TR200001821T2 - 10-Deasetilbakatin III'ün C-10 konumunda seçici bir şekilde asile edilmesi için alternatif yöntem - Google Patents

10-Deasetilbakatin III'ün C-10 konumunda seçici bir şekilde asile edilmesi için alternatif yöntem

Info

Publication number
TR200001821T2
TR200001821T2 TR2000/01821T TR200001821T TR200001821T2 TR 200001821 T2 TR200001821 T2 TR 200001821T2 TR 2000/01821 T TR2000/01821 T TR 2000/01821T TR 200001821 T TR200001821 T TR 200001821T TR 200001821 T2 TR200001821 T2 TR 200001821T2
Authority
TR
Turkey
Prior art keywords
iii
deacetylbaccatin iii
solution
baccatin
organic phase
Prior art date
Application number
TR2000/01821T
Other languages
English (en)
Inventor
J. Sisti Nicholas
Zygmunt Jan
R. Brinkman Herbert
C. Chander Madhavi
Liang Xian
D. Mcchesney James
Original Assignee
Napro I�O Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napro I�O Therapeutics, Inc. filed Critical Napro I�O Therapeutics, Inc.
Publication of TR200001821T2 publication Critical patent/TR200001821T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Paper (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Bulus, 10-Deasetilbakatin III'ün C-7 hidroksi konumu üzerindeki C-10 konumunda asile edildigi ve lithiumm tuzlarinin reaksiyon ayiraçlari olarak kullanildigi bir yöntemdir.
TR2000/01821T 1998-01-21 1999-01-21 10-Deasetilbakatin III'ün C-10 konumunda seçici bir şekilde asile edilmesi için alternatif yöntem TR200001821T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/010,285 US5914411A (en) 1998-01-21 1998-01-21 Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position

Publications (1)

Publication Number Publication Date
TR200001821T2 true TR200001821T2 (tr) 2001-01-22

Family

ID=21745026

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01821T TR200001821T2 (tr) 1998-01-21 1999-01-21 10-Deasetilbakatin III'ün C-10 konumunda seçici bir şekilde asile edilmesi için alternatif yöntem

Country Status (20)

Country Link
US (1) US5914411A (tr)
EP (1) EP1056736B1 (tr)
JP (1) JP2002501060A (tr)
KR (1) KR20010034082A (tr)
CN (1) CN1288463A (tr)
AT (1) ATE223394T1 (tr)
AU (1) AU741516B2 (tr)
BR (1) BR9907160A (tr)
CA (1) CA2312350A1 (tr)
DE (1) DE69902757T2 (tr)
DK (1) DK1056736T3 (tr)
EA (1) EA002576B1 (tr)
ES (1) ES2182484T3 (tr)
GE (1) GEP20022800B (tr)
IL (1) IL136043A0 (tr)
NO (1) NO20002923L (tr)
NZ (1) NZ505117A (tr)
PT (1) PT1056736E (tr)
TR (1) TR200001821T2 (tr)
WO (1) WO1999037632A1 (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
CA2331094A1 (en) 1998-05-01 1999-11-11 Herbert R. Brinkman Methods and useful intermediates for paclitaxel synthesis from c-7, c-10di-cbz 10-deacetylbaccatin iii
US6281368B1 (en) 2000-03-16 2001-08-28 Napro Biotherapeutics, Inc. Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
US6495705B2 (en) 2000-03-16 2002-12-17 Napro Biotherapeutics, Inc. Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
US6358996B1 (en) 2000-06-09 2002-03-19 Napro Biotherapeutics, Inc. Stable isotope labeling of paclitaxel
ATE431343T1 (de) * 2002-10-09 2009-05-15 Chatham Biotec Ltd Thio-analoga von paclitaxel und deren vorprodukte
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
BRPI0511109A (pt) * 2004-05-14 2007-11-27 Immunogen Inc método fácil para sintetizar compostos de baccatin iii

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5440057A (en) * 1993-08-20 1995-08-08 The Scripps Research Institute Access to taxol analogs
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position

Also Published As

Publication number Publication date
KR20010034082A (ko) 2001-04-25
ATE223394T1 (de) 2002-09-15
EP1056736A1 (en) 2000-12-06
GEP20022800B (en) 2002-09-25
EP1056736B1 (en) 2002-09-04
BR9907160A (pt) 2000-10-24
CA2312350A1 (en) 1999-07-29
JP2002501060A (ja) 2002-01-15
AU2465799A (en) 1999-08-09
EA200000782A1 (ru) 2000-12-25
EA002576B1 (ru) 2002-06-27
AU741516B2 (en) 2001-12-06
CN1288463A (zh) 2001-03-21
IL136043A0 (en) 2001-05-20
EP1056736A4 (en) 2001-04-11
US5914411A (en) 1999-06-22
NZ505117A (en) 2002-11-26
DE69902757T2 (de) 2003-01-09
NO20002923L (no) 2000-09-11
WO1999037632A1 (en) 1999-07-29
NO20002923D0 (no) 2000-06-08
DE69902757D1 (de) 2002-10-10
ES2182484T3 (es) 2003-03-01
PT1056736E (pt) 2002-12-31
DK1056736T3 (da) 2002-12-30

Similar Documents

Publication Publication Date Title
TR200001821T2 (tr) 10-Deasetilbakatin III'ün C-10 konumunda seçici bir şekilde asile edilmesi için alternatif yöntem
KR910007525A (ko) 양모제
NO951281L (no) Fremgangsmåte for fremstilling av 10-desacetyl-baccatin-III
EA199900096A1 (ru) Способ ацилирования 10-деацетилбаккатина iii селективно в положение с-10
Burkard et al. New Fluorous Photoaffinity Labels (F‐PAL) and Their Application in V‐ATPase Inhibition Studies
EA199801068A1 (ru) Способ получения доцетаксела
KR840006207A (ko) 6-치환된-퀴놀린-5,6-퀴논의 제조방법
Mandai et al. A semisynthesis of paclitaxel via a 10-deacetylbaccatin III derivative bearing a β-keto ester appendage
EP1497276B1 (en) Conversion of taxane molecules
Oba et al. Facile Synthesis of 3‐Hydroxyglutamic Acids via Cyanation of Chiral N‐Acyliminium Cation Derived From (S)‐Malic Acid
Zhang et al. Facile and Efficient Synthesis of Substituted 1, 4‐Dithiafulvalenes from β‐Dicarbonyl Compounds
PT1082316E (pt) Processos e intermediarios uteis para a sintese de paclitaxel a partir de c-7,c-10-di-cbz-bacatina iii
ATE41160T1 (de) Verfahren zur herstellung von pregnan-derivaten.
Semakov et al. New Synthesis of Eremophilanes from Alantolactone
KR890002125A (ko) 4-아미노-6, 7-디메톡시 퀴나졸린 유도체의 제조방법.
Wang et al. Facile synthesis of 2-aroyl-3, 5-diarylthiophene
IL141304A0 (en) A method for the preparation of c-4 deacetyltaxane derivatives and the enzyme for use therein
Sultankhodzhaev Oxidation ofaconitine by potassium permanganate. A new N-de-ethyl-7, 17-secoimino derivative
EA200200163A1 (ru) Аминомодифицированные соединения псевдомицина
KR840000564A (ko) 세팔로스포란산의 제조방법
KR850007243A (ko) P-아미노페놀 유도체의 제조방법