KR100647951B1 - 리보플라빈의 정제 및 결정화 방법 - Google Patents
리보플라빈의 정제 및 결정화 방법 Download PDFInfo
- Publication number
- KR100647951B1 KR100647951B1 KR1019990044908A KR19990044908A KR100647951B1 KR 100647951 B1 KR100647951 B1 KR 100647951B1 KR 1019990044908 A KR1019990044908 A KR 1019990044908A KR 19990044908 A KR19990044908 A KR 19990044908A KR 100647951 B1 KR100647951 B1 KR 100647951B1
- Authority
- KR
- South Korea
- Prior art keywords
- riboflavin
- crystallization
- solution
- active charcoal
- filtration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/12—Heterocyclic compounds containing pteridine ring systems containing pteridine ring systems condensed with carbocyclic rings or ring systems
- C07D475/14—Benz [g] pteridines, e.g. riboflavin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
실시예 | 변형 (X-선 구조 분석에 따라) | 리보플라빈 함량 (HPLC에 따라) | 루미크롬 함량 (HPLC에 따라) | 루미플라빈 함량 (HPLC에 따라) | 아미노산 함량 |
1 | B | 98% | 0.08% | - | 0.1% |
2 | B | 98.9% | 0.15% | - | 0.06% |
3 | B | 99% | 0.15% | 0.25% | - |
Claims (1)
- 30℃를 초과하지 않는 온도에서 수성 무기산 용액 중에 안정한 변형 A인 바늘형 리보플라빈을 강력하게 혼합시키면서 용해시키는 단계, 생성된 용액에 활성 차콜을 첨가하는 단계, 용액에서 나온 용해된 불순물을 활성 차콜상에 흡착시킨 후, 활성 차콜을 함유하는 매질을 20 내지 200nm의 공극 크기를 갖는 세라믹 막에 대해 역류 여과시키는 단계, 생성된 여액을 30℃를 초과하지 않는 온도에서 5 내지 10배의 양(v/v)의 물로 처리하는 단계, 및 생성된 침전된 구형의 리보플라빈 결정을 원심분리 또는 여과에 의해 분리하는 단계를 포함하는, 리보플라빈의 정제 및 결정화 방법.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98119686 | 1998-10-19 | ||
EP98119686.8 | 1998-10-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20000029132A KR20000029132A (ko) | 2000-05-25 |
KR100647951B1 true KR100647951B1 (ko) | 2006-11-17 |
Family
ID=8232818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019990044908A KR100647951B1 (ko) | 1998-10-19 | 1999-10-16 | 리보플라빈의 정제 및 결정화 방법 |
Country Status (10)
Country | Link |
---|---|
US (1) | US6150364A (ko) |
EP (1) | EP0995749B1 (ko) |
JP (1) | JP4560155B2 (ko) |
KR (1) | KR100647951B1 (ko) |
CN (1) | CN1117752C (ko) |
AT (1) | ATE356125T1 (ko) |
BR (1) | BR9905331A (ko) |
CA (1) | CA2282908A1 (ko) |
DE (1) | DE59914237D1 (ko) |
ES (1) | ES2283090T3 (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6723346B1 (en) | 1999-04-30 | 2004-04-20 | Roche Vitamins Inc. | Process for preparing spray granules containing riboflavin |
DE10317051A1 (de) * | 2003-04-11 | 2004-10-21 | Basf Ag | Verfahren zur Herstellung von Riboflavin der Modifikation B/C in Granulatform |
WO2005014594A1 (en) * | 2003-07-22 | 2005-02-17 | Dsm Ip Assets B.V. | Process for the purification of riboflavin |
CN1765897B (zh) * | 2004-10-27 | 2010-06-23 | 上海凯赛生物技术研发中心有限公司 | 核黄素发酵液的提取工艺 |
TW200826957A (en) * | 2006-10-16 | 2008-07-01 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Purification processes for echinocandin-type compounds |
CN102809658A (zh) * | 2012-09-03 | 2012-12-05 | 南开大学 | 一种维生素b2的酶联免疫检测试剂盒 |
CN104473269A (zh) * | 2014-11-21 | 2015-04-01 | 安徽农业大学 | 一种提高水性溶液中核黄素光稳定性的方法及其应用 |
CN109851619B (zh) * | 2019-02-02 | 2021-04-23 | 赤峰制药股份有限公司 | 一种核黄素提纯工艺 |
CN110272424A (zh) * | 2019-06-29 | 2019-09-24 | 赤峰制药股份有限公司 | 一种从核黄素发酵液中提取核黄素的方法 |
CN111595961B (zh) * | 2020-04-30 | 2021-06-25 | 南京海纳医药科技股份有限公司 | 一种维生素b2有关物质的检测方法 |
CN112022832A (zh) * | 2020-09-24 | 2020-12-04 | 玉溪健坤生物药业有限公司 | 一种nad呼吸链高品质配方原料及制备软胶囊内容物的方法 |
CN113383748A (zh) * | 2021-07-16 | 2021-09-14 | 利津和顺北京鸭养殖有限公司 | 一种可提高肉鸭孵化率的肉鸭孵化方法 |
CN113943291B (zh) * | 2021-11-30 | 2023-09-08 | 湖北广济药业股份有限公司 | 一种核酸酶去除核黄素中的残留dna的方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307767A1 (en) * | 1987-09-18 | 1989-03-22 | F. Hoffmann-La Roche Ag | Novel form of riboflavin |
EP0730034A1 (en) * | 1995-03-03 | 1996-09-04 | F. Hoffmann-La Roche Ag | Purification of riboflavin |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA633852A (en) * | 1962-01-02 | Merck And Co. | Preparation of a free-flowing form of riboflavin | |
US2324800A (en) * | 1941-08-14 | 1943-07-20 | Pfizer Charles & Co | Purification of riboflavin |
US2603633A (en) * | 1950-01-26 | 1952-07-15 | Commercial Solvents Corp | Crystalline form of riboflavin |
US2797215A (en) * | 1955-04-28 | 1957-06-25 | Commercial Solvents Corp | Production of type a riboflavin crystals |
DE3421714A1 (de) * | 1984-06-12 | 1985-12-12 | Basf Ag, 6700 Ludwigshafen | Verfahren zur reinigung von riboflavin |
JPH07102290B2 (ja) * | 1987-02-18 | 1995-11-08 | 三井研削砥石株式会社 | 濾過方法 |
JPH01254222A (ja) * | 1988-03-31 | 1989-10-11 | Kubota Ltd | 膜分離処理方法 |
DE4014262A1 (de) * | 1990-05-04 | 1991-11-07 | Basf Ag | Gut rieselfaehige, nichtstaubende bindemittelfreie riboflavinspruehgranulate oder -mikrogranulate aus reinem riboflavin und ein verfahren zu deren herstellung |
DE4021274A1 (de) * | 1990-07-04 | 1992-01-09 | Basf Ag | Verfahren zur reinigung von fermentativ hergestelltem riboflavin |
CN1056845C (zh) * | 1995-03-03 | 2000-09-27 | 弗·哈夫曼-拉罗切有限公司 | 核黄素的纯化 |
-
1999
- 1999-09-20 CA CA002282908A patent/CA2282908A1/en not_active Abandoned
- 1999-10-12 CN CN99121368A patent/CN1117752C/zh not_active Expired - Lifetime
- 1999-10-13 EP EP99120364A patent/EP0995749B1/de not_active Expired - Lifetime
- 1999-10-13 AT AT99120364T patent/ATE356125T1/de not_active IP Right Cessation
- 1999-10-13 DE DE59914237T patent/DE59914237D1/de not_active Expired - Lifetime
- 1999-10-13 ES ES99120364T patent/ES2283090T3/es not_active Expired - Lifetime
- 1999-10-15 JP JP29306399A patent/JP4560155B2/ja not_active Expired - Lifetime
- 1999-10-16 KR KR1019990044908A patent/KR100647951B1/ko active IP Right Grant
- 1999-10-18 BR BR9905331-4A patent/BR9905331A/pt not_active Application Discontinuation
- 1999-10-19 US US09/420,824 patent/US6150364A/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307767A1 (en) * | 1987-09-18 | 1989-03-22 | F. Hoffmann-La Roche Ag | Novel form of riboflavin |
EP0730034A1 (en) * | 1995-03-03 | 1996-09-04 | F. Hoffmann-La Roche Ag | Purification of riboflavin |
Also Published As
Publication number | Publication date |
---|---|
JP4560155B2 (ja) | 2010-10-13 |
JP2000128880A (ja) | 2000-05-09 |
BR9905331A (pt) | 2000-08-15 |
CN1117752C (zh) | 2003-08-13 |
EP0995749A1 (de) | 2000-04-26 |
US6150364A (en) | 2000-11-21 |
CA2282908A1 (en) | 2000-04-19 |
KR20000029132A (ko) | 2000-05-25 |
EP0995749B1 (de) | 2007-03-07 |
CN1251365A (zh) | 2000-04-26 |
DE59914237D1 (de) | 2007-04-19 |
ATE356125T1 (de) | 2007-03-15 |
ES2283090T3 (es) | 2007-10-16 |
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