ES2182484T3 - Nuevo procedimiento de acilacion selectiva de 10-desacetilbacatina iii en la posicion c-10. - Google Patents
Nuevo procedimiento de acilacion selectiva de 10-desacetilbacatina iii en la posicion c-10.Info
- Publication number
- ES2182484T3 ES2182484T3 ES99904208T ES99904208T ES2182484T3 ES 2182484 T3 ES2182484 T3 ES 2182484T3 ES 99904208 T ES99904208 T ES 99904208T ES 99904208 T ES99904208 T ES 99904208T ES 2182484 T3 ES2182484 T3 ES 2182484T3
- Authority
- ES
- Spain
- Prior art keywords
- iii
- solution
- baccatin
- deacetilbacatine
- acilation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Paper (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Procedimiento de acilación de la 10- desacetilbacatina III en una posición C-10 sobre una posición hidroxilo C-7 de la misma, que comprende las etapas siguientes: (a) disolución de una cantidad seleccionada de 10- desacetilbacatina III en un solvente etérico aceptable, para formar una primera solución; (b) mezcla de una solución que contiene una sal de litio en la primera solución, para formar una segunda solución. (c) adición de una base seleccionada de una base trialquilamina y piridina a la segunda solución, para formar de este modo una tercera solución; y (d) combinación de la tercera solución con un agente acilante para formar una cuarta solución, de tal modo que la bacatina III se forme en la cuarta solución.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/010,285 US5914411A (en) | 1998-01-21 | 1998-01-21 | Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2182484T3 true ES2182484T3 (es) | 2003-03-01 |
Family
ID=21745026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99904208T Expired - Lifetime ES2182484T3 (es) | 1998-01-21 | 1999-01-21 | Nuevo procedimiento de acilacion selectiva de 10-desacetilbacatina iii en la posicion c-10. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5914411A (es) |
| EP (1) | EP1056736B1 (es) |
| JP (1) | JP2002501060A (es) |
| KR (1) | KR20010034082A (es) |
| CN (1) | CN1288463A (es) |
| AT (1) | ATE223394T1 (es) |
| AU (1) | AU741516B2 (es) |
| BR (1) | BR9907160A (es) |
| CA (1) | CA2312350A1 (es) |
| DE (1) | DE69902757T2 (es) |
| DK (1) | DK1056736T3 (es) |
| EA (1) | EA002576B1 (es) |
| ES (1) | ES2182484T3 (es) |
| GE (1) | GEP20022800B (es) |
| IL (1) | IL136043A0 (es) |
| NO (1) | NO20002923L (es) |
| NZ (1) | NZ505117A (es) |
| PT (1) | PT1056736E (es) |
| TR (1) | TR200001821T2 (es) |
| WO (1) | WO1999037632A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| US6448417B1 (en) | 1998-05-01 | 2002-09-10 | Napro Biotherapeutics, Inc. | Methods and useful intermediates for paclitaxel synthesis from C-7, C-10 di-cbz 10-deacetylbaccatin III |
| US6281368B1 (en) | 2000-03-16 | 2001-08-28 | Napro Biotherapeutics, Inc. | Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III |
| US6495705B2 (en) | 2000-03-16 | 2002-12-17 | Napro Biotherapeutics, Inc. | Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes |
| US6358996B1 (en) | 2000-06-09 | 2002-03-19 | Napro Biotherapeutics, Inc. | Stable isotope labeling of paclitaxel |
| EP1562927B1 (en) * | 2002-10-09 | 2009-05-13 | Chatham Biotec Ltd. | Thio-analogues of paclitaxel and intermediates thereof |
| US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
| BRPI0511109A (pt) * | 2004-05-14 | 2007-11-27 | Immunogen Inc | método fácil para sintetizar compostos de baccatin iii |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
| US5440057A (en) * | 1993-08-20 | 1995-08-08 | The Scripps Research Institute | Access to taxol analogs |
| US5750736A (en) * | 1996-07-11 | 1998-05-12 | Napro Biotherapeutics, Inc. | Method for acylating 10-deacetylbaccatin III selectively at the c-10 position |
-
1998
- 1998-01-21 US US09/010,285 patent/US5914411A/en not_active Expired - Fee Related
-
1999
- 1999-01-21 BR BR9907160-6A patent/BR9907160A/pt not_active IP Right Cessation
- 1999-01-21 JP JP2000528555A patent/JP2002501060A/ja active Pending
- 1999-01-21 EA EA200000782A patent/EA002576B1/ru not_active IP Right Cessation
- 1999-01-21 WO PCT/US1999/001384 patent/WO1999037632A1/en not_active Application Discontinuation
- 1999-01-21 IL IL13604399A patent/IL136043A0/xx unknown
- 1999-01-21 CA CA002312350A patent/CA2312350A1/en not_active Abandoned
- 1999-01-21 TR TR2000/01821T patent/TR200001821T2/xx unknown
- 1999-01-21 EP EP99904208A patent/EP1056736B1/en not_active Expired - Lifetime
- 1999-01-21 AT AT99904208T patent/ATE223394T1/de not_active IP Right Cessation
- 1999-01-21 ES ES99904208T patent/ES2182484T3/es not_active Expired - Lifetime
- 1999-01-21 DE DE69902757T patent/DE69902757T2/de not_active Expired - Fee Related
- 1999-01-21 KR KR1020007007691A patent/KR20010034082A/ko not_active Application Discontinuation
- 1999-01-21 NZ NZ505117A patent/NZ505117A/xx unknown
- 1999-01-21 PT PT99904208T patent/PT1056736E/pt unknown
- 1999-01-21 DK DK99904208T patent/DK1056736T3/da active
- 1999-01-21 CN CN99802200A patent/CN1288463A/zh active Pending
- 1999-01-21 GE GEAP19995525A patent/GEP20022800B/en unknown
- 1999-01-21 AU AU24657/99A patent/AU741516B2/en not_active Ceased
-
2000
- 2000-06-08 NO NO20002923A patent/NO20002923L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ505117A (en) | 2002-11-26 |
| NO20002923D0 (no) | 2000-06-08 |
| ATE223394T1 (de) | 2002-09-15 |
| DK1056736T3 (da) | 2002-12-30 |
| JP2002501060A (ja) | 2002-01-15 |
| EP1056736A1 (en) | 2000-12-06 |
| AU741516B2 (en) | 2001-12-06 |
| GEP20022800B (en) | 2002-09-25 |
| EP1056736B1 (en) | 2002-09-04 |
| DE69902757T2 (de) | 2003-01-09 |
| US5914411A (en) | 1999-06-22 |
| EA002576B1 (ru) | 2002-06-27 |
| CN1288463A (zh) | 2001-03-21 |
| EA200000782A1 (ru) | 2000-12-25 |
| BR9907160A (pt) | 2000-10-24 |
| DE69902757D1 (de) | 2002-10-10 |
| WO1999037632A1 (en) | 1999-07-29 |
| CA2312350A1 (en) | 1999-07-29 |
| TR200001821T2 (tr) | 2001-01-22 |
| EP1056736A4 (en) | 2001-04-11 |
| NO20002923L (no) | 2000-09-11 |
| IL136043A0 (en) | 2001-05-20 |
| PT1056736E (pt) | 2002-12-31 |
| KR20010034082A (ko) | 2001-04-25 |
| AU2465799A (en) | 1999-08-09 |
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