AR018304A2 - Acido clavulanico y composicion que lo contiene - Google Patents
Acido clavulanico y composicion que lo contieneInfo
- Publication number
- AR018304A2 AR018304A2 ARP990100913A ARP990100913A AR018304A2 AR 018304 A2 AR018304 A2 AR 018304A2 AR P990100913 A ARP990100913 A AR P990100913A AR P990100913 A ARP990100913 A AR P990100913A AR 018304 A2 AR018304 A2 AR 018304A2
- Authority
- AR
- Argentina
- Prior art keywords
- clavulanic acid
- composition containing
- clavam
- production
- composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Abstract
Acido clavulánico que es obtenible por la fermentacion de un microorganismo que tiene facultades para la produccion de 5R-clavam y una produccionbaja o nula de 5S-clavam; y composicion que lo contiene.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9702218.0A GB9702218D0 (en) | 1997-02-04 | 1997-02-04 | Novel product |
Publications (1)
Publication Number | Publication Date |
---|---|
AR018304A2 true AR018304A2 (es) | 2001-11-14 |
Family
ID=10807030
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980100451A AR011100A1 (es) | 1997-02-04 | 1998-02-02 | Adn obtenible de s. clavuligerus, vector que comprende dicho adn, organismo hospedador, s. clavuligerus, procedimiento para mejorar la produccion de5r-clavam en un microorganismo adecuado, microorganismo que tiene las facultades para la produccion de 5r-clavam y una produccion baja o nula de 5s- |
ARP990100913A AR018304A2 (es) | 1997-02-04 | 1999-03-04 | Acido clavulanico y composicion que lo contiene |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980100451A AR011100A1 (es) | 1997-02-04 | 1998-02-02 | Adn obtenible de s. clavuligerus, vector que comprende dicho adn, organismo hospedador, s. clavuligerus, procedimiento para mejorar la produccion de5r-clavam en un microorganismo adecuado, microorganismo que tiene las facultades para la produccion de 5r-clavam y una produccion baja o nula de 5s- |
Country Status (32)
Country | Link |
---|---|
US (5) | US6936458B1 (es) |
EP (2) | EP0970198B1 (es) |
JP (2) | JP4227199B2 (es) |
KR (2) | KR20050053794A (es) |
CN (2) | CN1192107C (es) |
AP (1) | AP1320A (es) |
AR (2) | AR011100A1 (es) |
AT (1) | ATE312926T1 (es) |
AU (1) | AU735782B2 (es) |
BG (1) | BG103704A (es) |
BR (1) | BR9807144A (es) |
CA (1) | CA2279207A1 (es) |
DE (1) | DE69832783T2 (es) |
DZ (1) | DZ2413A1 (es) |
EA (1) | EA003773B1 (es) |
ES (1) | ES2255149T3 (es) |
GB (1) | GB9702218D0 (es) |
HU (1) | HUP0001048A3 (es) |
ID (1) | ID22144A (es) |
IL (1) | IL131043A0 (es) |
MA (1) | MA24464A1 (es) |
MY (1) | MY140928A (es) |
NO (1) | NO993758L (es) |
NZ (1) | NZ336894A (es) |
OA (1) | OA11082A (es) |
PL (1) | PL334961A1 (es) |
SK (1) | SK105499A3 (es) |
TR (1) | TR199901862T2 (es) |
TW (2) | TW200307041A (es) |
UY (2) | UY24874A1 (es) |
WO (1) | WO1998033896A2 (es) |
ZA (1) | ZA98868B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001019959A1 (en) * | 1999-09-16 | 2001-03-22 | The Johns Hopkins University | Improvement of clavulanic acid production |
WO2001030977A2 (en) * | 1999-10-22 | 2001-05-03 | Smithkline Beecham P.L.C. | 5r clavam producing microorganisms with deleted lat and cvm genes |
GB0308696D0 (en) * | 2003-04-15 | 2003-05-21 | Glaxo Group Ltd | New process |
EP2589663A1 (en) | 2011-11-04 | 2013-05-08 | LEK Pharmaceuticals d.d. | Process for production of clavulanic acid |
CN107964522B (zh) * | 2018-01-04 | 2020-12-08 | 上海交通大学 | 海洋链霉菌dut11及其抗补体活性应用 |
EP3994154A1 (en) | 2019-07-05 | 2022-05-11 | GlaxoSmithKline Intellectual Property (No.2) Limited | Streptomyces clavuligerus |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4110165A (en) * | 1974-04-20 | 1978-08-29 | Beecham Group Limited | Process for the production of clavulanic acid |
SE421796B (sv) * | 1975-02-07 | 1982-02-01 | Glaxo Lab Ltd | Forfarande for rening av klavulansyra och dess salter |
GB1585661A (en) | 1976-06-08 | 1981-03-11 | Glaxo Lab Ltd | Clavam derivatives |
JPS589679B2 (ja) | 1977-02-24 | 1983-02-22 | 武田薬品工業株式会社 | 抗生物質の製造法 |
US4202819A (en) | 1979-05-04 | 1980-05-13 | Hoffman-La Roche Inc. | 2-(3-Alanyl)clavam antibiotic |
GB8521516D0 (en) * | 1985-08-29 | 1985-10-02 | Beecham Group Plc | Compounds |
GB9020683D0 (en) | 1990-09-22 | 1990-11-07 | Univ Strathclyde | Isolation of dna |
CA2108113C (en) * | 1993-10-08 | 2006-12-05 | Susan E. Jensen | Dna sequence encoding enzymes of clavulanic acid biosynthesis |
-
1997
- 1997-02-04 GB GBGB9702218.0A patent/GB9702218D0/en active Pending
-
1998
- 1998-01-27 MY MYPI98000390A patent/MY140928A/en unknown
- 1998-02-02 KR KR1020057007954A patent/KR20050053794A/ko not_active Application Discontinuation
- 1998-02-02 ID IDW990801A patent/ID22144A/id unknown
- 1998-02-02 WO PCT/EP1998/000644 patent/WO1998033896A2/en not_active Application Discontinuation
- 1998-02-02 EP EP98906924A patent/EP0970198B1/en not_active Expired - Lifetime
- 1998-02-02 CN CNB988037475A patent/CN1192107C/zh not_active Expired - Lifetime
- 1998-02-02 DE DE69832783T patent/DE69832783T2/de not_active Expired - Lifetime
- 1998-02-02 EP EP03078351A patent/EP1405913A3/en not_active Withdrawn
- 1998-02-02 EA EA199900718A patent/EA003773B1/ru not_active IP Right Cessation
- 1998-02-02 CA CA002279207A patent/CA2279207A1/en not_active Abandoned
- 1998-02-02 BR BR9807144-0A patent/BR9807144A/pt not_active IP Right Cessation
- 1998-02-02 PL PL98334961A patent/PL334961A1/xx unknown
- 1998-02-02 JP JP53256398A patent/JP4227199B2/ja not_active Expired - Lifetime
- 1998-02-02 MA MA24953A patent/MA24464A1/fr unknown
- 1998-02-02 SK SK1054-99A patent/SK105499A3/sk unknown
- 1998-02-02 AT AT98906924T patent/ATE312926T1/de not_active IP Right Cessation
- 1998-02-02 HU HU0001048A patent/HUP0001048A3/hu unknown
- 1998-02-02 NZ NZ336894A patent/NZ336894A/en unknown
- 1998-02-02 AR ARP980100451A patent/AR011100A1/es unknown
- 1998-02-02 TR TR1999/01862T patent/TR199901862T2/xx unknown
- 1998-02-02 IL IL13104398A patent/IL131043A0/xx unknown
- 1998-02-02 ES ES98906924T patent/ES2255149T3/es not_active Expired - Lifetime
- 1998-02-02 KR KR10-1999-7006973A patent/KR100514964B1/ko not_active IP Right Cessation
- 1998-02-02 AP APAP/P/1999/001614A patent/AP1320A/en active
- 1998-02-02 AU AU62953/98A patent/AU735782B2/en not_active Ceased
- 1998-02-02 CN CNA2004100105601A patent/CN1696301A/zh active Pending
- 1998-02-03 UY UY24874A patent/UY24874A1/es not_active Application Discontinuation
- 1998-02-03 ZA ZA9800868A patent/ZA98868B/xx unknown
- 1998-02-04 DZ DZ980023A patent/DZ2413A1/xx active
- 1998-05-12 TW TW092119091A patent/TW200307041A/zh unknown
- 1998-05-12 TW TW087107252A patent/TW589377B/zh not_active IP Right Cessation
- 1998-09-30 UY UY25197A patent/UY25197A1/es not_active IP Right Cessation
-
1999
- 1999-03-04 AR ARP990100913A patent/AR018304A2/es unknown
- 1999-07-09 US US09/350,702 patent/US6936458B1/en not_active Expired - Lifetime
- 1999-08-03 NO NO993758A patent/NO993758L/no not_active Application Discontinuation
- 1999-08-04 OA OA9900170A patent/OA11082A/en unknown
- 1999-09-01 BG BG103704A patent/BG103704A/xx unknown
-
2002
- 2002-02-08 US US10/071,338 patent/US20030022321A1/en not_active Abandoned
- 2002-11-07 US US10/289,980 patent/US20030124690A1/en not_active Abandoned
- 2002-11-07 US US10/214,519 patent/US20030166175A1/en not_active Abandoned
-
2004
- 2004-10-08 US US10/961,636 patent/US7344869B2/en not_active Expired - Fee Related
-
2008
- 2008-10-01 JP JP2008256485A patent/JP5042186B2/ja not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |