BR9813004A - Processo para produzir novos policetìdeos - Google Patents

Processo para produzir novos policetìdeos

Info

Publication number
BR9813004A
BR9813004A BR9813004-8A BR9813004A BR9813004A BR 9813004 A BR9813004 A BR 9813004A BR 9813004 A BR9813004 A BR 9813004A BR 9813004 A BR9813004 A BR 9813004A
Authority
BR
Brazil
Prior art keywords
polyketides
new polyketides
producing new
produce
modified pks
Prior art date
Application number
BR9813004-8A
Other languages
English (en)
Inventor
Chaitan Khosla
Rembert Pieper
Guanglin Luo
David E Cane
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of BR9813004A publication Critical patent/BR9813004A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: "PROCESSO PARA PRODUZIR POLICETìDEOS". Agrupamentos de genes PKS modificados que produzem novos policetídeos em um sistema eficiente em uma célula hospedeira ou em um extrato livre de células são descritos. Os novos policetídeos resultam da incorporação de dicetídeos de fórmula (1) ou (2), em que A é uma porção que ativa o dicetídeo, e pelo menos um dentre R^ 1^ e R^ 2^ é um substituinte diferente do que ocorre nativamente no dicetídeo normalmente processado pelo agrupamento de PKS modificado. Os policetídeos podem ser também glicosilados para prover antibióticos.
BR9813004-8A 1997-07-17 1998-07-17 Processo para produzir novos policetìdeos BR9813004A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/896,323 US6066721A (en) 1995-07-06 1997-07-17 Method to produce novel polyketides
PCT/US1998/014911 WO1999003986A2 (en) 1997-07-17 1998-07-17 Method to produce polyketides and polyketides

Publications (1)

Publication Number Publication Date
BR9813004A true BR9813004A (pt) 2002-02-05

Family

ID=25406015

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813004-8A BR9813004A (pt) 1997-07-17 1998-07-17 Processo para produzir novos policetìdeos

Country Status (13)

Country Link
US (3) US6066721A (pt)
EP (1) EP0996714A2 (pt)
JP (1) JP2001510038A (pt)
KR (1) KR20010021933A (pt)
CN (1) CN1267332A (pt)
AU (1) AU736972B2 (pt)
BR (1) BR9813004A (pt)
CA (1) CA2296728A1 (pt)
HU (1) HUP0003728A2 (pt)
IL (1) IL134074A0 (pt)
MX (1) MXPA00000623A (pt)
NZ (1) NZ502360A (pt)
WO (1) WO1999003986A2 (pt)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US6066721A (en) * 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US6927057B2 (en) 1993-09-20 2005-08-09 Kosan Biosciences Macrolide analogs
US6558942B1 (en) * 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US20030170725A1 (en) * 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
IL122859A0 (en) * 1995-07-06 1998-08-16 Univ Leland Stanford Junior Cell-free synthesis of polyketides
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
US6960453B1 (en) * 1996-07-05 2005-11-01 Biotica Technology Limited Hybrid polyketide synthases combining heterologous loading and extender modules
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US20040209322A1 (en) * 1997-04-30 2004-10-21 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US20080003648A1 (en) * 1997-04-30 2008-01-03 Chaitan Khosla Method to prepare macrolide analogs
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AU765821B2 (en) 1998-07-02 2003-10-02 Board Of Regents Of The Leland Stanford Junior University, The Methods for making polyketides
US6177262B1 (en) 1998-09-22 2001-01-23 Kosan Biosciences, Inc. Recombinant host cells for the production of polyketides
US6388099B2 (en) 1998-10-29 2002-05-14 Kosan Biosciences, Inc. Production of 8,8a-dihydroxy-6-deoxyerythronolide B
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
NZ511722A (en) 1998-11-20 2004-05-28 Kosan Biosciences Inc Recombinant methods and materials for producing epothilone and epothilone derivatives
AU3353500A (en) 1999-01-27 2000-08-18 Kosan Biosciences, Inc. Synthesis of oligoketides
EP1754700A3 (en) 1999-01-27 2007-05-09 Kosan Biosciences, Inc. Synthesis of oligoketides
WO2000047724A2 (en) 1999-02-09 2000-08-17 Board Of Trustees Of The Leland Stanford Junior University Methods to mediate polyketide synthase module effectiveness
US7001748B2 (en) * 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
US6458771B1 (en) 1999-04-16 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
WO2000063224A2 (en) 1999-04-16 2000-10-26 Kosan Biosciences, Inc. Macrolide antiinfective agents
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
AU783158B2 (en) * 1999-08-24 2005-09-29 Ariad Pharmaceuticals, Inc. 28-epirapalogs
US6524841B1 (en) 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
US7033818B2 (en) * 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
MXPA02003754A (es) * 1999-10-13 2003-10-14 Univ Leland Stanford Junior Biosintesis de sustratos de policetido sintasa.
US6939691B1 (en) 1999-10-13 2005-09-06 Board Of Trustees Of The Leland Stanford Junior University E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production
AU1231701A (en) * 1999-10-25 2001-05-08 Kosan Biosciences, Inc. Production of polyketides
ES2283344T3 (es) * 1999-10-29 2007-11-01 Kosan Biosciences, Inc. Analogos de la rapamicina.
EP1255763A2 (en) 2000-02-18 2002-11-13 Kosan Biosciences, Inc. Motilide compounds
CA2402398A1 (en) * 2000-02-24 2001-08-30 Kyowa Hakko Kogyo Co., Ltd. Process for producing avermectin derivative
WO2001092991A2 (en) 2000-05-30 2001-12-06 Kosan Biosciences, Inc. Design of polyketide synthase genes
CA2348145C (en) * 2001-05-22 2005-04-12 Surface Engineered Products Corporation Protective system for high temperature metal alloys
AU2001283275A1 (en) * 2000-08-09 2002-02-18 Kosan Biosciences, Inc. Bio-intermediates for use in the chemical synthesis of polyketides
US20030077759A1 (en) * 2000-12-28 2003-04-24 Zhihao Hu Plasmids for polyketide production
AU2003213757A1 (en) * 2002-03-04 2003-09-22 Brown University Research Foundation Methods to mediate polyketide synthase module effectiveness
WO2003106638A2 (en) * 2002-06-13 2003-12-24 Kosan Biosciences, Inc. Methods and cells for improved production of polyketides
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
WO2004007688A2 (en) 2002-07-15 2004-01-22 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
EP1527160A4 (en) * 2002-07-31 2005-09-14 Univ Leland Stanford Junior PRODUCTION OF GLYCOSYL MACROLIDES IN E. COLI
SI1532131T1 (sl) * 2002-08-29 2009-04-30 Pfizer Motilidne spojine
JP2006517090A (ja) * 2002-09-26 2006-07-20 コーサン バイオサイエンシーズ， インコーポレイテッド 合成遺伝子
WO2004029224A2 (en) * 2002-09-30 2004-04-08 Compound Therapeutics, Inc. Methods of engineering spatially conserved motifs in polypeptides
AU2003291534A1 (en) * 2002-11-12 2004-06-03 Kosan Biosciences, Inc. Method for producing polyketides
US7799904B2 (en) * 2003-06-13 2010-09-21 University Of Kentucky Research Foundation Gilvocarcin gene cluster, recombinant production and use thereof
US7459294B2 (en) * 2003-08-08 2008-12-02 Kosan Biosciences Incorporated Method of producing a compound by fermentation
EP2658855A2 (en) * 2010-12-31 2013-11-06 Acies Bio d.o.o. Novel polyketide compounds and methods of making same
PE20230431A1 (es) 2020-04-29 2023-03-08 Teneobio Inc Anticuerpos de cadena pesada multiespecificos con regiones constantes de cadena pesada modificadas

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551433A (en) * 1981-05-18 1985-11-05 Genentech, Inc. Microbial hybrid promoters
US4935340A (en) * 1985-06-07 1990-06-19 Eli Lilly And Company Method of isolating antibiotic biosynthetic genes
US4874748A (en) * 1986-03-24 1989-10-17 Abbott Laboratories Cloning vectors for streptomyces and use thereof in macrolide antibiotic production
US5149639A (en) * 1986-03-24 1992-09-22 Abbott Laboratories Biologically pure cultures of streptomyces and use thereof in macrolide antibiotic production
US5168052A (en) * 1988-03-28 1992-12-01 Eli Lilly And Company Method for producing 20-deoxotylosin
US5063155A (en) * 1988-03-28 1991-11-05 Eli Lilly And Company Method for producing 2"'-o-demethyltylosin
US5098837A (en) * 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5188944A (en) * 1990-06-22 1993-02-23 Merck & Co., Inc. Process for the glycosylation of avermectin agylcones
US5475099A (en) * 1990-08-15 1995-12-12 Calgene Inc. Plant fatty acid synthases
US5824513A (en) * 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US5514544A (en) * 1991-07-26 1996-05-07 Eli Lilly And Company Activator gene for macrolide biosynthesis
US6066721A (en) * 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
ATE297992T1 (de) * 1993-09-20 2005-07-15 Univ Leland Stanford Junior Recombinante herstellung aromatischer polyketiden
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
IL122859A0 (en) * 1995-07-06 1998-08-16 Univ Leland Stanford Junior Cell-free synthesis of polyketides
ATE328069T1 (de) * 1995-10-13 2006-06-15 Harvard College Phosphopantethenyltransferasen und deren verwendungen
CA2197524A1 (en) * 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
CA2197160C (en) * 1996-02-22 2007-05-01 Stanley Gene Burgett Platenolide synthase gene
US6271255B1 (en) * 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
AU732909B2 (en) * 1997-04-30 2001-05-03 Board Of Trustees Of The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold

Also Published As

Publication number Publication date
WO1999003986A3 (en) 1999-04-08
US6066721A (en) 2000-05-23
IL134074A0 (en) 2001-04-30
EP0996714A2 (en) 2000-05-03
AU736972B2 (en) 2001-08-09
CA2296728A1 (en) 1999-01-28
NZ502360A (en) 2001-11-30
CN1267332A (zh) 2000-09-20
MXPA00000623A (es) 2002-04-24
US20010024811A1 (en) 2001-09-27
US6261816B1 (en) 2001-07-17
WO1999003986A2 (en) 1999-01-28
JP2001510038A (ja) 2001-07-31
KR20010021933A (ko) 2001-03-15
HUP0003728A2 (hu) 2001-02-28
AU8412398A (en) 1999-02-10

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.