HK1041007A1 - 截尾海兔肽15衍生物 - Google Patents

截尾海兔肽15衍生物

Info

Publication number
HK1041007A1
HK1041007A1 HK02101870.1A HK02101870A HK1041007A1 HK 1041007 A1 HK1041007 A1 HK 1041007A1 HK 02101870 A HK02101870 A HK 02101870A HK 1041007 A1 HK1041007 A1 HK 1041007A1
Authority
HK
Hong Kong
Prior art keywords
dolastatin
derivatives
Prior art date
Application number
HK02101870.1A
Other languages
English (en)
Inventor
K‧瑞特爾
B‧傑森
A‧哈普特
A‧柯林格
T‧巴勞扎瑞
W‧阿姆伯格
Original Assignee
巴斯福股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 巴斯福股份公司 filed Critical 巴斯福股份公司
Publication of HK1041007A1 publication Critical patent/HK1041007A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK02101870.1A 1998-07-08 2002-03-12 截尾海兔肽15衍生物 HK1041007A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/112,249 US5985837A (en) 1998-07-08 1998-07-08 Dolastatin 15 derivatives
PCT/US1999/014099 WO2000002906A1 (en) 1998-07-08 1999-06-23 Dolastatin 15 derivatives

Publications (1)

Publication Number Publication Date
HK1041007A1 true HK1041007A1 (zh) 2002-06-28

Family

ID=22342878

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02101870.1A HK1041007A1 (zh) 1998-07-08 2002-03-12 截尾海兔肽15衍生物

Country Status (14)

Country Link
US (2) US5985837A (zh)
EP (1) EP1093460A1 (zh)
JP (1) JP2002520335A (zh)
KR (1) KR20010053428A (zh)
CN (1) CN1312817A (zh)
AU (1) AU4708199A (zh)
BR (1) BR9911932A (zh)
CA (1) CA2332641A1 (zh)
HK (1) HK1041007A1 (zh)
HU (1) HUP0103560A3 (zh)
IL (1) IL140578A0 (zh)
NO (1) NO20010046L (zh)
WO (1) WO2000002906A1 (zh)
ZA (1) ZA200100169B (zh)

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BR112015010436A2 (pt) 2012-11-07 2017-08-22 Pfizer Anticorpos anti-notch3 e conjugados anticorpo-fármaco
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
AU2014228822A1 (en) 2013-03-15 2015-10-01 Memorial Sloan-Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
EP3689910A3 (en) 2014-09-23 2020-12-02 F. Hoffmann-La Roche AG Method of using anti-cd79b immunoconjugates
WO2017058808A1 (en) * 2015-10-02 2017-04-06 Sirenas Llc Anti-cancer compounds and conjugates thereof
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof
EP4319820A1 (en) 2021-04-10 2024-02-14 Profoundbio Us Co. Folr1 binding agents, conjugates thereof and methods of using the same
CA3216459A1 (en) 2021-04-23 2022-10-27 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
CN118119409A (zh) 2021-09-03 2024-05-31 东丽株式会社 癌的治疗和/或预防用药物组合物

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Also Published As

Publication number Publication date
CN1312817A (zh) 2001-09-12
HUP0103560A3 (en) 2002-05-28
NO20010046L (no) 2001-03-02
US5985837A (en) 1999-11-16
ZA200100169B (en) 2002-01-08
AU4708199A (en) 2000-02-01
NO20010046D0 (no) 2001-01-04
WO2000002906A1 (en) 2000-01-20
HUP0103560A2 (hu) 2002-02-28
BR9911932A (pt) 2001-10-16
JP2002520335A (ja) 2002-07-09
EP1093460A1 (en) 2001-04-25
US20010018422A1 (en) 2001-08-30
CA2332641A1 (en) 2000-01-20
IL140578A0 (en) 2002-02-10
KR20010053428A (ko) 2001-06-25

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