IT1277926B1 - Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire - Google Patents

Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire

Info

Publication number
IT1277926B1
IT1277926B1 IT95RM000589A ITRM950589A IT1277926B1 IT 1277926 B1 IT1277926 B1 IT 1277926B1 IT 95RM000589 A IT95RM000589 A IT 95RM000589A IT RM950589 A ITRM950589 A IT RM950589A IT 1277926 B1 IT1277926 B1 IT 1277926B1
Authority
IT
Italy
Prior art keywords
treat
pharmaceutical compositions
immunogens
preparation
prevent
Prior art date
Application number
IT95RM000589A
Other languages
English (en)
Inventor
Gennaro Ciliberto
Rocco Savino
Riccardo Cortese
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Publication of ITRM950589A0 publication Critical patent/ITRM950589A0/it
Priority to IT95RM000589A priority Critical patent/IT1277926B1/it
Priority to EP96930345A priority patent/EP0858345B1/en
Priority to DE69624498T priority patent/DE69624498T2/de
Priority to DK96930345T priority patent/DK0858345T3/da
Priority to KR1019980701561A priority patent/KR100279539B1/ko
Priority to JP51104897A priority patent/JP3157837B2/ja
Priority to RU98105679/14A priority patent/RU2182014C2/ru
Priority to AT96930345T priority patent/ATE226446T1/de
Priority to AU69428/96A priority patent/AU703300B2/en
Priority to PT96930345T priority patent/PT858345E/pt
Priority to CA002229045A priority patent/CA2229045C/en
Priority to ES96930345T priority patent/ES2183007T3/es
Priority to CNB961972955A priority patent/CN1138562C/zh
Priority to MX9801550A priority patent/MX9801550A/es
Priority to PCT/IT1996/000164 priority patent/WO1997009064A1/en
Publication of ITRM950589A1 publication Critical patent/ITRM950589A1/it
Application granted granted Critical
Publication of IT1277926B1 publication Critical patent/IT1277926B1/it
Priority to HK99100962A priority patent/HK1015708A1/xx
Priority to US09/559,950 priority patent/US6706261B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Noise Elimination (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT95RM000589A 1995-09-01 1995-09-01 Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire IT1277926B1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT95RM000589A IT1277926B1 (it) 1995-09-01 1995-09-01 Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire
AU69428/96A AU703300B2 (en) 1995-09-01 1996-08-22 Use of muteins of wild-type cytokines as immunogens
CA002229045A CA2229045C (en) 1995-09-01 1996-08-22 Use of muteins of wild-type cytokines as immunogens
DK96930345T DK0858345T3 (da) 1995-09-01 1996-08-22 Anvendelse af muteiner af vildtypecytokiner som immunogener
KR1019980701561A KR100279539B1 (ko) 1995-09-01 1996-08-22 야생형 시토킨의 뮤테인의 면역원으로서의 용도
JP51104897A JP3157837B2 (ja) 1995-09-01 1996-08-22 免疫原としての野生型サイトカインのミューティンの使用
RU98105679/14A RU2182014C2 (ru) 1995-09-01 1996-08-22 Использование мутеинов цитокинов дикого типа в качестве иммуногенов
AT96930345T ATE226446T1 (de) 1995-09-01 1996-08-22 Muteine von wildtyp-cytokinen und ihre verwendung als immunogene
EP96930345A EP0858345B1 (en) 1995-09-01 1996-08-22 Use of muteins of wild-type cytokines as immunogens
PT96930345T PT858345E (pt) 1995-09-01 1996-08-22 Uso de muteinas de citocinas do tipo selvagem como imunogenios
DE69624498T DE69624498T2 (de) 1995-09-01 1996-08-22 Muteine von wildtyp-cytokinen und ihre verwendung als immunogene
ES96930345T ES2183007T3 (es) 1995-09-01 1996-08-22 Empleo de muteinas de citoquinas de tipo salvaje como inmunogenos.
CNB961972955A CN1138562C (zh) 1995-09-01 1996-08-22 野生型细胞因子的突变蛋白作为免疫原的用途
MX9801550A MX9801550A (es) 1995-09-01 1996-08-22 Uso de muteinas de citocinas de tipo silvestre como inmunogenos.
PCT/IT1996/000164 WO1997009064A1 (en) 1995-09-01 1996-08-22 Use of muteins of wild-type cytokines as immunogens
HK99100962A HK1015708A1 (en) 1995-09-01 1999-03-09 Use of muteins of wild-type cytokines as immunogens.
US09/559,950 US6706261B1 (en) 1995-09-01 2000-04-27 Compositions and methods comprising immunogenic muteins of interleukin-6

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95RM000589A IT1277926B1 (it) 1995-09-01 1995-09-01 Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire

Publications (3)

Publication Number Publication Date
ITRM950589A0 ITRM950589A0 (it) 1995-09-01
ITRM950589A1 ITRM950589A1 (it) 1997-03-01
IT1277926B1 true IT1277926B1 (it) 1997-11-12

Family

ID=11403544

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95RM000589A IT1277926B1 (it) 1995-09-01 1995-09-01 Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire

Country Status (17)

Country Link
US (1) US6706261B1 (it)
EP (1) EP0858345B1 (it)
JP (1) JP3157837B2 (it)
KR (1) KR100279539B1 (it)
CN (1) CN1138562C (it)
AT (1) ATE226446T1 (it)
AU (1) AU703300B2 (it)
CA (1) CA2229045C (it)
DE (1) DE69624498T2 (it)
DK (1) DK0858345T3 (it)
ES (1) ES2183007T3 (it)
HK (1) HK1015708A1 (it)
IT (1) IT1277926B1 (it)
MX (1) MX9801550A (it)
PT (1) PT858345E (it)
RU (1) RU2182014C2 (it)
WO (1) WO1997009064A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025277A1 (en) * 1999-10-07 2001-04-12 Maxygen Aps Single-chain antagonist polypeptides
FR2812813B1 (fr) * 2000-08-09 2004-11-26 Neovacs Utilisation d'immunogenes pour traiter ou prevenir au sein des tumeurs malignes les dereglements immunitaires induits par des facteurs extracellulaires
IL161672A0 (en) * 2004-04-29 2004-09-27 Yeda Res & Dev Compositions and methods for therapy of chemotherapy-induced neuropathy
FR2978964B1 (fr) 2011-08-09 2015-02-20 Conservatoire Nat Arts Composition vaccinale anti-il-6
WO2015024148A1 (zh) * 2013-08-23 2015-02-26 中国科学院微生物研究所 异源动物细胞因子突变体疫苗

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2677654B1 (fr) 1991-06-17 1995-11-17 Pasteur Merieux Serums Vacc Composes a effet immunogene anti-cytokine, a effet immunogene anticytostatique ou a effet vaccinal anti-infection a hiv.
US5338833A (en) * 1992-07-23 1994-08-16 The University Of North Carolina At Chapel Hill Carboxy terminal IL-6 muteins
IT1263022B (it) * 1992-11-06 1996-07-23 Angeletti P Ist Richerche Bio Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica.
IT1261787B (it) * 1993-06-23 1996-06-03 Angeletti P Ist Richerche Bio Metodologia per la selezione di superagonisti, antagonisti e super- antagonisti di ormoni del cui complesso recettoriale fa parte gp 130.
WO1997010338A1 (en) 1995-09-12 1997-03-20 Chiron Corporation Improved interleukin-6 receptor antagonist

Also Published As

Publication number Publication date
JPH10511111A (ja) 1998-10-27
DE69624498T2 (de) 2003-06-18
EP0858345B1 (en) 2002-10-23
ITRM950589A0 (it) 1995-09-01
AU703300B2 (en) 1999-03-25
ITRM950589A1 (it) 1997-03-01
EP0858345A1 (en) 1998-08-19
MX9801550A (es) 1998-05-31
PT858345E (pt) 2003-02-28
ES2183007T3 (es) 2003-03-16
US6706261B1 (en) 2004-03-16
KR100279539B1 (ko) 2001-02-01
DK0858345T3 (da) 2003-02-24
CA2229045C (en) 2005-10-25
CA2229045A1 (en) 1997-03-13
DE69624498D1 (de) 2002-11-28
HK1015708A1 (en) 1999-10-22
JP3157837B2 (ja) 2001-04-16
WO1997009064A1 (en) 1997-03-13
CN1198098A (zh) 1998-11-04
KR19990044321A (ko) 1999-06-25
RU2182014C2 (ru) 2002-05-10
CN1138562C (zh) 2004-02-18
AU6942896A (en) 1997-03-27
ATE226446T1 (de) 2002-11-15

Similar Documents

Publication Publication Date Title
FR2677654B1 (fr) Composes a effet immunogene anti-cytokine, a effet immunogene anticytostatique ou a effet vaccinal anti-infection a hiv.
BR9907995A (pt) Métodos imunológicos para modular miostatina em sujeitos vertebrados
DK0689449T3 (da) Præparater til anvendelse i humanterapi, kendetegnet ved kombination af et muramylpeptid med en cytokin
DK209088A (da) Medicinpraeparater, deres fremstilling og anvendelse
ATE271063T1 (de) Purin-l-nukleoside, deren analoga und verwendungen
ES2103276T3 (es) Composicion para la activacion del sistema inmunitario.
BR0010612A (pt) Vacinas
PT966447E (pt) Moleculas pequenas uteis no tratamento de doencas inflamatorias
NZ291262A (en) E. coli heat-labile enterotoxin derivatives and their use as oral adjuvants
BR0107972A (pt) Uso de uma proteìna ou polinucleotìdeo tat do hiv, nef do hiv, ou tat do hiv ligado(a) a uma proteìna ou polinucleotìdeo nef do hiv (nef-tat), e de uma proteìna ou polinucleotìdeo gp120 do hiv, método para imunizar um ser humano contra o hiv, e, composição de vacina para o uso humano
AR008799A1 (es) Composicion de vacuna para prevenir o tratar el paludismo; uso de dicha composicion para elaborar medicamentos y metodo para dicha profilaxis y dichotratamiento
BR9709845B1 (pt) preparaÇço aquosa de insulina, formulaÇço farmacÊutica parenteral, e, processso para aumentar a estabilidade quÍmica de uma preparaÇço de insulina.
AU1813701A (en) Interleukin-1 muteins useful as vaccine adjuvants
BR9610679A (pt) Antígenos de leishmania para uso na terapia e disgnose da leishmaniose
EP1471936A4 (en) HIV VACCINE AND METHOD OF USE
BR9815404A (pt) Composição adjuvante para estimular uma eficiente resposta imunológica a uma substância antigênica, vacina para administração a um animal, processo para estimular uma resposta imunológica eficaz em um animal a uma substância antigênica, e, uso da composição adjuvante.
IT1277926B1 (it) Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire
DK1146906T3 (da) Mukosalt afgivelsessystem
DE3851456D1 (de) Synergetische immunostimulierende Zusammensetzung und ihre Verwendung.
ES2089286T3 (es) Nuevas 2-amino-5-ciano-1,4-dihidropiridinas, procedimiento para su preparacion y su uso en medicamentos.
EE9800315A (et) Meetod südamepuudulikkuse käitlemiseks endoteliini antagonistide abil
IT1299264B1 (it) Composizioni farmaceutiche topiche utili per il trattamento di patologie cutanee su base infiammatoria, immunitaria o proliferativa
YU39396A (sh) Upotreba izolovanog prirodnog proteina gojaznosti za pripremu leka i njegova farmaceutska formulacija
DE69637435D1 (de) Saponin-zusammensetzungen und deren verwendung
BR0207899A (pt) Imunógeno de combinação para administração sequencial dos componentes para evocar uma resposta imune contra o papilomavìrus, produto farmacêutico, uso de um produto farmacêutico, e, método para evocar uma resposta imune contra o papilomavìrus em um paciente

Legal Events

Date Code Title Description
0001 Granted