EA200000782A1 - Альтернативный способ селективного ацилирования 10-деацетилбаккатина iii по 10-ому положению - Google Patents

Альтернативный способ селективного ацилирования 10-деацетилбаккатина iii по 10-ому положению

Info

Publication number
EA200000782A1
EA200000782A1 EA200000782A EA200000782A EA200000782A1 EA 200000782 A1 EA200000782 A1 EA 200000782A1 EA 200000782 A EA200000782 A EA 200000782A EA 200000782 A EA200000782 A EA 200000782A EA 200000782 A1 EA200000782 A1 EA 200000782A1
Authority
EA
Eurasian Patent Office
Prior art keywords
iii
solution
baccatin
deacethilbacacatine
organic phase
Prior art date
Application number
EA200000782A
Other languages
English (en)
Other versions
EA002576B1 (ru
Inventor
Николас Дж. Систи
Ян Зигмунт
Герберт Р. Бринкман
Мадхави С. Чандер
Ксиан Лианг
Джеймс Д. МакЧесни
Original Assignee
Напро Биотерапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Напро Биотерапьютикс, Инк. filed Critical Напро Биотерапьютикс, Инк.
Publication of EA200000782A1 publication Critical patent/EA200000782A1/ru
Publication of EA002576B1 publication Critical patent/EA002576B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Paper (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Способ ацилирования 10-деацетилбаккатина III по положению C-10 в большей степени, чем по гидроксилу в положении C-7, заключающийся в том, что в качестве реагентов используют соли лития.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000782A 1998-01-21 1999-01-21 Способ селективного ацилирования 10-деацетилбаккатина iii EA002576B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/010,285 US5914411A (en) 1998-01-21 1998-01-21 Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position
PCT/US1999/001384 WO1999037632A1 (en) 1998-01-21 1999-01-21 Alternate method for acylating 10-deacetylbaccatin iii selectively at the c-10 position

Publications (2)

Publication Number Publication Date
EA200000782A1 true EA200000782A1 (ru) 2000-12-25
EA002576B1 EA002576B1 (ru) 2002-06-27

Family

ID=21745026

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000782A EA002576B1 (ru) 1998-01-21 1999-01-21 Способ селективного ацилирования 10-деацетилбаккатина iii

Country Status (20)

Country Link
US (1) US5914411A (ru)
EP (1) EP1056736B1 (ru)
JP (1) JP2002501060A (ru)
KR (1) KR20010034082A (ru)
CN (1) CN1288463A (ru)
AT (1) ATE223394T1 (ru)
AU (1) AU741516B2 (ru)
BR (1) BR9907160A (ru)
CA (1) CA2312350A1 (ru)
DE (1) DE69902757T2 (ru)
DK (1) DK1056736T3 (ru)
EA (1) EA002576B1 (ru)
ES (1) ES2182484T3 (ru)
GE (1) GEP20022800B (ru)
IL (1) IL136043A0 (ru)
NO (1) NO20002923L (ru)
NZ (1) NZ505117A (ru)
PT (1) PT1056736E (ru)
TR (1) TR200001821T2 (ru)
WO (1) WO1999037632A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
CA2331094A1 (en) 1998-05-01 1999-11-11 Herbert R. Brinkman Methods and useful intermediates for paclitaxel synthesis from c-7, c-10di-cbz 10-deacetylbaccatin iii
US6281368B1 (en) 2000-03-16 2001-08-28 Napro Biotherapeutics, Inc. Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
US6495705B2 (en) 2000-03-16 2002-12-17 Napro Biotherapeutics, Inc. Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
US6358996B1 (en) 2000-06-09 2002-03-19 Napro Biotherapeutics, Inc. Stable isotope labeling of paclitaxel
ATE431343T1 (de) * 2002-10-09 2009-05-15 Chatham Biotec Ltd Thio-analoga von paclitaxel und deren vorprodukte
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
BRPI0511109A (pt) * 2004-05-14 2007-11-27 Immunogen Inc método fácil para sintetizar compostos de baccatin iii

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5440057A (en) * 1993-08-20 1995-08-08 The Scripps Research Institute Access to taxol analogs
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position

Also Published As

Publication number Publication date
KR20010034082A (ko) 2001-04-25
ATE223394T1 (de) 2002-09-15
TR200001821T2 (tr) 2001-01-22
EP1056736A1 (en) 2000-12-06
GEP20022800B (en) 2002-09-25
EP1056736B1 (en) 2002-09-04
BR9907160A (pt) 2000-10-24
CA2312350A1 (en) 1999-07-29
JP2002501060A (ja) 2002-01-15
AU2465799A (en) 1999-08-09
EA002576B1 (ru) 2002-06-27
AU741516B2 (en) 2001-12-06
CN1288463A (zh) 2001-03-21
IL136043A0 (en) 2001-05-20
EP1056736A4 (en) 2001-04-11
US5914411A (en) 1999-06-22
NZ505117A (en) 2002-11-26
DE69902757T2 (de) 2003-01-09
NO20002923L (no) 2000-09-11
WO1999037632A1 (en) 1999-07-29
NO20002923D0 (no) 2000-06-08
DE69902757D1 (de) 2002-10-10
ES2182484T3 (es) 2003-03-01
PT1056736E (pt) 2002-12-31
DK1056736T3 (da) 2002-12-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU