BR9813756A - Derivados da acronicina, seu processo de preparo e as composições farmacêuticas que as contêm - Google Patents

Derivados da acronicina, seu processo de preparo e as composições farmacêuticas que as contêm

Info

Publication number
BR9813756A
BR9813756A BR9813756-5A BR9813756A BR9813756A BR 9813756 A BR9813756 A BR 9813756A BR 9813756 A BR9813756 A BR 9813756A BR 9813756 A BR9813756 A BR 9813756A
Authority
BR
Brazil
Prior art keywords
group
acronicine
derivatives
pharmaceutical compositions
preparation process
Prior art date
Application number
BR9813756-5A
Other languages
English (en)
Inventor
Michel Koch
Francois Tillequin
Sylvie Michel
Ghanem Atassi
Alain Pierre
Bruno Pfeiffer
Pierre Renard
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of BR9813756A publication Critical patent/BR9813756A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DA ACRONICINA, SEU PROCESSO DE PREPARO E AS COMPOSIçõES FARMACêUTICAS QUE AS CONTêM"<D>. Compostos de fórmula (I) nos quais X, Y representam um átomo de hidrogênio, de halogênio ou um grupamento hidróxi, mercapto, ciano, nitro, alquila, alcóxi, trihalogenoalquila, amino eventualmente substituído, metilenodióxi ou etilenodióxi, R~ 1~ representa um átomo de hidrogênio ou um grupamento alquila, R~ 2~ representa um átomo de hidrogênio ou um grupamento hidróxi, alquila, alcóxi, alquilcarbonilóxi, amino eventualmente substituído, R~ 3~, R~ 4~ representam um átomo de hidrogênio ou um grupamento alquila. A representa um grupamento -CH=CH- ou um grupamento -CH(R~ 5~)-CH(R~ 6~) no qual R~ 5~ e R~ 6~ são tais conforme definidos na descrição. Os novos compostos possuem propriedades antitumorais, que os tornam particularmente adaptados para uma utilização no tratamento dos cânceres e notadamente dos tumores sólidos.
BR9813756-5A 1997-12-19 1998-12-18 Derivados da acronicina, seu processo de preparo e as composições farmacêuticas que as contêm BR9813756A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9716131A FR2772765B1 (fr) 1997-12-19 1997-12-19 Nouveaux derives de l'acronycine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1998/002785 WO1999032491A1 (fr) 1997-12-19 1998-12-18 Nouveaux derives de l'acronycine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR9813756A true BR9813756A (pt) 2000-10-03

Family

ID=9514822

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813756-5A BR9813756A (pt) 1997-12-19 1998-12-18 Derivados da acronicina, seu processo de preparo e as composições farmacêuticas que as contêm

Country Status (20)

Country Link
US (1) US6288073B1 (pt)
EP (1) EP1042326B1 (pt)
JP (1) JP3825630B2 (pt)
CN (1) CN1109686C (pt)
AT (1) ATE219491T1 (pt)
AU (1) AU738322B2 (pt)
BR (1) BR9813756A (pt)
CA (1) CA2315909C (pt)
DE (1) DE69806189T2 (pt)
DK (1) DK1042326T3 (pt)
ES (1) ES2179548T3 (pt)
FR (1) FR2772765B1 (pt)
HK (1) HK1033131A1 (pt)
HU (1) HUP0100342A3 (pt)
NO (1) NO20003106L (pt)
NZ (1) NZ504833A (pt)
PL (1) PL192814B1 (pt)
PT (1) PT1042326E (pt)
WO (1) WO1999032491A1 (pt)
ZA (1) ZA9811645B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2795071B1 (fr) * 1999-06-16 2001-07-27 Adir Nouveaux derives de carboxylate de 7-oxo-2,3,7,14- tetrahydro-1h-benzo[b]pyrano[3,2,h] acridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7056929B2 (en) * 2001-07-25 2006-06-06 Les Laboratoires Servier Benzo[b]pyrano[3,2-h]acridin-7-one compounds
FR2827864B1 (fr) * 2001-07-25 2005-09-16 Servier Lab Nouveaux derives de benzo[b]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2856687B1 (fr) * 2003-06-25 2005-09-16 Servier Lab Nouveaux derives de benzo[a]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2865734B1 (fr) * 2004-02-03 2006-05-19 Servier Lab NOUVAEUX DERIVES DE BENZO[b]CHROMENO-NAPHTHYRIDIN-7-ONE ET DE PYRANO[2'3':7,8]QUINO[2,3-b]QUINOXALIN-7-ONE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
FR2879600B1 (fr) * 2004-12-22 2007-02-09 Servier Lab Nouveaux derives cinnamates de benzo[b]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP4392502B2 (ja) * 2005-06-10 2010-01-06 国立大学法人 岡山大学 蛍光性アミノ酸誘導体
US11784731B2 (en) * 2021-03-09 2023-10-10 Apple Inc. Multi-phase-level signaling to improve data bandwidth over lossy channels

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2716197B1 (fr) * 1994-02-17 1996-04-19 Adir Nouveaux analogues de l'acronycine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
PT1042326E (pt) 2002-10-31
CN1109686C (zh) 2003-05-28
ES2179548T3 (es) 2003-01-16
JP2001526290A (ja) 2001-12-18
NZ504833A (en) 2001-11-30
PL341281A1 (en) 2001-04-09
JP3825630B2 (ja) 2006-09-27
FR2772765A1 (fr) 1999-06-25
DE69806189D1 (de) 2002-07-25
NO20003106L (no) 2000-08-16
US6288073B1 (en) 2001-09-11
CN1282332A (zh) 2001-01-31
HUP0100342A3 (en) 2003-04-28
ZA9811645B (en) 1999-06-24
NO20003106D0 (no) 2000-06-16
AU1766399A (en) 1999-07-12
ATE219491T1 (de) 2002-07-15
WO1999032491A1 (fr) 1999-07-01
PL192814B1 (pl) 2006-12-29
DE69806189T2 (de) 2003-02-13
HK1033131A1 (en) 2001-08-17
AU738322B2 (en) 2001-09-13
HUP0100342A2 (hu) 2001-09-28
CA2315909C (fr) 2007-01-02
EP1042326A1 (fr) 2000-10-11
FR2772765B1 (fr) 2000-03-17
EP1042326B1 (fr) 2002-06-19
DK1042326T3 (da) 2002-09-23
CA2315909A1 (fr) 1999-07-01

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Legal Events

Date Code Title Description
PC Transfer

Free format text: LES LABORATOIRES SERVIER (FR)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: C07D 491/052, C07D 491/14, C07D 498/14, A61K 31/44,A61P 35/00

Ipc: C07D 491/052 (2008.04), C07D 491/14 (2008.04), C07

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI