BR9916793A - Derivados de benzoxazol e medicamentos quecompreendem os mencionados derivados comoingredientes ativos - Google Patents
Derivados de benzoxazol e medicamentos quecompreendem os mencionados derivados comoingredientes ativosInfo
- Publication number
- BR9916793A BR9916793A BR9916793-0A BR9916793A BR9916793A BR 9916793 A BR9916793 A BR 9916793A BR 9916793 A BR9916793 A BR 9916793A BR 9916793 A BR9916793 A BR 9916793A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- lower alkyl
- derivatives
- active ingredients
- salts
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical class C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005189 alkyl hydroxy group Chemical group 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Patente de Invenção "DERIVADOS DE BENZOXAZOL EMEDICAMENTOS QUE COMPREENDEM OS MENCIONADOSDERIVADOS COMO INGREDIENTES ATIVOS". Caracterizadopelo fato de compreender um Composto representado pela fórmulageral (1) a seguir: em que R^ 1^ representa um átomo dehalogênio, R^ 2^ representa um átomo de hidrogênio ou um grupoalquila inferior e R^ 3^ representa um átomo de hidrogênio, umgrupo alquila inferior, um grupo alcoxila inferior, um grupo alquilainferior hidróxi, um átomo de halogênio ou um grupo aminosubstituído ou não substituído, em que um substituinte sobre ogrupo amino é selecionado a partir do grupo que consiste de umgrupo alquila inferior, um grupo alquenila inferior, um grupoalquilcarbonila inferior e um grupo protetor amino, ou um de seussais. O composto da presente invenção ou um de seus sais é útilcomo ingrediente ativo de medicamentos para o tratamentopreventivo e/ou terapêutico de condições de síndrome intestinalirritável e disfunção funcional do trato digestivo, ou condições dediarréia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33127498 | 1998-11-20 | ||
| PCT/JP1999/006491 WO2000031073A1 (fr) | 1998-11-20 | 1999-11-19 | Derives de benzoxazole et produits a base de ces derniers utilises comme ingredient actif |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9916793A true BR9916793A (pt) | 2001-11-13 |
Family
ID=18241866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9916793-0A BR9916793A (pt) | 1998-11-20 | 1999-11-19 | Derivados de benzoxazol e medicamentos quecompreendem os mencionados derivados comoingredientes ativos |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7045516B1 (pt) |
| EP (1) | EP1134220B1 (pt) |
| JP (1) | JP4557112B2 (pt) |
| KR (1) | KR100675033B1 (pt) |
| CN (1) | CN1333771A (pt) |
| AT (1) | ATE273974T1 (pt) |
| AU (1) | AU753797B2 (pt) |
| BR (1) | BR9916793A (pt) |
| CA (1) | CA2351446A1 (pt) |
| CZ (1) | CZ20011700A3 (pt) |
| DE (1) | DE69919575T2 (pt) |
| ES (1) | ES2222763T3 (pt) |
| HU (1) | HUP0104238A3 (pt) |
| ID (1) | ID30143A (pt) |
| IL (1) | IL143178A0 (pt) |
| NO (1) | NO20012443L (pt) |
| PL (1) | PL348426A1 (pt) |
| RU (1) | RU2204558C2 (pt) |
| SK (1) | SK6772001A3 (pt) |
| TR (1) | TR200101945T2 (pt) |
| TW (1) | TW520370B (pt) |
| WO (1) | WO2000031073A1 (pt) |
| ZA (1) | ZA200104620B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6660858B2 (en) * | 2001-03-28 | 2003-12-09 | Lion Bioscience Ag | 2-aminobenzoxazole derivatives and combinatorial libraries thereof |
| GB0203061D0 (en) * | 2002-02-08 | 2002-03-27 | Novartis Ag | Organic compounds |
| JP4399862B2 (ja) * | 2002-08-09 | 2010-01-20 | 味の素株式会社 | 腸疾患および内臓痛の治療薬 |
| EP1906951A4 (en) * | 2005-07-01 | 2009-05-27 | Dynogen Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR TREATING HYPOMOTILITY OF THE DIGESTIVE SYSTEM AND RELATED DISORDERS |
| WO2007110364A1 (en) | 2006-03-28 | 2007-10-04 | High Point Pharmaceuticals, Llc | Benzothiazoles having histamine h3 receptor activity |
| US8178666B2 (en) * | 2008-10-23 | 2012-05-15 | Albany Molecular Research, Inc. | 2-aminobenzoxazole process |
| KR101579688B1 (ko) | 2014-07-08 | 2015-12-24 | 재단법인 전남생물산업진흥원 | 좁쌀풀 추출물을 유효성분으로 함유하는 과민성 대장증후군에 의한 내장 통증 억제예방 또는 치료용 약학 조성물 |
| MX2022015770A (es) * | 2020-06-12 | 2023-01-19 | Hk Inno N Corp | Composicion farmaceutica que comprende un compuesto derivado de benzimidazol. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3193560B2 (ja) * | 1993-04-16 | 2001-07-30 | 明治製菓株式会社 | 新規ベンゾオキサゾール誘導体 |
| JP3520177B2 (ja) * | 1996-05-09 | 2004-04-19 | 明治製菓株式会社 | セロトニン５−ｈｔ３受容体部分活性薬 |
-
1999
- 1999-11-18 TW TW088120112A patent/TW520370B/zh active
- 1999-11-19 KR KR1020017006249A patent/KR100675033B1/ko not_active IP Right Cessation
- 1999-11-19 RU RU2001116715/04A patent/RU2204558C2/ru not_active IP Right Cessation
- 1999-11-19 CA CA002351446A patent/CA2351446A1/en not_active Abandoned
- 1999-11-19 HU HU0104238A patent/HUP0104238A3/hu unknown
- 1999-11-19 US US09/856,372 patent/US7045516B1/en not_active Expired - Fee Related
- 1999-11-19 PL PL99348426A patent/PL348426A1/xx unknown
- 1999-11-19 AU AU11850/00A patent/AU753797B2/en not_active Ceased
- 1999-11-19 JP JP2000583901A patent/JP4557112B2/ja not_active Expired - Fee Related
- 1999-11-19 EP EP99972633A patent/EP1134220B1/en not_active Expired - Lifetime
- 1999-11-19 IL IL14317899A patent/IL143178A0/xx unknown
- 1999-11-19 AT AT99972633T patent/ATE273974T1/de not_active IP Right Cessation
- 1999-11-19 CZ CZ20011700A patent/CZ20011700A3/cs unknown
- 1999-11-19 BR BR9916793-0A patent/BR9916793A/pt not_active IP Right Cessation
- 1999-11-19 ID IDW00200101321A patent/ID30143A/id unknown
- 1999-11-19 ES ES99972633T patent/ES2222763T3/es not_active Expired - Lifetime
- 1999-11-19 DE DE69919575T patent/DE69919575T2/de not_active Expired - Lifetime
- 1999-11-19 WO PCT/JP1999/006491 patent/WO2000031073A1/ja active IP Right Grant
- 1999-11-19 CN CN99815777A patent/CN1333771A/zh active Pending
- 1999-11-19 SK SK677-2001A patent/SK6772001A3/sk unknown
- 1999-11-19 TR TR2001/01945T patent/TR200101945T2/xx unknown
-
2001
- 2001-05-18 NO NO20012443A patent/NO20012443L/no not_active Application Discontinuation
- 2001-06-06 ZA ZA200104620A patent/ZA200104620B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2222763T3 (es) | 2005-02-01 |
| ATE273974T1 (de) | 2004-09-15 |
| SK6772001A3 (en) | 2001-12-03 |
| ID30143A (id) | 2001-11-08 |
| RU2204558C2 (ru) | 2003-05-20 |
| WO2000031073A1 (fr) | 2000-06-02 |
| CA2351446A1 (en) | 2000-06-02 |
| EP1134220A4 (en) | 2001-12-19 |
| JP4557112B2 (ja) | 2010-10-06 |
| TR200101945T2 (tr) | 2001-11-21 |
| KR20010086448A (ko) | 2001-09-12 |
| HUP0104238A2 (en) | 2002-08-28 |
| EP1134220B1 (en) | 2004-08-18 |
| HUP0104238A3 (en) | 2003-05-28 |
| PL348426A1 (en) | 2002-05-20 |
| NO20012443L (no) | 2001-07-12 |
| CN1333771A (zh) | 2002-01-30 |
| US7045516B1 (en) | 2006-05-16 |
| KR100675033B1 (ko) | 2007-01-29 |
| TW520370B (en) | 2003-02-11 |
| NO20012443D0 (no) | 2001-05-18 |
| EP1134220A1 (en) | 2001-09-19 |
| IL143178A0 (en) | 2002-04-21 |
| DE69919575D1 (de) | 2004-09-23 |
| DE69919575T2 (de) | 2005-09-29 |
| AU1185000A (en) | 2000-06-13 |
| ZA200104620B (en) | 2002-02-04 |
| AU753797B2 (en) | 2002-10-31 |
| CZ20011700A3 (cs) | 2001-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5O, 6O, 7O E 8O ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |