BR9814897A - S-óxido e s,s-dióxido de feniloxazolidinonas tetrahidrotiopirano - Google Patents

S-óxido e s,s-dióxido de feniloxazolidinonas tetrahidrotiopirano

Info

Publication number
BR9814897A
BR9814897A BR9814897-4A BR9814897A BR9814897A BR 9814897 A BR9814897 A BR 9814897A BR 9814897 A BR9814897 A BR 9814897A BR 9814897 A BR9814897 A BR 9814897A
Authority
BR
Brazil
Prior art keywords
tetrahydrothiopyrane
oxide
phenyloxazolidinones
dichloromethyl
ethyl
Prior art date
Application number
BR9814897-4A
Other languages
English (en)
Inventor
Toni-Jo Poel
Joseph P Martin Jr
Michael R Barbachyn
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BR9814897A publication Critical patent/BR9814897A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

<B>S-óXIDO E S,S-DIóXIDO DE FENILOXAZOLIDINONAS TETRAHIDROTIOPIRANO<D> A presente invenção fornece compostos da fórmula I e da fórmula II úteis como agentes antimicrobianos em que R1 é metil, etil, ciclopropil ou diclorometil; R2 e R3 são, independentemente, hidrogênio ou fluor; R4 é etil ou diclorometil. A invenção também se relaciona a um novel levantamento para determinar a atividade inibitória das oxazolidinonas em oxidase monoamina humana.
BR9814897-4A 1997-12-05 1998-11-23 S-óxido e s,s-dióxido de feniloxazolidinonas tetrahidrotiopirano BR9814897A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6783097P 1997-12-05 1997-12-05
US8949898P 1998-06-16 1998-06-16
US10018598P 1998-09-14 1998-09-14
PCT/US1998/024526 WO1999029688A1 (en) 1997-12-05 1998-11-23 S-oxide and s,s-dioxide tetrahydrothiopyran phenyloxazolidinones

Publications (1)

Publication Number Publication Date
BR9814897A true BR9814897A (pt) 2000-10-03

Family

ID=27371238

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814897-4A BR9814897A (pt) 1997-12-05 1998-11-23 S-óxido e s,s-dióxido de feniloxazolidinonas tetrahidrotiopirano

Country Status (22)

Country Link
US (2) US6083967A (pt)
EP (2) EP1254906A1 (pt)
JP (1) JP2001525408A (pt)
KR (1) KR20010032782A (pt)
CN (2) CN1532535A (pt)
AT (1) ATE231859T1 (pt)
AU (2) AU752454B2 (pt)
BR (1) BR9814897A (pt)
CA (1) CA2309026A1 (pt)
DE (1) DE69811117T2 (pt)
DK (1) DK1036074T3 (pt)
ES (1) ES2191985T3 (pt)
HK (1) HK1032970A1 (pt)
HU (1) HUP0100558A3 (pt)
ID (1) ID21450A (pt)
NO (1) NO316447B1 (pt)
NZ (1) NZ504930A (pt)
PL (1) PL340835A1 (pt)
SI (1) SI1036074T1 (pt)
SK (1) SK7692000A3 (pt)
TW (2) TWI239331B (pt)
WO (1) WO1999029688A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511468B1 (en) * 1997-10-17 2003-01-28 Micro Therapeutics, Inc. Device and method for controlling injection of liquid embolic composition
JP2002517498A (ja) 1998-06-05 2002-06-18 アストラゼネカ アクチボラグ 化学化合物
MY120189A (en) * 1999-11-04 2005-09-30 Upjohn Co Sultam and sultone derived oxazolidinones
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
WO2004014897A1 (en) 2002-08-12 2004-02-19 Pharmacia & Upjohn Company Llc N-aryl-2-oxazolidinones and their derivatives
DE60309504T2 (de) 2002-11-21 2007-05-16 Pharmacia & Upjohn Co. Llc, Kalamazoo N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5-carbosäureamid-derivate und verwandte verbindungen als antibakterielle mittel
DE10300111A1 (de) * 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
BRPI0616801B8 (pt) 2005-10-04 2021-05-25 Bayer Healthcare Ag "forma polimórfica de 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofenocarboxamida, seus processos de preparação e seus usos, medicamento, e processo para prevenção de coagulação de sangue in vitro
DE102005047558A1 (de) * 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
CN102262066A (zh) * 2011-06-16 2011-11-30 董理 一种检测单胺氧化酶含量的方法和试剂盒
CN104610479B (zh) * 2013-11-05 2017-03-29 中国石油化工股份有限公司 用于乙烯聚合的负载化茂金属催化剂及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1302422C (en) * 1986-09-03 1992-06-02 Margherita Strolin-Benedetti 5-aminoethyloxazolidin-2-one derivatives, process for the preparation thereofand their therapeutic use
US4885154A (en) * 1988-03-01 1989-12-05 Alza Corporation Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5130316A (en) * 1988-07-29 1992-07-14 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazlidinyl arylbenzene derivatives useful as antibacterial agents
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
JP2669579B2 (ja) * 1991-10-23 1997-10-29 エーザイ株式会社 オキサゾリドン誘導体
KR100257418B1 (ko) * 1991-11-01 2000-05-15 로렌스 티. 마이젠헬더 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논
CZ288788B6 (cs) * 1992-12-08 2001-09-12 Pharmacia & Upjohn Company Antibakteriální fenyloxazolidinony substituované troponem
US5968962A (en) * 1995-09-01 1999-10-19 Pharmacia & Upjohn Company Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
EP1254906A1 (en) 2002-11-06
ES2191985T3 (es) 2003-09-16
NO20002834L (no) 2000-07-21
NO316447B1 (no) 2004-01-26
KR20010032782A (ko) 2001-04-25
TW200307673A (en) 2003-12-16
NZ504930A (en) 2002-05-31
ATE231859T1 (de) 2003-02-15
CN1154645C (zh) 2004-06-23
AU752454B2 (en) 2002-09-19
CA2309026A1 (en) 1999-06-17
AU1796899A (en) 1999-06-28
SK7692000A3 (en) 2001-03-12
DE69811117D1 (de) 2003-03-06
HK1032970A1 (en) 2001-08-10
TW553942B (en) 2003-09-21
DK1036074T3 (da) 2003-06-23
HUP0100558A3 (en) 2002-08-28
HUP0100558A2 (hu) 2002-05-29
WO1999029688A1 (en) 1999-06-17
ID21450A (id) 1999-06-10
CN1278817A (zh) 2001-01-03
DE69811117T2 (de) 2003-07-17
AU2002301031B2 (en) 2005-08-25
EP1036074A1 (en) 2000-09-20
NO20002834D0 (no) 2000-06-02
JP2001525408A (ja) 2001-12-11
US6083967A (en) 2000-07-04
TWI239331B (en) 2005-09-11
EP1036074B1 (en) 2003-01-29
PL340835A1 (en) 2001-02-26
CN1532535A (zh) 2004-09-29
US6265178B1 (en) 2001-07-24
SI1036074T1 (en) 2003-08-31

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.