HK1019596A1 - Method for acylating 10-deacetylbaccatin iii selectively at the c-10 position - Google Patents

Method for acylating 10-deacetylbaccatin iii selectively at the c-10 position

Info

Publication number
HK1019596A1
HK1019596A1 HK99104736A HK99104736A HK1019596A1 HK 1019596 A1 HK1019596 A1 HK 1019596A1 HK 99104736 A HK99104736 A HK 99104736A HK 99104736 A HK99104736 A HK 99104736A HK 1019596 A1 HK1019596 A1 HK 1019596A1
Authority
HK
Hong Kong
Prior art keywords
acylating
baccatin iii
iii
solution
deacetylbaccatin iii
Prior art date
Application number
HK99104736A
Other languages
English (en)
Inventor
Nicholas J Sisti
Original Assignee
Napro Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napro Biotherapeutics Inc filed Critical Napro Biotherapeutics Inc
Publication of HK1019596A1 publication Critical patent/HK1019596A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK99104736A 1996-07-11 1999-10-25 Method for acylating 10-deacetylbaccatin iii selectively at the c-10 position HK1019596A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/678,759 US5750736A (en) 1996-07-11 1996-07-11 Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
PCT/US1997/012307 WO1998002427A1 (en) 1996-07-11 1997-07-09 Method for acylating 10-deacetylbaccatin iii selectively at the c-10 position

Publications (1)

Publication Number Publication Date
HK1019596A1 true HK1019596A1 (en) 2000-02-18

Family

ID=24724151

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99104736A HK1019596A1 (en) 1996-07-11 1999-10-25 Method for acylating 10-deacetylbaccatin iii selectively at the c-10 position

Country Status (16)

Country Link
US (1) US5750736A (xx)
EP (1) EP0918764B1 (xx)
JP (1) JP2000514458A (xx)
KR (1) KR20000023649A (xx)
CN (1) CN1096453C (xx)
AT (1) ATE266650T1 (xx)
AU (1) AU731651B2 (xx)
BR (1) BR9710234A (xx)
CA (1) CA2259906A1 (xx)
DE (1) DE69729100D1 (xx)
EA (1) EA002001B1 (xx)
HK (1) HK1019596A1 (xx)
IL (1) IL127850A (xx)
NO (1) NO986066L (xx)
NZ (1) NZ333889A (xx)
WO (1) WO1998002427A1 (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5914411A (en) * 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position
US6066749A (en) * 1998-05-01 2000-05-23 Napro Biotherapeutics, Inc. Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
WO1999057105A1 (en) 1998-05-01 1999-11-11 Napro Biotherapeutics, Inc. Methods and useful intermediates for paclitaxel synthesis from c-7, c-10 di-cbz baccatin iii
US6143902A (en) * 1999-06-21 2000-11-07 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof
US6136999A (en) * 1999-06-21 2000-10-24 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof
US6495705B2 (en) 2000-03-16 2002-12-17 Napro Biotherapeutics, Inc. Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
US6281368B1 (en) 2000-03-16 2001-08-28 Napro Biotherapeutics, Inc. Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
US6358996B1 (en) 2000-06-09 2002-03-19 Napro Biotherapeutics, Inc. Stable isotope labeling of paclitaxel
EP1562927B1 (en) * 2002-10-09 2009-05-13 Chatham Biotec Ltd. Thio-analogues of paclitaxel and intermediates thereof
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
FR2696463B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2750989B1 (fr) * 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa Procede de monoacylation d'hydroxy taxanes
EP0875508B1 (en) * 1997-05-02 2003-10-22 Pharmachemie B.V. Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes

Also Published As

Publication number Publication date
WO1998002427A1 (en) 1998-01-22
JP2000514458A (ja) 2000-10-31
NO986066L (no) 1999-03-05
DE69729100D1 (de) 2004-06-17
IL127850A0 (en) 1999-10-28
US5750736A (en) 1998-05-12
CA2259906A1 (en) 1998-01-22
CN1225089A (zh) 1999-08-04
IL127850A (en) 2001-11-25
NO986066D0 (no) 1998-12-22
EP0918764A1 (en) 1999-06-02
CN1096453C (zh) 2002-12-18
BR9710234A (pt) 2000-01-11
EA199900096A1 (ru) 1999-08-26
EA002001B1 (ru) 2001-10-22
NZ333889A (en) 1999-03-29
ATE266650T1 (de) 2004-05-15
EP0918764B1 (en) 2004-05-12
KR20000023649A (ko) 2000-04-25
EP0918764A4 (en) 1999-09-01
AU731651B2 (en) 2001-04-05
AU3800297A (en) 1998-02-09

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20060709