BR9909692A - 2-(indol-3-il)-etil]amidas de ácido 2-oxo-alcanóico substituìdas - Google Patents

2-(indol-3-il)-etil]amidas de ácido 2-oxo-alcanóico substituìdas

Info

Publication number
BR9909692A
BR9909692A BR9909692-7A BR9909692A BR9909692A BR 9909692 A BR9909692 A BR 9909692A BR 9909692 A BR9909692 A BR 9909692A BR 9909692 A BR9909692 A BR 9909692A
Authority
BR
Brazil
Prior art keywords
alkyl
substituted
indol
oxo
ethyl
Prior art date
Application number
BR9909692-7A
Other languages
English (en)
Inventor
Thomas Himmler
Franz Pirro
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BR9909692A publication Critical patent/BR9909692A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Patente de Invenção: <B>"[2-(INDOL-3-IL)-ETIL]AMIDAS DE áCIDO 2-OXO-ALCANóICO SUBSTITUìDAS"<D>. A invenção refere-se a novas [2-(indol-3-il)etil]amidas de ácido 2-oxo-alcanóico substituídas da fórmula geral (I), na qual R¹ representa C~ 1~-C~ 8~-alquila ou C~ 4~-C~ 8~-cicloalquila eventualmente ramificada, R² independente de R³ representa hidrogênio, C~ 1~-C~ 4~-alquila, C~ 1~-C~ 4~-alcóxi, C~ 1~-C~ 4~-tioalquila, fenila ou halogênio, R³, representa hidrogênio, C~ 1~-C~ 4~-alquila ou halogênio e R^ 4^ representa C~ 1~-C~ 6~-alquila, C~ 4~-C~ 6~-cicloalquila eventualmente ramificada, representa fenila eventualmente substituída uma até três vezes por C~ 1~-C~ 3~-alquila, C~ 1~-C~ 3~-alcóxi, C~ 1~-C~ 3~-tioalquila, halogênio, nitro ou amino ou representa benzila eventualmente substituída uma até três vezes por C~ 1~-C~ 3~-alquila, C~ 1~-C~ 3~-alcóxi, C~ 1~-C~ 3~-tioalquila, halogênio, nitro ou amino, processos para a sua preparação e seu emprego em agentes antibacterianos.
BR9909692-7A 1998-04-16 1999-04-03 2-(indol-3-il)-etil]amidas de ácido 2-oxo-alcanóico substituìdas BR9909692A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19816780A DE19816780A1 (de) 1998-04-16 1998-04-16 Substituierte 2-Oxo-alkansäure-[2-(indol-3-yl)-ethyl]amide
PCT/EP1999/002302 WO1999054301A1 (de) 1998-04-16 1999-04-03 Substituierte 2-oxo-alkansäure-[2-(indol-3-yl)-ethyl]amide

Publications (1)

Publication Number Publication Date
BR9909692A true BR9909692A (pt) 2000-12-19

Family

ID=7864659

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909692-7A BR9909692A (pt) 1998-04-16 1999-04-03 2-(indol-3-il)-etil]amidas de ácido 2-oxo-alcanóico substituìdas

Country Status (11)

Country Link
US (1) US6255335B1 (pt)
EP (1) EP1071664A1 (pt)
JP (1) JP2002512226A (pt)
KR (1) KR20010052236A (pt)
CN (1) CN1297437A (pt)
AU (1) AU752273B2 (pt)
BR (1) BR9909692A (pt)
CA (1) CA2328875A1 (pt)
DE (1) DE19816780A1 (pt)
HU (1) HUP0102099A3 (pt)
WO (1) WO1999054301A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
KR20070007103A (ko) * 2004-02-18 2007-01-12 아스트라제네카 아베 벤즈아미드 유도체 및 이의 글루코키나아제 활성화제로서의용도
JP2007523905A (ja) * 2004-02-18 2007-08-23 アストラゼネカ アクチボラグ 化合物
TW200600086A (en) 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
CA2581619A1 (en) * 2004-10-16 2006-04-20 Astrazeneca Ab Process for making phenoxy benzamide compounds
JP2008542247A (ja) * 2005-05-24 2008-11-27 アストラゼネカ アクチボラグ グルコキナーゼモジュレーターとしての２−フェニル置換イミダゾール［４，５ｂ］ピリジン／ピラジンおよびプリン誘導体
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
JP4651714B2 (ja) * 2005-07-09 2011-03-16 アストラゼネカ アクチボラグ 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
JP2009500442A (ja) * 2005-07-09 2009-01-08 アストラゼネカ アクチボラグ ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
TW200825060A (en) * 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
UY30822A1 (es) * 2006-12-21 2008-07-31 Astrazeneca Ab Fnueva forma cristalina de 3-{[5-azetidin-1-ylcabonyl)pyrazin-2-yl]oxy}-5-[1-methylethyloxy]-n-1h-pyrazol-3-ylbenzamida, composiciones conteniéndola, procesos de preparacion y aplicaciones
BRPI0917589A2 (pt) 2008-08-04 2015-11-17 Astrazeneca Ab composto, composição farmacêutica, uso de um composto, método para tratar doenças, processo, combinação farmacêutica, e, reação de metiloxirano-2-carboxilato (ix) com um álcool roh
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
WO2010116176A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
WO2010116177A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3217011A (en) 1965-05-07 1965-11-09 Sterling Drug Inc 1-(indolyglyoxalyl)-piperidines
US5569668A (en) 1995-03-29 1996-10-29 Webster; John M. Indole derivatives with antibacterial and antimycotic properties

Also Published As

Publication number Publication date
EP1071664A1 (de) 2001-01-31
JP2002512226A (ja) 2002-04-23
WO1999054301A1 (de) 1999-10-28
AU752273B2 (en) 2002-09-12
HUP0102099A3 (en) 2001-12-28
US6255335B1 (en) 2001-07-03
CA2328875A1 (en) 1999-10-28
DE19816780A1 (de) 1999-10-21
AU3605099A (en) 1999-11-08
HUP0102099A2 (hu) 2001-11-28
CN1297437A (zh) 2001-05-30
KR20010052236A (ko) 2001-06-25

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O,6O, 7O E 8O ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.