BR9911498A - Composto, composição farmacêutica, uso de um composto, e, processo para tratar de um paciente sofrendo de uma condição onde exista um benefìcio em reduzir a concentração de ácido graxo isento de plasma ou reduzir a frequência cardìaca - Google Patents

Composto, composição farmacêutica, uso de um composto, e, processo para tratar de um paciente sofrendo de uma condição onde exista um benefìcio em reduzir a concentração de ácido graxo isento de plasma ou reduzir a frequência cardìaca

Info

Publication number
BR9911498A
BR9911498A BR9911498-4A BR9911498A BR9911498A BR 9911498 A BR9911498 A BR 9911498A BR 9911498 A BR9911498 A BR 9911498A BR 9911498 A BR9911498 A BR 9911498A
Authority
BR
Brazil
Prior art keywords
compound
reducing
treat
plasma
benefit
Prior art date
Application number
BR9911498-4A
Other languages
English (en)
Inventor
David Edmund Bays
Richard Peter Charles Cousins
Hazel Joan Dyke
Colin David Eldred
Brian David Judkins
Martin Pass
Andrew Michael Kenneth Pennell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR9911498A publication Critical patent/BR9911498A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, E, PROCESSO PARA TRATAR DE UM PACIENTE SOFRENDO DE UMA CONDIçãO ONDE EXISTA UM BENEFìCIO EM REDUZIR A CONCENTRAçãO DE áCIDO GRAXO ISENTO DE PLASMA OU REDUZIR A FREQuêNCIA CARDìACA". Um composto de fórmula (I): que é um agonista no receptor de adenosina Al, em que Y, Z e W representam heteroátomos, e seus sais e solvatos, em particular, solvatos fisiologicamente aceitáveis e seus sais, para uso em terapia.
BR9911498-4A 1998-06-23 1999-06-21 Composto, composição farmacêutica, uso de um composto, e, processo para tratar de um paciente sofrendo de uma condição onde exista um benefìcio em reduzir a concentração de ácido graxo isento de plasma ou reduzir a frequência cardìaca BR9911498A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9813554.4A GB9813554D0 (en) 1998-06-23 1998-06-23 Chemical compounds
PCT/EP1999/004182 WO1999067262A1 (en) 1998-06-23 1999-06-21 Adenosine derivatives

Publications (1)

Publication Number Publication Date
BR9911498A true BR9911498A (pt) 2001-03-20

Family

ID=10834247

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911498-4A BR9911498A (pt) 1998-06-23 1999-06-21 Composto, composição farmacêutica, uso de um composto, e, processo para tratar de um paciente sofrendo de uma condição onde exista um benefìcio em reduzir a concentração de ácido graxo isento de plasma ou reduzir a frequência cardìaca

Country Status (40)

Country Link
US (2) US6492348B1 (pt)
EP (2) EP1447407A1 (pt)
JP (2) JP3378240B2 (pt)
KR (1) KR100612797B1 (pt)
CN (2) CN1616459A (pt)
AP (1) AP2000002014A0 (pt)
AR (1) AR018917A1 (pt)
AT (1) ATE277941T1 (pt)
AU (1) AU758018B2 (pt)
BG (1) BG65064B1 (pt)
BR (1) BR9911498A (pt)
CA (1) CA2335520C (pt)
CO (1) CO5040216A1 (pt)
DE (1) DE69920697T2 (pt)
EA (1) EA003828B1 (pt)
EE (1) EE04853B1 (pt)
ES (1) ES2226399T3 (pt)
GB (1) GB9813554D0 (pt)
GE (1) GEP20032958B (pt)
HK (1) HK1034978A1 (pt)
HR (1) HRP20000896B1 (pt)
HU (1) HUP0102453A3 (pt)
ID (1) ID27484A (pt)
IL (2) IL140284A0 (pt)
IS (1) IS5773A (pt)
MY (1) MY122481A (pt)
NO (1) NO318788B1 (pt)
NZ (1) NZ508915A (pt)
OA (1) OA11574A (pt)
PE (1) PE20000704A1 (pt)
PL (1) PL194087B1 (pt)
PT (1) PT1090019E (pt)
RS (1) RS50042B (pt)
SI (1) SI1090019T1 (pt)
SK (1) SK19582000A3 (pt)
TR (1) TR200100449T2 (pt)
TW (1) TW541312B (pt)
UA (1) UA64794C2 (pt)
WO (1) WO1999067262A1 (pt)
ZA (1) ZA200007514B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9813554D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
WO2001064202A2 (en) * 2000-03-01 2001-09-07 Euro-Celtique S.A. Tramadol for the treatment of functional gastrointestinal disorders
US20040162422A1 (en) * 2001-03-20 2004-08-19 Adrian Hall Chemical compounds
GB0106867D0 (en) * 2001-03-20 2001-05-09 Glaxo Group Ltd Process
GB0115178D0 (en) * 2001-06-20 2001-08-15 Glaxo Group Ltd Compounds
GB0115182D0 (en) * 2001-06-20 2001-08-15 Glaxo Group Ltd Medicaments
US6946449B2 (en) 2001-07-13 2005-09-20 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
US7713946B2 (en) 2002-07-11 2010-05-11 Cv Therapeutics, Inc. Partial and full agonists A1 adenosine receptors
US7157440B2 (en) 2001-07-13 2007-01-02 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
MXPA04008008A (es) 2002-02-19 2005-03-23 Cv Therapeutics Inc Agonistas parciales y completos de receptores de adenosina a1.
WO2003106475A2 (en) * 2002-06-17 2003-12-24 Glaxo Group Limited Process
DE60315164T2 (de) * 2002-08-15 2008-04-30 CV Therapeutics, Inc., Palo Alto Partielle und volle agonisten von a1-adenosinrezeptoren
WO2004055034A1 (en) * 2002-12-18 2004-07-01 Glaxo Group Limited Polymorph
WO2004055032A1 (en) * 2002-12-18 2004-07-01 Glaxo Group Limited Adenosine derivative in polymorph v form
WO2004055033A1 (en) * 2002-12-18 2004-07-01 Glaxo Group Limited Adenosine derivative in polymorph iv form
NZ541651A (en) 2003-02-03 2009-01-31 Cv Therapeutics Inc Partial and full agonists of A1 adenosine receptors
WO2005053712A1 (en) * 2003-12-02 2005-06-16 Glaxo Group Limited Use of adenonsine derivatives for treating dyslipidemia, obesity, cardiovascular risk factors, metabolic syndrome, polycystic ovary syndrome, niddm
GT200500281A (es) * 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0607954D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
ES2440317T3 (es) * 2006-04-21 2014-01-28 Novartis Ag Derivados de purina para su uso como agonistas del receptor de adenosina A2A
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607953D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607948D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
EP1903044A1 (en) * 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
AU2007316715A1 (en) * 2006-11-10 2008-05-15 Novartis Ag Cyclopentene diol monoacetate derivatives
US20090088403A1 (en) * 2007-05-07 2009-04-02 Randy Blakely A3 adenosine receptors as targets for the modulation of central serotonergic signaling
CN101712709A (zh) 2008-10-06 2010-05-26 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷及其调血脂的用途
EP2849566B1 (en) * 2012-02-11 2018-04-04 Academia Sinica Adenosine analogues for the treatment of pain
CR20170384A (es) 2015-02-24 2017-11-16 Pfizer Derivados de nucleosidos sustituidos utiles como agentes antineoplasicos
CN108864099A (zh) * 2018-09-08 2018-11-23 湖北荆洪生物科技股份有限公司 一种高纯6-糠氨基嘌呤的合成方法

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US4962194A (en) * 1987-04-02 1990-10-09 Warner-Lambert Company Method of preparing 51,N6-disubstituted adenosines from inosines
US5646128A (en) * 1989-09-15 1997-07-08 Gensia, Inc. Methods for treating adenosine kinase related conditions
US5244896A (en) * 1990-09-14 1993-09-14 Marion Merrell Dow Inc. Carbocyclic adenosine analogs useful as immunosuppressants
DK62592D0 (pt) * 1992-05-14 1992-05-14 Novo Nordisk As
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
ATE176668T1 (de) * 1993-07-23 1999-02-15 Merrell Pharma Inc Neue 9-n-bicyclische nucleosidverbindungen nützlich als selektive inhibitoren von proinflammatorische cytokinen
AU3255097A (en) * 1996-07-05 1998-02-02 Novo Nordisk A/S Novel (n)-alkoxyadenine derivatives acting as cytokine inhibitors
UA51716C2 (uk) * 1996-07-08 2002-12-16 Авентіс Фармасьютікалз Продактс Інк. Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
AU4377397A (en) 1996-10-14 1998-05-11 Novo Nordisk A/S Novel therapeutically active adenosine derivatives
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
AR017457A1 (es) 1998-02-14 2001-09-05 Glaxo Group Ltd Compuestos derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol, procesos para su preparacion, composiciones que los contienen y su uso en terapia para el tratamiento de enfermedades inflamatorias.
GB9813554D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
EP1090019A1 (en) 2001-04-11
EA003828B1 (ru) 2003-10-30
AR018917A1 (es) 2001-12-12
US6677316B2 (en) 2004-01-13
AU758018B2 (en) 2003-03-13
IL140284A (en) 2006-04-10
PE20000704A1 (es) 2000-08-03
IL140284A0 (en) 2002-02-10
GEP20032958B (en) 2003-04-25
ZA200007514B (en) 2002-01-23
ES2226399T3 (es) 2005-03-16
NO20006520L (no) 2001-02-14
JP2002518509A (ja) 2002-06-25
HUP0102453A3 (en) 2002-10-28
EP1447407A1 (en) 2004-08-18
DE69920697D1 (de) 2004-11-04
WO1999067262A1 (en) 1999-12-29
CA2335520A1 (en) 1999-12-29
GB9813554D0 (en) 1998-08-19
RS50042B (sr) 2008-11-28
TR200100449T2 (tr) 2001-08-21
SK19582000A3 (sk) 2001-11-06
US20030096788A1 (en) 2003-05-22
CN1202118C (zh) 2005-05-18
PT1090019E (pt) 2005-01-31
AP2000002014A0 (en) 2000-12-31
EE04853B1 (et) 2007-06-15
ATE277941T1 (de) 2004-10-15
KR20010083067A (ko) 2001-08-31
UA64794C2 (en) 2004-03-15
JP3378240B2 (ja) 2003-02-17
EA200001222A1 (ru) 2001-08-27
CO5040216A1 (es) 2001-05-29
CN1616459A (zh) 2005-05-18
ID27484A (id) 2001-04-12
KR100612797B1 (ko) 2006-08-17
HRP20000896B1 (en) 2006-03-31
MY122481A (en) 2006-04-29
JP2003040891A (ja) 2003-02-13
CN1314910A (zh) 2001-09-26
TW541312B (en) 2003-07-11
HK1034978A1 (en) 2001-11-09
OA11574A (en) 2004-07-21
NO318788B1 (no) 2005-05-09
NO20006520D0 (no) 2000-12-20
PL194087B1 (pl) 2007-04-30
US6492348B1 (en) 2002-12-10
EP1090019B1 (en) 2004-09-29
YU82800A (sh) 2003-04-30
PL345089A1 (en) 2001-12-03
DE69920697T2 (de) 2005-02-24
HRP20000896A2 (en) 2001-12-31
NZ508915A (en) 2003-09-26
EE200000784A (et) 2002-04-15
BG65064B1 (bg) 2007-01-31
BG105155A (en) 2001-09-28
SI1090019T1 (en) 2005-02-28
CA2335520C (en) 2007-02-20
IS5773A (is) 2000-12-15
HUP0102453A2 (hu) 2002-04-29
AU4514699A (en) 2000-01-10

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