BR9809860A - Processo para a produção contìnua de preparações sólidas, particuladas de substâncias bioativas, e, arranjo para executar o mesmo - Google Patents
Processo para a produção contìnua de preparações sólidas, particuladas de substâncias bioativas, e, arranjo para executar o mesmoInfo
- Publication number
- BR9809860A BR9809860A BR9809860-8A BR9809860A BR9809860A BR 9809860 A BR9809860 A BR 9809860A BR 9809860 A BR9809860 A BR 9809860A BR 9809860 A BR9809860 A BR 9809860A
- Authority
- BR
- Brazil
- Prior art keywords
- zone
- bioactive substances
- solid
- continuous production
- arrangement
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
- B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
- B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
- B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
- B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
- B29B7/58—Component parts, details or accessories; Auxiliary operations
- B29B7/72—Measuring, controlling or regulating
- B29B7/726—Measuring properties of mixture, e.g. temperature or density
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/80—Component parts, details or accessories; Auxiliary operations
- B29B7/82—Heating or cooling
- B29B7/826—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/80—Component parts, details or accessories; Auxiliary operations
- B29B7/88—Adding charges, i.e. additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/80—Component parts, details or accessories; Auxiliary operations
- B29B7/88—Adding charges, i.e. additives
- B29B7/90—Fillers or reinforcements, e.g. fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B9/00—Making granules
- B29B9/02—Making granules by dividing preformed material
- B29B9/06—Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B9/00—Making granules
- B29B9/12—Making granules characterised by structure or composition
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/022—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the choice of material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
- B29C48/402—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders the screws having intermeshing parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
- B29C48/875—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling for achieving a non-uniform temperature distribution, e.g. using barrels having both cooling and heating zones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/04—Particle-shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/268—Throttling of the flow, e.g. for cooperating with plasticising elements or for degassing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
- B29K2105/0035—Medical or pharmaceutical agents
Abstract
"PROCESSO PARA A PRODUçãO CONTìNUA DE PREPARAçõES SóLIDAS, PARTICULADAS DE SUBSTâNCIAS BIOATIVAS, E, ARRANJO PARA EXECUTAR O MESMO" Processo para a produção contínua de preparações particuladas sólidas, de substâncias bioativas, no qual as substâncias bioativas são homogeneamente dispersadas em uma matriz de auxiliares termoplásticos, em um extrusor de rosca dividido em uma pluralidade de zonas, em que existe primeiramente a fusão dos auxiliares de matriz e a mistura dos componentes bioativos com os auxiliares de matriz em uma zona aquecível, após a qual a mistura é resfriada, pré-triturada e finamente moída em uma zona de resfriamento, a geometria de rosca na zona de resfriamento sendo selecionada de tal forma que a zona de resfriamento consiste de uma zona de transporte, uma zona de mistura e uma zona de amassamento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19721467A DE19721467A1 (de) | 1997-05-22 | 1997-05-22 | Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe |
PCT/EP1998/002821 WO1998052684A1 (de) | 1997-05-22 | 1998-05-13 | Verfahren zur herstellung kleinteiliger zubereitungen biologisch aktiver stoffe |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9809860A true BR9809860A (pt) | 2000-06-27 |
BR9809860B1 BR9809860B1 (pt) | 2009-01-13 |
Family
ID=7830203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9809860-8A BR9809860B1 (pt) | 1997-05-22 | 1998-05-13 | processo para a produção contìnua de preparações sólidas, particuladas de substáncias bioativas, e, arranjo para executar o mesmo. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6318650B1 (pt) |
EP (1) | EP0988106B1 (pt) |
JP (1) | JP4173200B2 (pt) |
CN (1) | CN1105596C (pt) |
AT (1) | ATE204788T1 (pt) |
BR (1) | BR9809860B1 (pt) |
CA (1) | CA2286832C (pt) |
DE (2) | DE19721467A1 (pt) |
DK (1) | DK0988106T3 (pt) |
ES (1) | ES2162707T3 (pt) |
GR (1) | GR3036715T3 (pt) |
WO (1) | WO1998052684A1 (pt) |
Families Citing this family (78)
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IT1303671B1 (it) * | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio |
FR2776189A1 (fr) * | 1999-06-09 | 1999-09-24 | Lipha | Forme galenique a base de metformine a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption |
US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
WO2001034119A2 (en) | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
ATE324868T1 (de) * | 1999-12-09 | 2006-06-15 | Boots Co Plc | Komprimierte zubereitung enthaltend nichtsteroidale entzündungshemmer |
US20010036479A1 (en) * | 2000-01-14 | 2001-11-01 | Gillian Cave | Glyburide composition |
FR2804603B1 (fr) * | 2000-02-04 | 2004-01-23 | Rhodia Chimie Sa | Procede continu pour formuler sous forme de granules une ou plusieurs matieres actives pharmaceutiques |
US6499984B1 (en) * | 2000-05-22 | 2002-12-31 | Warner-Lambert Company | Continuous production of pharmaceutical granulation |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
US7883721B2 (en) | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
GB0102342D0 (en) | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
JP3444874B1 (ja) * | 2002-12-02 | 2003-09-08 | 高砂香料工業株式会社 | 顆粒状香料およびその製造方法 |
DE10300325A1 (de) | 2003-01-09 | 2004-07-22 | Hexal Ag | Granulat mit öliger Substanz, Herstellungsverfahren und Tablette |
EP1638527B1 (en) * | 2003-06-27 | 2006-10-25 | BIOPROGRESS S.p.A. | Composite product obtainable by cogrinding of an active principle with a copolymer n-vinyl-2-pyrrolidone/vinyl-acetate |
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DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
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JP2006176461A (ja) * | 2004-12-24 | 2006-07-06 | Dai Ichi Seiyaku Co Ltd | 粒状物 |
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EP3346991A1 (en) | 2015-09-10 | 2018-07-18 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
PT3445558T (pt) | 2016-04-22 | 2022-01-25 | Steerlife India Private Ltd | Processador de lóbulo fracionado e processo relacionado para extrusão de fundido quente |
ES2904866T3 (es) * | 2016-04-22 | 2022-04-06 | Steerlife India Private Ltd | Procesador de lóbulos fraccionarios y proceso relacionado para la granulación húmeda de material en polvo |
EP3492070A1 (en) | 2017-11-30 | 2019-06-05 | BIT Pharma GmbH | Process and device for preparing a solid dispersion |
CN109381434A (zh) * | 2018-12-03 | 2019-02-26 | 瀚晖制药有限公司 | 注射用亚胺培南西司他丁钠及其制作工艺 |
CN110882222B (zh) * | 2019-12-05 | 2021-12-03 | 北京博恩特药业有限公司 | 颗粒组合物及制备方法和应用 |
CN110859811B (zh) * | 2019-12-05 | 2021-12-07 | 北京博恩特药业有限公司 | 药物缓释组合物及制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3332629A1 (de) | 1983-09-09 | 1985-03-28 | Hermann Berstorff Maschinenbau Gmbh, 3000 Hannover | Verfahren und vorrichtung zum pulverisieren von polymeren |
DK172865B1 (da) | 1992-06-11 | 1999-08-23 | Perstorp Ab | Apparat til fremstilling af et granulat ud fra brugt termoplastisk materiale |
EP0582300B1 (en) | 1992-08-06 | 1998-01-07 | Toyota Jidosha Kabushiki Kaisha | Method and plant for continuously recycling waste parts with a coating made of synthetic resin |
EP0629479B1 (en) | 1993-06-16 | 1999-02-10 | Union Carbide Chemicals And Plastics Company, Inc. | Apparatus and process for continuously pelletizing synthetic thermoplastic materials |
DE4418837A1 (de) | 1994-05-30 | 1995-12-07 | Bayer Ag | Thermisches Granulierverfahren |
DE19522899C1 (de) * | 1995-06-23 | 1996-12-19 | Hexal Pharmaforschung Gmbh | Verfahren zum kontinuierlichen Ersintern eines Granulats |
-
1997
- 1997-05-22 DE DE19721467A patent/DE19721467A1/de not_active Withdrawn
-
1998
- 1998-05-13 CN CN98805101A patent/CN1105596C/zh not_active Expired - Fee Related
- 1998-05-13 CA CA002286832A patent/CA2286832C/en not_active Expired - Lifetime
- 1998-05-13 WO PCT/EP1998/002821 patent/WO1998052684A1/de active IP Right Grant
- 1998-05-13 BR BRPI9809860-8A patent/BR9809860B1/pt not_active IP Right Cessation
- 1998-05-13 ES ES98930687T patent/ES2162707T3/es not_active Expired - Lifetime
- 1998-05-13 AT AT98930687T patent/ATE204788T1/de active
- 1998-05-13 EP EP98930687A patent/EP0988106B1/de not_active Expired - Lifetime
- 1998-05-13 DK DK98930687T patent/DK0988106T3/da active
- 1998-05-13 JP JP54990598A patent/JP4173200B2/ja not_active Expired - Lifetime
- 1998-05-13 DE DE59801326T patent/DE59801326D1/de not_active Expired - Lifetime
- 1998-05-13 US US09/424,513 patent/US6318650B1/en not_active Expired - Lifetime
-
2001
- 2001-09-26 GR GR20010401572T patent/GR3036715T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2286832C (en) | 2006-03-07 |
ATE204788T1 (de) | 2001-09-15 |
BR9809860B1 (pt) | 2009-01-13 |
WO1998052684A1 (de) | 1998-11-26 |
DE19721467A1 (de) | 1998-11-26 |
CA2286832A1 (en) | 1998-11-26 |
CN1255877A (zh) | 2000-06-07 |
EP0988106B1 (de) | 2001-08-29 |
JP4173200B2 (ja) | 2008-10-29 |
DE59801326D1 (de) | 2001-10-04 |
CN1105596C (zh) | 2003-04-16 |
US6318650B1 (en) | 2001-11-20 |
EP0988106A1 (de) | 2000-03-29 |
DK0988106T3 (da) | 2001-10-08 |
ES2162707T3 (es) | 2002-01-01 |
JP2001527464A (ja) | 2001-12-25 |
GR3036715T3 (en) | 2001-12-31 |
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