BR9907160A - Processo para acilação de 10-deacetilbacatina iii em uma posição c-10 sobre uma posição hidróxi c-7 da mesma - Google Patents

Processo para acilação de 10-deacetilbacatina iii em uma posição c-10 sobre uma posição hidróxi c-7 da mesma

Info

Publication number
BR9907160A
BR9907160A BR9907160-6A BR9907160A BR9907160A BR 9907160 A BR9907160 A BR 9907160A BR 9907160 A BR9907160 A BR 9907160A BR 9907160 A BR9907160 A BR 9907160A
Authority
BR
Brazil
Prior art keywords
iii
deacetylbaccatin iii
solution
baccatin
acylation
Prior art date
Application number
BR9907160-6A
Other languages
English (en)
Inventor
Nicholas J Sisti
Jan Zygmunt
Herbert R Brinkman
Madhavi C Chander
Xian Liang
James D Mcchesney
Original Assignee
Napro Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napro Biotherapeutics Inc filed Critical Napro Biotherapeutics Inc
Publication of BR9907160A publication Critical patent/BR9907160A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Paper (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

''PROCESSO PARA ACILAçãO DE 10-DEACETILBACATINA III EM UMA POSIçãO C-10 SOBRE UMA POSIçãO HIDRóXI C-7 DA MESMA'' Processo para acilação de 10-deacetilbacatina III em uma posição C10 sobre uma posição C-7 hidróxi, em que os sais de lítio são usados como reagentes de reação.
BR9907160-6A 1998-01-21 1999-01-21 Processo para acilação de 10-deacetilbacatina iii em uma posição c-10 sobre uma posição hidróxi c-7 da mesma BR9907160A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/010,285 US5914411A (en) 1998-01-21 1998-01-21 Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position
PCT/US1999/001384 WO1999037632A1 (en) 1998-01-21 1999-01-21 Alternate method for acylating 10-deacetylbaccatin iii selectively at the c-10 position

Publications (1)

Publication Number Publication Date
BR9907160A true BR9907160A (pt) 2000-10-24

Family

ID=21745026

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907160-6A BR9907160A (pt) 1998-01-21 1999-01-21 Processo para acilação de 10-deacetilbacatina iii em uma posição c-10 sobre uma posição hidróxi c-7 da mesma

Country Status (20)

Country Link
US (1) US5914411A (pt)
EP (1) EP1056736B1 (pt)
JP (1) JP2002501060A (pt)
KR (1) KR20010034082A (pt)
CN (1) CN1288463A (pt)
AT (1) ATE223394T1 (pt)
AU (1) AU741516B2 (pt)
BR (1) BR9907160A (pt)
CA (1) CA2312350A1 (pt)
DE (1) DE69902757T2 (pt)
DK (1) DK1056736T3 (pt)
EA (1) EA002576B1 (pt)
ES (1) ES2182484T3 (pt)
GE (1) GEP20022800B (pt)
IL (1) IL136043A0 (pt)
NO (1) NO20002923L (pt)
NZ (1) NZ505117A (pt)
PT (1) PT1056736E (pt)
TR (1) TR200001821T2 (pt)
WO (1) WO1999037632A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
WO1999057105A1 (en) 1998-05-01 1999-11-11 Napro Biotherapeutics, Inc. Methods and useful intermediates for paclitaxel synthesis from c-7, c-10 di-cbz baccatin iii
US6495705B2 (en) 2000-03-16 2002-12-17 Napro Biotherapeutics, Inc. Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
US6281368B1 (en) 2000-03-16 2001-08-28 Napro Biotherapeutics, Inc. Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
US6358996B1 (en) 2000-06-09 2002-03-19 Napro Biotherapeutics, Inc. Stable isotope labeling of paclitaxel
EP1562927B1 (en) * 2002-10-09 2009-05-13 Chatham Biotec Ltd. Thio-analogues of paclitaxel and intermediates thereof
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
AU2005245396A1 (en) * 2004-05-14 2005-12-01 Immunogen, Inc. A facile method for synthesizing baccatin III compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5440057A (en) * 1993-08-20 1995-08-08 The Scripps Research Institute Access to taxol analogs
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position

Also Published As

Publication number Publication date
PT1056736E (pt) 2002-12-31
DE69902757T2 (de) 2003-01-09
DK1056736T3 (da) 2002-12-30
WO1999037632A1 (en) 1999-07-29
EP1056736B1 (en) 2002-09-04
JP2002501060A (ja) 2002-01-15
ES2182484T3 (es) 2003-03-01
NZ505117A (en) 2002-11-26
EP1056736A1 (en) 2000-12-06
TR200001821T2 (tr) 2001-01-22
CA2312350A1 (en) 1999-07-29
EA002576B1 (ru) 2002-06-27
ATE223394T1 (de) 2002-09-15
IL136043A0 (en) 2001-05-20
US5914411A (en) 1999-06-22
EP1056736A4 (en) 2001-04-11
GEP20022800B (en) 2002-09-25
DE69902757D1 (de) 2002-10-10
EA200000782A1 (ru) 2000-12-25
NO20002923D0 (no) 2000-06-08
AU2465799A (en) 1999-08-09
CN1288463A (zh) 2001-03-21
AU741516B2 (en) 2001-12-06
KR20010034082A (ko) 2001-04-25
NO20002923L (no) 2000-09-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.