BR9913942A - Polinucleotìdeo e polipeptìdeo isolado, vetor de expressão, célula cultivada, constructo de dna codificador de uma proteìna de fusão, processos de produção de uma proteìna, de fusão de um polipeptìdeo e de um anticorpo para o polipeptìdeo e de detecção, em uma amostra de teste, da presença de um modulador da atividade da proteìna zalpha11 e de um ligante de receptor zalpha11 dentro de uma amostra de teste, e, anticorpo - Google Patents

Polinucleotìdeo e polipeptìdeo isolado, vetor de expressão, célula cultivada, constructo de dna codificador de uma proteìna de fusão, processos de produção de uma proteìna, de fusão de um polipeptìdeo e de um anticorpo para o polipeptìdeo e de detecção, em uma amostra de teste, da presença de um modulador da atividade da proteìna zalpha11 e de um ligante de receptor zalpha11 dentro de uma amostra de teste, e, anticorpo

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Publication number
BR9913942A
BR9913942A BR9913942-1A BR9913942A BR9913942A BR 9913942 A BR9913942 A BR 9913942A BR 9913942 A BR9913942 A BR 9913942A BR 9913942 A BR9913942 A BR 9913942A
Authority
BR
Brazil
Prior art keywords
protein
zalpha11
polypeptide
antibody
test sample
Prior art date
Application number
BR9913942-1A
Other languages
English (en)
Inventor
Scott R Presnell
Darrell C Conklin
Julia E Novak
Angela K Hammond
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of BR9913942A publication Critical patent/BR9913942A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons

Abstract

"POLINUCLEOTìDEO E POLIPEPTìDEO ISOLADO, VETOR DE EXPRESSãO, CéLULA CULTIVADA, CONSTRUCTO DE DNA CODIFICADOR DE UMA PROTEìNA DE FUSãO, PROCESSOS DE PRODUçãO DE UMA PROTEìNA DE FUSãO, DE UM POLIPEPTìDEO E DE UM ANTICORPO PARA O POLIPEPTìDEO E DE DETECçãO, EM UMA AMOSTRA DE TESTE, DA PRESENçA DE UM MODULADOR DA ATIVIDADE DA PROTEìNA ZALPHA11 E DE UM LIGANTE DE RECEPTOR ZALPHA11 DENTRO DE UMA AMOSTRA DE TESTE, E, ANTICORPO". Novos polipeptídeos, polinucleotídeos codificadores de polipeptídeos, e composições relacionadas e processos são descritos para zalpha11, um novo receptor de citocina. Os polipeptídeos podem ser usados nos processos para a detecção de ligantes que estimulam a proliferação e/ou o desenvolvimento de células hematopoiéticas, linfóides e mielóides in vitro e in vivo. Os polipeptídeos receptores ligadores de ligante também podem ser utilizados para bloquear a atividade ligante in vitro e in vivo. Os polinucleotídeos codificadores de zalpha11, estão localizados no cromossomo 16, e podem ser empregados para identificar uma região do genona associada com estados doentios humanos. A presente invenção também inclui processos para a produção de proteína, usos das mesmas e anticorpos para as mesmas.
BR9913942-1A 1998-09-23 1999-09-23 Polinucleotìdeo e polipeptìdeo isolado, vetor de expressão, célula cultivada, constructo de dna codificador de uma proteìna de fusão, processos de produção de uma proteìna, de fusão de um polipeptìdeo e de um anticorpo para o polipeptìdeo e de detecção, em uma amostra de teste, da presença de um modulador da atividade da proteìna zalpha11 e de um ligante de receptor zalpha11 dentro de uma amostra de teste, e, anticorpo BR9913942A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15925498A 1998-09-23 1998-09-23
US26511799A 1999-03-09 1999-03-09
US34793099A 1999-07-06 1999-07-06
PCT/US1999/022149 WO2000017235A2 (en) 1998-09-23 1999-09-23 Cytokine receptor zalpha11

Publications (1)

Publication Number Publication Date
BR9913942A true BR9913942A (pt) 2001-10-16

Family

ID=27388288

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913942-1A BR9913942A (pt) 1998-09-23 1999-09-23 Polinucleotìdeo e polipeptìdeo isolado, vetor de expressão, célula cultivada, constructo de dna codificador de uma proteìna de fusão, processos de produção de uma proteìna, de fusão de um polipeptìdeo e de um anticorpo para o polipeptìdeo e de detecção, em uma amostra de teste, da presença de um modulador da atividade da proteìna zalpha11 e de um ligante de receptor zalpha11 dentro de uma amostra de teste, e, anticorpo

Country Status (18)

Country Link
EP (2) EP1115862B1 (pt)
JP (2) JP4704565B2 (pt)
KR (1) KR20010085838A (pt)
CN (1) CN1344320A (pt)
AU (1) AU772172B2 (pt)
BR (1) BR9913942A (pt)
CA (1) CA2343839C (pt)
CZ (1) CZ20011026A3 (pt)
DE (1) DE69941126D1 (pt)
DK (1) DK1115862T3 (pt)
EA (3) EA014417B1 (pt)
ES (1) ES2329741T3 (pt)
HU (1) HUP0103593A2 (pt)
IL (3) IL142164A0 (pt)
NO (1) NO20011460L (pt)
NZ (1) NZ510744A (pt)
PL (1) PL349068A1 (pt)
WO (1) WO2000017235A2 (pt)

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Also Published As

Publication number Publication date
EP2105446A3 (en) 2010-07-07
EA014417B1 (ru) 2010-12-30
AU6499899A (en) 2000-04-10
EA201001190A1 (ru) 2011-04-29
CN1344320A (zh) 2002-04-10
CA2343839C (en) 2012-09-11
WO2000017235A2 (en) 2000-03-30
JP2011015700A (ja) 2011-01-27
NZ510744A (en) 2003-02-28
AU772172B2 (en) 2004-04-08
EA006501B1 (ru) 2005-12-29
NO20011460D0 (no) 2001-03-22
JP2002526062A (ja) 2002-08-20
ES2329741T3 (es) 2009-11-30
DE69941126D1 (de) 2009-08-27
EP1115862A2 (en) 2001-07-18
PL349068A1 (en) 2002-07-01
EA200100276A1 (ru) 2001-10-22
EP1115862B1 (en) 2009-07-15
NO20011460L (no) 2001-05-23
KR20010085838A (ko) 2001-09-07
JP4704565B2 (ja) 2011-06-15
IL185764A0 (en) 2008-01-06
WO2000017235A3 (en) 2000-07-20
IL142164A0 (en) 2002-03-10
IL142164A (en) 2009-09-22
IL185764A (en) 2010-06-16
CZ20011026A3 (cs) 2001-08-15
EP2105446A2 (en) 2009-09-30
HUP0103593A2 (hu) 2002-01-28
DK1115862T3 (da) 2009-11-16
CA2343839A1 (en) 2000-03-30
EA200501461A1 (ru) 2006-02-24
EP2105446B1 (en) 2013-08-14

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