL298055A (en) | 2020-05-11 | 2023-01-01 | Janssen Pharmaceuticals Inc | Stabilized coronavirus spike protein fusion proteins |
| JP2023531554A (ja) | 2020-06-29 | 2023-07-24 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 呼吸器合胞体ウイルス感染に対するワクチンの組み合わせ |
| CA3187149A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Pharmaceuticals, Inc. | Stabilized corona virus spike protein fusion proteins |
| JP2022060169A (ja) | 2020-10-02 | 2022-04-14 | ファイザー・インク | Ｒｓｖ ｆタンパク質生産のための細胞培養工程 |
| WO2022175477A1 (en) | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv fb antigens |
| WO2022175479A1 (en) | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Vaccine combinations against respiratory syncytial virus strain a and b infections |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| EP4314019A2 (en) | 2021-04-01 | 2024-02-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
| WO2023020939A1 (en) | 2021-08-17 | 2023-02-23 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
| WO2023047349A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized coronavirus spike protein fusion proteins |
| WO2023047348A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized corona virus spike protein fusion proteins |
| WO2023111725A1 (en) | 2021-12-14 | 2023-06-22 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
| WO2023110618A1 (en) | 2021-12-16 | 2023-06-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
| WO2023196634A2 (en) | 2022-04-08 | 2023-10-12 | Flagship Pioneering Innovations Vii, Llc | Vaccines and related methods |
| WO2023217988A1 (en) | 2022-05-12 | 2023-11-16 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
| WO2024017682A1 (en) | 2022-07-18 | 2024-01-25 | Janssen Vaccines & Prevention B.V. | Rsv immunogens |
| WO2024030856A2 (en) | 2022-08-01 | 2024-02-08 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory proteins and related methods |
| WO2024061757A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Pre-fusion human piv1 f proteins |
| WO2024061753A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized trimeric class i fusion proteins |
| WO2024061759A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized coronavirus s proteins |
| WO2024074584A1 (en) | 2022-10-06 | 2024-04-11 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
| WO2024104947A2 (en) | 2022-11-14 | 2024-05-23 | Janssen Vaccines & Prevention B.V. | Influenza b virus vaccines and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| SE8405493D0 (sv) * | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| ATE71303T1 (de) * | 1986-01-14 | 1992-01-15 | Nederlanden Staat | Verfahren zur herstellung immunologischer komplexe und diese enthaltende pharmazeutische zusammensetzung. |
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| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| NL9002314A (nl) * | 1990-10-23 | 1992-05-18 | Nederlanden Staat | Immunogene complexen, in het bijzonder iscoms. |
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| SE9600647D0 (sv) | 1996-02-21 | 1996-02-21 | Bror Morein | Ny användning |
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| AUPO517897A0 (en) * | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| US6558670B1 (en) * | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
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| SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
-
2002
- 2002-07-05 SE SE0202110A patent/SE0202110D0/xx unknown
-
2003
- 2003-07-07 EP EP03738849A patent/EP1539231B1/en not_active Expired - Lifetime
- 2003-07-07 AT AT03738849T patent/ATE434443T1/de active
- 2003-07-07 CA CA2491457A patent/CA2491457C/en not_active Expired - Lifetime
- 2003-07-07 JP JP2004519469A patent/JP4636877B2/ja not_active Expired - Lifetime
- 2003-07-07 ES ES03738849T patent/ES2328474T3/es not_active Expired - Lifetime
- 2003-07-07 DE DE60328108T patent/DE60328108D1/de not_active Expired - Lifetime
- 2003-07-07 NZ NZ537661A patent/NZ537661A/en not_active IP Right Cessation
- 2003-07-07 BR BRPI0312472A patent/BRPI0312472B8/pt active IP Right Grant
- 2003-07-07 AU AU2003245220A patent/AU2003245220B2/en not_active Expired
- 2003-07-07 WO PCT/SE2003/001180 patent/WO2004004762A1/en active Application Filing
- 2003-07-07 US US10/520,022 patent/US20060121065A1/en not_active Abandoned
- 2003-07-07 DK DK03738849T patent/DK1539231T3/da active
-
2005
- 2005-01-04 ZA ZA200500073A patent/ZA200500073B/xx unknown
-
2014
- 2014-12-31 US US14/587,116 patent/US10729764B2/en active Active
-
2020
- 2020-03-19 US US16/823,836 patent/US20200215189A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2491457C (en) | 2012-09-04 |
| JP2006511451A (ja) | 2006-04-06 |
| WO2004004762A1 (en) | 2004-01-15 |
| ATE434443T1 (de) | 2009-07-15 |
| CA2491457A1 (en) | 2004-01-15 |
| ES2328474T3 (es) | 2009-11-13 |
| BRPI0312472B1 (pt) | 2019-07-16 |
| AU2003245220A1 (en) | 2004-01-23 |
| DK1539231T3 (da) | 2009-09-14 |
| US20060121065A1 (en) | 2006-06-08 |
| US20200215189A1 (en) | 2020-07-09 |
| BR0312472A (pt) | 2005-04-26 |
| US10729764B2 (en) | 2020-08-04 |
| SE0202110D0 (sv) | 2002-07-05 |
| EP1539231A1 (en) | 2005-06-15 |
| NZ537661A (en) | 2008-08-29 |
| EP1539231B1 (en) | 2009-06-24 |
| US20150209425A1 (en) | 2015-07-30 |
| JP4636877B2 (ja) | 2011-02-23 |
| ZA200500073B (en) | 2006-02-22 |
| DE60328108D1 (de) | 2009-08-06 |
| AU2003245220B2 (en) | 2009-04-23 |
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