BR9911932A - Composto - Google Patents

Composto

Info

Publication number
BR9911932A
BR9911932A BR9911932-3A BR9911932A BR9911932A BR 9911932 A BR9911932 A BR 9911932A BR 9911932 A BR9911932 A BR 9911932A BR 9911932 A BR9911932 A BR 9911932A
Authority
BR
Brazil
Prior art keywords
group
alkylene
acid residue
compound
formula
Prior art date
Application number
BR9911932-3A
Other languages
English (en)
Inventor
Kurt Ritter
Bernd Janssen
Andreas Haupt
Andreas Kling
Teresa Barlozzari
Wilhelm Amberg
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR9911932A publication Critical patent/BR9911932A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"COMPOSTO" Compostos da presente invenção incluem inibidores do crescimento celular, que são peptídeos de Fórmula (I): A - B - D - E - F - G e sais ácidos dos mesmos, em que A, D e E são resíduos de aminoácidos, B é um resíduo de <244>-aminoácido ou um resíduo de ácido <244>-hidróxi ácido, F é um resíduo de ácido aminobenzóico ou um resíduo de ácido aminociclocarboxilico, e G é um radical monovalente, tal que, por exemplo, um átomo de hidrogênio, um grupo amino, um grupo alquila, um alquil éter de alquileno, um alquil tioéter de alquileno, um aldeído de alquileno, uma amida de alquileno, um grupo <225>-hidroxilamino, um grupo hidrazido, um grupo alcóxi, um grupo tioalcóxi, um grupo aminóxi, um grupo oximato, um grupo aril alquileno, um éster de alquileno, um sulfóxido de alquileno ou uma sulfona de alquileno. Outro aspecto da presente invenção inclui composições farmacêuticas, que compreendem um composto de fórmula (1) e um veículo farmaceuticamente aceitável. Uma modalidade adicional da presente invenção consiste em um método para tratar câncer em um mamífero, tal que um humano, que compreende administrar ao mamífero uma quantidade efetiva de um composto de Fórmula (I) em uma composição farmaceuticamente aceitável.
BR9911932-3A 1998-07-08 1999-06-23 Composto BR9911932A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/112,249 US5985837A (en) 1998-07-08 1998-07-08 Dolastatin 15 derivatives
PCT/US1999/014099 WO2000002906A1 (en) 1998-07-08 1999-06-23 Dolastatin 15 derivatives

Publications (1)

Publication Number Publication Date
BR9911932A true BR9911932A (pt) 2001-10-16

Family

ID=22342878

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911932-3A BR9911932A (pt) 1998-07-08 1999-06-23 Composto

Country Status (14)

Country Link
US (2) US5985837A (pt)
EP (1) EP1093460A1 (pt)
JP (1) JP2002520335A (pt)
KR (1) KR20010053428A (pt)
CN (1) CN1312817A (pt)
AU (1) AU4708199A (pt)
BR (1) BR9911932A (pt)
CA (1) CA2332641A1 (pt)
HK (1) HK1041007A1 (pt)
HU (1) HUP0103560A3 (pt)
IL (1) IL140578A0 (pt)
NO (1) NO20010046L (pt)
WO (1) WO2000002906A1 (pt)
ZA (1) ZA200100169B (pt)

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US9156854B2 (en) * 2011-04-18 2015-10-13 Immunogen, Inc. Maytansinoid derivatives with sulfoxide linker
PL3327027T3 (pl) 2011-11-17 2021-06-28 Pfizer Inc. Cytotoksyczne peptydy i ich koniugaty przeciwciało lek
WO2014072897A1 (en) 2012-11-07 2014-05-15 Pfizer Inc. Anti-notch3 antibodies and antibody-drug conjugates
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
EP2972394A4 (en) 2013-03-15 2016-11-02 Sloan Kettering Inst Cancer HSP90 TARGETING CARDIAC IMAGING AND TREATMENT THEREOF
WO2016049214A1 (en) 2014-09-23 2016-03-31 Genentech, Inc. METHOD OF USING ANTI-CD79b IMMUNOCONJUGATES
WO2017058808A1 (en) * 2015-10-02 2017-04-06 Sirenas Llc Anti-cancer compounds and conjugates thereof
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2020247054A1 (en) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
CN117279664A (zh) 2021-04-10 2023-12-22 普方生物制药美国公司 Folr1结合剂、其偶联物及其使用方法
JP2024516631A (ja) 2021-04-23 2024-04-16 プロファウンドバイオ ユーエス カンパニー 抗ｃｄ７０抗体、そのコンジュゲートおよびこれを使用する方法
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Also Published As

Publication number Publication date
AU4708199A (en) 2000-02-01
HUP0103560A3 (en) 2002-05-28
NO20010046L (no) 2001-03-02
WO2000002906A1 (en) 2000-01-20
US20010018422A1 (en) 2001-08-30
KR20010053428A (ko) 2001-06-25
NO20010046D0 (no) 2001-01-04
HK1041007A1 (zh) 2002-06-28
CA2332641A1 (en) 2000-01-20
EP1093460A1 (en) 2001-04-25
US5985837A (en) 1999-11-16
ZA200100169B (en) 2002-01-08
JP2002520335A (ja) 2002-07-09
CN1312817A (zh) 2001-09-12
HUP0103560A2 (hu) 2002-02-28
IL140578A0 (en) 2002-02-10

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4O, 5O, 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.