NO986066L - FremgangsmÕte for acetylering av 10-deacetylbaccatin-III selektivt i C-10 posisjon - Google Patents

FremgangsmÕte for acetylering av 10-deacetylbaccatin-III selektivt i C-10 posisjon

Info

Publication number
NO986066L
NO986066L NO986066A NO986066A NO986066L NO 986066 L NO986066 L NO 986066L NO 986066 A NO986066 A NO 986066A NO 986066 A NO986066 A NO 986066A NO 986066 L NO986066 L NO 986066L
Authority
NO
Norway
Prior art keywords
iii
baccatin iii
deacetylbaccatin
solution
produce
Prior art date
Application number
NO986066A
Other languages
English (en)
Other versions
NO986066D0 (no
Inventor
Nicholas J Sisti
Original Assignee
Napro Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napro Biotherapeutics Inc filed Critical Napro Biotherapeutics Inc
Publication of NO986066D0 publication Critical patent/NO986066D0/no
Publication of NO986066L publication Critical patent/NO986066L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO986066A 1996-07-11 1998-12-22 FremgangsmÕte for acetylering av 10-deacetylbaccatin-III selektivt i C-10 posisjon NO986066L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/678,759 US5750736A (en) 1996-07-11 1996-07-11 Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
PCT/US1997/012307 WO1998002427A1 (en) 1996-07-11 1997-07-09 Method for acylating 10-deacetylbaccatin iii selectively at the c-10 position

Publications (2)

Publication Number Publication Date
NO986066D0 NO986066D0 (no) 1998-12-22
NO986066L true NO986066L (no) 1999-03-05

Family

ID=24724151

Family Applications (1)

Application Number Title Priority Date Filing Date
NO986066A NO986066L (no) 1996-07-11 1998-12-22 FremgangsmÕte for acetylering av 10-deacetylbaccatin-III selektivt i C-10 posisjon

Country Status (16)

Country Link
US (1) US5750736A (no)
EP (1) EP0918764B1 (no)
JP (1) JP2000514458A (no)
KR (1) KR20000023649A (no)
CN (1) CN1096453C (no)
AT (1) ATE266650T1 (no)
AU (1) AU731651B2 (no)
BR (1) BR9710234A (no)
CA (1) CA2259906A1 (no)
DE (1) DE69729100D1 (no)
EA (1) EA002001B1 (no)
HK (1) HK1019596A1 (no)
IL (1) IL127850A (no)
NO (1) NO986066L (no)
NZ (1) NZ333889A (no)
WO (1) WO1998002427A1 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5914411A (en) * 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position
US6066749A (en) * 1998-05-01 2000-05-23 Napro Biotherapeutics, Inc. Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
WO1999057105A1 (en) 1998-05-01 1999-11-11 Napro Biotherapeutics, Inc. Methods and useful intermediates for paclitaxel synthesis from c-7, c-10 di-cbz baccatin iii
US6143902A (en) * 1999-06-21 2000-11-07 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof
US6136999A (en) * 1999-06-21 2000-10-24 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof
US6495705B2 (en) 2000-03-16 2002-12-17 Napro Biotherapeutics, Inc. Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
US6281368B1 (en) 2000-03-16 2001-08-28 Napro Biotherapeutics, Inc. Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
US6358996B1 (en) 2000-06-09 2002-03-19 Napro Biotherapeutics, Inc. Stable isotope labeling of paclitaxel
EP1562927B1 (en) * 2002-10-09 2009-05-13 Chatham Biotec Ltd. Thio-analogues of paclitaxel and intermediates thereof
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
FR2696463B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2750989B1 (fr) * 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa Procede de monoacylation d'hydroxy taxanes
EP0875508B1 (en) * 1997-05-02 2003-10-22 Pharmachemie B.V. Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes

Also Published As

Publication number Publication date
WO1998002427A1 (en) 1998-01-22
JP2000514458A (ja) 2000-10-31
DE69729100D1 (de) 2004-06-17
IL127850A0 (en) 1999-10-28
US5750736A (en) 1998-05-12
HK1019596A1 (en) 2000-02-18
CA2259906A1 (en) 1998-01-22
CN1225089A (zh) 1999-08-04
IL127850A (en) 2001-11-25
NO986066D0 (no) 1998-12-22
EP0918764A1 (en) 1999-06-02
CN1096453C (zh) 2002-12-18
BR9710234A (pt) 2000-01-11
EA199900096A1 (ru) 1999-08-26
EA002001B1 (ru) 2001-10-22
NZ333889A (en) 1999-03-29
ATE266650T1 (de) 2004-05-15
EP0918764B1 (en) 2004-05-12
KR20000023649A (ko) 2000-04-25
EP0918764A4 (en) 1999-09-01
AU731651B2 (en) 2001-04-05
AU3800297A (en) 1998-02-09

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ATE223394T1 (de) Verahren zur selektiven acylierung von 10- deacetylbaccatin-iii in der c-10 position
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Legal Events

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