BR9813973A - Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo para o tratamento de um paciente sofrendo de uma condição. - Google Patents

Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo para o tratamento de um paciente sofrendo de uma condição.

Info

Publication number
BR9813973A
BR9813973A BR9813973-8A BR9813973A BR9813973A BR 9813973 A BR9813973 A BR 9813973A BR 9813973 A BR9813973 A BR 9813973A BR 9813973 A BR9813973 A BR 9813973A
Authority
BR
Brazil
Prior art keywords
compound
condition
pharmaceutical composition
preparing
treatment
Prior art date
Application number
BR9813973-8A
Other languages
English (en)
Inventor
Brian David Judkins
Philip Charles Box
Andrew Michael Kenneth Pennell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR9813973A publication Critical patent/BR9813973A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/167Purine radicals with ribosyl as the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives

Abstract

"COMPOSTO, PROCESSO PARA PREPARá-LO, USO DO MESMO, COMPOSIçãO FARMACêUTICA, E, PROCESSO PARA O TRATAMENTO DE UM PACIENTE SOFRENDO DE UMA CONDIçãO". Um composto de fórmula (I) em que R² representa alquila C~ 1-3~, halogênio ou hidrogênio, R³ representa um grupo alquila reto ou ramificado fluorado, de 1-6 átomos de carbono, e sais e solvatos dos mesmos, particularmente solvatos fisiologicamente aceitáveis e sais dos mesmos. Estes compostos são agonistas de receptor de adenosina A1.
BR9813973-8A 1997-11-08 1998-11-06 Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo para o tratamento de um paciente sofrendo de uma condição. BR9813973A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9723566.7A GB9723566D0 (en) 1997-11-08 1997-11-08 Chemical compounds
PCT/EP1998/007022 WO1999024450A2 (en) 1997-11-08 1998-11-06 Adensine a1 receptor agonists

Publications (1)

Publication Number Publication Date
BR9813973A true BR9813973A (pt) 2000-09-26

Family

ID=10821742

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813973-8A BR9813973A (pt) 1997-11-08 1998-11-06 Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo para o tratamento de um paciente sofrendo de uma condição.

Country Status (24)

Country Link
US (1) US6407076B1 (pt)
EP (1) EP1027363B1 (pt)
JP (1) JP2001522858A (pt)
KR (1) KR20010031883A (pt)
CN (1) CN1285842A (pt)
AP (1) AP2000001803A0 (pt)
AT (1) ATE242259T1 (pt)
AU (1) AU1232799A (pt)
BR (1) BR9813973A (pt)
CA (1) CA2309199A1 (pt)
DE (1) DE69815378T2 (pt)
EA (1) EA200000393A1 (pt)
EE (1) EE200000284A (pt)
ES (1) ES2201552T3 (pt)
GB (1) GB9723566D0 (pt)
HR (1) HRP20000276A2 (pt)
HU (1) HUP0004106A2 (pt)
IL (1) IL135965A0 (pt)
IS (1) IS5478A (pt)
NO (1) NO20002360L (pt)
PL (1) PL341091A1 (pt)
SK (1) SK6712000A3 (pt)
TR (1) TR200002157T2 (pt)
WO (1) WO1999024450A2 (pt)

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GB2372741A (en) * 2001-03-03 2002-09-04 Univ Leiden C2,8-Disubstituted adenosine derivatives and their different uses
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WO2004069185A2 (en) 2003-02-03 2004-08-19 Cv Therapeutics Inc. Partial and full agonists of a1 adenosine receptors
AR044519A1 (es) 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
US20050277615A1 (en) * 2004-05-17 2005-12-15 Can-Fite Biopharma Ltd. Pharmaceutical compositions having anti-inflammatory activity
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
WO2006028618A1 (en) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
EP1778712B1 (en) * 2004-08-02 2013-01-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
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GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
RU2421464C2 (ru) 2005-10-21 2011-06-20 Новартис Аг Человеческие антитела к il-13 и их терапевтическое применение
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
US8178509B2 (en) * 2006-02-10 2012-05-15 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
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US20100041662A1 (en) 2006-10-30 2010-02-18 Sandrine Ferrand Heterocyclic compounds as antiinflammatory agents
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
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Also Published As

Publication number Publication date
NO20002360L (no) 2000-07-05
EP1027363B1 (en) 2003-06-04
SK6712000A3 (en) 2001-01-18
AU1232799A (en) 1999-05-31
JP2001522858A (ja) 2001-11-20
ATE242259T1 (de) 2003-06-15
EE200000284A (et) 2001-08-15
DE69815378T2 (de) 2004-04-29
IS5478A (is) 2000-05-03
KR20010031883A (ko) 2001-04-16
TR200002157T2 (tr) 2000-11-21
GB9723566D0 (en) 1998-01-07
DE69815378D1 (de) 2003-07-10
CN1285842A (zh) 2001-02-28
ES2201552T3 (es) 2004-03-16
EP1027363A2 (en) 2000-08-16
NO20002360D0 (no) 2000-05-05
IL135965A0 (en) 2001-05-20
US6407076B1 (en) 2002-06-18
AP2000001803A0 (en) 2000-06-30
WO1999024450A3 (en) 1999-08-19
PL341091A1 (en) 2001-03-26
EA200000393A1 (ru) 2000-12-25
HRP20000276A2 (en) 2000-12-31
CA2309199A1 (en) 1999-05-20
WO1999024450A2 (en) 1999-05-20
HUP0004106A2 (hu) 2001-04-28

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