BR9905331A - Processo para a purificação e a cristalização de riboflavina - Google Patents

Processo para a purificação e a cristalização de riboflavina

Info

Publication number
BR9905331A
BR9905331A BR9905331-4A BR9905331A BR9905331A BR 9905331 A BR9905331 A BR 9905331A BR 9905331 A BR9905331 A BR 9905331A BR 9905331 A BR9905331 A BR 9905331A
Authority
BR
Brazil
Prior art keywords
riboflavin
crystallization
purification
degrees
cross
Prior art date
Application number
BR9905331-4A
Other languages
English (en)
Inventor
Gerhard Wagner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9905331A publication Critical patent/BR9905331A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/12—Heterocyclic compounds containing pteridine ring systems containing pteridine ring systems condensed with carbocyclic rings or ring systems
    • C07D475/14—Benz [g] pteridines, e.g. riboflavin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA A PURIFICAçãO E A CRISTALIZAçãO DE RIBOFLAVINA"<D>. Um processo para a purificação e a cristalização de riboflavina compreende dissolver a riboflavina com formato de agulha, de modificação estável A, em uma solução aquosa de ácido mineral, em uma temperatura não excedendo cerca de 30°C, com mistura intensiva, adicionar carvão vegetal ativo à solução resultante, após adsorção das impurezas dissolvidas a partir da solução sobre o carvão vegetal ativo, submeter o meio contendo o carvão vegetal ativo a uma filtração em contracorrente, sobre uma membrana cerâmica tendo um tamanho de poro de cerca de 20 a cerca de 200 nm, tratar o filtrado resultante com uma quantidade de água de cinco a dez vezes (vol./vol.), em uma temperatura não excedendo cerca de 30°C, e separar os cristais esféricos, precipitados, resultantes, de riboflavina por centrifugação ou filtração. Se desejado, os cristais esféricos assim obtidos de riboflavina podem ser lavados com água e subseq³entemente secos. A riboflavina assim purificada e cristalizada é adequada para aplicações farmacêuticas e de gêneros alimentícios.
BR9905331-4A 1998-10-19 1999-10-18 Processo para a purificação e a cristalização de riboflavina BR9905331A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98119686 1998-10-19

Publications (1)

Publication Number Publication Date
BR9905331A true BR9905331A (pt) 2000-08-15

Family

ID=8232818

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9905331-4A BR9905331A (pt) 1998-10-19 1999-10-18 Processo para a purificação e a cristalização de riboflavina

Country Status (10)

Country Link
US (1) US6150364A (pt)
EP (1) EP0995749B1 (pt)
JP (1) JP4560155B2 (pt)
KR (1) KR100647951B1 (pt)
CN (1) CN1117752C (pt)
AT (1) ATE356125T1 (pt)
BR (1) BR9905331A (pt)
CA (1) CA2282908A1 (pt)
DE (1) DE59914237D1 (pt)
ES (1) ES2283090T3 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723346B1 (en) 1999-04-30 2004-04-20 Roche Vitamins Inc. Process for preparing spray granules containing riboflavin
DE10317051A1 (de) 2003-04-11 2004-10-21 Basf Ag Verfahren zur Herstellung von Riboflavin der Modifikation B/C in Granulatform
CN1826342B (zh) 2003-07-22 2010-06-16 帝斯曼知识产权资产管理有限公司 对核黄素进行纯化的方法
CN1765897B (zh) * 2004-10-27 2010-06-23 上海凯赛生物技术研发中心有限公司 核黄素发酵液的提取工艺
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
CN102809658A (zh) * 2012-09-03 2012-12-05 南开大学 一种维生素b2的酶联免疫检测试剂盒
CN104473269A (zh) * 2014-11-21 2015-04-01 安徽农业大学 一种提高水性溶液中核黄素光稳定性的方法及其应用
CN109851619B (zh) * 2019-02-02 2021-04-23 赤峰制药股份有限公司 一种核黄素提纯工艺
CN110272424A (zh) * 2019-06-29 2019-09-24 赤峰制药股份有限公司 一种从核黄素发酵液中提取核黄素的方法
CN111595961B (zh) * 2020-04-30 2021-06-25 南京海纳医药科技股份有限公司 一种维生素b2有关物质的检测方法
CN112022832A (zh) * 2020-09-24 2020-12-04 玉溪健坤生物药业有限公司 一种nad呼吸链高品质配方原料及制备软胶囊内容物的方法
CN113383748A (zh) * 2021-07-16 2021-09-14 利津和顺北京鸭养殖有限公司 一种可提高肉鸭孵化率的肉鸭孵化方法
CN113943291B (zh) * 2021-11-30 2023-09-08 湖北广济药业股份有限公司 一种核酸酶去除核黄素中的残留dna的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA633852A (en) * 1962-01-02 Merck And Co. Preparation of a free-flowing form of riboflavin
US2324800A (en) * 1941-08-14 1943-07-20 Pfizer Charles & Co Purification of riboflavin
US2603633A (en) * 1950-01-26 1952-07-15 Commercial Solvents Corp Crystalline form of riboflavin
US2797215A (en) * 1955-04-28 1957-06-25 Commercial Solvents Corp Production of type a riboflavin crystals
DE3421714A1 (de) * 1984-06-12 1985-12-12 Basf Ag, 6700 Ludwigshafen Verfahren zur reinigung von riboflavin
JPH07102290B2 (ja) * 1987-02-18 1995-11-08 三井研削砥石株式会社 濾過方法
DE3882466T2 (de) * 1987-09-18 1993-11-11 Hoffmann La Roche Neue Form des Riboflavins.
JPH01254222A (ja) * 1988-03-31 1989-10-11 Kubota Ltd 膜分離処理方法
DE4014262A1 (de) * 1990-05-04 1991-11-07 Basf Ag Gut rieselfaehige, nichtstaubende bindemittelfreie riboflavinspruehgranulate oder -mikrogranulate aus reinem riboflavin und ein verfahren zu deren herstellung
DE4021274A1 (de) * 1990-07-04 1992-01-09 Basf Ag Verfahren zur reinigung von fermentativ hergestelltem riboflavin
EP0730034A1 (en) * 1995-03-03 1996-09-04 F. Hoffmann-La Roche Ag Purification of riboflavin
CN1056845C (zh) * 1995-03-03 2000-09-27 弗·哈夫曼-拉罗切有限公司 核黄素的纯化

Also Published As

Publication number Publication date
EP0995749A1 (de) 2000-04-26
KR20000029132A (ko) 2000-05-25
CN1251365A (zh) 2000-04-26
CA2282908A1 (en) 2000-04-19
KR100647951B1 (ko) 2006-11-17
EP0995749B1 (de) 2007-03-07
CN1117752C (zh) 2003-08-13
JP4560155B2 (ja) 2010-10-13
ES2283090T3 (es) 2007-10-16
ATE356125T1 (de) 2007-03-15
JP2000128880A (ja) 2000-05-09
DE59914237D1 (de) 2007-04-19
US6150364A (en) 2000-11-21

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]