BR9807144A - Microorganismos com produção acrescida de ácido clavulânico - Google Patents

Microorganismos com produção acrescida de ácido clavulânico

Info

Publication number
BR9807144A
BR9807144A BR9807144-0A BR9807144A BR9807144A BR 9807144 A BR9807144 A BR 9807144A BR 9807144 A BR9807144 A BR 9807144A BR 9807144 A BR9807144 A BR 9807144A
Authority
BR
Brazil
Prior art keywords
microorganisms
clavulanic acid
increased production
clavulanic
acid
Prior art date
Application number
BR9807144-0A
Other languages
English (en)
Inventor
Barry Barton
John Patrick Griffin
Cecilia Anders
Susan Jensen
Roy Henry Mosher
Ashish Sudhakar Paradkar
Original Assignee
Smithkline Beecham Plc
Univ Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, Univ Alberta filed Critical Smithkline Beecham Plc
Publication of BR9807144A publication Critical patent/BR9807144A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"MICROORGANISMOS COM PRODUçãO ACRESCIDA DE áCIDO CLAVULâNICO". Novos genes bacterianos, microorganismos e processsos para aperfeiçoar a fabricação de clavams 5R, por exemplo, ácido clavulânico.
BR9807144-0A 1997-02-04 1998-02-02 Microorganismos com produção acrescida de ácido clavulânico BR9807144A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9702218.0A GB9702218D0 (en) 1997-02-04 1997-02-04 Novel product
PCT/EP1998/000644 WO1998033896A2 (en) 1997-02-04 1998-02-02 Microorganisms with increased production of clavulanic acid

Publications (1)

Publication Number Publication Date
BR9807144A true BR9807144A (pt) 2000-01-25

Family

ID=10807030

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807144-0A BR9807144A (pt) 1997-02-04 1998-02-02 Microorganismos com produção acrescida de ácido clavulânico

Country Status (32)

Country Link
US (5) US6936458B1 (pt)
EP (2) EP1405913A3 (pt)
JP (2) JP4227199B2 (pt)
KR (2) KR20050053794A (pt)
CN (2) CN1192107C (pt)
AP (1) AP1320A (pt)
AR (2) AR011100A1 (pt)
AT (1) ATE312926T1 (pt)
AU (1) AU735782B2 (pt)
BG (1) BG103704A (pt)
BR (1) BR9807144A (pt)
CA (1) CA2279207A1 (pt)
DE (1) DE69832783T2 (pt)
DZ (1) DZ2413A1 (pt)
EA (1) EA003773B1 (pt)
ES (1) ES2255149T3 (pt)
GB (1) GB9702218D0 (pt)
HU (1) HUP0001048A3 (pt)
ID (1) ID22144A (pt)
IL (1) IL131043A0 (pt)
MA (1) MA24464A1 (pt)
MY (1) MY140928A (pt)
NO (1) NO993758L (pt)
NZ (1) NZ336894A (pt)
OA (1) OA11082A (pt)
PL (1) PL334961A1 (pt)
SK (1) SK105499A3 (pt)
TR (1) TR199901862T2 (pt)
TW (2) TW589377B (pt)
UY (2) UY24874A1 (pt)
WO (1) WO1998033896A2 (pt)
ZA (1) ZA98868B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7983400A (en) * 1999-09-16 2001-04-17 Johns Hopkins University, The Improvement of clavulanic acid production
EP1228218A2 (en) * 1999-10-22 2002-08-07 Smithkline Beecham Plc 5r clavam producing microorganisms with deleted lat and cvm genes
GB0308696D0 (en) * 2003-04-15 2003-05-21 Glaxo Group Ltd New process
EP2589663A1 (en) 2011-11-04 2013-05-08 LEK Pharmaceuticals d.d. Process for production of clavulanic acid
CN107964522B (zh) * 2018-01-04 2020-12-08 上海交通大学 海洋链霉菌dut11及其抗补体活性应用
EP3994154A1 (en) 2019-07-05 2022-05-11 GlaxoSmithKline Intellectual Property (No.2) Limited Streptomyces clavuligerus

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
SE421796B (sv) * 1975-02-07 1982-02-01 Glaxo Lab Ltd Forfarande for rening av klavulansyra och dess salter
GB1585661A (en) 1976-06-08 1981-03-11 Glaxo Lab Ltd Clavam derivatives
JPS589679B2 (ja) 1977-02-24 1983-02-22 武田薬品工業株式会社 抗生物質の製造法
US4202819A (en) 1979-05-04 1980-05-13 Hoffman-La Roche Inc. 2-(3-Alanyl)clavam antibiotic
GB8521516D0 (en) * 1985-08-29 1985-10-02 Beecham Group Plc Compounds
GB9020683D0 (en) 1990-09-22 1990-11-07 Univ Strathclyde Isolation of dna
CA2108113C (en) * 1993-10-08 2006-12-05 Susan E. Jensen Dna sequence encoding enzymes of clavulanic acid biosynthesis

Also Published As

Publication number Publication date
DE69832783T2 (de) 2006-07-20
ZA98868B (en) 1999-08-03
TW589377B (en) 2004-06-01
CN1251612A (zh) 2000-04-26
EP1405913A3 (en) 2004-08-04
US7344869B2 (en) 2008-03-18
EA003773B1 (ru) 2003-08-28
ID22144A (id) 1999-09-09
HUP0001048A2 (hu) 2000-08-28
PL334961A1 (en) 2000-03-27
SK105499A3 (en) 2000-05-16
EP0970198B1 (en) 2005-12-14
JP2001511001A (ja) 2001-08-07
EP1405913A2 (en) 2004-04-07
EA199900718A1 (ru) 2000-02-28
UY24874A1 (es) 2001-07-31
WO1998033896A2 (en) 1998-08-06
AP1320A (en) 2004-10-29
US20070298470A1 (en) 2007-12-27
AU735782B2 (en) 2001-07-12
JP4227199B2 (ja) 2009-02-18
US20030124690A1 (en) 2003-07-03
AR011100A1 (es) 2000-08-02
MY140928A (en) 2010-02-12
CN1696301A (zh) 2005-11-16
BG103704A (en) 2000-05-31
MA24464A1 (fr) 1998-10-01
UY25197A1 (es) 1998-11-27
ATE312926T1 (de) 2005-12-15
WO1998033896A3 (en) 1998-11-19
JP5042186B2 (ja) 2012-10-03
EP0970198A2 (en) 2000-01-12
IL131043A0 (en) 2001-01-28
US6936458B1 (en) 2005-08-30
US20030022321A1 (en) 2003-01-30
US20030166175A1 (en) 2003-09-04
AR018304A2 (es) 2001-11-14
ES2255149T3 (es) 2006-06-16
GB9702218D0 (en) 1997-03-26
AU6295398A (en) 1998-08-25
NZ336894A (en) 2001-08-31
KR100514964B1 (ko) 2005-09-15
HUP0001048A3 (en) 2001-09-28
TW200307041A (en) 2003-12-01
KR20000070723A (ko) 2000-11-25
TR199901862T2 (xx) 2000-12-21
CA2279207A1 (en) 1998-08-06
JP2009022298A (ja) 2009-02-05
DZ2413A1 (fr) 2003-01-04
KR20050053794A (ko) 2005-06-08
CN1192107C (zh) 2005-03-09
DE69832783D1 (de) 2006-01-19
AP9901614A0 (en) 1999-09-30
NO993758D0 (no) 1999-08-03
OA11082A (en) 2003-03-13
NO993758L (no) 1999-08-03

Similar Documents

Publication Publication Date Title
AU5485698A (en) Oxyiminopregnancarbolactone
ID24398A (id) Metode untuk menghasilkan asam l-amino
ZA963737B (en) Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism.
KR950703653A (ko) 트립토판 생산용 미생물 및 그 생산방법
EP0251584A3 (en) A synchronization service for a distributed operating system or the like
FR2783523B1 (fr) Fuco-oligosaccharides, enzyme pour leur preparation a partir des fucanes, bacterie productrice de l'enzyme et applications des fuco-oligosaccharides a la protection des plantes
IL151960A0 (en) Production of polyketides
HUP9801420A2 (hu) Eljárás L-aminosavak előállítására fermentálással
ATE299372T1 (de) Antiparasitäre mittel
AU6577996A (en) Fermented formula feed, its production, and uses
DE3771882D1 (de) Glycopeptide antibiotika, ihre herstellung und verwendung und mikroorganismen, die diese produzieren.
BR9807144A (pt) Microorganismos com produção acrescida de ácido clavulânico
AU2912297A (en) Antibiotic producing microbe
AU6475600A (en) Antibiotic caprazamycins and process for producing the same
BR0001342A (pt) Processo para a produção de l-aminoácidos por meio de fermentação usando bactérias corineformes
PT1307436E (pt) Processo para a preparacao de derivados de bacatina iii
ATE231510T1 (de) Penamsulfone als beta-laktamase inhibitoren
ECSP982392A (es) Nuevos compuestos
GB9424950D0 (en) Novel process
DE68901024D1 (de) Gegen anaerobe bakterien wirksame antibiotika, ihre produktion und enterobakter-staemme, die sie produzieren.
MX9505097A (es) 1,4-dihidropiridinas con estructura puente en la posicion 1,2, procedimiento para su obtencion y medicamentos que las contienen.
AU6301796A (en) Process to increase the production of clavam antibiotics
ES2149978T3 (es) Nuevo tiodepsipeptido aislado a partir de un actinomiceto marino.
MX9601913A (es) Agentes fungicidas ll-15g256-gamma, ll-15g256-delta y ll-15g256-epsilon producidos por ll-15g256 (hypoxylon oceanicum).
SE8302126D0 (sv) Forfarande for framstellning av antracyklinantibiotika med anticancerverkan, samt ny mikro-organismstam

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1928 DE 18/12/2007.