BR9811037A - Utilização de ligantes mhc classe ii como coadjuvante para vacinação e de lag-3 no tratamento do câncer - Google Patents

Utilização de ligantes mhc classe ii como coadjuvante para vacinação e de lag-3 no tratamento do câncer

Info

Publication number
BR9811037A
BR9811037A BR9811037-3A BR9811037A BR9811037A BR 9811037 A BR9811037 A BR 9811037A BR 9811037 A BR9811037 A BR 9811037A BR 9811037 A BR9811037 A BR 9811037A
Authority
BR
Brazil
Prior art keywords
lag
vaccination
mhc class
class
ligands
Prior art date
Application number
BR9811037-3A
Other languages
English (en)
Inventor
Frederic Triebel
Original Assignee
Roussy Inst Gustave
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussy Inst Gustave, Applied Research Systems filed Critical Roussy Inst Gustave
Publication of BR9811037A publication Critical patent/BR9811037A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"UTILIZAçãO DE LIGANTES MHC CLASSE II COMO COADJUVANTE PARA VACINAçãO E DE LAG-3 NO TRATAMENTO DO CâNCER"<D>. A presente invenção refere-se ao uso de ligante MHC classe II, tal como CD4 e LAG-3 para fabricação de um medicamento para prevenir ou tratar condições patológicas envolvendo uma resposta imune específica para antígeno, bem como o uso de LAG-3 em imunoterapia de câncer. A invenção também refere-se a composição farmacêutica compreendendo uma quantidade eficaz de um antígeno capaz de induzir uma resposta imune específica para antígeno, juntamente com uma quantidade eficaz de um ligante MHC classe II, onde o dito ligante MHC classe II está presente como um agente semelhante a coadjuvante.
BR9811037-3A 1997-07-25 1998-07-23 Utilização de ligantes mhc classe ii como coadjuvante para vacinação e de lag-3 no tratamento do câncer BR9811037A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97401800A EP0893507A1 (en) 1997-07-25 1997-07-25 Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment
PCT/EP1998/004621 WO1999004810A2 (en) 1997-07-25 1998-07-23 Use of mhc class ii ligands as adjuvant for vaccination and of lag-3 in cancer treatment

Publications (1)

Publication Number Publication Date
BR9811037A true BR9811037A (pt) 2000-08-01

Family

ID=8229825

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811037-3A BR9811037A (pt) 1997-07-25 1998-07-23 Utilização de ligantes mhc classe ii como coadjuvante para vacinação e de lag-3 no tratamento do câncer

Country Status (20)

Country Link
US (2) US6410509B1 (pt)
EP (3) EP0893507A1 (pt)
JP (1) JP4723722B2 (pt)
KR (1) KR100603075B1 (pt)
CN (1) CN1184320C (pt)
AT (2) ATE324455T1 (pt)
AU (1) AU753738B2 (pt)
BR (1) BR9811037A (pt)
CA (2) CA2293805C (pt)
DE (2) DE69834330T2 (pt)
DK (1) DK1002108T3 (pt)
EA (3) EA003740B1 (pt)
EE (1) EE200000039A (pt)
ES (1) ES2262242T3 (pt)
HK (1) HK1030014A1 (pt)
IL (2) IL134212A0 (pt)
NO (1) NO20000378D0 (pt)
PT (1) PT1002108E (pt)
UA (1) UA75322C2 (pt)
WO (1) WO1999004810A2 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE519779T1 (de) * 2001-09-19 2011-08-15 Roussy Inst Gustave An das glu-pro motiv-bindende proteine und peptide, diese enthaltende therapeutische zusammensetzungen und deren anwendungen
AU2004217526B2 (en) * 2003-02-28 2010-02-04 St. Jude Children's Research Hospital Inc. T cell regulation
KR20050082389A (ko) * 2004-02-18 2005-08-23 메덱스젠 주식회사 직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물
FR2868781B1 (fr) 2004-04-13 2008-02-22 Immutep Composition de vaccin comprenant un ligand cmh de classe ii couple a un antigene, procede de preparation et utilisations
EP2044949A1 (en) * 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
WO2011031139A1 (en) 2009-09-09 2011-03-17 Universiteit Utrecht Holding B.V. An ataq protein or a part thereof as a vaccine
SA110310855B1 (ar) 2009-11-13 2014-09-16 Laboratories Leti S L Unipersonal استخدام مصدر l3 و/ أو l5 كلقاح أو كوسيلة تشخيصية لمرض طفيلي
AR083829A1 (es) 2010-11-10 2013-03-27 Leti S L Unipersonal Lab Coadyuvante con potencialidad inmunogenica incrementada
GB201322626D0 (en) 2013-12-19 2014-02-05 Immutep S A Combined preparations for the treatment of cancer
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
CN103751778B (zh) * 2014-01-28 2016-09-28 复旦大学 3′-脱氧腺苷在制备广谱疫苗增效的免疫佐剂中的应用
US20150259420A1 (en) 2014-03-14 2015-09-17 Novartis Ag Antibody molecules to lag-3 and uses thereof
CN107001418A (zh) 2014-10-07 2017-08-01 Cytlimic公司 源于hsp70的肽、使用其的用于治疗或预防癌症的医药组合物、免疫诱导剂、及抗原呈递细胞的制造方法
US9827308B2 (en) 2014-12-10 2017-11-28 Wisconsin Alumni Research Foundation Mini-intronic plasmid DNA vaccines in combination with LAG3 blockade
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer
DK3269733T3 (da) 2015-03-09 2020-07-27 Cytlimic Inc Peptid afledt af gpc3, farmaceutisk sammensætning til behandling eller forebyggelse af cancer under anvendelse deraf, immunitetsinducer og fremgangsmåde til fremstilling af antigenpræsenterende celler
JP6311094B2 (ja) * 2015-04-07 2018-04-18 サイトリミック株式会社 医薬
EP3294324A1 (en) 2015-05-13 2018-03-21 Agenus Inc. Vaccines for treatment and prevention of cancer
MX2017016844A (es) 2015-07-16 2018-08-15 Biokine Therapeutics Ltd Composiciones y procedimientos para tratar cancer.
US10265379B2 (en) 2015-09-16 2019-04-23 Annabelle Rodriguez Oquendo Use of recombinant lymphocyte activation gene-3 as a companion therapeutic for patients at risk for cardiovascular disease and other chronic inflammatory diseases
US20180256633A1 (en) 2015-09-18 2018-09-13 Rijksuniversiteit Groningen Long chain inulin for stimulating an immune response
TW201813664A (zh) 2016-10-11 2018-04-16 賽多利克公司 醫藥
CN108204958A (zh) * 2016-12-19 2018-06-26 伊缪泰普有限公司 结合测定
EP3784688A2 (en) 2018-04-26 2021-03-03 Agenus Inc. Heat shock protein-binding peptide compositions and methods of use thereof
BR112021005221A2 (pt) * 2018-09-27 2021-06-15 Genocea Biosciences Inc. métodos de tratamento
JP2020138940A (ja) 2019-02-28 2020-09-03 テルモ株式会社 治療方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT88641B (pt) * 1987-10-02 1993-04-30 Genentech Inc Metodo para a preparacao de uma variante de adesao
JPH03505039A (ja) * 1988-08-22 1991-11-07 アメリカ合衆国 可溶性ｃｄ４を発現するレトロウイルスベクター、エイズの遺伝子治療法
JPH02231083A (ja) * 1988-08-31 1990-09-13 Eisai Co Ltd 組換ナチュラルキラー細胞活性化因子
EP0385909B1 (en) * 1989-03-03 1994-07-13 MicroGeneSys, Inc. A kit or composition for the prevention or treatment of HIV-1 infections
EP0394827A1 (en) * 1989-04-26 1990-10-31 F. Hoffmann-La Roche Ag Chimaeric CD4-immunoglobulin polypeptides
FR2656800B1 (fr) * 1990-01-08 1992-05-15 Roussy Inst Gustave Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
US5851828A (en) * 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
ES2249760T3 (es) * 1993-01-26 2006-04-01 The Trustees Of The University Of Pennsylvania (A Corporation Of Pennsylvania) Composiciones y procedimientos de administracion de materias geneticas.
SE510135C2 (sv) * 1994-05-05 1999-04-19 Berol Nobel Ab Vattenhaltig suspension av en cellulosaeter, sätt för dess framställning samt komposition
ATE352617T1 (de) * 1994-05-06 2007-02-15 Roussy Inst Gustave Lösliche polypeptidfraktionen des lag-3-proteins; verfahren zur herstellung; therapeutische zusamensetzung; antiidiotypischer antikörper
MX9700560A (es) * 1994-08-05 1997-05-31 Warner Lambert Co Metodo de uso de integrasa retroviral negativa transdominante en el tratamiento de infecciones retrovirales.
JP2001506122A (ja) * 1994-12-07 2001-05-15 エフ．ホフマン−ラ ロシュ アーゲー 免疫抑制作用を有するモノクローナル抗体断片
CN1171117A (zh) * 1994-12-23 1998-01-21 实验室奥姆公司 Mhc－ⅱ结合和/或mhc－ⅱ模拟分子用于预防和/或治疗炎性疾病的用途
DE69627527T2 (de) * 1995-12-28 2004-03-04 The Johns Hopkins University School Of Medicine Allogene parakrine cytokine tumor impfstoffe

Also Published As

Publication number Publication date
AU9254798A (en) 1999-02-16
WO1999004810A3 (en) 1999-07-08
UA75322C2 (en) 2006-04-17
EE200000039A (et) 2000-10-16
EA200300092A1 (ru) 2003-06-26
CN1265149A (zh) 2000-08-30
JP2001510806A (ja) 2001-08-07
JP4723722B2 (ja) 2011-07-13
CN1184320C (zh) 2005-01-12
US6410509B1 (en) 2002-06-25
EA003740B1 (ru) 2003-08-28
EP1002108B1 (en) 2006-04-26
IL134212A (en) 2012-03-29
ATE478956T1 (de) 2010-09-15
NO20000378L (no) 2000-01-25
ATE324455T1 (de) 2006-05-15
KR100603075B1 (ko) 2006-07-20
EP1698701B1 (en) 2010-08-25
KR20010021706A (ko) 2001-03-15
DK1002108T3 (da) 2006-08-21
EP1698701A1 (en) 2006-09-06
EA005405B1 (ru) 2005-02-24
ES2262242T3 (es) 2006-11-16
EA200000161A1 (ru) 2000-10-30
EP0893507A1 (en) 1999-01-27
AU753738B2 (en) 2002-10-24
CA2732570A1 (en) 1999-02-04
CA2293805C (en) 2011-05-03
CA2732570C (en) 2014-11-18
CA2293805A1 (en) 1999-02-04
DE69834330D1 (de) 2006-06-01
PT1002108E (pt) 2006-09-29
US20020192195A1 (en) 2002-12-19
WO1999004810A2 (en) 1999-02-04
HK1030014A1 (en) 2001-04-20
DE69841866D1 (de) 2010-10-07
IL134212A0 (en) 2001-04-30
EA200200565A1 (ru) 2002-10-31
NO20000378D0 (no) 2000-01-25
US7109026B2 (en) 2006-09-19
EP1002108A2 (en) 2000-05-24
DE69834330T2 (de) 2007-03-29

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