BR9915345A - Fragmento isolado de uma proteìna ou polipeptìdeo eliciador de resposta hipersensìvel, molécula de dna isolada, sistema de expressão, célula hospedeira, planta transgênica, semente de planta transgênica, e, métodos para comunicar às plantas resistência às doenças, para controle de insetos quanto às plantas, e para intensificar o crescimento de plantas - Google Patents
Fragmento isolado de uma proteìna ou polipeptìdeo eliciador de resposta hipersensìvel, molécula de dna isolada, sistema de expressão, célula hospedeira, planta transgênica, semente de planta transgênica, e, métodos para comunicar às plantas resistência às doenças, para controle de insetos quanto às plantas, e para intensificar o crescimento de plantasInfo
- Publication number
- BR9915345A BR9915345A BR9915345-9A BR9915345A BR9915345A BR 9915345 A BR9915345 A BR 9915345A BR 9915345 A BR9915345 A BR 9915345A BR 9915345 A BR9915345 A BR 9915345A
- Authority
- BR
- Brazil
- Prior art keywords
- plants
- isolated
- hypersensitive response
- plant growth
- transgenic plant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8283—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for virus resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/27—Erwinia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Insects & Arthropods (AREA)
- Pest Control & Pesticides (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
"FRAGMENTO ISOLADO DE UMA PROTEìNA OU POLIPEPTìDEO ELICIADOR DE RESPOSTA HIPERSENSìVEL, MOLéCULA DE DNA ISOLADA, SISTEMA DE EXPRESSãO, CéLULA HOSPEDEIRA, PLANTA TRANSGêNICA, SEMENTE DE PLANTA TRANSGêNICA, E, MéTODOS PARA COMUNICAR àS PLANTAS RESISTêNCIA àS DOENçAS, PARA CONTROLE DE INSETOS QUANTO àS PLANTAS, E PARA INTENSIFICAR O CRESCIMENTO DE PLANTAS". A presente invenção é direcionada a fragmentos ativos isolados de uma proteína ou polipeptídeo eliciador de resposta hipersensível cujo fragmento não elicia uma resposta hipersensível nas plantas. São também apresentadas moléculas de DNA isoladas que codificam tais fragmentos. Os fragmentos isolados de proteínas ou polipeptídeos eliciadores de resposta hipersensível de acordo com a presente invenção e as moléculas de DNA isoladas que codificam-nos, têm as seguintes atividades: comunicar resistências contra doenças às plantas, intensificar o crescimento das plantas, e/ou controlar os insetos sobre as plantas. Isto pode ser obtido pela aplicação dos fragmentos de um eliciador de resposta hipersensível em uma forma não infecciosa às plantas ou às sementes das plantas, sob condições eficazes para comunicar resistência às doenças, intensificar o crescimento das plantas, e/ou controlar os insetos nas plantas ou o crescimento das plantas a partir das sementes dessas plantas. Alternativamente, plantas transgênicas ou sementes de plantas transformadas com uma molécula de DNA codificando o fragmento podem ser fornecidas e as plantas trangênicas ou plantas resultantes das sementes de plantas transgênicas são cultivadas sob condições eficazes para comunicar resistência às doenças, para intensificar o crescimento das plantas, e/ou controlar os insetos sobre as plantas ou o crescimento das plantas a partir das sementes dessas plantas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10305098P | 1998-10-05 | 1998-10-05 | |
PCT/US1999/023181 WO2000020452A2 (en) | 1998-10-05 | 1999-10-05 | Hypersensitive response elicitor fragments which are active but do not elicit a hypersensitive response |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915345A true BR9915345A (pt) | 2001-07-31 |
Family
ID=22293092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915345-9A BR9915345A (pt) | 1998-10-05 | 1999-10-05 | Fragmento isolado de uma proteìna ou polipeptìdeo eliciador de resposta hipersensìvel, molécula de dna isolada, sistema de expressão, célula hospedeira, planta transgênica, semente de planta transgênica, e, métodos para comunicar às plantas resistência às doenças, para controle de insetos quanto às plantas, e para intensificar o crescimento de plantas |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1119582A2 (pt) |
JP (1) | JP2002526101A (pt) |
KR (1) | KR20010080011A (pt) |
CN (1) | CN1329619A (pt) |
AU (1) | AU6508599A (pt) |
BR (1) | BR9915345A (pt) |
CA (1) | CA2344593A1 (pt) |
HU (1) | HUP0104245A3 (pt) |
IL (1) | IL142324A0 (pt) |
MX (1) | MXPA01003461A (pt) |
NO (1) | NO20011729L (pt) |
PL (1) | PL348045A1 (pt) |
TR (1) | TR200100967T2 (pt) |
WO (1) | WO2000020452A2 (pt) |
ZA (1) | ZA200102536B (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7041876B2 (en) | 2000-01-26 | 2006-05-09 | Cornell Research Foundation, Inc. | Oomycete-resistant transgenic plants by virtue of pathogen-induced expression of a heterologous hypersensitive response elicitor |
US20020019337A1 (en) | 2000-04-19 | 2002-02-14 | Zhong-Min Wei | Treatment of fruits or vegetables with hypersensitive response elicitor to inhibit postharvest disease or desiccation |
CN1457363A (zh) * | 2000-06-16 | 2003-11-19 | 伊登生物科学有限公司 | 激发过敏反应的细菌harpin结构域及其应用 |
JP2002325519A (ja) * | 2000-09-07 | 2002-11-12 | Japan Tobacco Inc | 病害抵抗性植物及びその作出方法 |
KR100452106B1 (ko) * | 2002-02-15 | 2004-10-08 | 최진우 | 잰토모나스 악소노포디스 유래의 과민성 반응 유발인자 및그 용도 |
US9650647B2 (en) * | 2010-09-06 | 2017-05-16 | Temasek Life Sciences Laboratory Limited | Molecular interaction between XA10 and AVRXA10 |
CN107002091A (zh) * | 2014-10-01 | 2017-08-01 | 植物保健公司 | 过敏反应激发子肽及其用途 |
JP2017532981A (ja) | 2014-10-01 | 2017-11-09 | プラント ヘルス ケア インコーポレイテッド | 破壊された過敏感反応ボックスを有するエリシターペプチド及びその使用 |
WO2017176588A1 (en) | 2016-04-06 | 2017-10-12 | Plant Health Care, Inc. | Beneficial microbes for delivery of effector peptides or proteins and use thereof |
US10793608B2 (en) | 2016-04-06 | 2020-10-06 | Plant Health Care, Inc. | Hypersensitive response elicitor-derived peptides and use thereof |
KR102131937B1 (ko) * | 2018-10-10 | 2020-07-09 | 대구가톨릭대학교산학협력단 | YxaL 단백질 또는 이의 상동 단백질을 포함하는 식물 성장 촉진용 조성물 및 YxaL 단백질의 대량생산 방법 |
WO2022142976A1 (zh) * | 2020-12-31 | 2022-07-07 | 昆明锐斯得科技有限公司 | HrpN型多拟表位配体蛋白在食品、化妆品、保健品或制药中的应用 |
CN114437188B (zh) * | 2022-03-09 | 2023-08-04 | 华南农业大学 | 荔枝霜疫霉分泌型蛋白激发子PlPeL8及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6235974B1 (en) * | 1996-12-05 | 2001-05-22 | Cornell Research Foundation, Inc. | Hypersensitive response induced resistance in plants by seed treatment with a hypersensitive response elicitor |
US6277814B1 (en) * | 1997-01-27 | 2001-08-21 | Cornell Research Foundation, Inc. | Enhancement of growth in plants |
-
1999
- 1999-10-05 IL IL14232499A patent/IL142324A0/xx unknown
- 1999-10-05 KR KR1020017004332A patent/KR20010080011A/ko not_active Application Discontinuation
- 1999-10-05 PL PL99348045A patent/PL348045A1/xx unknown
- 1999-10-05 TR TR2001/00967T patent/TR200100967T2/xx unknown
- 1999-10-05 CA CA002344593A patent/CA2344593A1/en not_active Abandoned
- 1999-10-05 WO PCT/US1999/023181 patent/WO2000020452A2/en not_active Application Discontinuation
- 1999-10-05 JP JP2000574563A patent/JP2002526101A/ja active Pending
- 1999-10-05 MX MXPA01003461A patent/MXPA01003461A/es unknown
- 1999-10-05 CN CN99814028A patent/CN1329619A/zh active Pending
- 1999-10-05 EP EP99953057A patent/EP1119582A2/en not_active Withdrawn
- 1999-10-05 BR BR9915345-9A patent/BR9915345A/pt not_active Application Discontinuation
- 1999-10-05 AU AU65085/99A patent/AU6508599A/en not_active Abandoned
- 1999-10-05 HU HU0104245A patent/HUP0104245A3/hu unknown
-
2001
- 2001-03-28 ZA ZA200102536A patent/ZA200102536B/en unknown
- 2001-04-05 NO NO20011729A patent/NO20011729L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20010080011A (ko) | 2001-08-22 |
PL348045A1 (en) | 2002-05-06 |
WO2000020452A9 (en) | 2000-09-14 |
HUP0104245A2 (hu) | 2002-03-28 |
IL142324A0 (en) | 2002-03-10 |
WO2000020452A3 (en) | 2000-07-06 |
EP1119582A2 (en) | 2001-08-01 |
MXPA01003461A (es) | 2002-05-06 |
AU6508599A (en) | 2000-04-26 |
HUP0104245A3 (en) | 2003-12-29 |
NO20011729L (no) | 2001-06-05 |
CA2344593A1 (en) | 2000-04-13 |
ZA200102536B (en) | 2001-12-19 |
NO20011729D0 (no) | 2001-04-05 |
JP2002526101A (ja) | 2002-08-20 |
WO2000020452A2 (en) | 2000-04-13 |
TR200100967T2 (tr) | 2001-08-21 |
CN1329619A (zh) | 2002-01-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9809699A (pt) | Fragmento isolado de uma proteìna ou polipeptìdeo eliciador de resposta hipersensìvel de erwinia, molécula de dna isolada, sistema de expressão, célula hospedeira, planta transgênica, semente de planta transgênica, e, processos para conferir resistência a doença e intensificar crescimento de plantas e para controlar insetos para plantas | |
BR9915345A (pt) | Fragmento isolado de uma proteìna ou polipeptìdeo eliciador de resposta hipersensìvel, molécula de dna isolada, sistema de expressão, célula hospedeira, planta transgênica, semente de planta transgênica, e, métodos para comunicar às plantas resistência às doenças, para controle de insetos quanto às plantas, e para intensificar o crescimento de plantas | |
BR9807632A (pt) | Processo de controle de insetos para plantas | |
Udupa et al. | Effect of Tridax procumbens extracts on wound healing | |
BR9811132A (pt) | Molécula de dna isolada codificando um polipeptìdeo ou proteìna elicitor de resposta hipersensìvel, vetor de expressão, célula hospedeira, planta transgênica, semente de planta transgênica, processos para conferir resistência a doenças em plantas, para controlar insetos em plantas, para conferir resistência a doença em plantas, para melhorar o crescimento de plantas, para controlar insetos em plantas e para alterar a doença ou resposta hipersensìvel em uma planta, composição, anticorpo ou porção de ligação do mesmo | |
BR9811074A (pt) | Molécula de dna isolada, vetor de expressão, célula hospedeira, planta transgênica, semente de planta transgênica , polipeptìdeo ou proteìna elicitor de resposta hipersensìvel isolado, processos para conferir resistência a doenças em plantas, para melhorar o crescimento de plantas e para controle de insetos em plantas, e, composição | |
Ando et al. | Purification of sarcotoxin II, antibacterial proteins of Sarcophaga peregrina (flesh fly) larvae | |
Quinn et al. | Sweet itch: responses of clinically normal and affected horses to intradermal challenge with extracts of biting insects | |
Smookler | Properties of inhibitors of plant virus infection occurring in the leaves of species in the Chenopodiales | |
BR0208203A (pt) | Polipeptìdeo do fator vii, derivado do fator vii, composição, composição farmacêutica, construção de polinucleotìdeo, célula hospedeira eucariótica, animal transgênico, planta transgênica, e, métodos para produzir o polipeptìdeo do fator vii e um derivado do fator vii, uso de um derivado do fator vii, métodos para o tratamento de episódios de hemorragia ou distúrbios de hemorragia em um paciente ou para a intensificação do sistema hemostático normal e para inibir a formação de trobo em um paciente | |
Suseelan et al. | Purification and characterization of a lectin from wild sunflower (Helianthus tuberosus L.) tubers | |
BR9811079A (pt) | Molécula de dna isolada, polipeptìdeo ou proteìna elicitor de resposta hipersensìvel isolado, vetor de expressão, célula hospedeira, planta transgênica, semente de planta transgênica, processos para conferir resistência a doenças em plantas, para melhorar o crescimento de plantas, para controlar insentos em plantas, e, composição | |
WO2001098501A3 (en) | Hypersensitive response eliciting domains of bacterial harpins and use thereof | |
Ha et al. | Isolation and structure determination of a paralytic peptide from the hemolymph of the silkworm, Bombyx mori | |
BR0010687A (pt) | Peptìdeos e uso dos mesmos para controlar pragas | |
ATE74761T1 (de) | Verwendung von pflanzenpollenextrakten zur herstellung von das wachstum von tumorzellen hemmenden pharmazeutischen praeparaten und verfahren zu ihrer herstellung. | |
HUP0103789A2 (hu) | A Xanthomonas campestrisből származó, hiperszenzitív választ kiváltó anyag | |
Taylor et al. | Isolation and characterization of the 32.5 kDa protein from the venom of an endoparasitic wasp | |
Abdel-Moniem | The seed-head weevil, Larinus latus herbst (Coleoptera: Curculionidae) as a new record in Egypt on the milk thistle, Silybum marianum (L.)(Asteraceae: Compositaea) | |
Dhawan et al. | Cultivation and Breeding of Commercial Perfumery Grass Vetiver | |
BR102018013005A2 (pt) | Composição inseticida de extrato de agave híbrida para o combate ao mosquito aedes aegypti em qualquer uma de suas fases de vida | |
Ali et al. | Purification and characterization of three lectins extracted from Cassia fistula seeds and effect of various physical and chemical agents on their stability | |
ES2941432B2 (es) | Extracción de péptidos y glucosinolatos de material vegetal del género Brassica y uso de los mismos en aplicaciones cosméticas | |
US20230270119A1 (en) | Biostimulant and bioprotective peptides and their use in agriculture | |
Fiasal et al. | Effect of Growth Regulators and Melatonin on Growth and Production Active Substances of Mentha piperita L. in-Vitro |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |